Works by Brownell, Isaac

Results: 52

Spontaneous tumor regression and immunotherapy response demonstrate clonal T-cell expansion in Merkel cell carcinoma.

Published in:

NPJ Precision Oncology, 2025, v. 9, n. 1, p. 1, doi. 10.1038/s41698-025-00987-6

By:

Hallaert, Patrick;
Roman, John W.;
Baker, Mairead;
Hill, Natasha T.;
Marte, Jennifer L.;
Gulley, James L.;
Logemann, Nicholas;
Hudgens, Courtney W.;
Reuben, Alexandre;
Brownell, Isaac

Publication type:

Article

Melanoma in patients with GATA2 deficiency.

Published in:

Pigment Cell & Melanoma Research, 2018, v. 31, n. 2, p. 337, doi. 10.1111/pcmr.12671

By:

Nguyen, Jannett;
Alexander, Tiffany;
Jiang, Hong;
Hill, Natasha;
Abdullaev, Zied;
Pack, Svetlana D.;
Hsu, Amy P.;
Holland, Steven M.;
Hickstein, Dennis D.;
Engels, Eric A.;
Brownell, Isaac

Publication type:

Article

Merkel Cell Carcinoma Therapeutic Update.

Published in:

2016

By:

Cassler, Nicole;
Merrill, Dean;
Bichakjian, Christopher;
Brownell, Isaac;
Cassler, Nicole M;
Bichakjian, Christopher K

Publication type:

journal article

Intersectional Screening Identifies Synergistic Combinatorial Therapies for Merkel Cell Carcinoma.

Published in:

FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.03679

By:

Garman, Khalid;
Gelb, Tara;
Urban, Daniel;
Hall, Matthew;
Brownell, Isaac

Publication type:

Article

Hedgehog Signaling in Neonatal and Adult Lung.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2013, v. 48, n. 6, p. 703, doi. 10.1165/rcmb.2012-0347OC

By:

Liu, Li;
Kugler, Matthias C.;
Loomis, Cynthia A.;
Samdani, Rashmi;
Zhicheng Zhao;
Chen, Gregory J.;
Brandt, Julia P.;
Brownell, Isaac;
Joyner, Alexandra L.;
Rom, William N.;
Munger, John S.

Publication type:

Article

Evidence for Mycobacteria in Sarcoidosis.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2011, v. 45, n. 5, p. 899, doi. 10.1165/rcmb.2010-0433TR

By:

Brownell, Isaac;
Ramírez-Valle, Francisco;
Sanchez, Miguel;
Prystowsky, Stephen

Publication type:

Article

Risk of Superficial Fungal Infections in WHIM Syndrome.

Published in:

Dermatology & Therapy, 2025, v. 15, n. 5, p. 1173, doi. 10.1007/s13555-025-01396-0

By:

Strong, Jennifer;
Adhanom, Rutha;
Kim, Caleb S.;
Saito, Yoshine;
Meltzer, Jasmine C.;
Hallaert, Patrick;
Martinez, Sophia;
Salancy, Abigail;
Kong, Heidi H.;
Cowen, Edward W.;
Castelo-Soccio, Leslie;
Murphy, Philip M.;
McDermott, David H.;
Brownell, Isaac

Publication type:

Article

A hybrid machine learning approach for the personalized prognostication of aggressive skin cancers.

Published in:

NPJ Digital Medicine, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s41746-024-01329-9

By:

Andrew, Tom W.;
Alrawi, Mogdad;
Plummer, Ruth;
Reynolds, Nick;
Sondak, Vern;
Brownell, Isaac;
Lovat, Penny E.;
Rose, Aidan;
Shalhout, Sophia Z.

Publication type:

Article

Immunotherapy for skin cancer.

