Works by Brunsveld, Luc

Results: 96

14‐3‐3 Protein‐Protein Interactions: From Mechanistic Understanding to Their Small‐Molecule Stabilization.

Published in:

ChemBioChem, 2024, v. 25, n. 14, p. 1, doi. 10.1002/cbic.202400214

By:

Somsen, Bente A.;
Cossar, Peter J.;
Arkin, Michelle R.;
Brunsveld, Luc;
Ottmann, Christian

Publication type:

Article

Discovery of 14‐3‐3 PPI Stabilizers by Extension of an Amidine‐Substituted Thiophene Fragment.

Published in:

ChemBioChem, 2024, v. 25, n. 1, p. 1, doi. 10.1002/cbic.202300636

By:

Wu, Qi;
Centorrino, Federica;
Guillory, Xavier;
Wolter, Madita;
Ottmann, Christian;
Cossar, Peter J.;
Brunsveld, Luc

Publication type:

Article

Cucurbit[8]uril Reactivation of an Inactivated Caspase‐8 Mutant Reveals Differentiated Enzymatic Substrate Processing.

Published in:

ChemBioChem, 2018, v. 19, n. 23, p. 2490, doi. 10.1002/cbic.201800521

By:

Dang, Dung T.;
van Onzen, Arthur H. A. M.;
Dorland, Yvonne L.;
Brunsveld, Luc

Publication type:

Article

Supramolecular Systems in Biomedical Fields. Edited by Hans‐Jörg Schneider.

Published in:

ChemBioChem, 2018, v. 19, n. 3, p. 280, doi. 10.1002/cbic.201402120

By:

Brunsveld, Luc

Publication type:

Article

Integrin-Targeting Fluorescent Proteins: Exploration of RGD Insertion Sites.

Published in:

ChemBioChem, 2017, v. 18, n. 5, p. 441, doi. 10.1002/cbic.201600514

By:

Sonntag, Michael H.;
Schill, Jurgen;
Brunsveld, Luc

Publication type:

Article

Small-Molecule-Induced and Cooperative Enzyme Assembly on a 14-3-3 Scaffold.

Published in:

ChemBioChem, 2017, v. 18, n. 3, p. 331, doi. 10.1002/cbic.201600631

By:

den Hamer, Anniek;
Lemmens, Lenne J. M.;
Nijenhuis, Minke A. D.;
Ottmann, Christian;
Merkx, Maarten;
de Greef, Tom F. A.;
Brunsveld, Luc

Publication type:

Article

Synthesis of the Rheb and K-Ras4B GTPases.

Published in:

Angewandte Chemie, 2010, v. 122, n. 35, p. 6226, doi. 10.1002/ange.201001884

By:

Chen, Yong-Xiang;
Koch, Sebastian;
Uhlenbrock, Katharina;
Weise, Katrin;
Das, Debapratim;
Gremer, Lothar;
Brunsveld, Luc;
Wittinghofer, Alfred;
Winter, Roland;
Triola, Gemma;
Waldmann, Herbert

Publication type:

Article

Protein Dimerization Induced by Supramolecular Interactions with Cucurbit[8]uril.

Published in:

Angewandte Chemie, 2010, v. 122, n. 5, p. 907, doi. 10.1002/ange.200904413

By:

Nguyen, Hoang D.;
Dang, Dung T.;
van Dongen, Joost L. J.;
Brunsveld, Luc

Publication type:

Article

A Supramolecular Polymer as a Self-Assembling Polyvalent Scaffold.

Published in:

Angewandte Chemie, 2009, v. 121, n. 16, p. 2965, doi. 10.1002/ange.200900143

By:

Müller, Marion K.;
Brunsveld, Luc

Publication type:

Article

Lipidierte Ras- und Rab-Peptide und -Proteine: Synthese, Struktur und Funktion.

