Works by Brown, Christine E.

Results: 42

Human Neural Stem Cell Biodistribution and Predicted Tumor Coverage by a Diffusible Therapeutic in a Mouse Glioma Model.

Published in:

Stem Cells Translational Medicine, 2017, v. 6, n. 6, p. 1522, doi. 10.1002/sctm.16-0397

By:

Barish, Michael E.;
Herrmann, Kelsey;
Tang, Yang;
Argalian Herculian, Siranush;
Metz, Marianne;
Aramburo, Soraya;
Tirughana, Revathiswari;
Gutova, Margarita;
Annala, Alexander;
Moats, Rex A.;
Goldstein, Leanne;
Rockne, Russell C.;
Gutierrez, Jennifer;
Brown, Christine E.;
Ghoda, Lucy;
Aboody, Karen S.

Publication type:

Article

Neural Stem Cell-Mediated Delivery of Irinotecan-Activating Carboxylesterases to Glioma: Implications for Clinical Use.

Published in:

Stem Cells Translational Medicine, 2013, v. 2, n. 12, p. 983, doi. 10.5966/sctm.2012-0177

By:

METZ, MARIANNE Z.;
GUTOVA, MARGARITA;
LACEY, SIMON F.;
ABRAMYANTS, YELENA;
TIEN VO;
GILCHRIST, MEGAN;
TIRUGHANA, REVATHISWARI;
GHODA, LUCY Y.;
BARISH, MICHAEL E.;
BROWN, CHRISTINE E.;
NAJBAUER, JOSEPH;
POTTER, PHILIP M.;
PORTNOW, JANA;
SYNOLD, TIMOTHY W.;
ABOODY, KAREN S.

Publication type:

Article

Targeting Wnt signaling for improved glioma immunotherapy.

Published in:

Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1342625

By:

Gutova, Margarita;
Hibbard, Jonathan C.;
Ma, Eric;
Natri, Heini M.;
Adhikarla, Vikram;
Chimge, Nyam-Osor;
Runxiang Qiu;
Cu Nguyen;
Melendez, Elizabeth;
Aguilar, Brenda;
Starr, Renate;
Yin, Holly;
Rockne, Russel C.;
Masaya Ono;
Banovich, Nicholas E.;
Yate-Ching Yuan;
Brown, Christine E.;
Kahn, Michael

Publication type:

Article

PGE2-EP2/EP4 signaling elicits mesoCAR T cell immunosuppression in pancreatic cancer.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1209572

By:

Akbari, Behnia;
Soltantoyeh, Tahereh;
Shahosseini, Zahra;
Jadidi-Niaragh, Farhad;
Hadjati, Jamshid;
Brown, Christine E.;
Mirzaei, Hamid Reza

Publication type:

Article

Data driven model discovery and interpretation for CAR T-cell killing using sparse identification and latent variables.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1115536

By:

Brummer, Alexander B.;
Xella, Agata;
Woodall, Ryan;
Adhikarla, Vikram;
Cho, Heyrim;
Gutova, Margarita;
Brown, Christine E.;
Rockne, Russell C.

Publication type:

Article

PET of Adoptively Transferred Chimeric Antigen Receptor T Cells with <sup>89</sup>Zr-Oxine.

Published in:

Journal of Nuclear Medicine, 2018, v. 59, n. 10, p. 1531, doi. 10.2967/jnumed.117.206714

By:

Weist, Michael R.;
Starr, Renate;
Aguilar, Brenda;
Chea, Junie;
Miles, Joshua K.;
Poku, Erasmus;
Gerdts, Ethan;
Xin Yang;
Priceman, Saul J.;
Forman, Stephen J.;
Colcher, David;
Brown, Christine E.;
Shively, John E.

Publication type:

Article

Donor-derived CD19-targeted chimeric antigen receptor T cells in adult transplant recipients with relapsed/refractory acute lymphoblastic leukemia.

Published in:

Blood Cancer Journal, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41408-023-00881-z

By:

Aldoss, Ibrahim;
Khaled, Samer K.;
Wang, Yan;
Wang, Xiuli;
Palmer, Joycelynne;
Clark, Mary C.;
Wagner, Jamie R.;
Paul, Jinny;
Vyas, Vibhuti;
Brown, Christine E.;
Forman, Stephen J.

Publication type:

Article

Evaluation of the Immunomodulatory Effects of Radiation for Chimeric Antigen Receptor T Cell Therapy in Glioblastoma Multiforme.