Published in:

International Immunology, 2019, v. 31, n. 7, p. 465, doi. 10.1093/intimm/dxz012

By:

Paulson, Kelly G;
Lahman, Miranda C;
Chapuis, Aude G;
Brownell, Isaac

Publication type:

Article

Expression of FoxE4 and Rx Visualizes the Timing and Dynamics of Critical Processes Taking Place during Initial Stages of Vertebrate Eye Development.

Published in:

Developmental Neuroscience, 2004, v. 26, n. 5/6, p. 294, doi. 10.1159/000082271

By:

Zilinski, Carolyn;
Brownell, Isaac;
Hashimoto, Ryuju;
Medina-Martinez, Olga;
Swindell, Eric C.;
Jamrich, Milan

Publication type:

Article

Assessment of Cancer Cell Line Representativeness Using Microarrays for Merkel Cell Carcinoma.

Published in:

Journal of Investigative Dermatology, 2015, v. 135, n. 4, p. 1138, doi. 10.1038/jid.2014.518

By:

Daily, Kenneth;
Coxon, Amy;
Williams, Jonathan S;
Lee, Chyi-Chia R;
Coit, Daniel G;
Busam, Klaus J;
Brownell, Isaac

Publication type:

Article

Perivascular Hair Follicle Stem Cells Associate with a Venule Annulus.

Published in:

Journal of Investigative Dermatology, 2013, v. 133, n. 10, p. 2324, doi. 10.1038/jid.2013.167

By:

Xiao, Ying;
Woo, Wei-Meng;
Nagao, Keisuke;
Li, Wenling;
Terunuma, Atsushi;
Mukouyama, Yoh-suke;
Oro, Anthony E;
Vogel, Jonathan C;
Brownell, Isaac

Publication type:

Article

Merkel cell carcinoma expresses the immunoregulatory ligand CD200 and induces immunosuppressive macrophages and regulatory T cells.

Published in:

OncoImmunology, 2018, v. 7, n. 5, p. 1, doi. 10.1080/2162402X.2018.1426517

By:

Gaiser, Maria Rita;
Weis, Cleo-Aron;
Gaiser, Timo;
Jiang, Hong;
Buder-Bakhaya, Kristina;
Herpel, Esther;
Warth, Arne;
Xiao, Ying;
Miao, Lingling;
Brownell, Isaac

Publication type:

Article

Cancer‐testis antigens as biomarkers for Merkel cell carcinoma: Pitfalls and opportunities.

Published in:

Journal of Cutaneous Pathology, 2019, v. 46, n. 10, p. 748, doi. 10.1111/cup.13528

By:

Dasgeb, Bahar;
Mehregan, Darius;
Ring, Christina;
Nartker, Nathan;
Brownell, Isaac

Publication type:

Article

PD-L1 blockade with avelumab: A new paradigm for treating Merkel cell carcinoma.

Published in:

Cancer Biology & Therapy, 2017, v. 18, n. 12, p. 937, doi. 10.1080/15384047.2017.1394552

By:

Barkdull, Savannah;
Brownell, Isaac

Publication type:

Article

Low pH reprograms somatic murine cells into pluripotent stem cells.

Published in:

Cancer Biology & Therapy, 2014, v. 15, n. 6, p. 1, doi. 10.4161/cbt.28414

By:

Williams, Jonathan S.;
Ying Xiao;
Brownell, Isaac

Publication type:

Article

A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development.

Published in:

PLoS Genetics, 2016, v. 12, n. 7, p. 1, doi. 10.1371/journal.pgen.1006150

By:

Xiao, Ying;
Thoresen, Daniel T.;
Miao, Lingling;
Williams, Jonathan S.;
Wang, Chaochen;
Atit, Radhika P.;
Wong, Sunny Y.;
Brownell, Isaac

Publication type:

Article

Distinct Signatures of Genomic Copy Number Variants Define Subgroups of Merkel Cell Carcinoma Tumors.

