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Population Pharmacokinetics, Pharmacodynamics and Safety Properties of Trametinib in Dogs With Cancer: A Phase I Dose Escalating Clinical Trial.
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- Veterinary & Comparative Oncology, 2024, v. 22, n. 3, p. 410, doi. 10.1111/vco.12989
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- Article
Central Nervous System Antimicrobial Exposure and Proposed Dosing for Anthrax Meningitis.
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- Clinical Infectious Diseases, 2024, v. 78, n. 6, p. 1451, doi. 10.1093/cid/ciae093
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- Article
Next generation antibiotic combinations to combat pan-drug resistant Klebsiella pneumoniae.
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- Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-53130-z
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- Article
Central and peripheral lung deposition of fluticasone propionate dry powder inhaler formulations in humans characterized by population pharmacokinetics.
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- Pharmaceutical Research, 2023, v. 40, n. 5, p. 1177, doi. 10.1007/s11095-023-03472-6
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- Article
Postexposure Prophylaxis and Treatment of Bacillus anthracis Infections: A Systematic Review and Meta-analyses of Animal Models, 1947–2019.
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- Clinical Infectious Diseases, 2022, v. 75, p. S379, doi. 10.1093/cid/ciac591
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- Article
Synthesis and Structure–Activity Relationship of Thioacetamide-Triazoles against Escherichia coli.
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- Molecules, 2022, v. 27, n. 5, p. 1518, doi. 10.3390/molecules27051518
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- Article
Systematic Evaluation of the Effect of Formulation Variables on In Vitro Performance of Mometasone Furoate Suspension-Metered Dose Inhalers.
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- AAPS Journal, 2022, v. 24, n. 1, p. 1, doi. 10.1208/s12248-021-00638-1
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- Article
Aminoglycoside-resistance gene signatures are predictive of aminoglycoside MICs for carbapenem-resistant Klebsiella pneumoniae.
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- 2022
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- journal article
Effect of Different Piperacillin-Tazobactam Dosage Regimens on Synergy of the Combination with Tobramycin against Pseudomonas aeruginosa for the Pharmacokinetics of Critically Ill Patients in a Dynamic Infection Model.
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- Antibiotics (2079-6382), 2022, v. 11, n. 1, p. 101, doi. 10.3390/antibiotics11010101
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- Article
Evaluation of Meropenem‐Ciprofloxacin Combination Dosage Regimens for the Pharmacokinetics of Critically Ill Patients With Augmented Renal Clearance.
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- Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 4, p. 1104, doi. 10.1002/cpt.2191
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- Article
Combination Regimens of Favipiravir Plus Interferon Alpha Inhibit Chikungunya Virus Replication in Clinically Relevant Human Cell Lines.
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- Microorganisms, 2021, v. 9, n. 2, p. 307, doi. 10.3390/microorganisms9020307
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- Article
Determining the optimal dosing of a novel combination regimen of ceftazidime/avibactam with aztreonam against NDM-1-producing Enterobacteriaceae using a hollow-fibre infection model.
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- 2020
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- journal article
Evaluation of Tobramycin and Ciprofloxacin as a Synergistic Combination Against Hypermutable Pseudomonas Aeruginosa Strains via Mechanism-Based Modelling.
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- Pharmaceutics, 2019, v. 11, n. 9, p. 470, doi. 10.3390/pharmaceutics11090470
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- Article
Natural history of Acinetobacter baumannii infection in mice.
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- PLoS ONE, 2019, v. 14, n. 7, p. 1, doi. 10.1371/journal.pone.0219824
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- Article
Comparable Bioavailability and Disposition of Pefloxacin in Patients with Cystic Fibrosis and Healthy Volunteers Assessed via Population Pharmacokinetics.
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- Pharmaceutics, 2019, v. 11, n. 7, p. 323, doi. 10.3390/pharmaceutics11070323
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- Article
Novel Population Pharmacokinetic Approach to Explain the Differences between Cystic Fibrosis Patients and Healthy Volunteers via Protein Binding.
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- Pharmaceutics, 2019, v. 11, n. 6, p. 286, doi. 10.3390/pharmaceutics11060286
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- Article
Four Decades of β-Lactam Antibiotic Pharmacokinetics in Cystic Fibrosis.
