Works by Brugarolas, James

Results: 44

Systemic Treatment of Locally Advanced or Metastatic Non-Clear Cell Renal Cell Carcinoma.

Published in:

Cancers, 2025, v. 17, n. 9, p. 1527, doi. 10.3390/cancers17091527

By:

Vento, Joseph;
Zhang, Tian;
Kapur, Payal;
Hammers, Hans;
Brugarolas, James;
Qin, Qian

Publication type:

Article

Radiation-induced cell cycle arrest compromised by p21 deficiency.

Published in:

Nature, 1995, v. 377, n. 6549, p. 552, doi. 10.1038/377552a0

By:

Brugarolas, James;
Chandrasekaran, Chiltra

Publication type:

Article

Characteristics and Outcomes of T1a Renal Cell Carcinoma Presenting with Metastasis.

Published in:

Cancers, 2025, v. 17, n. 3, p. 364, doi. 10.3390/cancers17030364

By:

Wang, Luke;
Guer, Melis;
Puri, Dhruv;
Liu, Franklin;
Dhanji, Sohail;
Meagher, Margaret F.;
Shah, Aastha;
Ghassemzadeh, Saeed;
Javier-DesLoges, Juan;
Brugarolas, James;
Kapur, Payal;
Bagrodia, Aditya;
Rose, Brent;
Murphy, James D.;
Derweesh, Ithaar H.;
McKay, Rana R.

Publication type:

Article

Adrenal Insufficiency following Stereotactic Ablative Radiotherapy (SAbR) of Adrenal Gland Metastases.

Published in:

Cancers, 2024, v. 16, n. 18, p. 3140, doi. 10.3390/cancers16183140

By:

Hamidi, Oksana;
Miljanic, Mihailo;
Tumyan, Gayane;
Christie, Alana;
Mirfakhraee, Sasan;
Ali, Sadia;
Dohopolski, Michael;
Gottumukkala, Sujana;
Brugarolas, James;
Timmerman, Robert;
Hannan, Raquibul

Publication type:

Article

Recent Advances in Renal Tumors with TSC/mTOR Pathway Abnormalities in Patients with Tuberous Sclerosis Complex and in the Sporadic Setting.

Published in:

Cancers, 2023, v. 15, n. 16, p. 4043, doi. 10.3390/cancers15164043

By:

Kapur, Payal;
Brugarolas, James;
Trpkov, Kiril

Publication type:

Article

Oncogenic KRAS Requires Complete Loss of BAP1 Function for Development of Murine Intrahepatic Cholangiocarcinoma.

Published in:

Cancers, 2021, v. 13, n. 22, p. 5709, doi. 10.3390/cancers13225709

By:

Marcus, Rebecca;
Ferri-Borgogno, Sammy;
Hosein, Abdel;
Foo, Wai Chin;
Ghosh, Bidyut;
Zhao, Jun;
Rajapakshe, Kimal;
Brugarolas, James;
Maitra, Anirban;
Gupta, Sonal

Publication type:

Article

Stereotactic radiation therapy of renal cancer inferior vena cava tumor thrombus.

Published in:

Cancer Biology & Therapy, 2015, v. 16, n. 5, p. 657, doi. 10.1080/15384047.2015.1026506

By:

Hannan, Raquibul;
Margulis, Vitaly;
Chun, Stephen G;
Cannon, Nathan;
Kim, D W Nathan;
Abdulrahman, Ramzi E;
Sagalowsky, Arthur;
Pedrosa, Ivan;
Choy, Hak;
Brugarolas, James;
Timmerman, Robert D

Publication type:

Article

Regulation of TFEB and V-ATPases by mTORC1.

Published in:

EMBO Journal, 2011, v. 30, n. 16, p. 3242, doi. 10.1038/emboj.2011.257

By:

Peña-Llopis, Samuel;
Vega-Rubin-de-Celis, Silvia;
Schwartz, Jacob C;
Wolff, Nicholas C;
Tran, Tram Anh T;
Zou, Lihua;
Xie, Xian-Jin;
Corey, David R;
Brugarolas, James

Publication type:

Article

mTORC1 activation in childhood ependymoma and response to sirolimus.