Published in:

Cancers, 2021, v. 13, n. 5, p. 1134, doi. 10.3390/cancers13051134

By:

Hill, Natasha T.;
Kim, David;
Busam, Klaus J.;
Chu, Emily Y.;
Green, Clayton;
Brownell, Isaac;
Lui, Virve Koljonen; Weng-Onn;
Becker, Jürgen C.

Publication type:

Article

Challenges documenting racial disparities in Merkel cell carcinoma.

Published in:

Cancer Biology & Therapy, 2022, v. 23, n. 1, p. 1, doi. 10.1080/15384047.2022.2145842

By:

Martin, Mackenzie R.;
Mohsin, Noreen;
Vilasi, Serena;
Reed, Danielle;
Brownell, Isaac

Publication type:

Article

The crippling financial toxicity of cancer in the United States.

Published in:

Cancer Biology & Therapy, 2019, v. 20, n. 10, p. 1301, doi. 10.1080/15384047.2019.1632132

By:

Collado, Loren;
Brownell, Isaac

Publication type:

Article

Diffuse lichen planus-like keratoses and clinical pseudo-progression associated with avelumab treatment for Merkel cell carcinoma, a case report.

Published in:

2019

By:

Cardis, Michael A.;
Jiang, Hong;
Strauss, Julius;
Gulley, James L.;
Brownell, Isaac

Publication type:

journal article

Early objective response to avelumab treatment is associated with improved overall survival in patients with metastatic Merkel cell carcinoma.

Published in:

Cancer Immunology, Immunotherapy, 2019, v. 68, n. 4, p. 609, doi. 10.1007/s00262-018-02295-4

By:

D'Angelo, Sandra P.;
Hunger, Matthias;
Brohl, Andrew S.;
Nghiem, Paul;
Bhatia, Shailender;
Hamid, Omid;
Mehnert, Janice M.;
Terheyden, Patrick;
Shih, Kent C.;
Brownell, Isaac;
Lebbé, Céleste;
Lewis, Karl D.;
Linette, Gerald P.;
Milella, Michele;
Schlichting, Michael;
Hennessy, Meliessa H.;
Bharmal, Murtuza

Publication type:

Article

First-line pembrolizumab plus androgen deprivation therapy for locally advanced microsatellite instability-high prostate cancer in a patient with Muir-Torre syndrome: A case report.

Published in:

Frontiers in Oncology, 2023, v. 13, p. 1, doi. 10.3389/fonc.2023.1126476

By:

Atiq, Mohammad O.;
Pastor, Danielle M.;
Karzai, Fatima;
Hankin, Amy R.;
Turkbey, Baris;
Cordes, Lisa M.;
Brownell, Isaac;
Liu, Yi;
Chesnut, Gregory T.;
Madan, Ravi A.

Publication type:

Article

Case Report: The immune architecture of immunotherapy-induced cutaneous sarcoidosis resembles peritumoral inflammation.

Published in:

2025

By:

Wang, Catherine J.;
Strong, Jennifer;
Gatti-Mays, Margaret E.;
Lassoued, Wiem;
Sater, Sam;
Strauss, Julius;
Redman, Jason M.;
Schlom, Jeffrey;
Gulley, James L.;
Brownell, Isaac

Publication type:

Case Study

Selective radiotherapy for the treatment of head and neck Merkel cell carcinoma.

Published in:

Cancer (0008543X), 2012, v. 118, n. 16, p. 3937, doi. 10.1002/cncr.26738

By:

Lok, Benjamin;
Khan, Sabrina;
Mutter, Robert;
Liu, Jeffrey;
Fields, Ryan;
Pulitzer, Melissa;
Shi, Weiji;
Zhang, Zhigang;
Kraus, Dennis;
Pfister, David;
Busam, Klaus J.;
Brownell, Isaac;
Lee, Nancy

Publication type:

Article

Mosaic partial deletion of the PTEN gene in a patient with Cowden syndrome.

