Works matching AU Bruning, John B.

Results: 47

Approaches to Introduce Helical Structure in Cysteine‐Containing Peptides with a Bimane Group.

Published in:

ChemBioChem, 2021, v. 22, n. 17, p. 2711, doi. 10.1002/cbic.202100241

By:

Horsfall, Aimee J.;
McDougal, Daniel P.;
Scanlon, Denis B.;
Bruning, John B.;
Abell, Andrew D.

Publication type:

Article

Targeting PCNA with Peptide Mimetics for Therapeutic Purposes.

Published in:

ChemBioChem, 2020, v. 21, n. 4, p. 442, doi. 10.1002/cbic.201900275

By:

Horsfall, Aimee J.;
Abell, Andrew D.;
Bruning, John B.

Publication type:

Article

An In Crystallo Reaction with an Engineered Cytochrome P450 Peroxygenase.

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 8, p. 1, doi. 10.1002/chem.202303335

By:

Lee, Joel H. Z.;
Bruning, John B.;
Bell, Stephen G.

Publication type:

Article

The Oxidation of Oxygen and Sulfur‐Containing Heterocycles by Cytochrome P450 Enzymes.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 50, p. 1, doi. 10.1002/chem.202301371

By:

Podgorski, Matthew N.;
Keto, Angus B.;
Coleman, Tom;
Bruning, John B.;
De Voss, James J.;
Krenske, Elizabeth H.;
Bell, Stephen G.

Publication type:

Article

Investigating the Active Oxidants Involved in Cytochrome P450 Catalyzed Sulfoxidation Reactions.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 72, p. 1, doi. 10.1002/chem.202202428

By:

Podgorski, Matthew N.;
Coleman, Tom;
Churchman, Luke R.;
Bruning, John B.;
De Voss, James J.;
Bell, Stephen G.

Publication type:

Article

Enabling Aromatic Hydroxylation in a Cytochrome P450 Monooxygenase Enzyme through Protein Engineering.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 67, p. 1, doi. 10.1002/chem.202201895

By:

Coleman, Tom;
Lee, Joel Z. H.;
Kirk, Alicia M.;
Doherty, Daniel Z.;
Podgorski, Matthew N.;
Pinidiya, Dilshi K.;
Bruning, John B.;
De Voss, James J.;
Krenske, Elizabeth H.;
Bell, Stephen G.

Publication type:

Article

The Stereoselective Oxidation of para‐Substituted Benzenes by a Cytochrome P450 Biocatalyst.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 59, p. 14765, doi. 10.1002/chem.202102757

By:

Chao, Rebecca R.;
Lau, Ian C.‐K.;
Coleman, Tom;
Churchman, Luke R.;
Child, Stella A.;
Lee, Joel H. Z.;
Bruning, John B.;
De Voss, James J.;
Bell, Stephen G.

Publication type:

Article

Structural insights into the antifungal drug target guanosine monophosphate synthase from Aspergillus fumigatus.

Published in:

Acta Crystallographica: Section D, Structural Biology, 2022, v. 78, n. 2, p. 248, doi. 10.1107/S2059798321012031

By:

Nguyen, Stephanie;
Jovcevski, Blagojce;
Pukala, Tara L.;
Bruning, John B.

Publication type:

Article

Combining random microseed matrix screening and the magic triangle for the efficient structure solution of a potential lysin from bacteriophage P68.

Published in:

Acta Crystallographica: Section D, Structural Biology, 2019, v. 75, n. 7, p. 670, doi. 10.1107/S2059798319009008

By:

Truong, Jia Quyen;
Panjikar, Santosh;
Shearwin-Whyatt, Linda;
Bruning, John B.;
Shearwin, Keith E.

Publication type:

Article

Precipitant–ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase.

Published in:

Acta Crystallographica: Section D, Structural Biology, 2018, v. 74, n. 10, p. 965, doi. 10.1107/S2059798318010136

By:

Thompson, Andrew P.;
Wegener, Kate L.;
Booker, Grant W.;
Polyak, Steven W.;
Bruning, John B.

Publication type:

Article

Crystal Structure of Bovine Alpha-Chymotrypsin in Space Group P65.

Published in:

Crystals (2073-4352), 2018, v. 8, n. 12, p. 460, doi. 10.3390/cryst8120460

By:

Marshall, Andrew C.;
Keiller, Benjamin G.;
Pederick, Jordan L.;
Abell, Andrew D.;
Bruning, John B.

Publication type:

Article

Rare variants in single-minded 1 (SIM1) are associated with severe obesity.

