Works by Buckner, Frederick S.

Results: 26
    1

    Structurally Simple Farnesyltransferase Inhibitors Arrest the Growth of Malaria ParasitesThis work was supported by the Medicines for Malaria Venture (MMV) and NIH grants CA67771 and AI054384. S.-Y.C. thanks the Postdoctoral Fellowship Program of Korea Science & Engineering Foundation (KOSEF). O.H. gratefully acknowledges a postdoctoral fellowship of the German Academy of Natural Scientists Leopoldina (BMBF-LPD 9901/8-77). We thank David Floyd, Lou Lombardo and David Williams from Bristol-Myers Squibb for helpful suggestions.

    Published in:
    Angewandte Chemie, 2005, v. 117, n. 31, p. 4981, doi. 10.1002/ange.200500674
    By:
    • Matthew P. Glenn;
    • Sung-Youn Chang;
    • Oliver Hucke;
    • Christophe L. M. J. Verlinde;
    • Kasey Rivas;
    • Carrie Hornéy;
    • Kohei Yokoyama;
    • Frederick S. Buckner;
    • Prakash R. Pendyala;
    • Debopam Chakrabarti;
    • Michael Gelb;
    • Wesley C. Van Voorhis;
    • Saïd M. Sebti;
    • Andrew D. Hamilton
    Publication type:
    Article
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    Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness.

    Published in:
    PLoS Neglected Tropical Diseases, 2014, v. 8, n. 4, p. 1, doi. 10.1371/journal.pntd.0002775
    By:
    • Koh, Cho Yeow;
    • Kim, Jessica E.;
    • Wetzel, Allan B.;
    • de van der Schueren, Will J.;
    • Shibata, Sayaka;
    • Ranade, Ranae M.;
    • Liu, Jiyun;
    • Zhang, Zhongsheng;
    • Gillespie, J. Robert;
    • Buckner, Frederick S.;
    • Verlinde, Christophe L. M. J.;
    • Fan, Erkang;
    • Hol, Wim G. J.
    Publication type:
    Article
    6

    Structures of <i>Trypanosoma brucei</i> Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness.

    Published in:
    PLoS Neglected Tropical Diseases, 2014, v. 8, n. 4, p. 1, doi. 10.1371/journal.pntd.0002775
    By:
    • Koh, Cho Yeow;
    • Kim, Jessica E.;
    • Wetzel, Allan B.;
    • de van der Schueren, Will J.;
    • Shibata, Sayaka;
    • Ranade, Ranae M.;
    • Liu, Jiyun;
    • Zhang, Zhongsheng;
    • Gillespie, J. Robert;
    • Buckner, Frederick S.;
    • Verlinde, Christophe L. M. J.;
    • Fan, Erkang;
    • Hol, Wim G. J.
    Publication type:
    Article
    7

    Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 Å resolution reveals intriguing extra electron density in the active site.

    Published in:
    Proteins, 2006, v. 62, n. 3, p. 570, doi. 10.1002/prot.20801
    By:
    • Robien, Mark A.;
    • Bosch, Jürgen;
    • Buckner, Frederick S.;
    • Van Voorhis, Wesley C. E.;
    • Worthey, Elizabeth A.;
    • Myler, Peter;
    • Mehlin, Christopher;
    • Boni, Erica E.;
    • Kalyuzhniy, Oleksandr;
    • Anderson, Lori;
    • Lauricella, Angela;
    • Gulde, Stacy;
    • Luft, Joseph R.;
    • DeTitta, George;
    • Caruthers, Jonathan M.;
    • Hodgson, Keith O.;
    • Soltis, Michael;
    • Zucker, Frank;
    • Verlinde, Christophe L. M. J.;
    • Merritt, Ethan A.
    Publication type:
    Article
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    Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies.

    Published in:
    Molecular Microbiology, 2008, v. 68, n. 1, p. 37, doi. 10.1111/j.1365-2958.2008.06131.x
    By:
    • Arakaki, Tracy L.;
    • Buckner, Frederick S.;
    • Gillespie, J. Robert;
    • Malmquist, Nicholas A.;
    • Phillips, Margaret A.;
    • Kalyuzhniy, Oleksandr;
    • Luft, Joseph R.;
    • DeTitta, George T.;
    • Verlinde, Christophe L. M. J.;
    • Van Voorhis, Wesley C.;
    • Hol, Wim G. J.;
    • Merritt, Ethan A.
    Publication type:
    Article
    15

    Structurally Simple Farnesyltransferase Inhibitors Arrest the Growth of Malaria ParasitesThis work was supported by the Medicines for Malaria Venture (MMV) and NIH grants CA67771 and AI054384. S.-Y.C. thanks the Postdoctoral Fellowship Program of Korea Science & Engineering Foundation (KOSEF). O.H. gratefully acknowledges a postdoctoral fellowship of the German Academy of Natural Scientists Leopoldina (BMBF-LPD 9901/8-77). We thank David Floyd, Lou Lombardo and David Williams from Bristol-Myers Squibb for helpful suggestions.

    Published in:
    Angewandte Chemie International Edition, 2005, v. 44, n. 31, p. 4903, doi. 10.1002/anie.200500674
    By:
    • Matthew P. Glenn;
    • Sung-Youn Chang;
    • Oliver Hucke;
    • Christophe L. M. J. Verlinde;
    • Kasey Rivas;
    • Carrie Hornéy;
    • Kohei Yokoyama;
    • Frederick S. Buckner;
    • Prakash R. Pendyala;
    • Debopam Chakrabarti;
    • Michael Gelb;
    • Wesley C. Van Voorhis;
    • Saïd M. Sebti;
    • Andrew D. Hamilton
    Publication type:
    Article
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    Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors.

    Published in:
    Nature Structural & Molecular Biology, 2010, v. 17, n. 5, p. 602, doi. 10.1038/nsmb.1818
    By:
    • Ojo, Kayode K.;
    • Larson, Eric T.;
    • Keyloun, Katelyn R.;
    • Castaneda, Lisa J.;
    • DeRocher, Amy E.;
    • Inampudi, Krishna K.;
    • Kim, Jessica E.;
    • Arakaki, Tracy L.;
    • Murphy, Ryan C.;
    • Li Zhang;
    • Napuli, Alberto J.;
    • Maly, Dustin J.;
    • Verlinde, Christophe L. M. J.;
    • Buckner, Frederick S.;
    • Parsons, Marilyn;
    • Hol, Wim G. J.;
    • Merritt, Ethan A.;
    • Van Voorhis, Wesley C.
    Publication type:
    Article
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    Genomic-scale prioritization of drug targets: the TDR Targets database.

    Published in:
    2008
    By:
    • Agüero, Fernán;
    • Al-Lazikani, Bissan;
    • Aslett, Martin;
    • Berriman, Matthew;
    • Buckner, Frederick S.;
    • Campbell, Robert K.;
    • Carmona, Santiago;
    • Carruthers, Ian M.;
    • Chan, A. W. Edith;
    • Chen, Feng;
    • Crowther, Gregory J.;
    • Doyle, Maria A.;
    • Hertz-Fowler, Christiane;
    • Hopkins, Andrew L.;
    • McAllister, Gregg;
    • Nwaka, Solomon;
    • Overington, John P.;
    • Pain, Arnab;
    • Paolini, Gaia V.;
    • Pieper, Ursula
    Publication type:
    research
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