Published in:

Familial Cancer, 2014, v. 13, n. 3, p. 459, doi. 10.1007/s10689-014-9709-4

By:

Salo-Mullen, Erin;
Shia, Jinru;
Brownell, Isaac;
Allen, Peter;
Girotra, Monica;
Robson, Mark;
Offit, Kenneth;
Guillem, Jose;
Markowitz, Arnold;
Stadler, Zsofia

Publication type:

Article

PRGN-2009 and bintrafusp alfa for patients with advanced or metastatic human papillomavirus-associated cancer.

Published in:

Cancer Immunology, Immunotherapy, 2025, v. 74, n. 5, p. 1, doi. 10.1007/s00262-025-04009-z

By:

Floudas, Charalampos S.;
Goswami, Meghali;
Donahue, Renee N.;
Strauss, Julius;
Pastor, Danielle M.;
Redman, Jason M.;
Brownell, Isaac;
Turkbey, Evrim B.;
Steinberg, Seth M.;
Cordes, Lisa M.;
Marté, Jennifer L.;
Khan, Maheen H.;
McMahon, Sheri;
Lamping, Elizabeth;
Manu, Michell;
Manukyan, Manuk;
Brough, Douglas E.;
Lankford, Amy;
Jochems, Caroline;
Schlom, Jeffrey

Publication type:

Article

96. Human Papilloma Viruses Associated Diseases in a Cohort of Patients with Idiopathic CD4 Lymphopenia.

Published in:

Open Forum Infectious Diseases, 2019, v. 6, p. S9, doi. 10.1093/ofid/ofz359.020

By:

Mystakelis, Harry;
Laidlaw, Elizabeth;
Anderson, Megan;
Ye, Peiying;
Manion, Maura;
Brownell, Isaac;
Sereti, Irini;
Lisco, Andrea

Publication type:

Article

Mycophenolate mofetil inhibits Merkel cell carcinoma growth.

Published in:

British Journal of Dermatology, 2024, v. 190, n. 4, p. 593, doi. 10.1093/bjd/ljae018

By:

Garman, Khalid A;
Thoreson, Nicholas;
Strong, Jennifer;
Hallaert, Patrick;
Gelb, Tara;
Shen, Min;
Hall, Matthew D;
Brownell, Isaac

Publication type:

Article

Robust Production of Merkel Cell Polyomavirus Oncogene Specific T Cells From Healthy Donors for Adoptive Transfer.

Published in:

Frontiers in Immunology, 2020, v. 11, p. N.PAG, doi. 10.3389/fimmu.2020.592721

By:

Davies, Sarah I.;
Barrett, John;
Wong, Susan;
Chang, Mark Jesse;
Muranski, Pawel J.;
Brownell, Isaac

Publication type:

Article

BRAF Inhibitors for the Treatment of Papulopustular Eruptions from MAPK Pathway Inhibitors.

Published in:

American Journal of Clinical Dermatology, 2020, v. 21, n. 6, p. 759, doi. 10.1007/s40257-020-00539-7

By:

Wang, Catherine J.;
Brownell, Isaac

Publication type:

Article

ATOH1, TFAP2B, and CEACAM6 as Immunohistochemical Markers to Distinguish Merkel Cell Carcinoma and Small Cell Lung Cancer.

Published in:

Cancers, 2024, v. 16, n. 4, p. 788, doi. 10.3390/cancers16040788

By:

Vilasi, Serena M.;
Nguyen, Jannett;
Wang, Catherine J.;
Miao, Lingling;
Daily, Kenneth;
Eid, Mary;
Song, Joon Seon;
Jiang, Hong;
Ylaya, Kris;
Busam, Klaus J.;
Gaiser, Maria R.;
Hewitt, Stephen M.;
Brownell, Isaac

Publication type:

Article

The Merkel Cell Carcinoma Patient Registry: From Promise to Prototype to Patient.