Published in:

Cells (2073-4409), 2024, v. 13, n. 13, p. 1075, doi. 10.3390/cells13131075

By:

Akhavan, David;
Subham, Siddharth;
Jeppson, John D.;
Aguilar, Brenda;
Wong, Robyn A.;
Hibbard, Jonathan C.;
Hui, Susanta;
Wong, Jeffrey Y. C.;
Forman, Stephen J.;
Alizadeh, Darya;
Brown, Christine E.

Publication type:

Article

Spatiotemporal analysis of glioma heterogeneity reveals COL1A1 as an actionable target to disrupt tumor progression.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-31340-1

By:

Comba, Andrea;
Faisal, Syed M.;
Dunn, Patrick J.;
Argento, Anna E.;
Hollon, Todd C.;
Al-Holou, Wajd N.;
Varela, Maria Luisa;
Zamler, Daniel B.;
Quass, Gunnar L.;
Apostolides, Pierre F.;
Abel II, Clifford;
Brown, Christine E.;
Kish, Phillip E.;
Kahana, Alon;
Kleer, Celina G.;
Motsch, Sebastien;
Castro, Maria G.;
Lowenstein, Pedro R.

Publication type:

Article

Outsmarting trogocytosis to boost CAR NK/T cell therapy.

Published in:

Molecular Cancer, 2023, v. 22, n. 1, p. 1, doi. 10.1186/s12943-023-01894-9

By:

Ramezani, Faezeh;
Panahi Meymandi, Ahmad Reza;
Akbari, Behnia;
Tamtaji, Omid Reza;
Mirzaei, Hamed;
Brown, Christine E.;
Mirzaei, Hamid Reza

Publication type:

Article

Chimeric Antigen Receptors T Cell Therapy in Solid Tumor: Challenges and Clinical Applications.

Published in:

Frontiers in Immunology, 2017, p. 1, doi. 10.3389/fimmu.2017.01850

By:

Mirzaei, Hamid R.;
Rodriguez, Analiz;
Shepphird, Jennifer;
Brown, Christine E.;
Badie, Behnam

Publication type:

Article

L1 Cell Adhesion Molecule-Specific Chimeric Antigen Receptor-Redirected Human T Cells Exhibit Specific and Efficient Antitumor Activity against Human Ovarian Cancer in Mice.

Published in:

PLoS ONE, 2016, v. 11, n. 1, p. 1, doi. 10.1371/journal.pone.0146885

By:

Hong, Hao;
Brown, Christine E.;
Ostberg, Julie R.;
Priceman, Saul J.;
Chang, Wen-Chung;
Weng, Lihong;
Lin, Paul;
Wakabayashi, Mark T.;
Jensen, Michael C.;
Forman, Stephen J.

Publication type:

Article

Preclinical Evaluation of CAR T Cell Function: In Vitro and In Vivo Models.

Published in:

2022

By:

Si, Xiaohui;
Xiao, Lu;
Brown, Christine E.;
Wang, Dongrui

Publication type:

Literature Review

Dose-dependent thresholds of dexamethasone destabilize CAR T-cell treatment efficacy.

Published in:

PLoS Computational Biology, 2022, v. 18, n. 1, p. 1, doi. 10.1371/journal.pcbi.1009504

By:

Brummer, Alexander B.;
Yang, Xin;
Ma, Eric;
Gutova, Margarita;
Brown, Christine E.;
Rockne, Russell C.

Publication type:

Article

IL-13Rα2/TGF-β bispecific CAR-T cells counter TGF-β-mediated immune suppression and potentiate anti-tumor responses in glioblastoma.

Published in:

Neuro-Oncology, 2024, v. 26, n. 10, p. 1850, doi. 10.1093/neuonc/noae126

By:

Hou, Andrew J;
Shih, Ryan M;
Uy, Benjamin R;
Shafer, Amanda;
Chang, ZeNan L;
Comin-Anduix, Begonya;
Guemes, Miriam;
Galic, Zoran;
Phyu, Su;
Okada, Hideho;
Grausam, Katie B;
Breunig, Joshua J;
Brown, Christine E;
Nathanson, David A;
Prins, Robert M;
Chen, Yvonne Y

Publication type:

Article

Off-the-shelf, steroid-resistant, IL13Rα2-specific CAR T cells for treatment of glioblastoma.

