Works by Brotchie, Jonathan M.

Results: 70

Reproducibility of a Parkinsonism-related metabolic brain network in non-human primates: A descriptive pilot study with FDG PET.

Published in:

2015

By:

Ma, Yilong;
Johnston, Tom H.;
Peng, Shichun;
Zuo, Chuantao;
Koprich, James B.;
Fox, Susan H.;
Guan, Yihui;
Eidelberg, David;
Brotchie, Jonathan M.

Publication type:

journal article

Management of impulse control disorders in Parkinson's disease: Controversies and future approaches.

Published in:

Movement Disorders, 2015, v. 30, n. 2, p. 150, doi. 10.1002/mds.26099

By:

Samuel, Michael;
Rodriguez‐Oroz, Maria;
Antonini, Angelo;
Brotchie, Jonathan M.;
Ray Chaudhuri, Kallol;
Brown, Richard G.;
Galpern, Wendy R.;
Nirenberg, Melissa J.;
Okun, Michael S.;
Lang, Anthony E.

Publication type:

Article

Rotigotine polyoxazoline conjugate SER-214 provides robust and sustained antiparkinsonian benefit.

Published in:

Movement Disorders, 2013, v. 28, n. 12, p. 1675, doi. 10.1002/mds.25625

By:

Eskow Jaunarajs, Karen L.;
Standaert, David G.;
Viegas, Tacey X.;
Bentley, Michael D.;
Fang, Zhihao;
Dizman, Bekir;
Yoon, Kunsang;
Weimer, Rebecca;
Ravenscroft, Paula;
Johnston, Tom H.;
Hill, Michael P.;
Brotchie, Jonathan M.;
Moreadith, Randall W.

Publication type:

Article

Novel nondopaminergic targets for motor features of Parkinson's disease: Review of recent trials.

Published in:

Movement Disorders, 2013, v. 28, n. 2, p. 131, doi. 10.1002/mds.25273

By:

Kalia, Lorraine V.;
Brotchie, Jonathan M.;
Fox, Susan H.

Publication type:

Article

Increased levels of 5-HT1A receptor binding in ventral visual pathways in Parkinson's disease.

Published in:

2012

By:

Huot P;
Johnston TH;
Visanji NP;
Darr T;
Pires D;
Hazrati LN;
Brotchie JM;
Fox SH;
Huot, Philippe;
Johnston, Tom H;
Visanji, Naomi P;
Darr, Tayyeba;
Pires, Donna;
Hazrati, Lili-Naz;
Brotchie, Jonathan M;
Fox, Susan H

Publication type:

journal article

Increased levels of 5-HT1A receptor binding in ventral visual pathways in Parkinson's disease.

Published in:

Movement Disorders, 2012, v. 27, n. 6, p. 735, doi. 10.1002/mds.24964

By:

Huot, Philippe;
Johnston, Tom H.;
Visanji, Naomi P.;
Darr, Tayyeba;
Pires, Donna;
Hazrati, Lili-Naz;
Brotchie, Jonathan M.;
Fox, Susan H.

Publication type:

Article

The selective mu-opioid receptor antagonist adl5510 reduces levodopa-induced dyskinesia without affecting antiparkinsonian action in mptp-lesioned macaque model of Parkinson's disease.

Published in:

Movement Disorders, 2011, v. 26, n. 7, p. 1225, doi. 10.1002/mds.23631

By:

Koprich, James B.;
Fox, Susan H.;
Johnston, Tom H.;
Goodman, Allan;
Le Bourdonnec, Bertrand;
Dolle, Roland E.;
DeHaven, Robert N.;
DeHaven-Hudkins, Diane L.;
Little, Patrick J.;
Brotchie, Jonathan M.

Publication type:

Article

The α2 adrenergic antagonist fipamezole improves quality of levodopa action in Parkinsonian primates.

Published in:

Movement Disorders, 2010, v. 25, n. 13, p. 2084, doi. 10.1002/mds.23172

By:

Johnston, Tom H.;
Fox, Susan H.;
Piggott, Matthew J.;
Savola, Juha-Matti;
Brotchie, Jonathan M.

Publication type:

Article

Increased 5-HT2A receptors in the temporal cortex of parkinsonian patients with visual hallucinations.

Published in:

Movement Disorders, 2010, v. 25, n. 10, p. 1399, doi. 10.1002/mds.23083

By:

Huot, Philippe;
Johnston, Tom H.;
Darr, Tayyeba;
Hazrati, Lili-Naz;
Visanji, Naomi P.;
Pires, Donna;
Brotchie, Jonathan M.;
Fox, Susan H.

