Works by Brun, Reto

Results: 114
    1

    Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins.

    Published in:
    Angewandte Chemie, 2010, v. 122, n. 33, p. 5829, doi. 10.1002/ange.201001026
    By:
    • O'Neill, Paul M.;
    • Amewu, Richard K.;
    • Nixon, Gemma L.;
    • Bousejra ElGarah, Fatima;
    • Mungthin, Mathirut;
    • Chadwick, James;
    • Shone, Alison E.;
    • Vivas, Livia;
    • Lander, Hollie;
    • Barton, Victoria;
    • Muangnoicharoen, Sant;
    • Bray, Patrick G.;
    • Davies, Jill;
    • Park, B. Kevin;
    • Wittlin, Sergio;
    • Brun, Reto;
    • Preschel, Michael;
    • Zhang, Kesheng;
    • Ward, Stephen A.
    Publication type:
    Article
    2
    3
    4

    Discovery of dual function acridones as a new antimalarial chemotype.

    Published in:
    Nature, 2009, v. 459, n. 7244, p. 270, doi. 10.1038/nature07937
    By:
    • Kelly, Jane X.;
    • Smilkstein, Martin J.;
    • Brun, Reto;
    • Wittlin, Sergio;
    • Cooper, Roland A.;
    • Lane, Kristin D.;
    • Janowsky, Aaron;
    • Johnson, Robert A.;
    • Dodean, Rozalia A.;
    • Winter, Rolf;
    • Hinrichs, David J.;
    • Riscoe, Michael K.
    Publication type:
    Article
    5

    Identification of an antimalarial synthetic trioxolane drug development candidate.

    Published in:
    Nature, 2004, v. 430, n. 7002, p. 900, doi. 10.1038/nature02779
    By:
    • Vennerstrom, Jonathan L.;
    • Arbe-Barnes, Sarah;
    • Brun, Reto;
    • Charman, Susan A.;
    • Chiu, Francis C. K.;
    • Chollet, Jacques;
    • Dong, Yuxiang;
    • Dorn, Arnulf;
    • Hunziker, Daniel;
    • Matile, Hugues;
    • McIntosh, Kylie;
    • Padmanilayam, Maniyan;
    • Tomas, Josefina Santo;
    • Scheurer, Christian;
    • Scorneaux, Bernard;
    • Tang, Yuanqing;
    • Urwyler, Heinrich;
    • Wittlin, Sergio;
    • Charman, William N.
    Publication type:
    Article
    6
    7

    Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys.

    Published in:
    PLoS Neglected Tropical Diseases, 2015, v. 9, n. 2, p. 1, doi. 10.1371/journal.pntd.0003409
    By:
    • Thuita, John K.;
    • Wolf, Kristina K.;
    • Murilla, Grace A.;
    • Bridges, Arlene S.;
    • Boykin, David W.;
    • Mutuku, James N.;
    • Liu, Qiang;
    • Jones, Susan K.;
    • Gem, Charles O.;
    • Ching, Shelley;
    • Tidwell, Richard R.;
    • Wang, Michael Z.;
    • Paine, Mary F.;
    • Brun, Reto
    Publication type:
    Article
    8

    Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys.

    Published in:
    PLoS Neglected Tropical Diseases, 2015, v. 9, n. 2, p. 1, doi. 10.1371/journal.pntd.0003409
    By:
    • Thuita, John K.;
    • Wolf, Kristina K.;
    • Murilla, Grace A.;
    • Bridges, Arlene S.;
    • Boykin, David W.;
    • Mutuku, James N.;
    • Liu, Qiang;
    • Jones, Susan K.;
    • Gem, Charles O.;
    • Ching, Shelley;
    • Tidwell, Richard R.;
    • Wang, Michael Z.;
    • Paine, Mary F.;
    • Brun, Reto
    Publication type:
    Article
    9
    10
    11

    Safety, Pharmacokinetic, and Efficacy Studies of Oral DB868 in a First Stage Vervet Monkey Model of Human African Trypanosomiasis.