Published in:

Angewandte Chemie, 2006, v. 118, n. 40, p. 6774, doi. 10.1002/ange.200600855

By:

Luc Brunsveld;
Jürgen Kuhlmann;
Kirill Alexandrov;
Alfred Wittinghofer;
Roger S. Goody;
Herbert Waldmann

Publication type:

Article

Relationship between Side-Chain Polarity and the Self-Assembly Characteristics of Perylene Diimide Derivatives in Aqueous Solution.

Published in:

ChemistryOpen, 2017, v. 6, n. 2, p. 266, doi. 10.1002/open.201600133

By:

Schill, JurgEN;
Milroy, Lech ‐ Gustav;
Lugger, Jody A. M.;
SchENning, Albertus P. H. J.;
Brunsveld, Luc

Publication type:

Article

Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-57241-7

By:

Katz, Liora S.;
Visser, Emira J.;
Plitzko, Kathrin F.;
Pennings, Marloes A. M.;
Cossar, Peter J.;
Tse, Isabelle L.;
Kaiser, Markus;
Brunsveld, Luc;
Ottmann, Christian;
Scott, Donald K.

Publication type:

Article

From Tethered to Freestanding Stabilizers of 14‐3‐3 Protein‐Protein Interactions through Fragment Linking.

Published in:

Angewandte Chemie, 2023, v. 135, n. 37, p. 1, doi. 10.1002/ange.202308004

By:

Visser, Emira J.;
Jaishankar, Priyadarshini;
Sijbesma, Eline;
Pennings, Marloes A. M.;
Vandenboorn, Edmee M. F.;
Guillory, Xavier;
Neitz, R. Jeffrey;
Morrow, John;
Dutta, Shubhankar;
Renslo, Adam R.;
Brunsveld, Luc;
Arkin, Michelle R.;
Ottmann, Christian

Publication type:

Article

Hydrophobicity Directed Chiral Self‐Assembly and Aggregation‐Induced Emission: Diacetylene‐Cored Pseudopeptide Chiral Dopants.

Published in:

Angewandte Chemie, 2022, v. 134, n. 42, p. 1, doi. 10.1002/ange.202209806

By:

Maurya, Govind P.;
Verma, Deepak;
Sinha, Aloka;
Brunsveld, Luc;
Haridas, V.

Publication type:

Article

DNA‐Mediated Protein Shuttling between Coacervate‐Based Artificial Cells.

Published in:

Angewandte Chemie, 2022, v. 134, n. 17, p. 1, doi. 10.1002/ange.202115041

By:

Mashima, Tsuyoshi;
van Stevendaal, Marleen H. M. E.;
Cornelissens, Femke R. A.;
Mason, Alexander F.;
Rosier, Bas J. H. M.;
Altenburg, Wiggert J.;
Oohora, Koji;
Hirayama, Shota;
Hayashi, Takashi;
van Hest, Jan C. M.;
Brunsveld, Luc

Publication type:

Article

Dynamic Protease Activation on a Multimeric Synthetic Protein Scaffold via Adaptable DNA‐Based Recruitment Domains.

Published in:

Angewandte Chemie, 2021, v. 133, n. 20, p. 11362, doi. 10.1002/ange.202102160

By:

Mashima, Tsuyoshi;
Rosier, Bas J. H. M.;
Oohora, Koji;
Greef, Tom F. A.;
Hayashi, Takashi;
Brunsveld, Luc

Publication type:

Article

Assembly of Dynamic Supramolecular Polymers on a DNA Origami Platform.

Published in:

Angewandte Chemie, 2021, v. 133, n. 14, p. 7690, doi. 10.1002/ange.202016244

By:

Schill, Jurgen;
Rosier, Bas J. H. M.;
Gumí Audenis, Berta;
Magdalena Estirado, Eva;
Greef, Tom F. A.;
Brunsveld, Luc

Publication type:

Article

Fragment‐Based Stabilizers of Protein–Protein Interactions through Imine‐Based Tethering.

