Works by Broersen, Laus M.

Results: 43

Gut-brain and brain-gut axis in Parkinson's disease models: Effects of a uridine and fish oil diet.

Published in:

Nutritional Neuroscience, 2018, v. 21, n. 6, p. 391, doi. 10.1080/1028415X.2017.1294555

By:

Perez-Pardo, Paula;
Dodiya, Hemraj B.;
Broersen, Laus M.;
Douna, Hidde;
van Wijk, Nick;
Lopes da Silva, Sofia;
Garssen, Johan;
Keshavarzian, Ali;
Kraneveld, Aletta D.

Publication type:

Article

Promising Effects of Neurorestorative Diets on Motor, Cognitive, and Gastrointestinal Dysfunction after Symptom Development in a Mouse Model of Parkinson's Disease.

Published in:

Frontiers in Aging Neuroscience, 2017, v. 9, p. 1, doi. 10.3389/fnagi.2017.00057

By:

Perez-Pardo, Paula;
de Jong, Esther M.;
Broersen, Laus M.;
van Wijk, Nick;
Attali, Amos;
Garssen, Johan;
Kraneveld, Aletta D.

Publication type:

Article

A medical food Souvenaid® for Alzheimer patients can be used safely in combination with an acetylcholinesterase inhibitor in an aged rat model

Published in:

2010

By:

de Wilde, Martijn C.;
van Wijk, Nick;
Kuipers, Almar A.M.;
Broersen, Laus M.;
Kamphuis, Patrick J.;
Garthoff, Jossie A.;
Speijers, Gerrit J.A.

Publication type:

Abstract

Multi-nutrient supplementation induces changes in synaptic protein expression in PC12 cells, relevant to Alzheimer's disease

Published in:

2010

By:

Savelkoul, Paul J.M.;
Merkes, Mandy M.;
Kuipers, Almar A.;
Kiliaan, Amanda J.;
Hageman, Robert J.J.;
Broersen, Laus M.;
Kamphuis, Patrick J.

Publication type:

Abstract

B-vitamin supplementation is necessary for the brain gamma-secretase activity reducing effects of docosahexaenoic acid and uridine monophosphate

Published in:

2010

By:

Broersen, Laus M.;
van Wijk, Nick;
Kuchenbecker, Johanna;
Kuipers, Almar A.M.;
de Wilde, Martijn C.;
Grimm, Marcus O.W.;
Hartmann, Tobias;
Kamphuis, Patrick J.

Publication type:

Abstract

P2-432: Multinutrient dietary intervention reduces beta-amyloid plaque burden and neurodegeneration in APPswe/PS1dE9 transgenic mice

Published in:

2008

By:

Groenendijk, Martine;
Kuipers, Almar A.M.;
Leenders, Inge;
de Wilde, Martijn C.;
Broersen, Laus M.;
Kiliaan, Amanda J.;
Kamphuis, Patrick J.

Publication type:

Abstract

P2-427: Combined nutrient incubation improves receptor function stimulation over single nutrient incubation in pheochromocytoma cells

Published in:

2008

By:

de Wilde, Martijn C.;
Leenders, Inge;
Kuipers, Almar A.M.;
van Wijk, Nick;
Kamphuis, Patrick J.;
Broersen, Laus M.

Publication type:

Abstract

P2-421: A multinutrient intervention but not omega-3 PUFA-rich fish oil by itself reduces depression relevant to Alzheimer's disease

Published in:

2008

By:

Broersen, Laus M.;
de Wilde, Martijn C.;
Balvers, Martin;
Olivier, Berend;
Kamphuis, Patrick J.

Publication type:

Abstract

P2-394: Multinutrient approach in Alzheimer's disease: Rationale for combined beneficial effects of nutrients in disease management

Published in:

2008

By:

Kamphuis, Patrick J.;
van der Beek, Eline;
Broersen, Laus M.;
Wurtman, Richard J.;
Groenendijk, Martine

Publication type:

Abstract

P1-048: DHA-enriched diet and cholesterol containing Typical Western Diet influence Alzheimer-like pathology, cognition and the cerebral vasculature in APPSwe/PS1dE9 mice

Published in:

2008

By:

Hooijmans, Carlijn R.;
van der Zee, C.E.E.M.;
Dederen, Pieter J.;
Reijmer, Yael D.;
Brouwer, Katrien M.;
van Groen, Thomas;
Broersen, Laus M.;
Lütjohann, Dieter;
Heerschap, Arend;
Kiliaan, Amanda J.

Publication type:

Abstract

P2-016: Dietary intervention reduces inflammation and depression relevant to Alzheimer’s disease

Published in:

2006

By:

de Wilde, Martijn C.;
Schouten, Bastiaan;
Balvers, Martin;
Kamphuis, Patrick J.;
van der Beek, Eline M.;
Broersen, Laus M.

