Works by Brouwers, Nathalie

Results: 42

TANGO2 is an acyl-CoA binding protein.

Published in:

Journal of Cell Biology, 2025, v. 224, n. 5, p. 1, doi. 10.1083/jcb.202410001

By:

Leonardo Lujan, Agustin;
Foresti, Ombretta;
Wojnacki, Jose;
Bigliani, Gonzalo;
Brouwers, Nathalie;
Jesus Pena, Maria;
Androulaki, Stefania;
Tomomi Hashidate-Yoshida;
Kalyukina, Maria;
Novoselov, Sergey S.;
Shindou, Hideo;
Malhotra, Vivek

Publication type:

Article

The pathway of unconventional protein secretion involves CUPS and a modified trans-Golgi network.

Published in:

Journal of Cell Biology, 2025, v. 224, n. 5, p. 1, doi. 10.1083/jcb.202312120

By:

Curwin, Amy J.;
Kurokawa, Kazuo;
Bigliani, Gonzalo;
Brouwers, Nathalie;
Akihiko Nakano;
Malhotra, Vivek

Publication type:

Article

Tetraspanin-8 sequesters syntaxin-2 to control biphasic release propensity of mucin granules.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-39277-9

By:

Wojnacki, José;
Lujan, Agustin Leonardo;
Brouwers, Nathalie;
Aranda-Vallejo, Carla;
Bigliani, Gonzalo;
Rodriguez, Maria Pena;
Foresti, Ombretta;
Malhotra, Vivek

Publication type:

Article

Meta-Analysis of Rare CLU Variants Shows Association With Alzheimer's Risk and Calls Attention To The CLU Beta-Subunit

Published in:

2011

By:

Bettens, Karolien;
Brouwers, Nathalie;
Engelborghs, Sebastiaan;
Lambert, Jean-Charles;
Vandenberghe, Rik;
Pasquier, Florence;
De Deyn, Peter;
Amouyel, Philippe;
Van Broeckhoven, Christine;
Sleegers, Kristel

Publication type:

Abstract

Risk For Alzheimer's Associated With A Copy Number Variation In The Complement Receptor 1 Increasing C3b/C4b Binding Sites

Published in:

2011

By:

Brouwers, Nathalie;
Van Cauwenberghe, Caroline;
Engelborghs, Sebastiaan;
Lambert, Jean-Charles;
Bettens, Karolien;
Le Bastard, Nathalie;
Pasquier, Florence;
Vandenberghe, Rik;
De Deyn, Peter;
Cruts, Marc;
Amouyel, Philippe;
Sleegers, Kristel;
Van Broeckhoven, Christine

Publication type:

Abstract

In-depth molecular genetic analysis of CLU in Alzheimer's disease

Published in:

2010

By:

Bettens, Karolien;
Brouwers, Nathalie;
Gil, Ana;
Van Miegroet, Helen;
Engelborghs, Sebastiaan;
De Deyn, Peter P.;
Vandenberghe, Rik;
Sleegers, Kristel;
Van Broeckhoven, Christine

Publication type:

Abstract

APP and BACE1 miRNA genetic variability in risk for Alzheimer's disease

Published in:

2009

By:

Bettens, Karolien;
Brouwers, Nathalie;
Van Miegroet, Helen;
Engelborghs, Sebastiaan;
De Deyn, Peter;
Theuns, Jessie;
Sleegers, Kristel;
Van Broeckhoven, Christine

Publication type:

Abstract

Novel APP mutation p.E682K at the β’ processing site is associated with early-onset Alzheimer's disease

Published in:

2009

By:

Brouwers, Nathalie;
Vandenberghe, Rik;
Bettens, Karolien;
Van den Broeck, Marleen;
Brys, Jolien;
Van Miegroet, Helen;
Sleegers, Kristel;
Van Broeckhoven, Christine

Publication type:

Abstract

P3-266: GAB2 and risk for Alzheimer's dementia in a Belgian population

Published in:

2008

By:

Sleegers, Kristel;
Bettens, Karolien;
Engelborghs, Sebastiaan;
Brouwers, Nathalie;
van Miegroet, Helen;
De Deyn, Peter P.;
Van Broeckhoven, Christine

Publication type:

Abstract

P3-206: Genetic variability at the progranulin locus contributes to risk for Alzheimer's disease

Published in:

2008

By:

Brouwers, Nathalie;
Sleegers, Kristel;
Engelborghs, Sebastiaan;
Maurer-Stroh, Sébastian;
Gijselinck, Ilse;
van der Zee, Julie;
Pickut, Barbara;
Van den Broeck, Marleen;
Mattheijssens, Maria;
Peeters, Karin;
Schymkowitz, Joost;
Rousseau, Frédéric;
Martin, Jean-Jacques;
Cruts, Marc;
De Deyn, Peter Paul;
Van Broeckhoven, Christine

Publication type:

Abstract

P3-202: The neuronal sorting receptor SORL1 is genetically associated with increased risk for late-onset Alzheimer's disease in the Belgian population

Published in:

2008

By:

Bettens, Karolien;
Brouwers, Nathalie;
Engelborghs, Sebastiaan;
De Deyn, Peter;
Van Broeckhoven, Christine;
Sleegers, Kristel

Publication type:

Abstract

P1-321: Contribution of dementia genes to Alzheimer’s disease in Belgium

Published in:

2006

By:

Brouwers, Nathalie;
Sleegers, Kristel;
Theuns, Jessie;
Engelborghs, Sebastiaan;
Bogaerts, Veerle;
Serneels, Sally;
Kamali, Kenan;
Van den Broeck, Marleen;
Cruts, Marc;
De Deyn, Peter-Paul;
Van Broeckhoven, Christine

Publication type:

Abstract

O2-02-08: Duplication of the APP locus in a Dutch family with early-onset Alzheimer dementia

Published in:

2006

By:

Sleegers, Kristel;
Brouwers, Nathalie;
Gijselinck, Ilse;
Theuns, Jessie;
Goossens, Dirk;
Del-Favero, Jurgen;
Cruts, Marc;
van Duijn, Cornelia M.;
Van Broeckhoven, Christine

Publication type:

Abstract

P1-321: Contribution of dementia genes to Alzheimer’s disease in Belgium

Published in:

2006

By:

Brouwers, Nathalie;
Sleegers, Kristel;
Theuns, Jessie;
Engelborghs, Sebastiaan;
Bogaerts, Veerle;
Serneels, Sally;
Kamali, Kenan;
Van den Broeck, Marleen;
Cruts, Marc;
De Deyn, Peter-Paul;
Van Broeckhoven, Christine

Publication type:

Abstract

O2-02-08: Duplication of the APP locus in a Dutch family with early-onset Alzheimer dementia

Published in:

2006

By:

Sleegers, Kristel;
Brouwers, Nathalie;
Gijselinck, Ilse;
Theuns, Jessie;
Goossens, Dirk;
Del-Favero, Jurgen;
Cruts, Marc;
van Duijn, Cornelia M.;
Van Broeckhoven, Christine

Publication type:

Abstract

Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β′-site increases Aβ generation.

Published in:

EMBO Molecular Medicine, 2011, v. 3, n. 5, p. 291, doi. 10.1002/emmm.201100138

By:

Zhou, Lujia;
Brouwers, Nathalie;
Benilova, Iryna;
Vandersteen, Annelies;
Mercken, Marc;
Van Laere, Koen;
Van Damme, Philip;
Demedts, David;
Van Leuven, Fred;
Sleegers, Kristel;
Broersen, Kerensa;
Van Broeckhoven, Christine;
Vandenberghe, Rik;
De Strooper, Bart

Publication type:

Article

Reply.

Published in:

Annals of Neurology, 2010, v. 68, n. 1, p. 119, doi. 10.1002/ana.22056

By:

Sleegers, Kristel;
Brouwers, Nathalie;
Van Broeckhoven, Christine

Publication type:

Article

Serum biomarker for progranulin-associated frontotemporal lobar degeneration.

Published in:

Annals of Neurology, 2009, v. 65, n. 5, p. 603, doi. 10.1002/ana.21621

By:

Sleegers, Kristel;
Brouwers, Nathalie;
Van Damme, Philip;
Engelborghs, Sebastiaan;
Gijselinck, Ilse;
van der Zee, Julie;
Peeters, Karin;
Mattheijssens, Maria;
Cruts, Marc;
Vandenberghe, Rik;
De Deyn, Peter P.;
Robberecht, Wim;
Van Broeckhoven, Christine

Publication type:

Article

GRASP55 REGULATES IRE1α ACTIVITY WHICH IN MACROPHAGES CONTROLS INTERLEUKIN-1β SECRETION AND AGGREGATION.