Published in:

Neuro-Oncology, 2022, v. 24, n. 8, p. 1318, doi. 10.1093/neuonc/noac024

By:

Brown, Christine E;
Rodriguez, Analiz;
Palmer, Joycelynne;
Ostberg, Julie R;
Naranjo, Araceli;
Wagner, Jamie R;
Aguilar, Brenda;
Starr, Renate;
Weng, Lihong;
Synold, Timothy W;
Tran, Vivi;
Wang, Shelley;
Reik, Andreas;
D'Apuzzo, Massimo;
Ressler, Julie A;
Zhou, Yuanyue;
Mendel, Matthew;
Gregory, Philip D;
Holmes, Michael C;
Tang, Winson W

Publication type:

Article

Co-stimulatory signaling determines tumor antigen sensitivity and persistence of CAR T cells targeting PSCA+ metastatic prostate cancer.

Published in:

OncoImmunology, 2018, v. 7, n. 2, p. N.PAG, doi. 10.1080/2162402X.2017.1380764

By:

Priceman, Saul J.;
Gerdts, Ethan A.;
Tilakawardane, Dileshni;
Kennewick, Kelly T.;
Murad, John P.;
Park, Anthony K.;
Jeang, Brook;
Yamaguchi, Yukiko;
Yang, Xin;
Urak, Ryan;
Weng, Lihong;
Chang, Wen-Chung;
Wright, Sarah;
Pal, Sumanta;
Reiter, Robert E.;
Wu, Anna M.;
Brown, Christine E.;
Forman, Stephen J.

Publication type:

Article

Comparison of naïve and central memory derived CD8 effector cell engraftment fitness and function following adoptive transfer.

Published in:

OncoImmunology, 2016, v. 5, n. 1, p. 1, doi. 10.1080/2162402X.2015.1072671

By:

Wang, Xiuli;
Wong, ChingLam W.;
Urak, Ryan;
Taus, Ellie;
Aguilar, Brenda;
Chang, Wen-Chung;
Mardiros, Armen;
Budde, Lihua E.;
Brown, Christine E.;
Forman, Stephen J.;
Berger, Carolina;
Jensen, Michael C.

Publication type:

Article

Neural Stem Cell-Mediated Enzyme/Prodrug Therapy for Glioma: Preclinical Studies.

Published in:

Science Translational Medicine, 2013, v. 5, n. 184, p. 1, doi. 10.1126/scitranslmed.3005365

By:

Aboody, Karen S.;
Najbauer, Joseph;
Metz, Marianne Z.;
D'Apuzzo, Massimo;
Gutova, Margarita;
Annala, Alexander J.;
Synold, Timothy W.;
Couture, Larry A.;
Blanchard, Suzette;
Moats, Rex A.;
Garcia, Elizabeth;
Aramburo, Soraya;
Valenzuela, Valerie V.;
Frank, Richard T.;
Barish, Michael E.;
Brown, Christine E.;
Kim, Seung U.;
Badie, Behnam;
Portnow, Jana

Publication type:

Article

Chimeric Antigen Receptors With Mutated IgG4 Fc Spacer Avoid Fc Receptor Binding and Improve T Cell Persistence and Antitumor Efficacy.

Published in:

Molecular Therapy, 2015, v. 23, n. 4, p. 757, doi. 10.1038/mt.2014.208

By:

Jonnalagadda, Mahesh;
Mardiros, Armen;
Urak, Ryan;
Wang, Xiuli;
Hoffman, Lauren J;
Bernanke, Alyssa;
Chang, Wen-Chung;
Bretzlaff, William;
Starr, Renate;
Priceman, Saul;
Ostberg, Julie R;
Forman, Stephen J;
Brown, Christine E

Publication type:

Article

1045. Targeted Elimination of the Brain Tumor Initiating Cell Population with Adoptively Transferred T Cells.

Published in:

Molecular Therapy, 2006, v. 13, p. S401, doi. 10.1016/j.ymthe.2006.08.1141

By:

Brown, Christine E.;
Starr, Renate;
Korta, Dorota;
Aguilar, Brenda;
Jensen, Michael C.

Publication type:

Article

272. Conversion of a Tumor-Binding Peptide Identified by Phage Display to a Functional Chimeric T-Cell Antigen Receptor.

Published in:

Molecular Therapy, 2006, v. 13, p. S104, doi. 10.1016/j.ymthe.2006.08.326

By:

Pameijer, Colette R. J.;
Hamlett, Araceli;
Meechovet, Bessie;
Buckmaster, Jamie;
Aguilar, Brenda;
Wright, Christine;
Chung Chang, Wen-;
Brown, Christine E.;
Jensen, Michael C.