    Published in:
    PLoS Neglected Tropical Diseases, 2013, v. 7, n. 6, p. 1, doi. 10.1371/journal.pntd.0002230
    By:
    • Thuita, John K.;
    • Wolf, Kristina K.;
    • Murilla, Grace A.;
    • Liu, Qiang;
    • Mutuku, James N.;
    • Chen, Yao;
    • Bridges, Arlene S.;
    • Mdachi, Raymond E.;
    • Ismail, Mohamed A.;
    • Ching, Shelley;
    • Boykin, David W.;
    • Hall, James Edwin;
    • Tidwell, Richard R.;
    • Paine, Mary F.;
    • Brun, Reto;
    • Wang, Michael Zhuo
    Publication type:
    Article
    12

    Safety, Pharmacokinetic, and Efficacy Studies of Oral DB868 in a First Stage Vervet Monkey Model of Human African Trypanosomiasis.

    Published in:
    PLoS Neglected Tropical Diseases, 2013, v. 7, n. 6, p. 1, doi. 10.1371/journal.pntd.0002230
    By:
    • Thuita, John K.;
    • Wolf, Kristina K.;
    • Murilla, Grace A.;
    • Liu, Qiang;
    • Mutuku, James N.;
    • Chen, Yao;
    • Bridges, Arlene S.;
    • Mdachi, Raymond E.;
    • Ismail, Mohamed A.;
    • Ching, Shelley;
    • Boykin, David W.;
    • Hall, James Edwin;
    • Tidwell, Richard R.;
    • Paine, Mary F.;
    • Brun, Reto;
    • Wang, Michael Zhuo
    Publication type:
    Article
    13

    Naphthoquinone Derivatives Exert Their Antitrypanosomal Activity via a Multi-Target Mechanism.

    Published in:
    PLoS Neglected Tropical Diseases, 2013, v. 7, n. 1, p. 1, doi. 10.1371/journal.pntd.0002012
    By:
    • Pieretti, Simone;
    • Haanstra, Jurgen R.;
    • Mazet, Muriel;
    • Perozzo, Remo;
    • Bergamini, Christian;
    • Prati, Federica;
    • Fato, Romana;
    • Lenaz, Giorgio;
    • Capranico, Giovanni;
    • Brun, Reto;
    • Bakker, Barbara M.;
    • Michels, Paul A. M.;
    • Scapozza, Leonardo;
    • Bolognesi, Maria Laura;
    • Cavalli, Andrea
    Publication type:
    Article
    14
    15
    16
    17
    18
    19
    20
    21

    Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.

    Published in:
    2016
    By:
    • Le Bihan, Amélie;
    • de Kanter, Ruben;
    • Angulo-Barturen, Iñigo;
    • Binkert, Christoph;
    • Boss, Christoph;
    • Brun, Reto;
    • Brunner, Ralf;
    • Buchmann, Stephan;
    • Burrows, Jeremy;
    • Dechering, Koen J.;
    • Delves, Michael;
    • Ewerling, Sonja;
    • Ferrer, Santiago;
    • Fischli, Christoph;
    • Gamo–Benito, Francisco Javier;
    • Gnädig, Nina F.;
    • Heidmann, Bibia;
    • Jiménez-Díaz, María Belén;
    • Leroy, Didier;
    • Martínez, Maria Santos
    Publication type:
    journal article
    22
    23
    24
    25

    Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins.

    Published in:
    Angewandte Chemie International Edition, 2010, v. 49, n. 33, p. 5693, doi. 10.1002/anie.201001026
    By:
    • O'Neill, Paul M.;
    • Amewu, Richard K.;
    • Nixon, Gemma L.;
    • Bousejra ElGarah, Fatima;
    • Mungthin, Mathirut;
    • Chadwick, James;
    • Shone, Alison E.;
    • Vivas, Livia;
    • Lander, Hollie;
    • Barton, Victoria;
    • Muangnoicharoen, Sant;
    • Bray, Patrick G.;
    • Davies, Jill;
    • Park, B. Kevin;
    • Wittlin, Sergio;
    • Brun, Reto;
    • Preschel, Michael;
    • Zhang, Kesheng;
    • Ward, Stephen A.
    Publication type:
    Article
    26

    African Buffalo Serum Contains Novel Trypanocidal Protein.