Published in:

Angewandte Chemie, 2020, v. 132, n. 48, p. 21704, doi. 10.1002/ange.202008585

By:

Wolter, Madita;
Valenti, Dario;
Cossar, Peter J.;
Levy, Laura M.;
Hristeva, Stanimira;
Genski, Thorsten;
Hoffmann, Torsten;
Brunsveld, Luc;
Tzalis, Dimitrios;
Ottmann, Christian

Publication type:

Article

Designed Asymmetric Protein Assembly on a Symmetric Scaffold.

Published in:

Angewandte Chemie, 2020, v. 132, n. 29, p. 12211, doi. 10.1002/ange.202003626

By:

Lemmens, Lenne J. M.;
Roodhuizen, Job A. L.;
Greef, Tom F. A.;
Markvoort, Albert J.;
Brunsveld, Luc

Publication type:

Article

Rationally Designed Semisynthetic Natural Product Analogues for Stabilization of 14‐3‐3 Protein–Protein Interactions.

Published in:

Angewandte Chemie, 2018, v. 130, n. 41, p. 13658, doi. 10.1002/ange.201806584

By:

Andrei, Sebastian A.;
de Vink, Pim;
Sijbesma, Eline;
Han, Ling;
Brunsveld, Luc;
Kato, Nobuo;
Ottmann, Christian;
Higuchi, Yusuke

Publication type:

Article

Functional Classification and Interaction Selectivity Landscape of the Human SH3 Domain Superfamily.

Published in:

Cells (2073-4409), 2024, v. 13, n. 2, p. 195, doi. 10.3390/cells13020195

By:

Kazemein Jasemi, Neda S.;
Mehrabipour, Mehrnaz;
Magdalena Estirado, Eva;
Brunsveld, Luc;
Dvorsky, Radovan;
Ahmadian, Mohammad R.

Publication type:

Article

Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-31206-6

By:

Stevers, Loes M.;
Wolter, Madita;
Carlile, Graeme W.;
Macdonald, Dwight;
Richard, Luc;
Gielkens, Frank;
Hanrahan, John W.;
Thomas, David Y.;
Chakka, Sai Kumar;
Peterson, Mark L.;
Thomas, Helmut;
Brunsveld, Luc;
Ottmann, Christian

Publication type:

Article

Quantification of the lung cancer tumor marker CYFRA 21-1 using protein precipitation, immunoaffinity bottom-up LC-MS/MS.

Published in:

Clinical Chemistry & Laboratory Medicine, 2024, v. 62, n. 4, p. 720, doi. 10.1515/cclm-2023-0795

By:

Genet, Sylvia A.A.M.;
van den Wildenberg, Sebastian A.H.;
Broeren, Maarten A.C.;
van Dongen, Joost L.J.;
Brunsveld, Luc;
Scharnhorst, Volkher;
van de Kerkhof, Daan

Publication type:

Article

Optimizing charge state distribution is a prerequisite for accurate protein biomarker quantification with LC-MS/MS, as illustrated by hepcidin measurement.

Published in:

Clinical Chemistry & Laboratory Medicine, 2018, v. 56, n. 9, p. 1490, doi. 10.1515/cclm-2018-0013

By:

Schmitz, Ellen M. H.;
Leijten, Niels M.;
van Dongen, Joost L. J.;
Broeren, Maarten A. C.;
Milroy, Lech G.;
Brunsveld, Luc;
Scharnhorst, Volkher;
van de Kerkhof, Daan

Publication type:

Article

Real life dabigatran and metabolite concentrations, focused on inter-patient variability and assay differences in patients with atrial fibrillation.

Published in:

Clinical Chemistry & Laboratory Medicine, 2017, v. 55, n. 12, p. 2002, doi. 10.1515/cclm-2016-0681

By:

Boonen, Kristel;
Schmitz, Ellen;
Rozestraten, Fleur;
van den Heuvel, Dennis;
Brunsveld, Luc;
van der Voort, Pepijn;
van de Kerkhof, Daan

Publication type:

Article

Therapeutic drug monitoring of infliximab: performance evaluation of three commercial ELISA kits.

