Found: 15

Select item for more details and to access through your institution.

  • Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS and AML.

    Published in:
    Science Translational Medicine, 2024, v. 16, n. 728, p. 1, doi. 10.1126/scitranslmed.ade2774
    By:
    • Wheeler, Emily C.;
    • Martin, Benjamin J. E.;
    • Doyle, William C.;
    • Neaher, Sofia;
    • Conway, Caroline A.;
    • Pitton, Caroline N.;
    • Gorelov, Rebecca A.;
    • Donahue, Melanie;
    • Jann, Johann C.;
    • Abdel-Wahab, Omar;
    • Taylor, Justin;
    • Seiler, Michael;
    • Buonamici, Silvia;
    • Pikman, Yana;
    • Garcia, Jacqueline S.;
    • Belizaire, Roger;
    • Adelman, Karen;
    • Tothova, Zuzana
    Publication type:
    Article

  • Intron retention is a hallmark and spliceosome represents a therapeutic vulnerability in aggressive prostate cancer.

    Published in:
    Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-15815-7
    By:
    • Zhang, Dingxiao;
    • Hu, Qiang;
    • Liu, Xiaozhuo;
    • Ji, Yibing;
    • Chao, Hsueh-Ping;
    • Liu, Yan;
    • Tracz, Amanda;
    • Kirk, Jason;
    • Buonamici, Silvia;
    • Zhu, Ping;
    • Wang, Jianmin;
    • Liu, Song;
    • Tang, Dean G.
    Publication type:
    Article

  • Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators.

    Published in:
    Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-018-08150-5
    By:
    • Aird, Daniel;
    • Teng, Teng;
    • Huang, Chia-Ling;
    • Pazolli, Ermira;
    • Banka, Deepti;
    • Cheung-Ong, Kahlin;
    • Eifert, Cheryl;
    • Furman, Craig;
    • Wu, Zhenhua Jeremy;
    • Seiler, Michael;
    • Buonamici, Silvia;
    • Fekkes, Peter;
    • Karr, Craig;
    • Palacino, James;
    • Park, Eunice;
    • Smith, Peter G.;
    • Yu, Lihua;
    • Mizui, Yoshiharu;
    • Warmuth, Markus;
    • Chicas, Agustin
    Publication type:
    Article

  • SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.

    Published in:
    Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-07620-0
    By:
    • Tzelepis, Konstantinos;
    • De Braekeleer, Etienne;
    • Aspris, Demetrios;
    • Barbieri, Isaia;
    • Vijayabaskar, M. S.;
    • Liu, Wen-Hsin;
    • Gozdecka, Malgorzata;
    • Metzakopian, Emmanouil;
    • Toop, Hamish D.;
    • Dudek, Monika;
    • Robson, Samuel C.;
    • Hermida-Prado, Francisco;
    • Yang, Yu Hsuen;
    • Babaei-Jadidi, Roya;
    • Garyfallos, Dimitrios A.;
    • Ponstingl, Hannes;
    • Dias, Joao M. L.;
    • Gallipoli, Paolo;
    • Seiler, Michael;
    • Buonamici, Silvia
    Publication type:
    Article

  • Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.

    Published in:
    Nature Communications, 2017, v. 8, n. 5, p. 15522, doi. 10.1038/ncomms15522
    By:
    • Teng, Teng;
    • Tsai, Jennifer HC;
    • Puyang, Xiaoling;
    • Seiler, Michael;
    • Peng, Shouyong;
    • Prajapati, Sudeep;
    • Aird, Daniel;
    • Buonamici, Silvia;
    • Caleb, Benjamin;
    • Chan, Betty;
    • Corson, Laura;
    • Feala, Jacob;
    • Fekkes, Peter;
    • Gerard, Baudouin;
    • Karr, Craig;
    • Korpal, Manav;
    • Liu, Xiang;
    • T. Lowe, Jason;
    • Mizui, Yoshiharu;
    • Palacino, James
    Publication type:
    Article

  • Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities.

    Published in:
    Nature Medicine, 2013, v. 19, n. 11, p. 1518, doi. 10.1038/nm.3328
    By:
    • Gruber Filbin, Mariella;
    • Dabral, Sukriti K;
    • Pazyra-Murphy, Maria F;
    • Ramkissoon, Shakti;
    • Kung, Andrew L;
    • Pak, Ekaterina;
    • Chung, Jarom;
    • Theisen, Matthew A;
    • Sun, Yanping;
    • Franchetti, Yoko;
    • Sun, Yu;
    • Shulman, David S;
    • Redjal, Navid;
    • Tabak, Barbara;
    • Beroukhim, Rameen;
    • Wang, Qi;
    • Zhao, Jean;
    • Dorsch, Marion;
    • Buonamici, Silvia;
    • Ligon, Keith L
    Publication type:
    Article

  • A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.

    Published in:
    Nature, 2011, v. 473, n. 7346, p. 230, doi. 10.1038/nature09999
    By:
    • Klinakis, Apostolos;
    • Lobry, Camille;
    • Abdel-Wahab, Omar;
    • Oh, Philmo;
    • Haeno, Hiroshi;
    • Buonamici, Silvia;
    • van De Walle, Inge;
    • Cathelin, Severine;
    • Trimarchi, Thomas;
    • Araldi, Elisa;
    • Liu, Cynthia;
    • Ibrahim, Sherif;
    • Beran, Miroslav;
    • Zavadil, Jiri;
    • Efstratiadis, Argiris;
    • Taghon, Tom;
    • Michor, Franziska;
    • Levine, Ross L.;
    • Aifantis, Iannis
    Publication type:
    Article

  • Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway.

