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Hit and lead criteria in drug discovery for infectious diseases of the developing world.
Published in:
2015
By:
- Katsuno, Kei;
- Burrows, Jeremy N.;
- Duncan, Ken;
- van Huijsduijnen, Rob Hooft;
- Kaneko, Takushi;
- Kita, Kiyoshi;
- Mowbray, Charles E.;
- Schmatz, Dennis;
- Warner, Peter;
- Slingsby, B. T.;
- Hooft van Huijsduijnen, Rob
Publication type:
journal article
The Parasite Reduction Ratio (PRR) Assay Version 2: Standardized Assessment of Plasmodium falciparum Viability after Antimalarial Treatment In Vitro.
Published in:
Pharmaceuticals (14248247), 2023, v. 16, n. 2, p. 163, doi. 10.3390/ph16020163
By:
- Walz, Annabelle;
- Duffey, Maëlle;
- Aljayyoussi, Ghaith;
- Sax, Sibylle;
- Leroy, Didier;
- Besson, Dominique;
- Burrows, Jeremy N.;
- Cherkaoui-Rbati, Mohammed H.;
- Gobeau, Nathalie;
- Westwood, Marie-Anne;
- Siethoff, Christoph;
- Gamo, Francisco-Javier;
- Mäser, Pascal;
- Wittlin, Sergio
Publication type:
Article
A Proposed Target Product Profile and Developmental Cascade for New Cryptosporidiosis Treatments.
Published in:
PLoS Neglected Tropical Diseases, 2015, v. 9, n. 10, p. 1, doi. 10.1371/journal.pntd.0003987
By:
- Huston, Christopher D.;
- Spangenberg, Thomas;
- Burrows, Jeremy;
- Willis, Paul;
- Wells, Timothy N. C.;
- van Voorhis, Wesley
Publication type:
Article
The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases.
Published in:
PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0062906
By:
- Spangenberg, Thomas;
- Burrows, Jeremy N.;
- Kowalczyk, Paul;
- McDonald, Simon;
- Wells, Timothy N. C.;
- Willis, Paul
Publication type:
Article
P. falciparum In Vitro Killing Rates Allow to Discriminate between Different Antimalarial Mode-of-Action.
Published in:
PLoS ONE, 2012, v. 7, n. 2, p. 1, doi. 10.1371/journal.pone.0030949
By:
- Sanz, Laura M.;
- Crespo, Benigno;
- De-Cózar, Cristina;
- Ding, Xavier C.;
- Llergo, Jose L.;
- Burrows, Jeremy N.;
- García-Bustos, Jose F.;
- Gamo, Francisco-Javier
Publication type:
Article
Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus.
Published in:
Parasites & Vectors, 2017, v. 10, p. 1, doi. 10.1186/s13071-017-2191-8
By:
- Yaqing Jiao;
- Sarah Preston;
- Hongjian Song;
- Jabbar, Abdul;
- Yuxiu Liu;
- Baell, Jonathan;
- Hofmann, Andreas;
- Hutchinson, Dana;
- Tao Wang;
- Koehler, Anson V.;
- Fisher, Gillian M.;
- Andrews, Katherine T.;
- Laleu, Benoît;
- Palmer, Michael J.;
- Burrows, Jeremy N.;
- Wells, Timothy N. C.;
- Qingmin Wang;
- Gasser, Robin B.
Publication type:
Article
Actives from MMV Open Access Boxes? A suggested way forward.
Published in:
PLoS Pathogens, 2021, v. 17, n. 4, p. 1, doi. 10.1371/journal.ppat.1009384
By:
- Samby, Kirandeep;
- Willis, Paul A.;
- Burrows, Jeremy N.;
- Laleu, Benoît;
- Webborn, Peter J. H.
Publication type:
Article
Author Correction: Arylmethylamino steroids as antiparasitic agents.
Published in:
2019
By:
- Krieg, Reimar;
- Jortzik, Esther;
- Goetz, Alice-Anne;
- Blandin, Stéphanie;
- Wittlin, Sergio;
- Elhabiri, Mourad;
- Rahbari, Mahsa;
- Nuryyeva, Selbi;
- Voigt, Kerstin;
- Dahse, Hans-Martin;
- Brakhage, Axel;
- Beckmann, Svenja;
- Quack, Thomas;
- Grevelding, Christoph G.;
- Pinkerton, Anthony B.;
- Schönecker, Bruno;
- Burrows, Jeremy;
- Davioud-Charvet, Elisabeth;
- Rahlfs, Stefan;
- Becker, Katja
Publication type:
Correction Notice
Arylmethylamino steroids as antiparasitic agents.