Publication type:

Article

Effect of histamine H2 receptor antagonism on levodopa-induced dyskinesia in the MPTP-macaque model of Parkinson's disease.

Published in:

Movement Disorders, 2010, v. 25, n. 10, p. 1379, doi. 10.1002/mds.23069

By:

Johnston, Tom H.;
van der Meij, Anne;
Brotchie, Jonathan M.;
Fox, Susan H.

Publication type:

Article

Serotonin and Parkinson's disease: On movement, mood, and madness.

Published in:

Movement Disorders, 2009, v. 24, n. 9, p. 1255, doi. 10.1002/mds.22473

By:

Fox, Susan H.;
Chuang, Rosalind;
Brotchie, Jonathan M.

Publication type:

Article

The nociceptin/orphanin FQ (NOP) receptor antagonist J-113397 enhances the effects of levodopa in the MPTP-lesioned nonhuman primate model of Parkinson's disease.

Published in:

Movement Disorders, 2008, v. 23, n. 13, p. 1922, doi. 10.1002/mds.22086

By:

Visanji, Naomi P.;
de Bie, Rob M.A.;
Johnston, Tom H.;
McCreary, Andrew C.;
Brotchie, Jonathan M.;
Fox, Susan H.

Publication type:

Article

Levodopa-induced dyskinesias.

Published in:

2007

By:

Fabbrini, Giovanni;
Brotchie, Jonathan M.;
Grandas, Francisco;
Nomoto, Masahiro;
Goetz, Christopher G.

Publication type:

journal article

Antiparkinsonian effects of the novel D3/D2 dopamine receptor agonist, S32504, in MPTP-lesioned marmosets: Mediation by D2, not D3, dopamine receptors.

Published in:

Movement Disorders, 2006, v. 21, n. 12, p. 2090, doi. 10.1002/mds.21106

By:

Hill, Michael P.;
Ravenscroft, Paula;
McGuire, Steven G.;
Brotchie, Jonathan M.;
Crossman, Alan R.;
Rochat, Catherine;
Millan, Mark J.

Publication type:

Article

Pharmacological characterization of psychosis-like behavior in the MPTP-lesioned nonhuman primate model of Parkinson's disease.

Published in:

Movement Disorders, 2006, v. 21, n. 11, p. 1879, doi. 10.1002/mds.21073

By:

Visanji, Naomi P.;
Gomez-Ramirez, Jordi;
Johnston, Tom H.;
Pires, Donna;
Voon, Valerie;
Brotchie, Jonathan M.;
Fox, Susan H.

Publication type:

Article

Translation of nondopaminergic treatments for levodopa-induced dyskinesia from MPTP-lesioned nonhuman primates to phase IIa clinical studies: Keys to success and roads to failure.

Published in:

Movement Disorders, 2006, v. 21, n. 10, p. 1578, doi. 10.1002/mds.20936

By:

Fox, Susan H.;
Lang, Anthony E.;
Brotchie, Jonathan M.

Publication type:

Article

Histamine H3 receptor agonists reduce.

Published in:

Movement Disorders, 2006, v. 21, n. 6, p. 839, doi. 10.1002/mds.20828

By:

Gomez-Ramirez, Jordi;
Johnston, Tom H.;
Visanji, Naomi P.;
Fox, Susan H.;
Brotchie, Jonathan M.

Publication type:

Article

Nondopaminergic mechanisms in levodopa-induced dyskinesia.

Published in:

Movement Disorders, 2005, v. 20, n. 8, p. 919, doi. 10.1002/mds.20612

By:

Brotchie, Jonathan M.

Publication type:

Article

Novel antiepileptic drug levetiracetam decreases dyskinesia elicited by L-dopa and ropinirole in the MPTP-lesioned marmoset.

Published in:

Movement Disorders, 2003, v. 18, n. 11, p. 1301, doi. 10.1002/mds.10542

By:

Michael P. Hill;
Erwan Bezard;
Steven G. McGuire;
Alan R. Crossman;
Jonathan M. Brotchie;
Ann Michel;
Renee Grimée;
Henrik Klitgaard

Publication type:

Article

Fipamezole (JP-1730) is a potent α2 adrenergic receptor antagonist that reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.

Published in:

Movement Disorders, 2003, v. 18, n. 8, p. 872, doi. 10.1002/mds.10464

By:

Savola, Juha-Matti;
Hill, Michael;
Engstrom, Mia;
Merivuori, Hannele;
Wurster, Siegfried;
McGuire, Steven G.;
Fox, Susan H.;
Crossman, Alan R.;
Brotchie, Jonathan M.