Published in:

2011

By:

Bowers, Daniel;
Kucejova, Blanka;
Margraf, Linda;
Gargan, Lynn;
Brugarolas, James

Publication type:

Report

The complex relationship between TFEB transcription factor phosphorylation and subcellular localization.

Published in:

EMBO Journal, 2018, v. 37, n. 11, p. 1, doi. 10.15252/embj.201798804

By:

Puertollano, Rosa;
Ferguson, Shawn M.;
Brugarolas, James;
Ballabio, Andrea

Publication type:

Article

Improving Renal Tumor Biopsy Prognostication With BAP1 Analyses.

Published in:

Archives of Pathology & Laboratory Medicine, 2022, v. 146, n. 2, p. 154, doi. 10.5858/arpa.2020-0413-OA

By:

Kapur, Payal;
Setoodeh, Sasan;
Araj, Ellen;
Jingsheng Yan;
Malladi, Venkat S.;
Cadeddu, Jeffrey A.;
Christie, Alana;
Brugarolas, James

Publication type:

Article

Establishing a human renal cell carcinoma tumorgraft platform for preclinical drug testing.

Published in:

Nature Protocols, 2014, v. 9, n. 8, p. 1848, doi. 10.1038/nprot.2014.108

By:

Pavía-Jiménez, Andrea;
Tcheuyap, Vanina Toffessi;
Brugarolas, James

Publication type:

Article

Genetic risk assessment for hereditary renal cell carcinoma: Clinical consensus statement.

Published in:

Cancer (0008543X), 2021, v. 127, n. 21, p. 3957, doi. 10.1002/cncr.33679

By:

Bratslavsky, Gennady;
Mendhiratta, Neil;
Daneshvar, Michael;
Brugarolas, James;
Ball, Mark W.;
Metwalli, Adam;
Nathanson, Katherine L.;
Pierorazio, Phillip M.;
Boris, Ronald S.;
Singer, Eric A.;
Carlo, Maria I.;
Daly, Mary B.;
Henske, Elizabeth P.;
Hyatt, Colette;
Middleton, Lindsay;
Morris, Gloria;
Jeong, Anhyo;
Narayan, Vivek;
Rathmell, W. Kimryn;
Vaishampayan, Ulka

Publication type:

Article

Loss of BAP1 protein expression is an independent marker of poor prognosis in patients with low-risk clear cell renal cell carcinoma.

Published in:

Cancer (0008543X), 2014, v. 120, n. 7, p. 1059, doi. 10.1002/cncr.28521

By:

Joseph, Richard W.;
Kapur, Payal;
Serie, Daniel J.;
Eckel‐Passow, Jeanette E.;
Parasramka, Mansi;
Ho, Thai;
Cheville, John C.;
Frenkel, Eugene;
Rakheja, Dinesh;
Brugarolas, James;
Parker, Alexander

Publication type:

Article

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways.

Published in:

Nature Medicine, 2004, v. 10, n. 6, p. 594, doi. 10.1038/nm1052

By:

Majumder, Pradip K.;
Febbo, Phillip G.;
Bikoff, Rachel;
Berger, Raanan;
Qi Xue;
McMahon, Louis M.;
Manola, Judith;
Brugarolas, James;
McDonnell, Timothy J.;
Golub, Todd R.;
Loda, Massimo;
Lane, Heidi A.;
Sellers, William R.

Publication type:

Article

Fibroblast Growth Factor Receptor-Dependent and -Independent Paracrine Signaling by Sunitinib-Resistant Renal Cell Carcinoma.