Published in:

Journal of Experimental & Molecular Biology, 2019, v. 20, n. 3, p. 48

By:

CHIRITOIU, MARIOARA;
BROUWERS, NATHALIE;
TURACCHIO, GABRIELE;
PIROZZI, MARINELLA;
PETRESCU, STEFANA M.;
MALHOTRA, VIVEK

Publication type:

Article

No association of CSF biomarkers with APOE{varepsilon}4, plaque and tangle burden in definite Alzheimers disease.

Published in:

Brain: A Journal of Neurology, 2007, v. 130, n. 9, p. 2320

By:

Sebastiaan Engelborghs;
Kristel Sleegers;
Patrick Cras;
Nathalie Brouwers;
Sally Serneels;
Evelyn De Leenheir;
Jean-Jacques Martin;
Eugeen Vanmechelen;
Christine Van Broeckhoven;
Peter Paul De Deyn

Publication type:

Article

Genetic risk and transcriptional variability of amyloid precursor protein in Alzheimer's disease.

Published in:

Brain: A Journal of Neurology, 2006, v. 129, n. 11, p. 2984, doi. 10.1093/brain/awl212

By:

Nathalie Brouwers;
Kristel Sleegers;
Sebastiaan Engelborghs;
Veerle Bogaerts;
Sally Serneels;
Kenan Kamali;
Ellen Corsmit;
Evelyn De Leenheir;
Jean-Jacques Martin;
Peter P. De Deyn;
Christine Van Broeckhoven;
Jessie Theuns

Publication type:

Article

APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy.

Published in:

Brain: A Journal of Neurology, 2006, v. 129, n. 11, p. 2977, doi. 10.1093/brain/awl203

By:

Kristel Sleegers;
Nathalie Brouwers;
Ilse Gijselinck;
Jessie Theuns;
Dirk Goossens;
Jan Wauters;
Jurgen Del-Favero;
Marc Cruts;
Cornelia M. van Duijn;
Christine Van Broeckhoven

Publication type:

Article

APP and BACE1 miRNA genetic variability has no major role in risk for Alzheimer disease.

Published in:

Human Mutation, 2009, v. 30, n. 8, p. 1207, doi. 10.1002/humu.21027

By:

Bettens, Karolien;
Brouwers, Nathalie;
Engelborghs, Sebastiaan;
Van Miegroet, Helen;
De Deyn, Peter P.;
Theuns, Jessie;
Sleegers, Kristel;
Van Broeckhoven, Christine

Publication type:

Article

Relative contribution of simple mutations vs. copy number variations in five Parkinson disease genes in the Belgian population.

Published in:

Human Mutation, 2009, v. 30, n. 7, p. 1054, doi. 10.1002/humu.21007

By:

Nuytemans, Karen;
Meeus, Bram;
Crosiers, David;
Brouwers, Nathalie;
Goossens, Dirk;
Engelborghs, Sebastiaan;
Pals, Philippe;
Pickut, Barbara;
Van den Broeck, Marleen;
Corsmit, Ellen;
Cras, Patrick;
De Deyn, Peter P.;
Del-Favero, Jurgen;
Van Broeckhoven, Christine;
Theuns, Jessie

Publication type:

Article

No association between CALHM1 and risk for Alzheimer dementia in a Belgian population.

Published in:

Human Mutation, 2009, v. 30, n. 4, p. E570, doi. 10.1002/humu.20990

By:

Sleegers, Kristel;
Brouwers, Nathalie;
Bettens, Karolien;
Engelborghs, Sebastiaan;
van Miegroet, Helen;
De Deyn, Peter P;
Van Broeckhoven, Christine

Publication type:

Article

Common variation in GRB-associated Binding Protein 2 (GAB2) and increased risk for Alzheimer dementia.

Published in:

Human Mutation, 2009, v. 30, n. 2, p. E338, doi. 10.1002/humu.20909

By:

Sleegers, Kristel;
Bettens, Karolien;
Brouwers, Nathalie;
Engelborghs, Sebastiaan;
van Miegroet, Helen;
De Deyn, Peter P;
Van Broeckhoven, Christine

Publication type:

Article

SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population.

Published in:

Human Mutation, 2008, v. 29, n. 5, p. 769, doi. 10.1002/humu.20725

By:

Bettens, Karolien;
Brouwers, Nathalie;
Engelborghs, Sebastiaan;
De Deyn, Peter P.;
Van Broeckhoven, Christine;
Sleegers, Kristel

Publication type:

Article

Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia.