Publication type:

Article

Effects of CB1 cannabinoid receptor modulating compounds on the hyperkinesia induced by high-dose levodopa in the reserpine-treated rat model of Parkinson's disease.

Published in:

Movement Disorders, 2003, v. 18, n. 2, p. 138, doi. 10.1002/mds.10312

By:

Segovia, Gregorio;
Mora, Francisco;
Crossman, Alan R.;
Brotchie, Jonathan M.

Publication type:

Article

Characterisation of striatal NMDA receptors involved in the generation of parkinsonian symptoms: intrastriatal microinjection studies in the 6-OHDA-lesioned rat.

Published in:

2002

By:

Nash, Joanne E.;
Brotchie, Jonathan M.

Publication type:

journal article

Randomised, double-blind, placebo-controlled trial to assess the potential of cannabinoid receptor stimulation in the treatment of dystonia.

Published in:

2002

By:

Fox, Susan H.;
Kellett, Mark;
Moore, A. Peter;
Crossman, Alan R.;
Brotchie, Jonathan M.

Publication type:

journal article

Neural mechanisms underlying peak-dose dyskinesia induced by levodopa and apomorphine are distinct: Evidence from the effects of the alpha2 adrenoceptor antagonist idazoxan.

Published in:

Movement Disorders, 2001, v. 16, n. 4, p. 642, doi. 10.1002/mds.1148

By:

Fox, Susan H.;
Henry, Brian;
Hill, Micheal P.;
Peggs, David;
Crossman, Alan R.;
Brotchie, Jonathan M.

Publication type:

Article

5-HT2C receptor binding is increased in the substantia nigra pars reticulata in Parkinson's disease.

Published in:

Movement Disorders, 2000, v. 15, n. 6, p. 1064, doi. 10.1002/1531-8257(200011)15:6<1064::AID-MDS1002>3.0.CO;2-C

By:

Fox, Susan H.;
Brotchie, Jonathan M.

Publication type:

Article

The α2-adrenergic receptor antagonist idazoxan reduces dyskinesia and enhances anti-parkinsonian actions of L-dopa in the MPTP-lesioned primate model of Parkinson's disease.

Published in:

Movement Disorders, 1999, v. 14, n. 5, p. 744, doi. 10.1002/1531-8257(199909)14:5<744::AID-MDS1006>3.0.CO;2-7

By:

Henry, Brian;
Fox, Susan H.;
Peggs, David;
Crossman, Alan R.;
Brotchie, Jonathan M.

Publication type:

Article

Adjuncts to dopamine replacement: A pragmatic approach to reducing the problem of dyskinesia in Parkinson's disease.

Published in:

Movement Disorders, 1998, v. 13, n. 6, p. 871, doi. 10.1002/mds.870130603

By:

Brotchie, Jonathan M.

Publication type:

Article

[3H]-2-Deoxyglucose uptake study in mutant dystonic hamsters: Abnormalities in discrete brain regions of the motor system.

Published in:

Movement Disorders, 1998, v. 13, n. 4, p. 718, doi. 10.1002/mds.870130419

By:

Richter, Angelika;
Brotchie, Jonathan M.;
Crossman, Alan R.;
Löscher, Wolfgang

Publication type:

Article

Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson's disease.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-06832-1

By:

Matschke, Lina A.;
Komadowski, Marlene A.;
Stöhr, Annette;
Lee, Bolam;
Henrich, Martin T.;
Griesbach, Markus;
Rinné, Susanne;
Geibl, Fanni F.;
Chiu, Wei-Hua;
Koprich, James B.;
Brotchie, Jonathan M.;
Kiper, Aytug K.;
Dolga, Amalia M.;
Oertel, Wolfgang H.;
Decher, Niels

Publication type:

Article

The Promise and Challenges of Developing miRNA-Based Therapeutics for Parkinson's Disease.

Published in:

Cells (2073-4409), 2020, v. 9, n. 4, p. 841, doi. 10.3390/cells9040841

By:

Titze-de-Almeida, Simoneide S.;
Soto-Sánchez, Cristina;
Fernandez, Eduardo;
Koprich, James B.;
Brotchie, Jonathan M.;
Titze-de-Almeida, Ricardo

Publication type:

Article

Alternating Hemiplegia of Childhood-Related Neural and Behavioural Phenotypes in Na+,K+-ATPase α3 Missense Mutant Mice.

Published in:

PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0060141

By:

Kirshenbaum, Greer S.;
Dawson, Neil;
Mullins, Jonathan G. L.;
Johnston, Tom H.;
Drinkhill, Mark J.;
Edwards, Ian J.;
Fox, Susan H.;
Pratt, Judith A.;
Brotchie, Jonathan M.;
Roder, John C.;
Clapcote, Steven J.