Publication type:

Abstract

P1-026: Changes in cerebral hemodynamics and Alzheimer’s pathology in aged APP/PS1 mice supplemented with docosahexanoic acid (DHA) and cholesterol enriched diets

Published in:

2006

By:

Hooijmans, Carlijn R.;
Rutters, Femke;
Dederen, Pieter J.;
Heerschap, Arend;
Tanila, Heikki;
van Groen, Thomas;
Broersen, Laus M.;
Lütjohann, Dieter;
Kiliaan, Amanda J.

Publication type:

Abstract

P2-016: Dietary intervention reduces inflammation and depression relevant to Alzheimer’s disease

Published in:

2006

By:

de Wilde, Martijn C.;
Schouten, Bastiaan;
Balvers, Martin;
Kamphuis, Patrick J.;
van der Beek, Eline M.;
Broersen, Laus M.

Publication type:

Abstract

P1-026: Changes in cerebral hemodynamics and Alzheimer’s pathology in aged APP/PS1 mice supplemented with docosahexanoic acid (DHA) and cholesterol enriched diets

Published in:

2006

By:

Hooijmans, Carlijn R.;
Rutters, Femke;
Dederen, Pieter J.;
Heerschap, Arend;
Tanila, Heikki;
van Groen, Thomas;
Broersen, Laus M.;
Lütjohann, Dieter;
Kiliaan, Amanda J.

Publication type:

Abstract

Plant Sterols the Better Cholesterol in Alzheimer's Disease? A Mechanistical Study.

Published in:

Journal of Neuroscience, 2013, v. 33, n. 41, p. 16072, doi. 10.1523/JNEUROSCI.1506-13.2013

By:

Burg, Verena K.;
Grimm, Heike S.;
Rothhaar, Tatjana L.;
Grösgen, Sven;
Hundsdörfer, Benjamin;
Haupentha, Viola J.;
Zimmer, Valerie C.;
Mett, Janine;
Weingartner, Oliver;
Laufs, Ulrich;
Broersen, Laus M.;
Tanila, Heikki;
Vanmierlo, Tim;
Lutjohann, Dieter;
Hartmann, Tobias;
Grimm, Marcus O. W.

Publication type:

Article

Additive Effects of Levodopa and a Neurorestorative Diet in a Mouse Model of Parkinson's Disease.

Published in:

Frontiers in Aging Neuroscience, 2018, p. 1, doi. 10.3389/fnagi.2018.00237

By:

Perez-Pardo, Paula;
Broersen, Laus M.;
Kliest, Tessa;
van Wijk, Nick;
Attali, Amos;
Garssen, Johan;
Kraneveld, Aletta D.

Publication type:

Article

Stroke patients have lower blood levels of nutrients that are relevant for recovery: a systematic review and meta-analysis.

Published in:

Frontiers in Stroke, 2023, p. 1, doi. 10.3389/fstro.2023.1274555

By:

Broersen, Laus M.;
Guida, Sonia;
Cetinyurek-Yavuz, Aysun;
van Wijk, Nick;
van Helvoort, Ardy;
Michael-Titus, Adina T.;
Lansink, Mirian

Publication type:

Article

Therapeutic effects of dietary intervention on neuroinflammation and brain metabolism in a rat model of photothrombotic stroke.

Published in:

CNS Neuroscience & Therapeutics, 2019, v. 25, n. 1, p. 36, doi. 10.1111/cns.12976

By:

Kurtys, Ewelina;
Casteels, Cindy;
Real, Caroline C.;
Eisel, Ulrich L. M.;
Verkuyl, J. Martin;
Broersen, Laus M.;
Klein, Hans C.;
Dierckx, Rudi A. J. O.;
Doorduin, Janine;
Vries, Erik F. J.

Publication type:

Article

A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice.

Published in:

Neural Plasticity, 2016, p. 1, doi. 10.1155/2016/6846721

By:

Wiesmann, Maximilian;
Zerbi, Valerio;
Jansen, Diane;
Haast, Roy;
Lütjohann, Dieter;
Broersen, Laus M.;
Heerschap, Arend;
Kiliaan, Amanda J.

Publication type:

Article

A new ketogenic formulation improves functional outcome and reduces tissue loss following traumatic brain injury in adult mice.

Published in:

Theranostics, 2021, v. 11, n. 1, p. 346, doi. 10.7150/thno.48995

By:

Thau-Zuchman, Orli;
Svendsen, Linda;
Dyall, Simon C.;
Paredes-Esquivel, Ursula;
Rhodes, Molly;
Priestley, John V.;
Feichtinger, René G.;
Kofler, Barbara;
Lotstra, Susanne;
Verkuy, J. Martin;
Hageman, Robert J.;
Broersen, Laus M.;
van Wijk, Nick;
Silva, Jose P.;
Tremoleda, Jordi L.;
Michael-Titus, Adina T.

