Works by Brouwer, Kim L. R.

Results: 43

Nanoparticle Drug Delivery Can Reduce the Hepatotoxicity of Therapeutic Cargo.

Published in:

Small, 2020, v. 16, n. 7, p. 1, doi. 10.1002/smll.201906360

By:

Yang, Feifei;
Medik, Yusra;
Li, Liantao;
Tian, Xi;
Fu, Dong;
Brouwer, Kim L. R.;
Wagner, Kyle;
Sun, Bo;
Sendi, Hossein;
Mi, Yu;
Wang, Andrew Z.

Publication type:

Article

Plasma Bile Acid Concentrations in Patients with Human Immunodeficiency Virus Infection Receiving Protease Inhibitor Therapy: Possible Implications for Hepatotoxicity.

Published in:

Pharmacotherapy, 2010, v. 30, n. 1, p. 17, doi. 10.1592/phco.30.1.17

By:

McRae, MaryPeace;
Rezk, Naser L.;
Bridges, Arlene S.;
Corbett, Amanda H.;
Tien, Hsiao-Chuan;
Brouwer, Kim L. R.;
Kashuba, Angela D. M.

Publication type:

Article

Contribution of Morphine-6-Glucuronide to Antinociception following Intravenous Administration of Morphine to Healthy Volunteers.

Published in:

Journal of Clinical Pharmacology, 2002, v. 42, n. 5, p. 569, doi. 10.1177/009127000204200511

By:

Murthy, Bindu P.;
Pollack, Gary M.;
Brouwer, Kim L. R.

Publication type:

Article

Hepatic Bile Acid Transporters and Drug-induced Hepatotoxicity.

Published in:

Toxicologic Pathology, 2023, v. 51, n. 7/8, p. 405, doi. 10.1177/01926233231212255

By:

Saran, Chitra;
Brouwer, Kim L. R.

Publication type:

Article

Probe Cocktail to Assess Transporter Function in Sandwich-Cultured Human Hepatocytes.

Published in:

2019

By:

Cen Guo;
Brouwer, Kenneth R.;
Stewart, Paul W.;
Moseley, Caroline;
Brouwer, Kim L. R.;
Guo, Cen;
Mosley, Caroline

Publication type:

journal article

Analysis of human C24 bile acids metabolome in serum and urine based on enzyme digestion of conjugated bile acids and LC-MS determination of unconjugated bile acids.

Published in:

Analytical & Bioanalytical Chemistry, 2018, v. 410, n. 21, p. 5287, doi. 10.1007/s00216-018-1183-7

By:

Zhu, Pingping;
Zhang, Jian;
Chen, Yujie;
Yin, Shanshan;
Su, Mingming;
Xie, Guoxiang;
Brouwer, Kim L. R.;
Liu, Changxiao;
Lan, Ke;
Jia, Wei

Publication type:

Article

Effect of mTOR inhibitors on sodium taurocholate cotransporting polypeptide (NTCP) function in vitro.

Published in:

Frontiers in Pharmacology, 2023, v. 14, p. 01, doi. 10.3389/fphar.2023.1147495

By:

Saran, Chitra;
Ho, Henry;
hHonkakoski, Paavo;
Brouwer, Kim L. R.

Publication type:

Article

Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.

Published in:

Clinical Pharmacology & Therapeutics, 2015, v. 98, n. 3, p. 266, doi. 10.1002/cpt.176

By:

Brouwer, KLR;
Aleksunes, LM;
Brandys, B;
Giacoia, GP;
Knipp, G;
Lukacova, V;
Meibohm, B;
Nigam, SK;
Rieder, M;
de Wildt, SN;
Abdel‐Rahman, Susan;
Aleksunse, Lauren M.;
Baker, Sharyn D.;
Bolger, Michael B.;
Brandys, Barbara;
Brouwer, Kim L. R.;
Bush, Kevin T.;
Clancy, Barbara;
DeSesso, John M.;
Fisher, Jeffery

Publication type:

Article

Membrane transporters in drug development.