Publication type:

Article

The Monoamine Re-Uptake Inhibitor UWA-101 Improves Motor Fluctuations in the MPTP-Lesioned Common Marmoset.

Published in:

PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0045587

By:

Huot, Philippe;
Johnston, Tom H.;
Gandy, Michael N.;
Reyes, M. Gabriela;
Fox, Susan H.;
Piggott, Matthew J.;
Brotchie, Jonathan M.;
Sgambato-Faure, Veronique

Publication type:

Article

Progressive Neurodegeneration or Endogenous Compensation in an Animal Model of Parkinson's Disease Produced by Decreasing Doses of Alpha-Synuclein.

Published in:

PLoS ONE, 2011, v. 6, n. 3, p. 1, doi. 10.1371/journal.pone.0017698

By:

Koprich, James B.;
Johnston, Tom H.;
Huot, Philippe;
Reyes, M. Gabriela;
Espinosa, Maria;
Brotchie, Jonathan M.

Publication type:

Article

Cannabinoids Decrease Corticostriatal Synaptic Transmission via an Effect on Glutamate Uptake.

Published in:

Journal of Neuroscience, 2003, v. 23, n. 35, p. 11073, doi. 10.1523/JNEUROSCI.23-35-11073.2003

By:

Brown, Timothy M.;
Brotchie, Jonathan M.;
Fitzjohn, Stephen M.

Publication type:

Article

A novel MDMA analogue, UWA-101, that lacks psychoactivity and cytotoxicity, enhances L-DOPA benefit in parkinsonian primates.

Published in:

FASEB Journal, 2012, v. 26, n. 5, p. 2154, doi. 10.1096/fj.11-195016

By:

Johnston, Tom H.;
Millar, Zak;
Huot, Philippe;
Wagg, Keith;
Thiele, Sherri;
Salomonczyk, Danielle;
Yong-Kee, Christopher J.;
Gandy, Michael N.;
McIldowie, Matthew;
Lewis, Katie D.;
Gomez-Ramirez, Jordi;
Joohyung Lee;
Fox, Susan H.;
Martin-Iverson, Mathew;
Nash, Joanne E.;
Piggott, Matthew J.;
Brotchie, Jonathan M.

Publication type:

Article

A role for endocannabinoids in the generation of parkinsonism and levodopa-induced dyskinesia in MPTP-lesioned non-human primate models of Parkinson's disease.

Published in:

FASEB Journal, 2005, v. 19, n. 9, p. 1140, doi. 10.1096/fj.04-3010fje

By:

Van der Stelt, Mario;
Fox, Susan H.;
Hill, Michael;
Crossman, Alan R.;
Petrosino, Stefania;
Di Marzo, Vincenzo;
Brotchie, Jonathan M.

Publication type:

Article

Sonic hedgehog is a neuromodulator in the adult subthalamic nucleus.

Published in:

FASEB Journal, 2003, v. 17, n. 15, p. 2337, doi. 10.1096/fj.03-0291fje

By:

Bezard, Erwan;
Baufreton, Jerome;
Owens, Geraint;
Crossman, Alan R.;
Dudek, Hank;
Taupignon, Anne;
Brotchie, Jonathan M.

Publication type:

Article

Selective preservation of MeCP2 in catecholaminergic cells is sufficient to improve the behavioral phenotype of male and female Mecp2-deficient mice.

Published in:

Human Molecular Genetics, 2013, v. 22, n. 2, p. 358, doi. 10.1093/hmg/dds433

By:

Lang, Min;
Wither, Robert G.;
Brotchie, Jonathan M.;
Wu, Chiping;
Zhang, Liang;
Eubanks, James H.

Publication type:

Article

Modulation of GABAergic transmission in the globus pallidus by the synthetic cannabinoid WIN 55,212-2.

Published in:

Synapse, 1996, v. 22, n. 4, p. 382, doi. 10.1002/(SICI)1098-2396(199604)22:4<382::AID-SYN9>3.0.CO;2-7

By:

Maneuf, Yannick P.;
Crossman, Alan R.;
Brotchie, Jonathan M.

Publication type:

Article

Reply to "Can STN DBS protect both nigral somata and innervation of the striatum?".

Published in:

2017

By:

Koprich, James B.;
Brotchie, Jonathan M.;
Musacchio, Thomas;
Volkmann, Jens;
Ip, Chi Wang

Publication type:

Letter

Subthalamic nucleus deep brain stimulation is neuroprotective in the A53T α-synuclein Parkinson's disease rat model.