Published in:

Journal of Registry Management, 2022, v. 49, n. 1, p. 4

By:

Miller, David M.;
Shalhout, Sophia Z.;
Saqlain, Farees;
Patel, Vishal A.;
Tsai, Kenneth Y.;
Elayavilli, Ravikumar Komandur;
Louv, Bill;
Brownell, Isaac;
Wong, Michael K.

Publication type:

Article

Forkhead Foxe3 maps to the dysgenetic lens locus and is critical in lens development and differentiation.

Published in:

Genesis: The Journal of Genetics & Development, 2000, v. 27, n. 2, p. 81, doi. 10.1002/1526-968X(200006)27:2<81::AID-GENE50>3.0.CO;2-N

By:

Brownell, Isaac;
Dirksen, Marli;
Jamrich, Milan

Publication type:

Article

Recalcitrant tinea capitis in WHIM syndrome.

Published in:

Skin Health & Disease, 2025, v. 5, n. 1, p. 41, doi. 10.1093/skinhd/vzae002

By:

Meltzer, Jasmine C;
Strong, Jennifer;
Martinez, Sophia;
Salancy, Abigail;
Adhanom, Rutha;
Cowen, Edward W;
Castelo-Soccio, Leslie;
Murphy, Philip M;
McDermott, David H;
Brownell, Isaac

Publication type:

Article

Merkel cells and touch domes: more than mechanosensory functions?

Published in:

Experimental Dermatology, 2014, v. 23, n. 10, p. 692, doi. 10.1111/exd.12456

By:

Xiao, Ying;
Williams, Jonathan S.;
Brownell, Isaac

Publication type:

Article

Longitudinal lift biopsy technique with flat fixation for the diagnosis of mycosis fungoides.

Published in:

International Journal of Dermatology, 2011, v. 50, n. 7, p. 875, doi. 10.1111/j.1365-4632.2010.04806.x

By:

Brooks, Christine;
Pulitzer, Melissa P.;
Brownell, Isaac

Publication type:

Article

PD-L1 inhibition with avelumab for metastatic Merkel cell carcinoma.

Published in:

Expert Review of Clinical Pharmacology, 2018, v. 11, n. 4, p. 345, doi. 10.1080/17512433.2018.1445966

By:

Gaiser, Maria Rita;
Bongiorno, Michelle;
Brownell, Isaac

Publication type:

Article

Avelumab: a new standard for treating metastatic Merkel cell carcinoma.

Published in:

2018

By:

Baker, Mairead;
Cordes, Lisa;
Brownell, Isaac

Publication type:

journal article

Anti-PD-L1 Treatment Induced Central Diabetes Insipidus.

Published in:

2017

By:

Zhao, Chen;
Tella, Sri Harsha;
Del Rivero, Jaydira;
Kommalapati, Anuhya;
Ebenuwa, Ifechukwude;
Gulley, James;
Strauss, Julius;
Brownell, Isaac

Publication type:

journal article

Merkel Cell Carcinoma and Immunosuppression, UV Radiation, and Merkel Cell Polyomavirus.

Published in:

JAMA Dermatology, 2025, v. 161, n. 1, p. 47, doi. 10.1001/jamadermatol.2024.4607

By:

Tribble, Jacob T.;
Pfeiffer, Ruth M.;
Brownell, Isaac;
Cahoon, Elizabeth K.;
Sargen, Michael R.;
Shiels, Meredith S.;
Luo, Qianlai;
Cohen, Colby;
Drezner, Kate;
Hernandez, Brenda;
Moreno, Adrianne;
Pawlish, Karen;
Saafir-Callaway, Brittani;
Engels, Eric A.;
Volesky-Avellaneda, Karena D.

Publication type:

Article

Considerations Regarding Mohs Surgery for Early-Stage Merkel Cell Carcinoma.

Published in:

2024

By:

Venna, Suraj S.;
Goff, Peter H.;
Brownell, Isaac

Publication type:

Letter

Genetic Risk Factors for Early-Onset Merkel Cell Carcinoma.