Published in:

2010

By:

Giacomini, Kathleen M.;
Shiew-Mei Huang;
Tweedie, Donald J.;
Benet, Leslie Z.;
Brouwer, Kim L. R.;
Xiaoyan Chu;
Dahlin, Amber;
Evers, Raymond;
Fischer, Volker;
Hillgren, Kathleen M.;
Hoffmaster, Keith A.;
Ishikawa, Toshihisa;
Keppler, Dietrich;
Kim, Richard B.;
Lee, Caroline A.;
Niemi, Mikko;
Polli, Joseph W.;
Sugiyama, Yuichi;
Swaan, Peter W.;
Ware, Joseph A.

Publication type:

journal article

Antifungal Extraction by the Extracorporeal Membrane Oxygenation Circuit.

Published in:

Journal of Extra-Corporeal Technology, 2017, v. 49, n. 3, p. 150, doi. 10.1051/ject/201749150

By:

Watt, Kevin M.;
Cohen-Wolkowiez, Michael;
Williams, Duane C.;
Bonadonna, Desiree K.;
Cheifetz, Ira M.;
Thakker, Dhiren;
Benjamin, Daniel K.;
Brouwer, Kim L. R.

Publication type:

Article

Pregnancy-Related Hormones Increase UGT1A1-Mediated Labetalol Metabolism in Human Hepatocytes.

Published in:

Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2021.655320

By:

Khatri, Raju;
Fallon, John K.;
Sykes, Craig;
Kulick, Natasha;
Rementer, Rebecca J. B.;
Miner, Taryn A.;
Schauer, Amanda P.;
Kashuba, Angela D. M.;
Boggess, Kim A.;
Brouwer, Kim L. R.;
Smith, Philip C.;
Lee, Craig R.

Publication type:

Article

A multi-center preclinical study of gadoxetate DCE-MRI in rats as a biomarker of drug induced inhibition of liver transporter function.

Published in:

PLoS ONE, 2018, v. 13, n. 5, p. 1, doi. 10.1371/journal.pone.0197213

By:

Karageorgis, Anastassia;
Lenhard, Stephen C.;
Yerby, Brittany;
Forsgren, Mikael F.;
Liachenko, Serguei;
Johansson, Edvin;
Pilling, Mark A.;
Peterson, Richard A.;
Yang, Xi;
Williams, Dominic P.;
Ungersma, Sharon E.;
Morgan, Ryan E.;
Brouwer, Kim L. R.;
Jucker, Beat M.;
Hockings, Paul D.

Publication type:

Article

Altered Bile Acid Metabolome in Patients with Nonalcoholic Steatohepatitis.

Published in:

2015

By:

Ferslew, Brian;
Xie, Guoxiang;
Johnston, Curtis;
Su, Mingming;
Stewart, Paul;
Jia, Wei;
Brouwer, Kim;
Sidney Barritt, A.;
Ferslew, Brian C;
Johnston, Curtis K;
Stewart, Paul W;
Brouwer, Kim L R;
Sidney Barritt, A 4th;
Barritt, A Sidney 4th

Publication type:

journal article

Hepatic OATP1B zonal distribution: Implications for rifampicin‐mediated drug–drug interactions explored within a PBPK framework.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 9, p. 1513, doi. 10.1002/psp4.13188

By:

Hartauer, Mattie;
Murphy, William A.;
Brouwer, Kim L. R.;
Southall, Roz;
Neuhoff, Sibylle

Publication type:

Article

Altered bile acid and coproporphyrin‐I disposition in patients with autosomal dominant polycystic kidney disease.

Published in:

British Journal of Clinical Pharmacology, 2025, v. 91, n. 2, p. 353, doi. 10.1111/bcp.16221

By:

Tiley, Jacqueline B.;
Beaudoin, James J.;
Derebail, Vimal K.;
Murphy, William A.;
Park, Christine C.;
Veeder, Justin A.;
Tran, Lana;
Beers, Jessica L.;
Jia, Wei;
Stewart, Paul W.;
Brouwer, Kim L. R.

Publication type:

Article

Cyclophosphamide and 4-hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis.

Published in:

British Journal of Clinical Pharmacology, 2012, v. 74, n. 3, p. 445, doi. 10.1111/j.1365-2125.2012.04223.x

By:

Joy, Melanie S.;
La, Mary;
Wang, Jinzhao;
Bridges, Arlene S.;
Hu, Yichun;
Hogan, Susan L.;
Frye, Reginald F.;
Blaisdell, Joyce;
Goldstein, Joyce A.;
Dooley, Mary Anne;
Brouwer, Kim L. R.;
Falk, Ronald J.

