Works by Bruno, René

Results: 32

Atezolizumab and Bevacizumab in Patients with Unresectable Hepatocellular Carcinoma: Pharmacokinetic and Safety Assessments Based on Hepatic Impairment Status and Geographic Region.

Published in:

Liver Cancer (2235-1795), 2021, v. 10, n. 5, p. 485, doi. 10.1159/000515817

By:

Shemesh, Colby S.;
Chan, Phyllis;
Shao, Hui;
Xu, Derek-Zhen;
Combs, Daniel;
Vadhavkar, Shweta;
Bruno, René;
Wu, Benjamin

Publication type:

Article

Atezolizumab and Bevacizumab in Patients with Unresectable Hepatocellular Carcinoma: Pharmacokinetic and Safety Assessments Based on Hepatic Impairment Status and Geographic Region.

Published in:

Liver Cancer (2235-1795), 2021, v. 10, n. 5, p. 485, doi. 10.1159/000515817

By:

Shemesh, Colby S.;
Chan, Phyllis;
Shao, Hui;
Xu, Derek-Zhen;
Combs, Daniel;
Vadhavkar, Shweta;
Bruno, René;
Wu, Benjamin

Publication type:

Article

Multistate Pharmacometric Model to Define the Impact of Second‐Line Immunotherapies on the Survival Outcome of the IMpower131 Study.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 113, n. 4, p. 851, doi. 10.1002/cpt.2838

By:

Krishnan, Sreenath M.;
Friberg, Lena E.;
Mercier, François;
Zhang, Rong;
Wu, Ben;
Jin, Jin Y.;
Hoang, Tien;
Ballinger, Marcus;
Bruno, René;
Karlsson, Mats O.

Publication type:

Article

Association Between Tumor Size Kinetics and Survival in Patients With Urothelial Carcinoma Treated With Atezolizumab: Implication for Patient Follow‐Up.

Published in:

Clinical Pharmacology & Therapeutics, 2019, v. 106, n. 4, p. 810, doi. 10.1002/cpt.1450

By:

Tardivon, Coralie;
Desmée, Solène;
Kerioui, Marion;
Bruno, René;
Wu, Benjamin;
Mentré, France;
Mercier, François;
Guedj, Jérémie

Publication type:

Article

External validation of a tumor growth inhibition-overall survival model in non-small-cell lung cancer based on atezolizumab studies using alectinib data.

Published in:

Cancer Chemotherapy & Pharmacology, 2023, v. 92, n. 3, p. 205, doi. 10.1007/s00280-023-04558-z

By:

Kassir, Nastya;
Chan, Phyllis;
Dang, Steve;
Bruno, René

Publication type:

Article

Time-dependent population PK models of single-agent atezolizumab in patients with cancer.

Published in:

Cancer Chemotherapy & Pharmacology, 2021, v. 88, n. 2, p. 211, doi. 10.1007/s00280-021-04276-4

By:

Marchand, Mathilde;
Zhang, Rong;
Chan, Phyllis;
Quarmby, Valerie;
Ballinger, Marcus;
Sternheim, Nitzan;
Wu, Benjamin;
Jin, Jin Y.;
Bruno, René

Publication type:

Article

Alternative dosing regimens for atezolizumab: an example of model-informed drug development in the postmarketing setting.

Published in:

2019

By:

Morrissey, Kari M.;
Marchand, Mathilde;
Patel, Hina;
Zhang, Rong;
Wu, Benjamin;
Phyllis Chan, H.;
Mecke, Almut;
Girish, Sandhya;
Jin, Jin Y.;
Winter, Helen R.;
Bruno, René

Publication type:

journal article

Development of a modeling framework to simulate efficacy endpoints for motesanib in patients with thyroid cancer.

Published in:

Cancer Chemotherapy & Pharmacology, 2010, v. 66, n. 6, p. 1141, doi. 10.1007/s00280-010-1449-z

By:

Claret, Laurent;
Jian-Feng Lu;
Yu-Nien Sun;
Bruno, René

Publication type:

Article

Population pharmacokinetic/pharmacodynamic modeling for the time course of tumor shrinkage by motesanib in thyroid cancer patients.

Published in:

Cancer Chemotherapy & Pharmacology, 2010, v. 66, n. 6, p. 1151, doi. 10.1007/s00280-010-1456-0

By:

Jian-Feng Lu;
Claret, Laurent;
Sutjandra, Liviawati;
Kuchimanchi, Mita;
Melara, Rebeca;
Bruno, René;
Yu-Nien Sun

Publication type:

Article

Pan‐cancer population pharmacokinetics and exposure‐safety and ‐efficacy analyses of atezolizumab in patients with high tumor mutational burden.

Published in:

Pharmacology Research & Perspectives, 2020, v. 8, n. 6, p. 1, doi. 10.1002/prp2.685

By:

Shemesh, Colby S.;
Chan, Phyllis;
Legrand, Fatema A.;
Shames, David S.;
Das Thakur, Meghna;
Shi, Jane;
Bailey, Lorna;
Vadhavkar, Shweta;
He, Xian;
Zhang, Wei;
Bruno, René

Publication type:

Article

A Model-Based Meta-analysis to Compare Efficacy and Tolerability of Tramadol and Tapentadol for the Treatment of Chronic Non-Malignant Pain.