Published in:

Clinical Chemistry & Laboratory Medicine, 2016, v. 54, n. 7, p. 1211, doi. 10.1515/cclm-2015-0987

By:

Schmitz, Ellen M. H.;
van de Kerkhof, Daan;
Hamann, Dörte;
van Dongen, Joost L. J.;
Kuijper, Philip H. M.;
Brunsveld, Luc;
Scharnhorst, Volkher;
Broeren, Maarten A. C.

Publication type:

Article

Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction.

Published in:

FEBS Letters, 2017, v. 591, n. 16, p. 2449, doi. 10.1002/1873-3468.12723

By:

Doveston, Richard G.;
Kuusk, Ave;
Andrei, Sebastian A.;
Leysen, Seppe;
Cao, Qing;
Castaldi, Maria P.;
Hendricks, Adam;
Brunsveld, Luc;
Chen, Hongming;
Boyd, Helen;
Ottmann, Christian

Publication type:

Article

SH3-mediated targeting of Wrch1/RhoU by multiple adaptor proteins.

Published in:

Biological Chemistry, 2013, v. 394, n. 3, p. 421, doi. 10.1515/hsz-2012-0246

By:

Risse, Sarah L.;
Vaz, Belen;
Burton, Matthew F.;
Aspenström, Pontus;
Piekorz, Roland P.;
Brunsveld, Luc;
Ahmadian, Mohammad R.

Publication type:

Article

Supramolecular Control of Enzyme Activity through Cucurbit[8]uril-Mediated Dimerization.

Published in:

Angewandte Chemie International Edition, 2013, v. 52, n. 10, p. 2915, doi. 10.1002/anie.201208239

By:

Dang, Dung T.;
Nguyen, Hoang D.;
Merkx, Maarten;
Brunsveld, Luc

Publication type:

Article

Synthesis of the Rheb and K-Ras4B GTPases.

Published in:

Angewandte Chemie International Edition, 2010, v. 49, n. 35, p. 6090, doi. 10.1002/anie.201001884

By:

Chen, Yong-Xiang;
Koch, Sebastian;
Uhlenbrock, Katharina;
Weise, Katrin;
Das, Debapratim;
Gremer, Lothar;
Brunsveld, Luc;
Wittinghofer, Alfred;
Winter, Roland;
Triola, Gemma;
Waldmann, Herbert

Publication type:

Article

Protein Dimerization Induced by Supramolecular Interactions with Cucurbit[8]uril.

Published in:

Angewandte Chemie International Edition, 2010, v. 49, n. 5, p. 895, doi. 10.1002/anie.200904413

By:

Nguyen, Hoang D.;
Dang, Dung T.;
van Dongen, Joost L. J.;
Brunsveld, Luc

Publication type:

Article

A Supramolecular Polymer as a Self-Assembling Polyvalent Scaffold.

Published in:

Angewandte Chemie International Edition, 2009, v. 48, n. 16, p. 2921, doi. 10.1002/anie.200900143

By:

Müller, Marion K.;
Brunsveld, Luc

Publication type:

Article

Multivalent Protein Assembly Using Monovalent Self-Assembling Building Blocks.

Published in:

International Journal of Molecular Sciences, 2013, v. 14, n. 10, p. 21189, doi. 10.3390/ijms141021189

By:

Petkau-Milroy, Katja;
Sonntag, Michael H.;
Colditz, Alexander;
Brunsveld, Luc

Publication type:

Article

Immobilization of Ferrocene-Modified SNAP-Fusion Proteins.

Published in:

International Journal of Molecular Sciences, 2013, v. 14, n. 2, p. 4066, doi. 10.3390/ijms14024066

By:

Wasserberg, Dorothee;
Uhlenheuer, Dana A.;
Neirynck, Pauline;
Cabanas-Danés, Jordi;
Schenkel, Jan Hendrik;
Ravoo, Bart Jan;
Qi An;
Huskens, Jurriaan;
Milroy, Lech-Gustav;
Brunsveld, Luc;
Jonkheijm, Pascal

Publication type:

Article

Synthesis of C4-substituted 1,2,3,4-tetrahydroisoquinolin-6-ols as potential estrogen receptor modulators.