Publication type:

Article

Determination of the biliary excretion of piperacillin in humans using a novel method.

Published in:

British Journal of Clinical Pharmacology, 2006, v. 62, n. 3, p. 304, doi. 10.1111/j.1365-2125.2006.02662.x

By:

Ghibellini, Giulia;
Vasist, Lakshmi S.;
Hill, Terence E.;
Heizer, William D.;
Kowalsky, Richard J.;
Brouwer, Kim L. R.

Publication type:

Article

Developing evidence-based resources for evaluating postgraduate trainees in the biomedical sciences.

Published in:

PLoS ONE, 2022, v. 17, n. 12, p. 1, doi. 10.1371/journal.pone.0278297

By:

McLaughlin, Jacqueline E.;
Layton, Rebekah L.;
Watkins, Paul B.;
Nicholas, Robert A.;
Brouwer, Kim L. R.

Publication type:

Article

Physiologically Based Pharmacokinetic (PBPK) Model Predictions of Disease Mediated Changes in Drug Disposition in Patients with Nonalcoholic Fatty Liver Disease (NAFLD).

Published in:

Pharmaceutical Research, 2024, v. 41, n. 3, p. 441, doi. 10.1007/s11095-024-03664-8

By:

Adiwidjaja, Jeffry;
Spires, Jessica;
Brouwer, Kim L. R.

Publication type:

Article

Application of Pharmacokinetic Modeling to Characterize Hepatobiliary Disposition of Imaging Agents and Alterations due to Liver Injury in Isolated Perfused Rat Livers.

Published in:

Pharmaceutical Research, 2023, v. 40, n. 11, p. 2513, doi. 10.1007/s11095-023-03549-2

By:

Jeong, Angela;
Pastor, Catherine M.;
Brouwer, Kim L. R.

Publication type:

Article

Evaluation of <sup>99m</sup>Technetium-Mebrofenin and <sup>99m</sup>Technetium-Sestamibi as Specific Probes for Hepatic Transport Protein Function in Rat and Human Hepatocytes.

Published in:

Pharmaceutical Research, 2010, v. 27, n. 9, p. 1987, doi. 10.1007/s11095-010-0203-x

By:

Swift, Brandon;
Wei Yue;
Brouwer, Kim L. R.

Publication type:

Article

Relative bioavailability of tolvaptan administered via nasogastric tube and tolvaptan tablets swallowed intact.

Published in:

American Journal of Health-System Pharmacy, 2013, v. 70, n. 14, p. 1230, doi. 10.2146/ajhp120543

By:

MCNEELY, ELIZABETH B.;
TALAMEH, JASMINE A.;
ADAMS JR., KIRKWOOD F.;
HULL, J. HEYWARD;
SIMMONS, BRIAN;
HENRY, JILL;
BROUWER, KIM L. R.;
PATTERSON, J. HERBERT

Publication type:

Article

Quantitative Systems Toxicology Modeling Predicts that Reduced Biliary Efflux Contributes to Tolvaptan Hepatotoxicity.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 2, p. 433, doi. 10.1002/cpt.2007

By:

Beaudoin, James J.;
Brock, William J.;
Watkins, Paul B.;
Brouwer, Kim L. R.

Publication type:

Article

Intestinal P‐gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 1, p. 55, doi. 10.1002/cpt.1916

By:

Zamek‐Gliszczynski, Maciej J.;
Patel, Mitesh;
Yang, Xinning;
Lutz, Justin D.;
Chu, Xiaoyan;
Brouwer, Kim L. R.;
Lai, Yurong;
Lee, Caroline A.;
Neuhoff, Sibylle;
Paine, Mary F.;
Sugiyama, Yuichi;
Taskar, Kunal S.;
Galetin, Aleksandra

Publication type:

Article

Transporter‐Mediated Alterations in Patients With NASH Increase Systemic and Hepatic Exposure to an OATP and MRP2 Substrate.