Published in:

Molecular & Cellular Biology, 2016, v. 36, n. 13, p. 1836, doi. 10.1128/MCB.00189-16

By:

Tram Anh Tran;
Hon Sing Leong;
Pavia-Jimenez, Andrea;
Fedyshyn, Slavic;
Juan Yang;
Kucejova, Blanka;
Sivanand, Sharanya;
Spence, Patrick;
Xian-Jin Xie;
Peña-Llopis, Samuel;
Power, Nicholas;
Brugarolas, James

Publication type:

Article

Histopathology based AI model predicts anti-angiogenic therapy response in renal cancer clinical trial.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-57717-6

By:

Jasti, Jay;
Zhong, Hua;
Panwar, Vandana;
Jarmale, Vipul;
Miyata, Jeffrey;
Carrillo, Deyssy;
Christie, Alana;
Rakheja, Dinesh;
Modrusan, Zora;
Kadel III, Edward Ernest;
Beig, Niha;
Huseni, Mahrukh;
Brugarolas, James;
Kapur, Payal;
Rajaram, Satwik

Publication type:

Article

De novo prediction of cancer-associated T cell receptors for noninvasive cancer detection.

Published in:

Science Translational Medicine, 2020, v. 12, n. 557, p. 1, doi. 10.1126/scitranslmed.aaz3738

By:

Beshnova, Daria;
Ye, Jianfeng;
Onabolu, Oreoluwa;
Moon, Benjamin;
Zheng, Wenxin;
Fu, Yang-Xin;
Brugarolas, James;
Lea, Jayanthi;
Li, Bo

Publication type:

Article

Statistical clustering of parametric maps from dynamic contrast enhanced MRI and an associated decision tree model for non-invasive tumour grading of T1b solid clear cell renal cell carcinoma.

Published in:

2018

By:

Xi, Yin;
Yuan, Qing;
Zhang, Yue;
Madhuranthakam, Ananth J.;
Fulkerson, Michael;
Margulis, Vitaly;
Brugarolas, James;
Kapur, Payal;
Cadeddu, Jeffrey A.;
Pedrosa, Ivan

Publication type:

journal article

Tumor neoantigenicity assessment with CSiN score incorporates clonality and immunogenicity to predict immunotherapy outcomes.

Published in:

Science Immunology, 2020, v. 5, n. 44, p. 1, doi. 10.1126/sciimmunol.aaz3199

By:

Lu, Tianshi;
Wang, Shidan;
Xu, Lin;
Zhou, Qinbo;
Singla, Nirmish;
Gao, Jianjun;
Manna, Subrata;
Pop, Laurentiu;
Xie, Zhiqun;
Chen, Mingyi;
Luke, Jason J.;
Brugarolas, James;
Hannan, Raquibul;
Wang, Tao

Publication type:

Article

Pathological Response and Outcomes in Patients With Metastatic Renal Cell Carcinoma (mRCC) Receiving Immunotherapy-Based Therapies and Undergoing Deferred Cytoreductive Nephrectomy (CN).

Published in:

Clinical Genitourinary Cancer, 2024, v. 22, n. 5, p. N.PAG, doi. 10.1016/j.clgc.2024.102177

By:

Gunenc, Damla;
Issa, Wadih;
Gerald, Thomas;
Zhou, Qinhan;
Zhang, Song;
Ibezue, I. Chidera;
Bhanvadia, Raj;
Tachibana, Isamu;
Brugarolas, James;
Hammers, Hans;
Qin, Qian;
Kapur, Payal;
Woldu, Solomon;
Gaston, Kris;
Lotan, Yair;
Cadeddu, Jeffrey;
Wang, Andrew Z.;
Margulis, Vitaly;
Zhang, Tian

Publication type:

Article

Life-threatening hemoptysis in patients with metastatic kidney cancer.