Published in:
Nature Communications, 2017, v. 8, n. 2, p. 14478, doi. 10.1038/ncomms14478
By:
- Krieg, Reimar;
- Jortzik, Esther;
- Goetz, Alice-Anne;
- Blandin, Stéphanie;
- Wittlin, Sergio;
- Elhabiri, Mourad;
- Rahbari, Mahsa;
- Nuryyeva, Selbi;
- Voigt, Kerstin;
- Dahse, Hans-Martin;
- Brakhage, Axel;
- Beckmann, Svenja;
- Quack, Thomas;
- Grevelding, Christoph G.;
- Pinkerton, Anthony B.;
- Schönecker, Bruno;
- Burrows, Jeremy;
- Davioud-Charvet, Elisabeth;
- Rahlfs, Stefan;
- Becker, Katja
Publication type:
Article
The Antifungal Itraconazole Is a Potent Inhibitor of Chikungunya Virus Replication.
Published in:
Viruses (1999-4915), 2022, v. 14, n. 7, p. N.PAG, doi. 10.3390/v14071351
By:
- Policastro, Lucca R.;
- Dolci, Isabela;
- Godoy, Andre S.;
- Silva Júnior, José V. J.;
- Ruiz, Uriel E. A.;
- Santos, Igor A.;
- Jardim, Ana C. G.;
- Samby, Kirandeep;
- Burrows, Jeremy N.;
- Wells, Timothy N. C.;
- Gil, Laura H. V. G.;
- Oliva, Glaucius;
- Fernandes, Rafaela S.
Publication type:
Article
Development and application of a PBPK modeling strategy to support antimalarial drug development.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 9, p. 1335, doi. 10.1002/psp4.13013
By:
- Abla, Nada;
- Howgate, Eleanor;
- Rowland‐Yeo, Karen;
- Dickins, Maurice;
- Bergagnini‐Kolev, Mackenzie C.;
- Chen, Kuan‐Fu;
- McFeely, Savannah;
- Bonner, Jennifer J.;
- Santos, Laura G. A.;
- Gobeau, Nathalie;
- Burt, Howard;
- Barter, Zoe;
- Jones, Hannah M.;
- Wesche, David;
- Charman, Susan A.;
- Möhrle, Jörg J.;
- Burrows, Jeremy N.;
- Almond, Lisa M.
Publication type:
Article
In vitro and in vivo characterization of the antimalarial lead compound SSJ-I83 in Plasmodium models.
Published in:
Drug Design, Development & Therapy, 2013, v. 7, p. 1377, doi. 10.2147/DDDT.S51298
By:
- Schleiferböck, Sarah;
- Scheurer, Christian;
- Ihara, Masataka;
- Itoh, Isamu;
- Bathurst, Ian;
- Burrows, Jeremy N.;
- Fantauzzi, Pascal;
- Lotharius, Julie;
- Charman, Susan A.;
- Morizzi, Julia;
- Shackleford, David M.;
- White, Karen L.;
- Brun, Reto;
- Wittlin, Sergio
Publication type:
Article
Partnering to fight malaria in India: Past, present and future.
Published in:
Journal of Vector Borne Diseases, 2019, v. 56, n. 1, p. 15, doi. 10.4103/0972-9062.257769
By:
- Samby, Kirandeep;
- Ramachandruni, Hanu;
- Banerji, Jaya;
- Burrows, Jeremy N.;
- Daumerie, Penny Grewal;
- van Huijsduijnen, Rob A. M. Hooft;
- Duparc, Stephan;
- Wells, Timothy N. C.
Publication type:
Article
Blocking Plasmodium Development in Mosquitoes: A Powerful New Approach for Expanding Malaria Control Efforts.