Published in:

Journal of Clinical Investigation, 2013, v. 123, n. 7, p. 3042, doi. 10.1172/JCI68016

By:

Ramachandrappa, Shwetha;
Raimondo, Anne;
Cali, Anna M. G.;
Keogh, Julia M.;
Henning, Elana;
Saeed, Sadia;
Thompson, Amanda;
Garg, Sumedha;
Bochukova, Elena G.;
Brage, Soren;
Trowse, Victoria;
Wheeler, Eleanor;
Sullivan, Adrienne E.;
Dattani, Mehul;
Clayton, Peter E.;
Datta, Vippan;
Bruning, John B.;
Wareham, Nick J.;
O’Rahilly, Stephen;
Peet, Daniel J.

Publication type:

Article

Towards a High-Affinity Peptidomimetic Targeting Proliferating Cell Nuclear Antigen from Aspergillus fumigatus.

Published in:

Journal of Fungi, 2023, v. 9, n. 11, p. 1098, doi. 10.3390/jof9111098

By:

Vandborg, Bethiney C.;
Horsfall, Aimee J.;
Pederick, Jordan L.;
Abell, Andrew D.;
Bruning, John B.

Publication type:

Article

Simplified heavy‐atom derivatization of protein structures via co‐crystallization with the MAD tetragon tetrabromoterephthalic acid.

Published in:

Acta Crystallographica: Section F, Structural Biology Communications, 2021, v. 77, n. 5, p. 156, doi. 10.1107/S2053230X21004052

By:

Truong, Jia Q.;
Nguyen, Stephanie;
Bruning, John B.;
Shearwin, Keith E.

Publication type:

Article

Review of the Structural and Dynamic Mechanisms of PPARγ Partial Agonism.

Published in:

PPAR Research, 2015, v. 2015, p. 1, doi. 10.1155/2015/816856

By:

Kroker, Alice J.;
Bruning, John B.

Publication type:

Article

Structural plasticity in the oestrogen receptor ligand-binding domain.

Published in:

EMBO Reports, 2007, v. 8, n. 6, p. 563, doi. 10.1038/sj.embor.7400963

By:

Nettles, Kendall W;
Bruning, John B;
Gil, German;
O'Neill, Erin E;
Nowak, Jason;
Hughs, Alun;
Kim, Younchang;
DeSombre, Eugene R;
Dilis, Robert;
Hanson, Robert N;
Joachimiak, Andrzej;
Greene, Geoffrey L

Publication type:

Article

Structural plasticity in the oestrogen receptor ligand-binding domain.

Published in:

EMBO Reports, 2007, v. 8, n. 6, p. 610, doi. 10.1038/sj.embor.7401006

By:

Nettles, Kendall W;
Bruning, John B;
Gil, German;
O'Neill, Erin E;
Nowak, Jason;
Guo, Yuee;
Kim, Younchang;
DeSombre, Eugene R;
Dilis, Robert;
Hanson, Robert N;
Joachimiak, Andrzej;
Greene, Geoffrey L

Publication type:

Article

Acquired JAK2 mutations confer resistance to JAK inhibitors in cell models of acute lymphoblastic leukemia.

Published in:

NPJ Precision Oncology, 2021, v. 5, n. 1, p. 1, doi. 10.1038/s41698-021-00215-x

By:

Downes, Charlotte E. J.;
McClure, Barbara J.;
Bruning, John B.;
Page, Elyse;
Breen, James;
Rehn, Jacqueline;
Yeung, David T.;
White, Deborah L.

Publication type:

Article

Biochemical and structural characterization of meningococcal methylenetetrahydrofolate reductase.

Published in:

Protein Science: A Publication of the Protein Society, 2023, v. 32, n. 6, p. 1, doi. 10.1002/pro.4654

By:

Pantong, Wanita;
Pederick, Jordan L.;
Maenpuen, Somchart;
Tinikul, Ruchanok;
Jayapalan, Jaime J.;
Jovcevski, Blagojce;
Wegener, Kate L.;
Bruning, John B.;
Salaemae, Wanisa

Publication type:

Article

New insights into the evolutionary history of plant sorbitol dehydrogenase.

Published in:

BMC Plant Biology, 2015, v. 15, n. 1, p. 1, doi. 10.1186/s12870-015-0478-5

By:

Yong Jia;
Wong, Darren C. J.;
Sweetman, Crystal;
Bruning, John B.;
Ford, Christopher M.