Published in:

Clinical Genitourinary Cancer, 2023, v. 21, n. 4, p. 497, doi. 10.1016/j.clgc.2023.01.011

By:

Patel, Viral M.;
Elias, Roy;
Asokan, Annapoorani;
Sharma, Akanksha;
Christie, Alana;
Pedrosa, Ivan;
Hsienchang Chiu;
Reznik, Scott;
Hannan, Raquibul;
Timmerman, Robert;
Brugarolas, James

Publication type:

Article

Chronic Use of Proton Pump Inhibitors Is Associated With an Increased Risk of Immune Checkpoint Inhibitor Colitis in Renal Cell Carcinoma.

Published in:

Clinical Genitourinary Cancer, 2022, v. 20, n. 3, p. 260, doi. 10.1016/j.clgc.2022.01.017

By:

Jianyi Yin;
Elias, Roy;
Lan Peng;
Levonyak, Nicholas;
Asokan, Annapoorani;
Christie, Alana;
Kubiliun, Nisa;
Brugarolas, James;
Hammers, Hans J.

Publication type:

Article

Summary from the Kidney Cancer Association's Inaugural Think Thank: Coalition for a Cure.

Published in:

Clinical Genitourinary Cancer, 2021, v. 19, n. 2, p. 167, doi. 10.1016/j.clgc.2020.10.005

By:

Rini, Brian;
Abel, E. Jason;
Albiges, Laurence;
Bex, Axel;
Brugarolas, James;
Bukowski, Ronald M.;
Coleman, Jonathan A.;
Drake, Charles G.;
Figlin, Robert A.;
Futreal, Andy;
Hammers, Hans;
Powles, Thomas;
Rathmell, W. Kimryn;
Ricketts, Christopher J.;
Turajlic, Samra;
Wood, Christopher G.;
Leibovich, Bradley C.

Publication type:

Article

Magnetic Resonance Imaging Radiomics Analyses for Prediction of High-Grade Histology and Necrosis in Clear Cell Renal Cell Carcinoma: Preliminary Experience.

Published in:

Clinical Genitourinary Cancer, 2021, v. 19, n. 1, p. 12, doi. 10.1016/j.clgc.2020.05.011

By:

Dwivedi, Durgesh K.;
Yin Xi;
Kapur, Payal;
Madhuranthakam, Ananth J.;
Lewis, Matthew A.;
Udayakumar, Durga;
Rasmussen, Robert;
Qing Yuan;
Bagrodia, Aditya;
Margulis, Vitaly;
Fulkerson, Michael;
Brugarolas, James;
Cadeddu, Jeffrey A.;
Pedrosa, Ivan

Publication type:

Article

DEFOR: depth- and frequency-based somatic copy number alteration detector.

Published in:

Bioinformatics, 2019, v. 35, n. 19, p. 3824, doi. 10.1093/bioinformatics/btz170

By:

Zhang, He;
Zhan, Xiaowei;
Brugarolas, James;
Xie, Yang

Publication type:

Article

Whole‐body MRI for metastatic cancer detection using T2‐weighted imaging with fat and fluid suppression.

Published in:

Magnetic Resonance in Medicine, 2018, v. 80, n. 4, p. 1402, doi. 10.1002/mrm.27117

By:

Wang, Xinzeng;
Pirasteh, Ali;
Brugarolas, James;
Rofsky, Neil M.;
Lenkinski, Robert E.;
Pedrosa, Ivan;
Madhuranthakam, Ananth J.

Publication type:

Article

Loss of Tsc1, but not Pten, in renal tubular cells causes polycystic kidney disease by activating mTORC1.

Published in:

Human Molecular Genetics, 2009, v. 18, n. 22, p. 4428, doi. 10.1093/hmg/ddp398

By:

Zhou, Jing;
Brugarolas, James;
Parada, Luis F.

Publication type:

Article

PML restrains p53 activity and cellular senescence in clear cell renal cell carcinoma.