Published in:
American Journal of Tropical Medicine & Hygiene, 2019, v. 101, n. 4, p. 734, doi. 10.4269/ajtmh.19-0318
By:
- Burrows, Jeremy;
- Fidock, David A.;
- Miller, Robert Scott;
- Rees, Sarah
Publication type:
Article
New developments in anti-malarial target candidate and product profiles.
Published in:
Malaria Journal, 2017, v. 16, p. 1, doi. 10.1186/s12936-016-1675-x
By:
- Burrows, Jeremy N.;
- Duparc, Stephan;
- Gutteridge, Winston E.;
- van Huijsduijnen, Rob Hooft;
- Kaszubska, Wiweka;
- Macintyre, Fiona;
- Mazzuri, Sébastien;
- Möhrle, Jörg J.;
- Wells, Timothy N. C.
Publication type:
Article
Microbiology: Malaria runs rings round artemisinin.
Published in:
Nature, 2015, v. 520, n. 7549, p. 628, doi. 10.1038/nature14387
By:
- Burrows, Jeremy
Publication type:
Article
Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone.
Published in:
Communications Biology, 2019, v. 2, n. 1, p. N.PAG, doi. 10.1038/s42003-019-0397-3
By:
- Skinner-Adams, Tina S.;
- Fisher, Gillian M.;
- Riches, Andrew G.;
- Hutt, Oliver E.;
- Jarvis, Karen E.;
- Wilson, Tony;
- von Itzstein, Mark;
- Chopra, Pradeep;
- Antonova-Koch, Yevgeniya;
- Meister, Stephan;
- Winzeler, Elizabeth A.;
- Clarke, Mary;
- Fidock, David A.;
- Burrows, Jeremy N.;
- Ryan, John H.;
- Andrews, Katherine T.
Publication type:
Article
MAIP: a web service for predicting blood‐stage malaria inhibitors.
Published in:
Journal of Cheminformatics, 2021, v. 13, n. 1, p. 1, doi. 10.1186/s13321-021-00487-2
By:
- Bosc, Nicolas;
- Felix, Eloy;
- Arcila, Ricardo;
- Mendez, David;
- Saunders, Martin R.;
- Green, Darren V. S.;
- Ochoada, Jason;
- Shelat, Anang A.;
- Martin, Eric J.;
- Iyer, Preeti;
- Engkvist, Ola;
- Verras, Andreas;
- Duffy, James;
- Burrows, Jeremy;
- Gardner, J. Mark F.;
- Leach, Andrew R.
Publication type:
Article
MAIP: a web service for predicting blood‐stage malaria inhibitors.
Published in:
Journal of Cheminformatics, 2021, v. 13, n. 1, p. 1, doi. 10.1186/s13321-021-00487-2
By:
- Bosc, Nicolas;
- Felix, Eloy;
- Arcila, Ricardo;
- Mendez, David;
- Saunders, Martin R.;
- Green, Darren V. S.;
- Ochoada, Jason;
- Shelat, Anang A.;
- Martin, Eric J.;
- Iyer, Preeti;
- Engkvist, Ola;
- Verras, Andreas;
- Duffy, James;
- Burrows, Jeremy;
- Gardner, J. Mark F.;
- Leach, Andrew R.
Publication type:
Article
A discovery and development roadmap for new endectocidal transmission-blocking agents in malaria.
Published in:
Malaria Journal, 2018, v. 17, n. 1, p. N.PAG, doi. 10.1186/s12936-018-2598-5
By:
- Burrows, Jeremy;
- Slater, Hannah;
- Macintyre, Fiona;
- Rees, Sarah;
- Thomas, Anna;
- Okumu, Fredros;
- Hooft van Huijsduijnen, Rob;
- Duparc, Stephan;
- Wells, Timothy N. C.
Publication type:
Article
Injectable anti-malarials revisited: discovery and development of new agents to protect against malaria.
Published in:
Malaria Journal, 2018, v. 17, n. 1, p. N.PAG, doi. 10.1186/s12936-018-2549-1
By:
- Macintyre, Fiona;
- Ramachandruni, Hanu;
- Burrows, Jeremy N.;
- Holm, René;
- Thomas, Anna;
- Möhrle, Jörg J.;
- Duparc, Stephan;
- Hooft van Huijsduijnen, Rob;
- Greenwood, Brian;
- Gutteridge, Winston E.;
- Wells, Timothy N. C.;
- Kaszubska, Wiweka
Publication type:
Article
Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.