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- 2019
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- journal article
Optimization of Voriconazole Therapy for the Treatment of Invasive Fungal Infections in Adults.
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- Clinical Pharmacology & Therapeutics, 2018, v. 104, n. 5, p. 957, doi. 10.1002/cpt.1012
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- Article
Prolonged and continuous antibacterial and anti-biofilm activities of thin films embedded with gentamicin-loaded mesoporous silica nanoparticles.
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- Applied Nanoscience, 2018, v. 8, n. 6, p. 1471, doi. 10.1007/s13204-018-0807-8
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- Article
Development of an Enantioselective and Biomarker-Informed Translational Population Pharmacokinetic/Pharmacodynamic Model for Etodolac.
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- AAPS Journal, 2017, v. 19, n. 6, p. 1814, doi. 10.1208/s12248-017-0138-9
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- Article
Effect of Sipjeondaebo-Tang on the Pharmacokinetics of S-1, an Anticancer Agent, in Rats Evaluated by Population Pharmacokinetic Modeling.
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- Molecules, 2017, v. 22, n. 9, p. 1488, doi. 10.3390/molecules22091488
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- Article
Alterations in Pharmacokinetics of Gemcitabine and Erlotinib by Concurrent Administration of Hyangsayukgunja-Tang, a Gastroprotective Herbal Medicine.
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- Molecules, 2017, v. 22, n. 9, p. 1515, doi. 10.3390/molecules22091515
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- Article
Pharmacodynamics of dose-escalated 'front-loading' polymyxin B regimens against polymyxin-resistant mcr-1-harbouring Escherichia coli.
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- 2017
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- journal article
Polymyxin-resistant, carbapenem-resistant Acinetobacter baumannii is eradicated by a triple combination of agents that lack individual activity.
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- 2017
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- journal article
High-intensity meropenem combinations with polymyxin B: new strategies to overcome carbapenem resistance in Acinetobacter baumannii.
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- 2017
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- journal article
Polymyxin B in combination with doripenem against heteroresistant Acinetobacter baumannii: pharmacodynamics of new dosing strategies.
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- 2016
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- journal article
Resistance suppression by high-intensity, short-duration aminoglycoside exposure against hypermutable and non-hypermutable Pseudomonas aeruginosa.
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- 2016
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- journal article
Effect of different renal function on antibacterial effects of piperacillin against Pseudomonas aeruginosa evaluated via the hollow-fibre infection model and mechanism-based modelling.
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- 2016
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- journal article
Voriconazole pharmacokinetics following HSCT: results from the BMT CTN 0101 trial.
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- 2016
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- journal article
Placental transfer and mammary excretion of a novel angiotensin receptor blocker fimasartan in rats.
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- BMC Pharmacology & Toxicology, 2016, v. 17, p. 1, doi. 10.1186/s40360-016-0080-y
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- Article
Polymyxin Resistance in Acinetobacter baumannii: Genetic Mutations and Transcriptomic Changes in Response to Clinically Relevant Dosage Regimens.
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- Scientific Reports, 2016, p. 26233, doi. 10.1038/srep26233
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- Article
Distinguishing Antimicrobial Models with Different Resistance Mechanisms via Population Pharmacodynamic Modeling.
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- PLoS Computational Biology, 2016, v. 12, n. 3, p. 1, doi. 10.1371/journal.pcbi.1004782
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- Article
Optimizing Polymyxin Combinations Against Resistant Gram-Negative Bacteria.
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- Infectious Diseases & Therapy, 2015, v. 4, n. 4, p. 391, doi. 10.1007/s40121-015-0093-7
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- Article
Population Pharmacokinetic Modeling of the Enterohepatic Recirculation of Fimasartan in Rats, Dogs, and Humans.
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- AAPS Journal, 2015, v. 17, n. 5, p. 1210, doi. 10.1208/s12248-015-9764-2
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- Article
Colistin and doripenem combinations against Pseudomonas aeruginosa: profiling the time course of synergistic killing and prevention of resistance.
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- Journal of Antimicrobial Chemotherapy (JAC), 2015, v. 70, n. 5, p. 1434, doi. 10.1093/jac/dku567
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- Article
Shape does matter: short high-concentration exposure minimizes resistance emergence for fluoroquinolones in Pseudomonas aeruginosa.