Published in:

EMBO Molecular Medicine, 2024, v. 16, n. 6, p. 1324, doi. 10.1038/s44321-024-00077-3

By:

Simoni, Matilde;
Menegazzi, Chiara;
Fracassi, Cristina;
Biffi, Claudia C;
Genova, Francesca;
Tenace, Nazario Pio;
Lucianò, Roberta;
Raimondi, Andrea;
Tacchetti, Carlo;
Brugarolas, James;
Mazza, Davide;
Bernardi, Rosa

Publication type:

Article

Identification of CREB3L1 as a Biomarker Predicting Doxorubicin Treatment Outcome.

Published in:

PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0129233

By:

Denard, Bray;
Pavia-Jimenez, Andrea;
Chen, Weina;
Williams, Noelle S.;
Naina, Harris;
Collins, Robert;
Brugarolas, James;
Ye, Jin

Publication type:

Article

The cyclin kinase inhibitor p21WAF1/CIP1 is required for glomerular hypertrophy in experimental diabetic nephropathy.

Published in:

Kidney International, 1999, v. 56, n. 5, p. 1691, doi. 10.1046/j.1523-1755.1999.00728.x

By:

Al-Douahji, Mouhannad;
Brugarolas, James;
Brown, Paul A.J.;
Stehman-Breen, Catherine O.;
Alpers, Charles E.;
Shankland, Stuart J.

Publication type:

Article

The cyclin kinase inhibitor p21CIP1/WAF1 limits glomerular epithelial cell proliferation in experimental glomerulonephritis.

Published in:

Kidney International, 1999, v. 55, n. 6, p. 2349, doi. 10.1046/j.1523-1755.1999.00504.x

By:

Kim, Yoon-Goo;
Alpers, Charles E.;
Brugarolas, James;
Johnson, Richard J.;
Couser, William G.;
Shankland, Stuart J.

Publication type:

Article

BAP1 and PBRM1 in metastatic clear cell renal cell carcinoma: tumor heterogeneity and concordance with paired primary tumor.

Published in:

2017

By:

Eckel-Passow, Jeanette E.;
Serie, Daniel J.;
Cheville, John C.;
Ho, Thai H.;
Kapur, Payal;
Brugarolas, James;
Houston Thompson, R.;
Leibovich, Bradley C.;
Kwon, Eugene D.;
Joseph, Richard W.;
Parker, Alexander S.;
Thompson, R Houston

Publication type:

journal article

Multi-disciplinary surgical approach to the management of patients with renal cell carcinoma with venous tumor thrombus: 15 year experience and lessons learned.

Published in:

2016

By:

Gayed, Bishoy A.;
Youssef, Ramy;
Darwish, Oussama;
Kapur, Payal;
Bagrodia, Aditya;
Brugarolas, James;
Raj, Ganesh;
DiMaio, J. Michael;
Sagalowsky, Arthur;
Margulis, Vitaly

Publication type:

journal article

Prospective evaluation of plasma levels of ANGPT2, TuM2PK, and VEGF in patients with renal cell carcinoma.

Published in:

2015

By:

Gayed, Bishoy A.;
Gillen, Jessica;
Christie, Alana;
Peña-Llopis, Samuel;
Xian-Jin Xie;
Jingsheng Yan;
Karam, Jose A.;
Raj, Ganesh;
Sagalowsky, Arthur I.;
Lotan, Yair;
Margulis, Vitaly;
Brugarolas, James;
Xie, Xian-Jin;
Yan, Jingsheng

Publication type:

journal article

SCINA: A Semi-Supervised Subtyping Algorithm of Single Cells and Bulk Samples.

Published in:

Genes, 2019, v. 10, n. 7, p. 531, doi. 10.3390/genes10070531

By:

Zhang, Ze;
Luo, Danni;
Zhong, Xue;
Choi, Jin Huk;
Ma, Yuanqing;
Wang, Stacy;
Mahrt, Elena;
Guo, Wei;
Stawiski, Eric W;
Modrusan, Zora;
Seshagiri, Somasekar;
Kapur, Payal;
Hon, Gary C.;
Brugarolas, James;
Wang, Tao

Publication type:

Article

Multistep regulation of TFEB by MTORC1.