Published in:
2016
By:
- Le Bihan, Amélie;
- de Kanter, Ruben;
- Angulo-Barturen, Iñigo;
- Binkert, Christoph;
- Boss, Christoph;
- Brun, Reto;
- Brunner, Ralf;
- Buchmann, Stephan;
- Burrows, Jeremy;
- Dechering, Koen J.;
- Delves, Michael;
- Ewerling, Sonja;
- Ferrer, Santiago;
- Fischli, Christoph;
- Gamo–Benito, Francisco Javier;
- Gnädig, Nina F.;
- Heidmann, Bibia;
- Jiménez-Díaz, María Belén;
- Leroy, Didier;
- Martínez, Maria Santos
Publication type:
journal article
Identification of Plasmodium falciparum Mitochondrial Malate: Quinone Oxidoreductase Inhibitors from the Pathogen Box.
Published in:
Genes, 2019, v. 10, n. 6, p. 471, doi. 10.3390/genes10060471
By:
- Wang, Xinying;
- Miyazaki, Yukiko;
- Inaoka, Daniel Ken;
- Hartuti, Endah Dwi;
- Watanabe, Yoh-Ichi;
- Shiba, Tomoo;
- Harada, Shigeharu;
- Saimoto, Hiroyuki;
- Burrows, Jeremy Nicholas;
- Benito, Francisco Javier Gamo;
- Nozaki, Tomoyoshi;
- Kita, Kiyoshi
Publication type:
Article
Screening and hit evaluation of a chemical library against blood-stage Plasmodium falciparum.
Published in:
Malaria Journal, 2014, v. 13, n. 1, p. 1, doi. 10.1186/1475-2875-13-190
By:
- Avery, Vicky M.;
- Bashyam, Sridevi;
- Burrows, Jeremy N.;
- Duffy, Sandra;
- Papadatos, George;
- Puthukkuti, Shyni;
- Sambandan, Yuvaraj;
- Singh, Shivendra;
- Spangenberg, Thomas;
- Waterson, David;
- Willis, Paul
Publication type:
Article
Designing the next generation of medicines for malaria control and eradication.
Published in:
Malaria Journal, 2013, v. 12, n. 1, p. 1, doi. 10.1186/1475-2875-12-187
By:
- Burrows, Jeremy N.;
- Van Huijsduijnen, Rob Hooft;
- Möhrle, Jörg J.;
- Oeuvray, Claude;
- Wells, Timothy N. C.
Publication type:
Article
The global pipeline of new medicines for the control and elimination of malaria.
Published in:
Malaria Journal, 2012, v. 11, n. 1, p. 316, doi. 10.1186/1475-2875-11-316
By:
- Anthony, Melinda P;
- Burrows, Jeremy N;
- Duparc, Stephan;
- JMoehrle, Joerg;
- Wells, Timothy NC
Publication type:
Article
Protein target similarity is positive predictor of in vitro antipathogenic activity: a drug repurposing strategy for Plasmodium falciparum.
Published in:
Journal of Cheminformatics, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13321-024-00856-7
By:
- Mogire, Reagan M.;
- Miruka, Silviane A.;
- Juma, Dennis W.;
- McNamara, Case W.;
- Andagalu, Ben;
- Burrows, Jeremy N.;
- Chenu, Elodie;
- Duffy, James;
- Ogutu, Bernhards R.;
- Akala, Hoseah M.
Publication type:
Article
Screening the pandemic response box identified benzimidazole carbamates, Olorofim and ravuconazole as promising drug candidates for the treatment of eumycetoma.
Published in:
PLoS Neglected Tropical Diseases, 2022, v. 16, n. 2, p. 1, doi. 10.1371/journal.pntd.0010159
By:
- Lim, Wilson;
- Nyuykonge, Bertrand;
- Eadie, Kimberly;
- Konings, Mickey;
- Smeets, Juli;
- Fahal, Ahmed;
- Bonifaz, Alexandro;
- Todd, Matthew;
- Perry, Benjamin;
- Samby, Kirandeep;
- Burrows, Jeremy;
- Verbon, Annelies;
- van de Sande, Wendy
Publication type:
Article

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