Published in:

2017

By:

Musacchio, Thomas;
Rebenstorff, Maike;
Fluri, Felix;
Brotchie, Jonathan M.;
Volkmann, Jens;
Koprich, James B.;
Ip, Chi Wang

Publication type:

journal article

Inflammasome inhibition protects dopaminergic neurons from α-synuclein pathology in a model of progressive Parkinson's disease.

Published in:

Journal of Neuroinflammation, 2023, v. 20, n. 1, p. 1, doi. 10.1186/s12974-023-02759-0

By:

Grotemeyer, Alexander;
Fischer, Judith F.;
Koprich, James B.;
Brotchie, Jonathan M.;
Blum, Robert;
Volkmann, Jens;
Ip, Chi Wang

Publication type:

Article

Expansion of regulatory T cells by CD28 superagonistic antibodies attenuates neurodegeneration in A53T-α-synuclein Parkinson's disease mice.

Published in:

Journal of Neuroinflammation, 2022, v. 19, n. 1, p. 1, doi. 10.1186/s12974-022-02685-7

By:

Badr, Mohammad;
McFleder, Rhonda L.;
Wu, Jingjing;
Knorr, Susanne;
Koprich, James B.;
Hünig, Thomas;
Brotchie, Jonathan M.;
Volkmann, Jens;
Lutz, Manfred B.;
Ip, Chi Wang

Publication type:

Article

AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson's disease.

Published in:

Acta Neuropathologica Communications, 2017, v. 5, p. 1, doi. 10.1186/s40478-017-0416-x

By:

Chi Wang Ip;
Klaus, Laura-Christin;
Karikari, Akua A.;
Visanji, Naomi P.;
Brotchie, Jonathan M.;
Lang, Anthony E.;
Volkmann, Jens;
Koprich, James B.

Publication type:

Article

Tor1a+/- mice develop dystonia-like movements via a striatal dopaminergic dysregulation triggered by peripheral nerve injury.

Published in:

Acta Neuropathologica Communications, 2016, v. 4, p. 1, doi. 10.1186/s40478-016-0375-7

By:

Chi Wang Ip;
Isaias, Ioannis U.;
Kusche-Tekin, Burak B.;
Klein, Dennis;
Groh, Janos;
Knorr, Susanne;
Toyka, Klaus V.;
Volkmann, Jens;
O'Leary, Aet;
Reif, Andreas;
Higuchi, Takahiro;
Koprich, James B.;
Brotchie, Jonathan M.

Publication type:

Article

Paradoxical action of the cannabinoid WIN 55,212-2 in stimulated and basal cyclic AMP accumulation in rat globus pallidus slices.

Published in:

British Journal of Pharmacology, 1997, v. 120, n. 8, p. 1397, doi. 10.1038/sj.bjp.0701101

By:

Maneuf, Yannick P.;
Brotchie, Jonathan M.

Publication type:

Article

Towards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parkinson’s Disease: Optimization of AAV1/2 Delivery Parameters to Drive Sustained Expression of Alpha Synuclein and Dopaminergic Degeneration in Macaque.

Published in:

PLoS ONE, 2016, v. 11, n. 11, p. 1, doi. 10.1371/journal.pone.0167235

By:

Koprich, James B.;
Johnston, Tom H.;
Reyes, Gabriela;
Omana, Vanessa;
Brotchie, Jonathan M.

Publication type:

Article

Exosome markers of LRRK2 kinase inhibition.

Published in:

NPJ Parkinson's Disease, 2020, v. 6, n. 1, p. 1, doi. 10.1038/s41531-020-00138-7

By:

Wang, Shijie;
Kelly, Kaela;
Brotchie, Jonathan M.;
Koprich, James B.;
West, Andrew B.

Publication type:

Article

Targeted delivery of an Mecp2 transgene to forebrain neurons improves the behavior of female Mecp2-deficient mice.

Published in:

Human Molecular Genetics, 2008, v. 17, n. 10, p. 1386, doi. 10.1093/hmg/ddn026

By:

Jugloff, Denis G.M.;
Vandamme, Katrina;
Logan, Richard;
Visanji, Naomi P.;
Brotchie, Jonathan M.;
Eubanks, James H.

Publication type:

Article

Pros and cons of a prion-like pathogenesis in Parkinson's disease.

Published in:

BMC Neurology, 2011, v. 11, n. 1, p. 74, doi. 10.1186/1471-2377-11-74

By:

Hilker, Ruediger;
Brotchie, Jonathan M.;
Chapman, Joab

Publication type:

Article