Publication type:

Article

A structural model of the human plasminogen and Aspergillus fumigatus enolase complex.

Published in:

Proteins, 2022, v. 90, n. 8, p. 1509, doi. 10.1002/prot.26331

By:

Nguyen, Stephanie;
Jovcevski, Blagojce;
Truong, Jia Q.;
Pukala, Tara L.;
Bruning, John B.

Publication type:

Article

Rational Design of a 310‐Helical PIP‐Box Mimetic Targeting PCNA, the Human Sliding Clamp.

Published in:

Chemistry - A European Journal, 2018, v. 24, n. 44, p. 11238, doi. 10.1002/chem.201803280

By:

Wegener, Kate L.;
McGrath, Amy E.;
Dixon, Nicholas E.;
Oakley, Aaron J.;
Scanlon, Denis B.;
Abell, Andrew D.;
Bruning, John B.

Publication type:

Article

Front Cover: Rational Design of a 310‐Helical PIP‐Box Mimetic Targeting PCNA, the Human Sliding Clamp (Chem. Eur. J. 44/2018).

Published in:

Chemistry - A European Journal, 2018, v. 24, n. 44, p. 11234, doi. 10.1002/chem.201803279

By:

Wegener, Kate L.;
McGrath, Amy E.;
Dixon, Nicholas E.;
Oakley, Aaron J.;
Scanlon, Denis B.;
Abell, Andrew D.;
Bruning, John B.

Publication type:

Article

Rational Design of a 310‐Helical PIP‐Box Mimetic Targeting PCNA, the Human Sliding Clamp.

Published in:

Chemistry - A European Journal, 2018, v. 24, n. 44, p. 11325, doi. 10.1002/chem.201801734

By:

Wegener, Kate L.;
McGrath, Amy E.;
Dixon, Nicholas E.;
Oakley, Aaron J.;
Scanlon, Denis B.;
Abell, Andrew D.;
Bruning, John B.

Publication type:

Article

Structural mechanism for signal transduction in RXR nuclear receptor heterodimers.

Published in:

Nature Communications, 2015, v. 6, n. 8, p. 8013, doi. 10.1038/ncomms9013

By:

Kojetin, Douglas J.;
Matta-Camacho, Edna;
Hughes, Travis S.;
Srinivasan, Sathish;
Nwachukwu, Jerome C.;
Cavett, Valerie;
Nowak, Jason;
Chalmers, Michael J.;
Marciano, David P.;
Kamenecka, Theodore M.;
Shulman, Andrew I.;
Rance, Mark;
Griffin, Patrick R.;
Bruning, John B.;
Nettles, Kendall W.

Publication type:

Article

Pharmacological repression of PPARγ promotes osteogenesis.

Published in:

Nature Communications, 2015, v. 6, n. 6, p. 7443, doi. 10.1038/ncomms8443

By:

Marciano, David P.;
Kuruvilla, Dana S.;
Boregowda, Siddaraju V.;
Asteian, Alice;
Hughes, Travis S.;
Garcia-Ordonez, Ruben;
Corzo, Cesar A.;
Khan, Tanya M.;
Novick, Scott J.;
Park, HaJeung;
Kojetin, Douglas J.;
Phinney, Donald G.;
Bruning, John B.;
Kamenecka, Theodore M.;
Griffin, Patrick R.

Publication type:

Article

Macrocyclic Protease Inhibitors with Reduced Peptide Character.

Published in:

Angewandte Chemie, 2014, v. 126, n. 30, p. 7962, doi. 10.1002/ange.201404301

By:

Chua, Krystle C. H.;
Pietsch, Markus;
Zhang, Xiaozhou;
Hautmann, Stephanie;
Chan, Hon Y.;
Bruning, John B.;
Gütschow, Michael;
Abell, Andrew D.

Publication type:

Article

HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00978-7

By:

Jie Zheng;
Mi Ra Chang;
Stites, Ryan E.;
Yong Wang;
Bruning, John B.;
Pascal, Bruce D.;
Novick, Scott J.;
Garcia-Ordonez, Ruben D.;
Stayrook, Keith R.;
Chalmers, Michael J.;
Dodge, Jeffrey A.;
Griffin, Patrick R.

Publication type:

Article

Exploring the Factors which Result in Cytochrome P450 Catalyzed Desaturation Versus Hydroxylation.

Published in:

Chemistry - An Asian Journal, 2022, v. 17, n. 24, p. 1, doi. 10.1002/asia.202200986

By:

Coleman, Tom;
Doherty, Daniel Z.;
Zhang, Ting;
Podgorski, Matthew N.;
Qiao, Ruihong;
Lee, Joel H. Z.;
Bruning, John B.;
De Voss, James J.;
Zhou, Weihong;
Bell, Stephen G.