Published in:

JAMA Dermatology, 2024, v. 160, n. 2, p. 172, doi. 10.1001/jamadermatol.2023.5362

By:

Mohsin, Noreen;
Hunt, Devin;
Yan, Jia;
Jabbour, Austin J.;
Nghiem, Paul;
Choi, Jaehyuk;
Zhang, Yue;
Freeman, Alexandra F.;
Bergerson, Jenna R. E.;
Dell'Orso, Stefania;
Lachance, Kristina;
Kulikauskas, Rima;
Collado, Loren;
Cao, Wenjia;
Lack, Justin;
Similuk, Morgan;
Seifert, Bryce A.;
Ghosh, Rajarshi;
Walkiewicz, Magdalena A.;
Brownell, Isaac

Publication type:

Article

Differences in Merkel Cell Carcinoma Presentation and Outcomes Among Racial and Ethnic Groups.

Published in:

JAMA Dermatology, 2023, v. 159, n. 5, p. 536, doi. 10.1001/jamadermatol.2023.0061

By:

Mohsin, Noreen;
Martin, Mackenzie R.;
Reed, Danielle J.;
Vilasi, Serena M.;
Miao, Lingling;
Hill, Natasha T.;
Brownell, Isaac

Publication type:

Article

Voriconazole and the Risk of Keratinocyte Carcinomas Among Lung Transplant Recipients in the United States.

Published in:

2020

By:

D'Arcy, Monica E.;
Pfeiffer, Ruth M.;
Rivera, Donna R.;
Hess, Gregory P.;
Cahoon, Elizabeth K.;
Arron, Sarah T.;
Brownell, Isaac;
Cowen, Edward W.;
Israni, Ajay K.;
Triplette, Matthew A.;
Yanik, Elizabeth L.;
Engels, Eric A.

Publication type:

journal article

Identification of natural product modulators of Merkel cell carcinoma cell growth and survival.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-93097-9

By:

Smith, Emily A.;
Hill, Natasha T.;
Gelb, Tara;
Garman, Khalid A.;
Goncharova, Ekaterina I.;
Bokesch, Heidi R.;
Kim, Chang-Kwon;
Wendt, Karen L.;
Cichewicz, Robert H.;
Gustafson, Kirk R.;
Brownell, Isaac;
Henrich, Curtis J.

Publication type:

Article

Innumerable lentigines in a mother and daughter.

Published in:

2019

By:

Cardis, Michael A.;
Hathaway, Olanda;
Brownell, Isaac

Publication type:

Case Study

Allergic Contact Dermatitis to Gamma-Irradiated WEBCOL Alcohol Prep Pads.

Published in:

Pediatric Dermatology, 2013, v. 30, n. 6, p. e281, doi. 10.1111/j.1525-1470.2012.01727.x

By:

Firoz, Elnaz F.;
Turnbull, Rowena K.;
Loomis, Cynthia A.;
Brownell, Isaac

Publication type:

Article

An Investigation of Structure–Activity Relationships and Cell Death Mechanisms of the Marine Alkaloids Discorhabdins in Merkel Cell Carcinoma Cells.

Published in:

Marine Drugs, 2023, v. 21, n. 9, p. 474, doi. 10.3390/md21090474

By:

Orfanoudaki, Maria;
Smith, Emily A.;
Hill, Natasha T.;
Garman, Khalid A.;
Brownell, Isaac;
Copp, Brent R.;
Grkovic, Tanja;
Henrich, Curtis J.

Publication type:

Article

Severe Defects in Proliferation and Differentiation of Lens Cells in Foxe3 Null Mice.

Published in:

Molecular & Cellular Biology, 2005, v. 25, n. 20, p. 8854, doi. 10.1128/MCB.25.20.8854-8863.2005

By:

Medina-Martinez, Olga;
Brownell, Isaac;
Amaya-Manzanares, Felipe;
Qiyong Hu;
Behringer, Richard R.;
Jamrich, Milan

Publication type:

Article