Published in:

Autophagy, 2017, v. 13, n. 3, p. 464, doi. 10.1080/15548627.2016.1271514

By:

Vega-Rubin-de-Celis, Silvia;
Peña-Llopis, Samuel;
Konda, Meghan;
Brugarolas, James

Publication type:

Article

Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes.

Published in:

Nature Genetics, 2015, v. 47, n. 1, p. 13, doi. 10.1038/ng.3146

By:

Durinck, Steffen;
Stawiski, Eric W;
Pedrosa, Ivan;
de Sauvage, Frederic J;
Pavía-Jiménez, Andrea;
Toffessi-Tcheuyap, Vanina;
Peña-Llopis, Samuel;
Holloman, Eboni;
Hill, Haley M;
Brugarolas, James;
Modrusan, Zora;
Jaiswal, Bijay S;
Zhang, Na;
Nguyen, Thong T;
Pahuja, Kanika Bajaj;
Chen, Ying-Jiun;
Chaudhuri, Subhra;
Heldens, Sherry;
Jackson, Marlena;
Guillory, Joseph

Publication type:

Article

Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor.

Published in:

Nature Chemical Biology, 2011, v. 7, n. 10, p. 712, doi. 10.1038/nchembio.645

By:

Mata, Miguel A;
Satterly, Neal;
Versteeg, Gijs A;
Frantz, Doug;
Wei, Shuguang;
Williams, Noelle;
Schmolke, Mirco;
Peña-Llopis, Samuel;
Brugarolas, James;
Forst, Christian V;
White, Michael A;
García-Sastre, Adolfo;
Roth, Michael G;
Fontoura, Beatriz M A

Publication type:

Article

Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor Receptor Inactivation by Sunitinib Results in Tsc1/Tsc2-Dependent Inhibition of TORC1.

Published in:

Molecular & Cellular Biology, 2013, v. 33, n. 19, p. 3762, doi. 10.1128/MCB.01570-12

By:

Tran, Tram Anh;
Kinch, Lisa;
Peña-Llopis, Samuel;
Kockel, Lutz;
Grishin, Nick;
Jiang, Huaqi;
Brugarolas, James

Publication type:

Article

Cell-Type-Dependent Regulation of mTORC1 by REDD1 and the Tumor Suppressors TSC1/TSC2 and LKB1 in Response to Hypoxia.

Published in:

Molecular & Cellular Biology, 2011, v. 31, n. 9, p. 1870, doi. 10.1128/MCB.01393-10

By:

Wolff, Nicholas C.;
Vega-Rubin-de-Celis, Silvia;
Xian-Jin Xie;
Castrillon, Diego H.;
Kabbani, Wareef;
Brugarolas, James

Publication type:

Article

Extended Disease Control with Unconventional Cabozantinib Dose Increase in Metastatic Renal Cell Carcinoma.

Published in:

Kidney Cancer (2468-4562), 2022, v. 6, n. 1, p. 69, doi. 10.3233/KCA-210117

By:

Sharma, Akanksha;
Elias, Roy;
Christie, Alana;
Williams, Noelle S.;
Pedrosa, Ivan;
Bjarnason, Georg A.;
Brugarolas, James

Publication type:

Article

Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes.

Published in:

Nature Immunology, 2012, v. 14, n. 1, p. 61, doi. 10.1038/ni.2475

By:

Hasan, Maroof;
Koch, James;
Rakheja, Dinesh;
Pattnaik, Asit K;
Brugarolas, James;
Dozmorov, Igor;
Levine, Beth;
Wakeland, Edward K;
Lee-Kirsch, Min Ae;
Yan, Nan

Publication type:

Article

TFEB, a novel mTORC1 effector implicated in lysosome biogenesis, endocytosis and autophagy.

Published in:

Cell Cycle, 2011, v. 10, n. 23, p. 3987, doi. 10.4161/cc.10.23.18251

By:

Peña-Llopis, Samuel;
Brugarolas, James

Publication type:

Article