Publication type:

Article

DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 5, p. 556, doi. 10.1038/nsmb.2046

By:

Jun Zhang;
Chalmers, Michael J.;
Stayrook, Keith R.;
Burris, Lorri L.;
Yongjun Wang;
Busby, Scott A.;
Pascal, Bruce D.;
Garcia-Ordonez, Ruben D.;
Bruning, John B.;
Istrate, Monica A.;
Kojetin, Douglas J.;
Dodge, Jeffrey A.;
Burris, Thomas P.;
Griffin, Patrick R.

Publication type:

Article

Characterization of functionally deficient SIM2 variants found in patients with neurological phenotypes.

Published in:

Biochemical Journal, 2022, v. 479, n. 13, p. 1441, doi. 10.1042/BCJ20220209

By:

Button, Emily L.;
Rossi, Joseph J.;
McDougal, Daniel P.;
Bruning, John B.;
Peet, Daniel J.;
Bersten, David C.;
Rosenfeld, Jill A.;
Whitelaw, Murray L.

Publication type:

Article

Engineering potassium activation into biosynthetic thiolase.

Published in:

Biochemical Journal, 2021, v. 478, n. 15, p. 3047, doi. 10.1042/BCJ20210455

By:

Marshall, Andrew C.;
Bruning, John B.

Publication type:

Article

Structural and functional characterisation of the cytochrome P450 enzyme CYP268A2 from Mycobacterium marinum.

Published in:

Biochemical Journal, 2018, v. 475, n. 4, p. 705, doi. 10.1042/BCJ20170946

By:

Child, Stella A.;
Naumann, Elise F.;
Bruning, John B.;
Bell, Stephen G.

Publication type:

Article

Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2.

Published in:

Biochemical Journal, 2014, v. 461, n. 3, p. 403, doi. 10.1042/BJ20131618

By:

SULLIVAN, Adrienne E.;
RAIMONDO, Anne;
SCHWAB, Tanja A.;
BRUNING, John B.;
FROGUEL, Philippe;
FAROOQI, I. Sadaf;
PEET, Daniel J.;
WHITELAW, Murray L.

Publication type:

Article

Human Variants in the Neuronal Basic Helix-Loop-Helix/Per-Arnt-Sim (bHLH/PAS) Transcription Factor Complex NPAS4/ARNT2 Disrupt Function.

Published in:

PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0085768

By:

Bersten, David C.;
Bruning, John B.;
Peet, Daniel J.;
Whitelaw, Murray L.

Publication type:

Article

Antidiabetic actions of a non-agonist PPAR? ligand blocking Cdk5-mediated phosphorylation.

Published in:

Nature, 2011, v. 477, n. 7365, p. 477, doi. 10.1038/nature10383

By:

Jang Hyun Choi;
Banks, Alexander S.;
Kamenecka, Theodore M.;
Busby, Scott A.;
Chalmers, Michael J.;
Kumar, Naresh;
Kuruvilla, Dana S.;
Youseung Shin;
Yuanjun He;
Bruning, John B.;
Marciano, David P.;
Cameron, Michael D.;
Laznik, Dina;
Jurczak, Michael J.;
Schürer, Stephan C.;
Vidović, Dušica;
Shulman, Gerald I.;
Spiegelman, Bruce M.;
Griffin, Patrick R.

Publication type:

Article

Macrocyclic Protease Inhibitors with Reduced Peptide Character.

Published in:

Angewandte Chemie International Edition, 2014, v. 53, n. 30, p. 7828, doi. 10.1002/anie.201404301

By:

Chua, Krystle C. H.;
Pietsch, Markus;
Zhang, Xiaozhou;
Hautmann, Stephanie;
Chan, Hon Y.;
Bruning, John B.;
Gütschow, Michael;
Abell, Andrew D.

Publication type:

Article

Functional and structural characterization of Staphylococcus aureus N‐acetylglucosamine 1‐phosphate uridyltransferase (GlmU) reveals a redox‐sensitive acetyltransferase activity.

Published in:

Protein Science: A Publication of the Protein Society, 2025, v. 34, n. 4, p. 1, doi. 10.1002/pro.70111

By:

Pederick, Jordan L.;
Kumar, Akhil;
Pukala, Tara L.;
Bruning, John B.