Published in:

Human Mutation, 2007, v. 28, n. 4, p. 416, doi. 10.1002/humu.9484

By:

van der Zee, Julie;
Le Ber, Isabelle;
Maurer-Stroh, Sebastian;
Engelborghs, Sebastiaan;
Gijselinck, Ilse;
Camuzat, Agnès;
Brouwers, Nathalie;
Vandenberghe, Rik;
Sleegers, Kristel;
Hannequin, Didier;
Dermaut, Bart;
Schymkowitz, Joost;
Campion, Dominique;
Santens, Patrick;
Martin, Jean-Jacques;
Lacomblez, Lucette;
De Pooter, Tim;
Peeters, Karin;
Mattheijssens, Maria;
Vercelletto, Martine

Publication type:

Article

Role of Kif15 and its novel mitotic partner KBP in K-fiber dynamics and chromosome alignment.

Published in:

PLoS ONE, 2017, v. 12, n. 4, p. 1, doi. 10.1371/journal.pone.0174819

By:

Brouwers, Nathalie;
Mallol Martinez, Nuria;
Vernos, Isabelle

Publication type:

Article

Defects in lipid homeostasis reflect the function of TANGO2 in phospholipid and neutral lipid metabolism.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.85345

By:

Leonardo Lujan, Agustin;
Foresti, Ombretta;
Sugden, Conor;
Brouwers, Nathalie;
Mateo Farre, Alex;
Vignoli, Alessio;
Azamian, Mahshid;
Turner, Alicia;
Wojnacki, Jose;
Malhotra, Vivek

Publication type:

Article

Reactive oxygen species triggers unconventional secretion of antioxidants and Acb1.

Published in:

Journal of Cell Biology, 2020, v. 219, n. 4, p. 1, doi. 10.1083/jcb.201905028

By:

Cruz-Garcia, David;
Brouwers, Nathalie;
Malhotra, Vivek;
Curwin, Amy J.

Publication type:

Article

New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells.

Published in:

Journal of Cell Biology, 2019, v. 218, n. 11, p. 3861, doi. 10.1083/jcb.201902028

By:

Bassaganyas, Laia;
Popa, Stephanie J.;
Horlbeck, Max;
Puri, Claudia;
Stewart, Sarah E.;
Campelo, Felix;
Ashok, Anupama;
Butnaru, Cristian M.;
Brouwers, Nathalie;
Heydari, Kartoosh;
Ripoche, Jean;
Weissman, Jonathan;
Rubinsztein, David C.;
Schekman, Randy;
Malhotra, Vivek;
Moreau, Kevin;
Villeneuve, Julien

Publication type:

Article

A diacidic motif determines unconventional secretion of wild-type and ALS-linked mutant SOD1.

Published in:

Journal of Cell Biology, 2017, v. 216, n. 9, p. 2691, doi. 10.1083/jcb.201704056

By:

Cruz-Garcia, David;
Brouwers, Nathalie;
Duran, Juan M.;
Mora, Gabriel;
Curwin, Amy J.;
Malhotra, Vivek

Publication type:

Article

The CALHM1 P86L Polymorphism is a Genetic Modifier of Age at Onset in Alzheimer's Disease: a Meta-Analysis Study.

Published in:

Journal of Alzheimer's Disease, 2010, v. 22, n. 1, p. 247, doi. 10.3233/JAD-2010-100933

By:

Lambert, Jean-Charles;
Sleegers, Kristel;
González-Pérez, Antonio;
Ingelsson, Martin;
Beecham, Gary W.;
Hiltunen, Mikko;
Combarros, Onofre;
Bullido, Maria J.;
Brouwers, Nathalie;
Bettens, Karolien;
Berr, Claudine;
Pasquier, Florence;
Richard, Florence;
DeKosky, Steven T.;
Hannequin, Didier;
Haines, Jonathan L.;
Tognoni, Gloria;
Fiévet, Nathalie;
Dartigues, Jean-François;
Tzourio, Christophe

Publication type:

Article

Contribution of TARDBP to Alzheimer's Disease Genetic Etiology.