Published in:

ARKIVOC: Online Journal of Organic Chemistry, 2024, v. 2024, p. 1, doi. 10.24820/ark.5550190.p012.308

By:

Mabank, Tanya;
Chan Vinh Lam;
Brunsveld, Luc;
Green, Ivan R.;
van Otterlo, Willem A. L.

Publication type:

Article

Cooperativity in the Folding of Helical m-Phenylene Ethynylene Oligomers Based upon the `Sergeants-and-Soldiers' Principle.

Published in:

Chemistry - A European Journal, 2001, v. 7, n. 19, p. 4150, doi. 10.1002/1521-3765(20011001)7:19<4150::AID-CHEM4150>3.0.CO;2-F

By:

Prince, Ryan B.;
Moore, Jeffrey S.;
Brunsveld, Luc;
Meijer, E. W.

Publication type:

Article

Self-Assembling Multivalency - Supramolecular Polymers Assembled from Monovalent Mannose-Labelled Discotic Molecules.

Published in:

European Journal of Organic Chemistry, 2013, v. 2013, n. 17, p. 3470, doi. 10.1002/ejoc.201300057

By:

Petkau‐Milroy, Katja;
Brunsveld, Luc

Publication type:

Article

From Tethered to Freestanding Stabilizers of 14‐3‐3 Protein‐Protein Interactions through Fragment Linking.

Published in:

Angewandte Chemie International Edition, 2023, v. 62, n. 37, p. 1, doi. 10.1002/anie.202308004

By:

Visser, Emira J.;
Jaishankar, Priyadarshini;
Sijbesma, Eline;
Pennings, Marloes A. M.;
Vandenboorn, Edmee M. F.;
Guillory, Xavier;
Neitz, R. Jeffrey;
Morrow, John;
Dutta, Shubhankar;
Renslo, Adam R.;
Brunsveld, Luc;
Arkin, Michelle R.;
Ottmann, Christian

Publication type:

Article

Hydrophobicity Directed Chiral Self‐Assembly and Aggregation‐Induced Emission: Diacetylene‐Cored Pseudopeptide Chiral Dopants.

Published in:

Angewandte Chemie International Edition, 2022, v. 61, n. 42, p. 1, doi. 10.1002/anie.202209806

By:

Maurya, Govind P.;
Verma, Deepak;
Sinha, Aloka;
Brunsveld, Luc;
Haridas, V.

Publication type:

Article

DNA‐Mediated Protein Shuttling between Coacervate‐Based Artificial Cells.

Published in:

Angewandte Chemie International Edition, 2022, v. 61, n. 17, p. 1, doi. 10.1002/anie.202115041

By:

Mashima, Tsuyoshi;
van Stevendaal, Marleen H. M. E.;
Cornelissens, Femke R. A.;
Mason, Alexander F.;
Rosier, Bas J. H. M.;
Altenburg, Wiggert J.;
Oohora, Koji;
Hirayama, Shota;
Hayashi, Takashi;
van Hest, Jan C. M.;
Brunsveld, Luc

Publication type:

Article

Dynamic Protease Activation on a Multimeric Synthetic Protein Scaffold via Adaptable DNA‐Based Recruitment Domains.

Published in:

Angewandte Chemie International Edition, 2021, v. 60, n. 20, p. 11262, doi. 10.1002/anie.202102160

By:

Mashima, Tsuyoshi;
Rosier, Bas J. H. M.;
Oohora, Koji;
Greef, Tom F. A.;
Hayashi, Takashi;
Brunsveld, Luc

Publication type:

Article

Assembly of Dynamic Supramolecular Polymers on a DNA Origami Platform.

Published in:

Angewandte Chemie International Edition, 2021, v. 60, n. 14, p. 7612, doi. 10.1002/anie.202016244

By:

Schill, Jurgen;
Rosier, Bas J. H. M.;
Gumí Audenis, Berta;
Magdalena Estirado, Eva;
Greef, Tom F. A.;
Brunsveld, Luc

Publication type:

Article

Fragment‐Based Stabilizers of Protein–Protein Interactions through Imine‐Based Tethering.