Publication type:

Article

Coupling of receptor conformation and ligand orientation determine graded activity.

Published in:

Nature Chemical Biology, 2010, v. 6, n. 11, p. 837, doi. 10.1038/nchembio.451

By:

Bruning, John B;
Parent, Alexander A;
Gil, German;
Zhao, Min;
Nowak, Jason;
Pace, Margaret C;
Smith, Carolyn L;
Afonine, Pavel V;
Adams, Paul D;
Katzenellenbogen, John A;
Nettles, Kendall W

Publication type:

Article

Corrigendum: NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses.

Published in:

2008

By:

Nettles, Kendall W;
Bruning, John B;
Gil, German;
Nowak, Jason;
Sharma, Sanjay K;
Hahm, Johnnie B;
Kulp, Kristen;
Hochberg, Richard B;
Zhou, Haibing;
Katzenellenbogen, John A;
Katzenellenbogen, Benita S;
Kim, Younchang;
Joachimiak, Andrzej;
Greene, Geoffrey L

Publication type:

Correction Notice

NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses.

Published in:

Nature Chemical Biology, 2008, v. 4, n. 4, p. 241, doi. 10.1038/nchembio.76

By:

Nettles, Kendall W.;
Bruning, John B.;
Gil, German;
Nowak, Jason;
Sharma, Sanjay K.;
Hahm, Johnnie B.;
Kulp, Kristen;
Hochberg, Richard B.;
Haibing Zhou;
Katzenellenbogen, John A.;
Katzenellenbogen, Benita S.;
Younchang Kim;
Joachmiak, Andrzej;
Greene, Geoffrey L.

Publication type:

Article

Structural insights into the role of the acid-alcohol pair of residues required for dioxygen activation in cytochrome P450 enzymes.

Published in:

Journal of Biological Inorganic Chemistry (JBIC), 2020, v. 25, n. 4, p. 583, doi. 10.1007/s00775-020-01781-4

By:

Coleman, Tom;
Stok, Jeanette E.;
Podgorski, Matthew N.;
Bruning, John B.;
De Voss, James J.;
Bell, Stephen G.

Publication type:

Article

Vanishing white matter: Eukaryotic initiation factor 2B model and the impact of missense mutations.

Published in:

Molecular Genetics & Genomic Medicine, 2021, v. 9, n. 3, p. 1, doi. 10.1002/mgg3.1593

By:

Slynko, Inna;
Nguyen, Stephanie;
Hamilton, Eline M. C.;
Wisse, Lisanne E.;
Esch, Iwan J. P.;
Graaf, Chris;
Bruning, John B.;
Proud, Christopher G.;
Abbink, Truus E. M.;
Knaap, Marjo S.

Publication type:

Article

TSC-insensitive Rheb mutations induce oncogenic transformation through a combination of constitutively active mTORC1 signalling and proteome remodelling.

Published in:

Cellular & Molecular Life Sciences, 2021, v. 78, n. 8, p. 4035, doi. 10.1007/s00018-021-03825-7

By:

Xie, Jianling;
De Poi, Stuart P.;
Humphrey, Sean J.;
Hein, Leanne K.;
Bruning, John B.;
Pan, Wenru;
Selth, Luke A.;
Sargeant, Timothy J.;
Proud, Christopher G.

Publication type:

Article

Comparative functional and structural analysis of Pseudomonas aeruginosad‐alanine–d‐alanine ligase isoforms as prospective antibiotic targets.

Published in:

FEBS Journal, 2023, v. 290, n. 23, p. 5536, doi. 10.1111/febs.16932

By:

Pederick, Jordan L.;
Woolman, Jessica C.;
Bruning, John B.

Publication type:

Article

Nucleoside selectivity of Aspergillus fumigatus nucleoside‐diphosphate kinase.

Published in:

FEBS Journal, 2021, v. 288, n. 7, p. 2398, doi. 10.1111/febs.15607

By:

Nguyen, Stephanie;
Jovcevski, Blagojce;
Pukala, Tara L.;
Bruning, John B.

Publication type:

Article

Structure of the sliding clamp from the fungal pathogen Aspergillus fumigatus (Afum PCNA) and interactions with Human p21.

Published in:

FEBS Journal, 2017, v. 284, n. 6, p. 985, doi. 10.1111/febs.14035

By:

Marshall, Andrew C.;
Kroker, Alice J.;
Murray, Lauren A.M.;
Gronthos, Kahlia;
Rajapaksha, Harinda;
Wegener, Kate L.;
Bruning, John B.

Publication type:

Article