Publication type:

Article

619. Tumor-Derived Chemokine MCP-1/CCL2 Is Sufficient for Mediating Tumor Tropism of Adoptively Transferred T-Cells.

Published in:

Molecular Therapy, 2006, v. 13, p. S239, doi. 10.1016/j.ymthe.2006.08.694

By:

Brown, Christine E.;
Vishwanath, Reena;
Aguilar, Brenda;
WenChung Chang;
Jensen, Michael C.

Publication type:

Article

Targeting CEA in metastatic triple negative breast cancer with image-guided radiation followed by Fab-mediated chimeric antigen receptor (CAR) T-cell therapy.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2024.1499471

By:

Aniogo, Eric;
Kujawski, Maciej;
Awuah, Dennis;
Cha, Seung E.;
Espinosa, Ruby;
Hui, Susanta;
Ghimire, Hemendra;
Yazaki, Paul J.;
Brown, Christine E.;
Wang, Xiuli;
Shively, John E.

Publication type:

Article

CAR T cells for brain tumors: Lessons learned and road ahead.

Published in:

Immunological Reviews, 2019, v. 290, n. 1, p. 60, doi. 10.1111/imr.12773

By:

Akhavan, David;
Alizadeh, Darya;
Wang, Dongrui;
Weist, Michael R.;
Shepphird, Jennifer K.;
Brown, Christine E.

Publication type:

Article

Vitamin C, From Supplement to Treatment: A Re-Emerging Adjunct for Cancer Immunotherapy?

Published in:

Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.765906

By:

Kouakanou, Léonce;
Peters, Christian;
Brown, Christine E.;
Kabelitz, Dieter;
Wang, Leo D.

Publication type:

Article

Harnessing and Enhancing Macrophage Phagocytosis for Cancer Therapy.

Published in:

Frontiers in Immunology, 2021, v. 11, p. N.PAG, doi. 10.3389/fimmu.2021.635173

By:

Chen, Siqi;
Lai, Seigmund W. T.;
Brown, Christine E.;
Feng, Mingye

Publication type:

Article

Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16160-5

By:

Zah, Eugenia;
Nam, Eunwoo;
Bhuvan, Vinya;
Tran, Uyen;
Ji, Brenda Y.;
Gosliner, Stanley B.;
Wang, Xiuli;
Brown, Christine E.;
Chen, Yvonne Y.

Publication type:

Article

Cytokine Induction of VCAM-1 but Not IL13Rα2 on Glioma Cells: A Tale of Two Antibodies.

Published in:

PLoS ONE, 2014, v. 9, n. 5, p. 1, doi. 10.1371/journal.pone.0095123

By:

Mahadev, Vaidehi;
Starr, Renate;
Wright, Sarah L.;
Martinez, Catalina;
Jensen, Michael C.;
Barish, Michael E.;
Forman, Stephen J.;
Brown, Christine E.

Publication type:

Article

A Novel Berbamine Derivative Inhibits Cell Viability and Induces Apoptosis in Cancer Stem-Like Cells of Human Glioblastoma, via Up-Regulation of miRNA-4284 and JNK/AP-1 Signaling.

Published in:

PLoS ONE, 2014, v. 9, n. 4, p. 1, doi. 10.1371/journal.pone.0094443

By:

Yang, Fan;
Nam, Sangkil;
Brown, Christine E.;
Zhao, Robin;
Starr, Renate;
Horne, David A.;
Malkas, Linda H.;
Jove, Richard;
Hickey, Robert J.

Publication type:

Article

Glioma IL13Rα2 Is Associated with Mesenchymal Signature Gene Expression and Poor Patient Prognosis.

Published in:

PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0077769

By:

Brown, Christine E.;
Warden, Charles D.;
Starr, Renate;
Deng, Xutao;
Badie, Behnam;
Yuan, Yate-Ching;
Forman, Stephen J.;
Barish, Michael E.

Publication type:

Article

Engineering Human T Cells for Resistance to Methotrexate and Mycophenolate Mofetil as an <i>In Vivo</i> Cell Selection Strategy.

Published in:

PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0065519

By:

Jonnalagadda, Mahesh;
Brown, Christine E.;
Chang, Wen-Chung;
Ostberg, Julie R.;
Forman, Stephen J.;
Jensen, Michael C.

Publication type:

Article

Contact and Encirclement of Glioma Cells In Vitro Is an Intrinsic Behavior of a Clonal Human Neural Stem Cell Line.

Published in:

PLoS ONE, 2012, v. 7, n. 12, p. 1, doi. 10.1371/journal.pone.0051859

By:

Khosh, Nousha;
Brown, Christine E.;
Aboody, Karen S.;
Barish, Michael E.