Published in:

Pain & Therapy, 2014, v. 3, n. 1, p. 31, doi. 10.1007/s40122-014-0023-5

By:

Mercier, François;
Claret, Laurent;
Prins, Klaas;
Bruno, René

Publication type:

Article

Modelling the association between biomarkers and clinical outcome: An introduction to nonlinear joint models.

Published in:

British Journal of Clinical Pharmacology, 2022, v. 88, n. 4, p. 1452, doi. 10.1111/bcp.15200

By:

Kerioui, Marion;
Bertrand, Julie;
Bruno, René;
Mercier, François;
Guedj, Jérémie;
Desmée, Solène

Publication type:

Article

Confounding factors in exposure–response analyses and mitigation strategies for monoclonal antibodies in oncology.

Published in:

British Journal of Clinical Pharmacology, 2021, v. 87, n. 6, p. 2493, doi. 10.1111/bcp.14662

By:

Kawakatsu, Sonoko;
Bruno, René;
Kågedal, Matts;
Li, Chunze;
Girish, Sandhya;
Joshi, Amita;
Wu, Benjamin

Publication type:

Article

Tumor Growth Inhibition-Overall Survival (TGI-OS) Model for Subgroup Analysis Based on Post-Randomization Factors: Application for Anti-drug Antibody (ADA) Subgroup Analysis of Atezolizumab in the IMpower150 Study.

Published in:

AAPS Journal, 2022, v. 24, n. 3, p. 1, doi. 10.1208/s12248-022-00710-4

By:

Yoshida, Kenta;
Chan, Phyllis;
Marchand, Mathilde;
Zhang, Rong;
Wu, Benjamin;
Ballinger, Marcus;
Sternheim, Nitzan;
Jin, Jin Y.;
Bruno, René

Publication type:

Article

Exposure-Response and Tumor Growth Inhibition Analyses of the Monovalent Anti-c-MET Antibody Onartuzumab (MetMAb) in the Second- and Third-Line Non-Small Cell Lung Cancer.

Published in:

AAPS Journal, 2017, v. 19, n. 2, p. 527, doi. 10.1208/s12248-016-0029-5

By:

Han, Kelong;
Chanu, Pascal;
Jonsson, Fredrik;
Winter, Helen;
Bruno, René;
Jin, Jin;
Stroh, Mark

Publication type:

Article

Evaluation of atezolizumab immunogenicity: Efficacy and safety (Part 2).

Published in:

CTS: Clinical & Translational Science, 2022, v. 15, n. 1, p. 141, doi. 10.1111/cts.13149

By:

Peters, Solange;
Galle, Peter R.;
Bernaards, Coen A.;
Ballinger, Marcus;
Bruno, René;
Quarmby, Valerie;
Ruppel, Jane;
Vilimovskij, Alexandr;
Wu, Benjamin;
Sternheim, Nitzan;
Reck, Martin

Publication type:

Article

Fisher information matrix for non-linear mixed-effects models: evaluation and application for optimal design of enoxaparin population pharmacokinetics.

Published in:

Statistics in Medicine, 2002, v. 21, n. 18, p. 2623, doi. 10.1002/sim.1041

By:

Retout, Sylvie;
Mentré, France;
Bruno, René

Publication type:

Article

Support to early clinical decisions in drug development and personalised medicine with checkpoint inhibitors using dynamic biomarker-overall survival models.

Published in:

British Journal of Cancer, 2023, v. 129, n. 9, p. 1383, doi. 10.1038/s41416-023-02190-5

By:

Bruno, René;
Chanu, Pascal;
Kågedal, Matts;
Mercier, Francois;
Yoshida, Kenta;
Guedj, Jérémie;
Li, Chunze;
Beyer, Ulrich;
Jin, Jin Y.

Publication type:

Article

Population pharmacokinetics and pharmacodynamics of enoxaparin in unstable angina and non-ST-segment elevation myocardial infarction.

Published in:

British Journal of Clinical Pharmacology, 2003, v. 56, n. 4, p. 407, doi. 10.1046/j.1365-2125.2003.01904.x

By:

Bruno, René;
Baille, Pascale;
Retout, Sylvie;
Vivier, Nicole;
Veyrat-Follet, Christine;
Sanderink, Ger-Jan;
Becker, Richard;
Antman, Elliott M.

Publication type:

Article

Nonlinear multilevel joint model for individual lesion kinetics and survival to characterize intra‐individual heterogeneity in patients with advanced cancer.

Published in:

Biometrics, 2023, v. 79, n. 4, p. 3752, doi. 10.1111/biom.13912

By:

Kerioui, Marion;
Beaulieu, Maxime;
Desmée, Solène;
Bertrand, Julie;
Mercier, François;
Jin, Jin Y.;
Bruno, René;
Guedj, Jérémie

Publication type:

Article

Intraindividual Pharmacokinetic Variability: Focus on Small‐Molecule Kinase Inhibitors.