Published in:

Clinical Pharmacology & Therapeutics, 2018, v. 104, n. 4, p. 749, doi. 10.1002/cpt.997

By:

Ali, Izna;
Slizgi, Jason R.;
Kaullen, Josh D.;
Brouwer, Kim L. R.;
Ivanovic, Marija;
Niemi, Mikko;
Stewart, Paul W.;
Barritt, IV, Alfred S.

Publication type:

Article

A MODIFIED RESIDUAL METHOD TO ESTIMATE THE ZERO-ORDER ABSORPTION RATE CONSTANT IN A ONE-COMPARTMENT MODEL.

Published in:

Biopharmaceutics & Drug Disposition, 1997, v. 18, n. 2, p. 93, doi. 10.1002/(SICI)1099-081X(199703)18:2<93::AID-BDD2>3.0.CO;2-1

By:

LIU, XINGRONG;
BROUWER, KIM L. R.;
POLLACK, GARY M.

Publication type:

Article

Lack of effect of ondansetron on the pharmacokinetics and analgesic effects of morphine and metabolites after single-dose morphine administration in healthy volunteers.

Published in:

British Journal of Clinical Pharmacology, 2001, v. 51, n. 4, p. 309, doi. 10.1046/j.1365-2125.2001.01369.x

By:

Crews,, Kristine Radomski;
Murthy,, Bindu P.;
Hussey, Elizabeth K.;
Passannante, Anthony N.;
Palmer, Jonathan L.;
Maixner, William;
Brouwer, Kim L. R.

Publication type:

Article

Lipidomics profiles in hepatocytes from nonalcoholic steatohepatitis patients differ markedly from in vitro-induced steatotic hepatocytes.

Published in:

FEBS Letters, 2022, v. 596, n. 11, p. 1445, doi. 10.1002/1873-3468.14318

By:

Kralj, Thomas;
Khatri, Raju;
Brouwer, Kenneth R.;
Brouwer, Kim L. R.;
Creek, Darren J.

Publication type:

Article

Inhibition of Human Hepatic Bile Acid Transporters by Tolvaptan and Metabolites: Contributing Factors to Drug-Induced Liver Injury?

Published in:

Toxicological Sciences, 2016, v. 149, n. 1, p. 237, doi. 10.1093/toxsci/kfv231

By:

Slizgi, Jason R.;
Yang Lu;
Brouwer, Kenneth R.;
Claire, Robert L. St.;
Freeman, Kimberly M.;
Pan, Maxwell;
Brock, William J.;
Brouwer, Kim L. R.

Publication type:

Article

Identification of Hepatic Phospholipidosis Inducers in Sandwich-Cultured Rat Hepatocytes, a Physiologically Relevant Model, Reveals Altered Basolateral Uptake and Biliary Excretion of Anionic Probe Substrates.

Published in:

Toxicological Sciences, 2014, v. 139, n. 1, p. 99, doi. 10.1093/toxsci/kfu033

By:

Ferslew, Brian C.;
Brouwer, Kim L. R.

Publication type:

Article

Differential Disposition of Chenodeoxycholic Acid versus Taurocholic Acid in Response to Acute Troglitazone Exposure in Rat Hepatocytes.

Published in:

Toxicological Sciences, 2011, v. 120, n. 2, p. 371, doi. 10.1093/toxsci/kfr014

By:

Marion, Tracy L.;
Perry, Cassandra H.;
St. Claire, Robert L.;
Yue, Wei;
Brouwer, Kim L. R.

Publication type:

Article

Xenobiotics Inhibit Hepatic Uptake and Biliary Excretion of Taurocholate in Rat Hepatocytes.

Published in:

Toxicological Sciences, 2005, v. 83, n. 2, p. 207, doi. 10.1093/toxsci/kfi020

By:

Kemp, Daniel C.;
Zamek-Gliszczynski, Maciej J.;
Brouwer, Kim L. R.

Publication type:

Article

A novel differentiated HuH-7 cell model to examine bile acid metabolism, transport and cholestatic hepatotoxicity.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-18174-z

By:

Saran, Chitra;
Fu, Dong;
Ho, Henry;
Klein, Abigail;
Fallon, John K.;
Honkakoski, Paavo;
Brouwer, Kim L. R.

Publication type:

Article

Can they imagine the future? A qualitative study exploring the skills employers seek in pharmaceutical sciences doctoral graduates.