    Published in:
    Nature Medicine, 2010, v. 16, n. 12, p. 1429, doi. 10.1038/nm.2251
    By:
    • Jagani, Zainab;
    • Mora-Blanco, E. Lorena;
    • Sansam, Courtney G.;
    • McKenna, Elizabeth S.;
    • Wilson, Boris;
    • Chen, Dongshu;
    • Klekota, Justin;
    • Tamayo, Pablo;
    • Nguyen, Phuong T. L.;
    • Tolstorukov, Michael;
    • Park, Peter J.;
    • Yoon-Jae Cho;
    • Hsiao, Kathy;
    • Buonamici, Silvia;
    • Pomeroy, Scott L.;
    • Mesirov, Jill P.;
    • Ruffner, Heinz;
    • Bouwmeester, Tewis;
    • Luchansky, Sarah J.;
    • Murtie, Joshua
    Publication type:
    Article

  • Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma.

    Published in:
    Science Translational Medicine, 2010, v. 2, n. 51, p. 1, doi. 10.1126/scitranslmed.3001599
    By:
    • Buonamici, Silvia;
    • Williams, Juliet;
    • Morrissey, Michael;
    • Wang, Anlai;
    • Guo, Ribo;
    • Vattay, Anthony;
    • Hsiao, Kathy;
    • Yuan, Jing;
    • Green, John;
    • Ospina, Beatriz;
    • Yu, Qunyan;
    • Ostrom, Lance;
    • Fordjour, Paul;
    • Anderson, Dustin L.;
    • Monahan, John E.;
    • Kelleher, Joseph F.;
    • Peukert, Stefan;
    • Pan, Shifeng;
    • Wu, Xu;
    • Maira, Sauveur-Michel
    Publication type:
    Article

  • CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia.

    Published in:
    Nature, 2009, v. 459, n. 7249, p. 1000, doi. 10.1038/nature08020
    By:
    • Buonamici, Silvia;
    • Trimarchi, Thomas;
    • Ruocco, Maria Grazia;
    • Reavie, Linsey;
    • Cathelin, Severine;
    • Mar, Brenton G.;
    • Klinakis, Apostolos;
    • Lukyanov, Yevgeniy;
    • Jen-Chieh Tseng;
    • Filiz Sen;
    • Gehrie, Eric;
    • Mengling Li;
    • Newcomb, Elizabeth;
    • Zavadil, Jiri;
    • Meruelo, Daniel;
    • Lipp, Martin;
    • Ibrahim, Sherif;
    • Efstratiadis, Argiris;
    • Zagzag, David;
    • Bromberg, Jonathan S.
    Publication type:
    Article

  • Molecular pathogenesis of T-cell leukaemia and lymphoma.

    Published in:
    2008
    By:
    • Aifantis, Iannis;
    • Raetz, Elizabeth;
    • Buonamici, Silvia
    Publication type:
    journal article

  • Targeting the NF-κB signaling pathway in Notch1-induced T-cell leukemia.

    Published in:
    Nature Medicine, 2007, v. 13, n. 1, p. 70, doi. 10.1038/nm1524
    By:
    • Vilimas, Tomas;
    • Mascarenhas, Joaquina;
    • Palomero, Teresa;
    • Mandal, Malay;
    • Buonamici, Silvia;
    • Meng, Fanyong;
    • Thompson, Benjamín;
    • Spaulding, Christina;
    • Macaroun, Sami;
    • Alegre, Maria-Luisa;
    • Kee, Barbara L;
    • Ferrando, Adolfo;
    • Miele, Lucio;
    • Aifantis, Iannis
    Publication type:
    Article

  • Rap1b is required for normal platelet function and hemostasis in mice.

    Published in:
    2005
    By:
    • Buonamici, Silvia;
    • Li, Donglan;
    • Chi, Yiqing;
    • Zhao, Rui;
    • Wang, Xuerong;
    • Brace, Larry;
    • Ni, Hongyu;
    • Saunthararajah, Yogen;
    • Nucifora, Giuseppina
    Publication type:
    Correction notice

  • EVI1 induces myelodysplastic syndrome in mice.

    Published in:
    2005
    By:
    • Buonamici, Silvia;
    • Li, Donglan;
    • Chi, Yiqing;
    • Zhao, Rui;
    • Wang, Xuerong;
    • Brace, Larry;
    • Ni, Hongyu;
    • Saunthararajah, Yogen;
    • Nucifora, Giuseppina
    Publication type:
    Correction notice

  • EVI1 induces myelodysplastic syndrome in mice.

    Published in:
    2004
    By:
    • Buonamici, Silvia;
    • Li, Donglan;
    • Chi, Yiqing;
    • Zhao, Rui;
    • Wang, Xuerong;
    • Brace, Larry;
    • Ni, Hongyu;
    • Saunthararajah, Yogen;
    • Nucifora, Giuseppina
    Publication type:
    journal article