Published in:

Angewandte Chemie International Edition, 2020, v. 59, n. 48, p. 21520, doi. 10.1002/anie.202008585

By:

Wolter, Madita;
Valenti, Dario;
Cossar, Peter J.;
Levy, Laura M.;
Hristeva, Stanimira;
Genski, Thorsten;
Hoffmann, Torsten;
Brunsveld, Luc;
Tzalis, Dimitrios;
Ottmann, Christian

Publication type:

Article

Designed Asymmetric Protein Assembly on a Symmetric Scaffold.

Published in:

Angewandte Chemie International Edition, 2020, v. 59, n. 29, p. 12113, doi. 10.1002/anie.202003626

By:

Lemmens, Lenne J. M.;
Roodhuizen, Job A. L.;
Greef, Tom F. A.;
Markvoort, Albert J.;
Brunsveld, Luc

Publication type:

Article

Using the IPTG-Inducible Pgrac212 Promoter for Overexpression of Human Rhinovirus 3C Protease Fusions in the Cytoplasm of Bacillus subtilis Cells.

Published in:

Current Microbiology, 2019, v. 76, n. 12, p. 1477, doi. 10.1007/s00284-019-01783-9

By:

Le, Vuong Duong;
Phan, Trang Thi Phuong;
Nguyen, Tri Minh;
Brunsveld, Luc;
Schumann, Wolfgang;
Nguyen, Hoang Duc

Publication type:

Article

Mutually Exclusive Cellular Uptake of Combinatorial Supramolecular Copolymers.

Published in:

Chemistry - A European Journal, 2018, v. 24, n. 61, p. 16445, doi. 10.1002/chem.201804045

By:

Van dun, Sam;
Schill, Jurgen;
Milroy, Lech‐gustav;
Brunsveld, Luc

Publication type:

Article

Synthesis and Self‐Assembly of Bay‐Substituted Perylene Diimide Gemini‐Type Surfactants as Off‐On Fluorescent Probes for Lipid Bilayers.

Published in:

Chemistry - A European Journal, 2018, v. 24, n. 30, p. 7734, doi. 10.1002/chem.201801022

By:

Schill, Jurgen;
van Dun, Sam;
Pouderoijen, Maarten J.;
Janssen, Henk M.;
Milroy, Lech‐Gustav;
Schenning, Albertus P. H. J.;
Brunsveld, Luc

Publication type:

Article

Synthesis and Crystal Structure of a Phosphorylated Estrogen Receptor Ligand Binding Domain.

Published in:

ChemBioChem, 2010, v. 11, n. 16, p. 2251, doi. 10.1002/cbic.201000532

By:

Möcklinghoff, Sabine;
Rose, Rolf;
Carraz, Maëlle;
Visser, Arie;
Ottmann, Christian;
Brunsveld, Luc

Publication type:

Article

Strong and Reversible Monovalent Supramolecular Protein Immobilization.

Published in:

ChemBioChem, 2010, v. 11, n. 2, p. 180, doi. 10.1002/cbic.200900599

By:

Young, Jacqui F.;
Nguyen, Hoang D.;
Yang, Lanti;
Huskens, Jurriaan;
Jonkheijm, Pascal;
Brunsveld, Luc

Publication type:

Article

Mapping the Isoprenoid Binding Pocket of PDEδ by a Semisynthetic, Photoactivatable N-Ras Lipoprotein.

Published in:

ChemBioChem, 2009, v. 10, n. 1, p. 98, doi. 10.1002/cbic.200800275

By:

Alexander, Michael;
Gerauer, Marc;
Pechlivanis, Markos;
Popkirova, Boriana;
Dvorsky, Radovan;
Brunsveld, Luc;
Waldmann, Herbert;
Kuhlmann, Jürgen

Publication type:

Article