Published in:

Journal of Alzheimer's Disease, 2010, v. 21, n. 2, p. 423, doi. 10.3233/JAD-2010-100198

By:

Brouwers, Nathalie;
Bettens, Karolien;
Gijselinck, Ilse;
Engelborghs, Sebastiaan;
Pickut, Barbara A.;
Van Miegroet, Helen;
Montoya, Ana Gil;
Mattheijssens, Maria;
Peeters, Karin;
De Deyn, Peter P.;
Cruts, Marc;
Sleegers, Kristel;
Van Broeckhoven, Christine

Publication type:

Article

Follow-Up Study of Susceptibility Loci for Alzheimer's Disease and Onset Age Identified by Genome-Wide Association.

Published in:

Journal of Alzheimer's Disease, 2010, v. 19, n. 4, p. 1169, doi. 10.3233/JAD-2010-1310

By:

Bettens, Karolien;
Brouwers, Nathalie;
Van Miegroet, Helen;
Gil, Ana;
Engelborghs, Sebastiaan;
De Deyn, Peter P.;
Vandenberghe, Rik;
Van Broeckhoven, Christine;
Sleegers, Kristel

Publication type:

Article

Potent amyloidogenicity and pathogenicity of A?43.

Published in:

Nature Neuroscience, 2011, v. 14, n. 8, p. 1023, doi. 10.1038/nn.2858

By:

Saito, Takashi;
Suemoto, Takahiro;
Brouwers, Nathalie;
Sleegers, Kristel;
Funamoto, Satoru;
Mihira, Naomi;
Matsuba, Yukio;
Yamada, Kazuyuki;
Nilsson, Per;
Takano, Jiro;
Nishimura, Masaki;
Iwata, Nobuhisa;
Van Broeckhoven, Christine;
Ihara, Yasuo;
Saido, Takaomi C.

Publication type:

Article

Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase.

Published in:

Journal of Neuroscience, 2011, v. 31, n. 5, p. 1885, doi. 10.1523/JNEUROSCI.5757-10.2011

By:

Capell, Anja;
Liebscher, Sabine;
Fellerer, Katrin;
Brouwers, Nathalie;
Willem, Michael;
Lammich, Sven;
Gijselinck, Ilse;
Bittner, Tobias;
Carlson, Aaron M.;
Sasse, Florenz;
Kunze, Brigitte;
Steinmetz, Heinrich;
Jansen, Rolf;
Dormann, Dorothee;
Sleegers, Kristel;
Cruts, Marc;
Herms, Jochen;
Van Broeckhoven, Christine;
Haass, Christian

Publication type:

Article

Association study of cholesterol-related genes in Alzheimer’s disease.

Published in:

Neurogenetics, 2007, v. 8, n. 3, p. 179, doi. 10.1007/s10048-007-0087-z

By:

Wollmer, M.;
Sleegers, Kristel;
Ingelsson, Martin;
Zekanowski, Cezary;
Brouwers, Nathalie;
Maruszak, Aleksandra;
Brunner, Fabienne;
Huynh, Kim-Dung;
Kilander, Lena;
Brundin, Rose-Marie;
Hedlund, Marie;
Giedraitis, Vilmantas;
Glaser, Anna;
Engelborghs, Sebastiaan;
Deyn, Peter;
Kapaki, Elisabeth;
Tsolaki, Magdalini;
Daniilidou, Makrina;
Molyva, Dimitra;
Paraskevas, George

Publication type:

Article

ESCRT-III drives the final stages of CUPS maturation for unconventional protein secretion.

Published in:

eLife, 2016, p. 1, doi. 10.7554/eLife.16299

By:

Curwin, Amy J.;
Brouwers, Nathalie;
Adell, Manuel Alonso Y.;
Teis, David;
Turacchio, Gabriele;
Parashuraman, Seetharaman;
Ronchi, Paolo;
Malhotra, Vivek

Publication type:

Article

TANGO1 recruits ERGIC membranes to the endoplasmic reticulum for procollagen export.

Published in:

eLife, 2015, p. 1, doi. 10.7554/eLife.10982

By:

Santos, António J. M.;
Raote, Ishier;
Scarpa, Margherita;
Brouwers, Nathalie;
Malhotra, Vivek

Publication type:

Article

Molecular genetics of Alzheimer's disease: An update.

Published in:

Annals of Medicine, 2008, v. 40, n. 8, p. 562, doi. 10.1080/07853890802186905

By:

Brouwers, Nathalie;
Sleegers, Kristel;
Van Broeckhoven, Christine

Publication type:

Article