Published in:

Clinical Pharmacology & Therapeutics, 2018, v. 103, n. 6, p. 956, doi. 10.1002/cpt.937

By:

Chatelut, Etienne;
Bruno, René;
Ratain, Mark J.

Publication type:

Article

Clinical trial simulation of docetaxel in patients with cancer as a tool for dosage optimization.

Published in:

Clinical Pharmacology & Therapeutics, 2000, v. 68, n. 6, p. 677, doi. 10.1067/mcp.2000.111948

By:

Veyrat-Follet, Christine;
Bruno, René;
Olivares, Robert;
Rhodes, Gerald R.;
Chaikin, Philip

Publication type:

Article

Population pharmacokinetics of riluzole in patients with amyotrophic lateral sclerosis.

Published in:

Clinical Pharmacology & Therapeutics, 1997, v. 62, n. 5, p. 518, doi. 10.1016/S0009-9236(97)90047-3

By:

Bruno, René;
Vivier, Nicole;
Montay, Guy;
Liboux, Aim éLe;
Powe, Larry K.;
Delumeau, Jean-Christophe;
Rhodes, Gerald R.

Publication type:

Article

Tumor growth and overall survival modeling to support decision making in phase Ib/II trials: A comparison of the joint and two‐stage approaches.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 6, p. 1017, doi. 10.1002/psp4.13137

By:

Marchand, Mathilde;
Gonçalves, Antonio;
Mercier, François;
Chanu, Pascal;
Jin, Jin Y.;
Guedj, Jérémie;
Bruno, René

Publication type:

Article

Comparison of two‐stage and joint TGI‐OS modeling using data from six atezolizumab clinical studies in patients with metastatic non‐small cell lung cancer.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 1, p. 68, doi. 10.1002/psp4.13057

By:

Gonçalves, Antonio;
Marchand, Mathilde;
Chan, Phyllis;
Jin, Jin Y.;
Guedj, Jérémie;
Bruno, René

Publication type:

Article

Update to improve reproducibility and interpretability: A response to "Machine Learning for Tumor Growth Inhibition".

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 3, p. 262, doi. 10.1002/psp4.12760

By:

Chan, Phyllis;
Lu, James;
Bruno, René;
Jin, Jin Y.

Publication type:

Article

Multistate model for pharmacometric analyses of overall survival in HER2‐negative breast cancer patients treated with docetaxel.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 10, p. 1255, doi. 10.1002/psp4.12693

By:

Krishnan, Sreenath M.;
Friberg, Lena E.;
Bruno, René;
Beyer, Ulrich;
Jin, Jin Y.;
Karlsson, Mats O.

Publication type:

Article

Prediction of overall survival in patients across solid tumors following atezolizumab treatments: A tumor growth inhibition–overall survival modeling framework.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 10, p. 1171, doi. 10.1002/psp4.12686

By:

Chan, Phyllis;
Marchand, Mathilde;
Yoshida, Kenta;
Vadhavkar, Shweta;
Wang, Nina;
Lin, Alyse;
Wu, Benjamin;
Ballinger, Marcus;
Sternheim, Nitzan;
Jin, Jin Y.;
Bruno, René

Publication type:

Article

Application of Machine Learning for Tumor Growth Inhibition – Overall Survival Modeling Platform.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 1, p. 59, doi. 10.1002/psp4.12576

By:

Chan, Phyllis;
Zhou, Xiaofei;
Wang, Nina;
Liu, Qi;
Bruno, René;
Jin, Jin Y.

Publication type:

Article

Tumor Time‐Course Predicts Overall Survival in Non‐Small Cell Lung Cancer Patients Treated with Atezolizumab: Dependency on Follow‐Up Time.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2020, v. 9, n. 2, p. 115, doi. 10.1002/psp4.12489

By:

Netterberg, Ida;
Bruno, René;
Chen, Ya‐Chi;
Winter, Helen;
Li, Chi‐Chung;
Jin, Jin Y.;
Friberg, Lena E.

Publication type:

Article

Prediction of overall survival or progression free survival by disease control rate at week 8 is independent of ethnicity: Western versus Chinese patients with first-line non-small cell lung cancer treated with chemotherapy with or without bevacizumab.

Published in:

Journal of Clinical Pharmacology, 2014, v. 54, n. 3, p. 253, doi. 10.1002/jcph.191

By:

Claret, Laurent;
Gupta, Manish;
Han, Kelong;
Joshi, Amita;
Sarapa, Nenad;
He, Jing;
Powell, Bob;
Bruno, René

Publication type:

Article

Bayesian inference using Hamiltonian Monte-Carlo algorithm for nonlinear joint modeling in the context of cancer immunotherapy.

Published in:

2020

By:

Kerioui, Marion;
Mercier, Francois;
Bertrand, Julie;
Tardivon, Coralie;
Bruno, René;
Guedj, Jérémie;
Desmée, Solène

Publication type:

journal article