Publication type:

Article

Genome-Wide Profiling Identified a Set of miRNAs that Are Differentially Expressed in Glioblastoma Stem Cells and Normal Neural Stem Cells.

Published in:

PLoS ONE, 2012, v. 7, n. 4, p. 1, doi. 10.1371/journal.pone.0036248

By:

Ming-Fei Lang;
Su Yang;
Chunnian Zhao;
Guoqiang Sun;
Kiyohito Murai;
Xiwei Wu;
Jinhui Wang;
Hanlin Gao;
Christine E. Brown;
Xiaoxuan Liu;
Jiehua Zhou;
Ling Peng;
JohnJ Rossi;
Yanhong Shi

Publication type:

Article

Cytotoxic T Lymphocyte Trafficking and Survival in an Augmented Fibrin Matrix Carrier.

Published in:

PLoS ONE, 2012, v. 7, n. 4, p. 1, doi. 10.1371/journal.pone.0034652

By:

Zhaoxia Zou;
Denny, Erin;
Brown, Christine E.;
Jensen, Michael C.;
Gang Li;
Fujii, Tatsuhiro;
Neman, Josh;
Jandial, Rahul;
Chen, Mike

Publication type:

Article

Corrigendum: Chimeric Antigen Receptors T Cell Therapy in Solid Tumor: Challenges and Clinical Applications.

Published in:

2019

By:

Mirzaei, Hamid R.;
Rodriguez, Analiz;
Shepphird, Jennifer;
Brown, Christine E.;
Badie, Behnam

Publication type:

Correction Notice

Significance of interleukin-13 receptor alpha 2–targeted glioblastoma therapy.

Published in:

Neuro-Oncology, 2014, v. 16, n. 10, p. 1304, doi. 10.1093/neuonc/nou045

By:

Thaci, Bart;
Brown, Christine E.;
Binello, Emanuela;
Werbaneth, Katherine;
Sampath, Prakash;
Sengupta, Sadhak

Publication type:

Article

Health inequity focus in pandemic preparedness and response plans.

Published in:

2022

By:

Mujica, Oscar J.;
Brown, Christine E.;
Victora, Cesar G.;
Goldblatt, Peter O.;
Barbosa da Silva Jr., Jarbas

Publication type:

Editorial

CAR macrophages with built-In CD47 blocker combat tumor antigen heterogeneity and activate T cells via cross-presentation.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-59326-9

By:

Chen, Siqi;
Wang, Yingyu;
Dang, Jessica;
Song, Nuozi;
Chen, Xiaoxin;
Wang, Jinhui;
Huang, Guo N.;
Brown, Christine E.;
Yu, Jianhua;
Weissman, Irving L.;
Rosen, Steven T.;
Feng, Mingye

Publication type:

Article

Chlorotoxin-directed CAR T cells for specific and effective targeting of glioblastoma.

Published in:

Science Translational Medicine, 2020, v. 12, n. 533, p. 1, doi. 10.1126/scitranslmed.aaw2672

By:

Wang, Dongrui;
Starr, Renate;
Chang, Wen-Chung;
Aguilar, Brenda;
Alizadeh, Darya;
Wright, Sarah L.;
Yang, Xin;
Brito, Alfonso;
Sarkissian, Aniee;
Ostberg, Julie R.;
Li, Li;
Shi, Yanhong;
Gutova, Margarita;
Aboody, Karen;
Badie, Behnam;
Forman, Stephen J.;
Barish, Michael E.;
Brown, Christine E.

Publication type:

Article

The future of cancer immunotherapy for brain tumors: a collaborative workshop.

Published in:

2022

By:

Brown, Christine E.;
Bucktrout, Samantha;
Butterfield, Lisa H.;
Futer, Olga;
Galanis, Evanthia;
Hormigo, Adilia;
Lim, Michael;
Okada, Hideho;
Prins, Robert;
Marr, Sara Siebel;
Tanner, Kirk

Publication type:

journal article

Structural and practical identifiability of contrast transport models for DCE-MRI.

Published in:

PLoS Computational Biology, 2024, v. 20, n. 5, p. 1, doi. 10.1371/journal.pcbi.1012106

By:

Conte, Martina;
Woodall, Ryan T.;
Gutova, Margarita;
Chen, Bihong T.;
Shiroishi, Mark S.;
Brown, Christine E.;
Munson, Jennifer M.;
Rockne, Russell C.

Publication type:

Article