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- Journal of Antimicrobial Chemotherapy (JAC), 2015, v. 70, n. 3, p. 818, doi. 10.1093/jac/dku437
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- Article
Controlling antibiotic release from mesoporous silica nano drug carriers via self-assembled polyelectrolyte coating.
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- Journal of Materials Science: Materials in Medicine, 2015, v. 26, n. 2, p. 1, doi. 10.1007/s10856-015-5444-0
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- Article
Powder Strength Distributions for Understanding De-agglomeration of Lactose Powders.
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- Pharmaceutical Research, 2012, v. 29, n. 10, p. 2926, doi. 10.1007/s11095-012-0799-0
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- Article
Pharmacodynamics of early, high-dose linezolid against vancomycin-resistant enterococci with elevated MICs and pre-existing genetic mutations.
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- Journal of Antimicrobial Chemotherapy (JAC), 2012, v. 67, n. 9, p. 2182, doi. 10.1093/jac/dks201
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- Article
Population Pharmacokinetics and Penetration into Prostatic, Seminal, and Vaginal Fluid for Ciprofloxacin, Levofloxacin, and Their Combination.
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- Chemotherapy (0009-3157), 2012, v. 57, n. 5, p. 402, doi. 10.1159/000329520
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- Article
Prediction of human pharmacokinetics and tissue distribution of apicidin, a potent histone deacetylase inhibitor, by physiologically based pharmacokinetic modeling.
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- Cancer Chemotherapy & Pharmacology, 2011, v. 68, n. 2, p. 465, doi. 10.1007/s00280-010-1502-y
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- Article
Development of a New Pre- and Post-Processing Tool (SADAPT-TRAN) for Nonlinear Mixed-Effects Modeling in S-ADAPT.
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- AAPS Journal, 2011, v. 13, n. 2, p. 201, doi. 10.1208/s12248-011-9257-x
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- Article
Performance and Robustness of the Monte Carlo Importance Sampling Algorithm Using Parallelized S-ADAPT for Basic and Complex Mechanistic Models.
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- AAPS Journal, 2011, v. 13, n. 2, p. 212, doi. 10.1208/s12248-011-9258-9
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- Article
Population Pharmacokinetics of a Novel Histone Deacetylase Inhibitor, Cyclo{(2S)-2-Amino-8-[(Aminocarbonyl)Hydrazono] Decanoyl-1-L-Tryptophyl-L-Isoleucyl-(2R)-2-Piperidinecarbonyl} (SD-2007), and Its Metabolic Conversion to Apicidin after Intravenous Injection and Oral Administration in Rats
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- Chemotherapy (0009-3157), 2011, v. 57, n. 3, p. 259, doi. 10.1159/000328027
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- Article
Application of Pharmacokinetic-Pharmacodynamic Modeling and the Justification of a Novel Fusidic Acid Dosing Regimen: Raising Lazarus From the Dead.
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- Clinical Infectious Diseases, 2011, v. 52, n. Suppl 7, p. S513, doi. 10.1093/cid/cir166
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- Article
Resurgence of Colistin: A Review of Resistance, Toxicity, Pharmacodynamics, and Dosing.
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- Pharmacotherapy, 2010, v. 30, n. 12, p. 1279, doi. 10.1592/phco.30.12.1279
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- Article
Nonlinear pharmacokinetics of piperacillin in healthy volunteers - implications for optimal dosage regimens.
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- British Journal of Clinical Pharmacology, 2010, v. 70, n. 5, p. 682, doi. 10.1111/j.1365-2125.2010.03750.x
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- Article
Competitive inhibition of renal tubular secretion of ciprofloxacin and metabolite by probenecid.
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- British Journal of Clinical Pharmacology, 2010, v. 69, n. 2, p. 167, doi. 10.1111/j.1365-2125.2009.03564.x
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- Article
The time course of drug effects.
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- Pharmaceutical Statistics, 2009, v. 8, n. 3, p. 176, doi. 10.1002/pst.393
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- Article
Multiple-pool cell lifespan models for neutropenia to assess the population pharmacodynamics of unbound paclitaxel from two formulations in cancer patients.
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- Cancer Chemotherapy & Pharmacology, 2009, v. 63, n. 6, p. 1035, doi. 10.1007/s00280-008-0828-1
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- Article