Published in:

PLoS ONE, 2019, v. 14, n. 9, p. 1, doi. 10.1371/journal.pone.0222422

By:

McLaughlin, Jacqueline E.;
Minshew, Lana M.;
Gonzalez, Daniel;
Lamb, Kelsey;
Klus, Nicholas J.;
Aubé, Jeffrey;
Cox, Wendy;
Brouwer, Kim L. R.

Publication type:

Article

Effects of PFAS on human liver transporters: implications for health outcomes.

Published in:

Toxicological Sciences, 2024, v. 200, n. 2, p. 213, doi. 10.1093/toxsci/kfae061

By:

Vujic, Ena;
Ferguson, Stephen S;
Brouwer, Kim L R

Publication type:

Article

Analytical and Omics-Based Advances in the Study of Drug-Induced Liver Injury.

Published in:

Toxicological Sciences, 2021, v. 183, n. 1, p. 1, doi. 10.1093/toxsci/kfab069

By:

Kralj, Thomas;
Brouwer, Kim L R;
Creek, Darren J

Publication type:

Article

Role of Organic Solute Transporter Alpha/Beta in Hepatotoxic Bile Acid Transport and Drug Interactions.

Published in:

Toxicological Sciences, 2020, v. 176, n. 1, p. 34, doi. 10.1093/toxsci/kfaa052

By:

Beaudoin, James J;
Bezençon, Jacqueline;
Sjöstedt, Noora;
Fallon, John K;
Brouwer, Kim L R

Publication type:

Article

Novel Mechanisms of Valproate Hepatotoxicity: Impaired Mrp2 Trafficking and Hepatocyte Depolarization.

Published in:

Toxicological Sciences, 2019, v. 171, n. 2, p. 431, doi. 10.1093/toxsci/kfz154

By:

Fu, Dong;
Cardona, Panli;
Ho, Henry;
Watkins, Paul B;
Brouwer, Kim L R

Publication type:

Article

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors.

Published in:

Toxicological Sciences, 2017, v. 155, n. 1, p. 61, doi. 10.1093/toxsci/kfw193

By:

Woodhead, Jeffrey L.;
Brock, William J.;
Roth, Sharin E.;
Shoaf, Susan E.;
Brouwer, Kim L. R.;
Church, Rachel;
Grammatopoulos, Tom N.;
Stiles, Linsey;
Siler, Scott Q.;
Howell, Brett A.;
Mosedale, Merrie;
Watkins, Paul B.;
Shoda, Lisl K. M.

Publication type:

Article

Knocking Down Transport: Applications of RNA Interference in The Study of Drug Transport Proteins.

Published in:

Drug Metabolism Reviews, 2005, v. 37, n. 4, p. 705, doi. 10.1080/03602530500364098

By:

Tian, Xianbin;
Zhang, Peijin;
Zamek-Gliszczynski, Maciej J.;
Brouwer, Kim L. R.

Publication type:

Article

Cytokine Regulation of P-Glycoprotein.

Published in:

Drug Metabolism Reviews, 2003, v. 35, n. 1, p. 19, doi. 10.1081/DMR-120018247

By:

McRae, Mary Peace;
Brouwer, Kim L. R.;
Kashuba, Angela D. M.

Publication type:

Article

Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury.

Published in:

Frontiers in Pharmacology, 2014, v. 5, p. 1, doi. 10.3389/fphar.2014.00240

By:

Woodhead, Jeffrey L.;
Kyunghee Yang;
Siler, Scott Q.;
Watkins, Paul B.;
Brouwer, Kim L. R.;
Barton, Hugh A.;
Howel, Brett A.;
Maggi, Adriana;
Lohman, Rink-Jan

Publication type:

Article

Effects of Probenecid on the pharmacokinetics and pharmacodynamics of adinazolam in humans.

Published in:

Clinical Pharmacology & Therapeutics, 1994, v. 56, n. 2, p. 133, doi. 10.1038/clpt.1994.116

By:

Golden, Pamela L;
Warner, Patricia E;
Fleishaker, Joseph C;
Jewell, Roxanne C;
Millikin, Steven;
Lyon, James;
Brouwer, Kim L R

Publication type:

Article