    Published in:
    Journal of Eukaryotic Microbiology, 1994, v. 41, n. 2, p. 95, doi. 10.1111/j.1550-7408.1994.tb01480.x
    By:
    • REDUTH, DAGMAR;
    • GROOTENHUIS, JAN G.;
    • OLUBAYO, REARDON O.;
    • MURANJAN, MADHAVI;
    • OTIENO-OMONDI, FREDERICK P.;
    • MORGAN, GRANT A.;
    • BRUN, RETO;
    • WILLIAMS, DIANA J. L.;
    • BLACK, SAMUEL J.
    Publication type:
    Article
    27
    28
    29
    30
    31
    32
    33
    34
    35
    36
    37
    38
    39
    40
    41
    42
    43
    44
    45
    46
    47

    Development of a Focused Library of Triazole‐Linked Privileged‐Structure‐Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections.

    Published in:
    ChemMedChem, 2018, v. 13, n. 7, p. 678, doi. 10.1002/cmdc.201700786
    By:
    • Uliassi, Elisa;
    • Piazzi, Lorna;
    • Belluti, Federica;
    • Mazzanti, Andrea;
    • Kaiser, Marcel;
    • Brun, Reto;
    • Moraes, Carolina B.;
    • Freitas‐Junior, Lucio H.;
    • Gul, Sheraz;
    • Kuzikov, Maria;
    • Ellinger, Bernhard;
    • Borsari, Chiara;
    • Costi, Maria Paola;
    • Bolognesi, Maria Laura
    Publication type:
    Article
    48

    Discovery and Characterization of ACT-451840: an Antimalarial Drug with a Novel Mechanism of Action.

    Published in:
    ChemMedChem, 2016, v. 11, n. 18, p. 1995, doi. 10.1002/cmdc.201600298
    By:
    • Boss, Christoph;
    • Aissaoui, Hamed;
    • Amaral, Nathalie;
    • Bauer, Aude;
    • Bazire, Stephanie;
    • Binkert, Christoph;
    • Brun, Reto;
    • Bürki, Cédric;
    • Ciana, Claire‐Lise;
    • Corminboeuf, Olivier;
    • Delahaye, Stephane;
    • Dollinger, Claire;
    • Fischli, Christoph;
    • Fischli, Walter;
    • Flock, Alexandre;
    • Frantz, Marie‐Céline;
    • Girault, Malory;
    • Grisostomi, Corinna;
    • Friedli, Astrid;
    • Heidmann, Bibia
    Publication type:
    Article
    49

    Back Cover: Discovery and Characterization of ACT-451840: an Antimalarial Drug with a Novel Mechanism of Action (ChemMedChem 18/2016).

    Published in:
    ChemMedChem, 2016, v. 11, n. 18, p. 2096, doi. 10.1002/cmdc.201600436
    By:
    • Boss, Christoph;
    • Aissaoui, Hamed;
    • Amaral, Nathalie;
    • Bauer, Aude;
    • Bazire, Stephanie;
    • Binkert, Christoph;
    • Brun, Reto;
    • Bürki, Cédric;
    • Ciana, Claire‐Lise;
    • Corminboeuf, Olivier;
    • Delahaye, Stephane;
    • Dollinger, Claire;
    • Fischli, Christoph;
    • Fischli, Walter;
    • Flock, Alexandre;
    • Frantz, Marie‐Céline;
    • Girault, Malory;
    • Grisostomi, Corinna;
    • Friedli, Astrid;
    • Heidmann, Bibia
    Publication type:
    Article
    50