Publication type:

Article

Neuroprotective Effects of a Specific Multi-Nutrient Intervention Against Aβ42-Induced Toxicity in Rats.

Published in:

Journal of Alzheimer's Disease, 2011, v. 27, n. 2, p. 327, doi. 10.3233/JAD-2011-110635

By:

de Wilde, Martijn C.;
Penke, Botond;
van der Beek, Eline M.;
Kuipers, Almar A.M.;
Kamphuis, Patrick J.;
Broersen, Laus M.

Publication type:

Article

Docosahexaenoic acid reduces amyloid-β(1-42) secretion in human AβPP-transfected CHO-cells by mechanisms other than inflammation related to PGE₂.

Published in:

2010

By:

de Wilde MC;
van der Beek EM;
Kiliaan AJ;
Leenders I;
Kuipers AA;
Kamphuis PJ;
Broersen LM;
de Wilde, Martijn C;
van der Beek, Eline M;
Kiliaan, Amanda J;
Leenders, Inge;
Kuipers, Almar A M;
Kamphuis, Patrick J;
Broersen, Laus M

Publication type:

journal article

Docosahexaenoic Acid Reduces Amyloid-β1-42 Secretion in Human AβPP-Transfected CHO-Cells by Mechanisms Other than Inflammation Related to PGE.

Published in:

Journal of Alzheimer's Disease, 2010, v. 21, n. 4, p. 1271, doi. 10.3233/JAD-2010-091255

By:

de Wilde, Martijn C.;
van der Beek, Eline M.;
Kiliaan, Amanda J.;
Leenders, Inge;
Kuipers, Almar A.M.;
Kamphuis, Patrick J.;
Broersen, Laus M.

Publication type:

Article

Effects of dietary tryptophan variations on extracellular serotonin in the dorsal hippocampus of rats.

Published in:

Psychopharmacology, 2004, v. 172, n. 2, p. 137, doi. 10.1007/s00213-003-1632-6

By:

van der Stelt, Hiske M.;
Broersen, Laus M.;
Olivier, Berend;
Westenberg, Herman G.M.

Publication type:

Article

A specific multi-nutrient formulation enhances M1 muscarinic acetylcholine receptor responses in vitro.

Published in:

Journal of Neurochemistry, 2012, v. 120, n. 4, p. 631, doi. 10.1111/j.1471-4159.2011.07616.x

By:

Savelkoul, Paul J. M.;
Janickova, Helena;
Kuipers, Almar A. M.;
Hageman, Robert J. J.;
Kamphuis, Patrick J.;
Dolezal, Vladimir;
Broersen, Laus M.

Publication type:

Article

Combined dietary folate, vitamin B-12, and vitamin B-6 intake influences plasma docosahexaenoic acid concentration in rats.

Published in:

Nutrition & Metabolism, 2012, v. 9, n. 1, p. 49, doi. 10.1186/1743-7075-9-49

By:

van Wijk, Nick;
Watkins, Carol J.;
Hageman, Robert J. J.;
Sijben, John W. C.;
Kamphuis, Patrick J. G. H.;
Wurtman, Richard J.;
Broersen, Laus M.

Publication type:

Article

Exploring effects of Souvenaid on cerebral glucose metabolism in Alzheimer's disease.

Published in:

Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2019, v. 5, n. 1, p. 492, doi. 10.1016/j.trci.2019.08.002

By:

Scheltens, Nienke M.E.;
Briels, Casper T.;
Yaqub, Maqsood;
Barkhof, Frederik;
Boellaard, Ronald;
Flier, Wiesje M.;
Schwarte, Lothar A.;
Teunissen, Charlotte E.;
Attali, Amos;
Broersen, Laus M.;
Berckel, Bart N.M.;
Scheltens, Philip

Publication type:

Article

Nutrition guidance within a multimodal intervention improves diet quality in prodromal Alzheimer's disease: Multimodal Preventive Trial for Alzheimer's Disease (MIND-ADmini).

Published in:

Alzheimer's Research & Therapy, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13195-024-01522-8

By:

Levak, Nicholas;
Lehtisalo, Jenni;
Thunborg, Charlotta;
Westman, Eric;
Andersen, Pia;
Andrieu, Sandrine;
Broersen, Laus M.;
Coley, Nicola;
Hartmann, Tobias;
Irving, Gerd Faxén;
Mangialasche, Francesca;
Ngandu, Tiia;
Pantel, Johannes;
Rosenberg, Anna;
Sindi, Shireen;
Soininen, Hilkka;
Solomon, Alina;
Wang, Rui;
Kivipelto, Miia

Publication type:

Article

A multidomain lifestyle intervention to maintain optimal cognitive functioning in Dutch older adults—study design and baseline characteristics of the FINGER-NL randomized controlled trial.

Published in:

Alzheimer's Research & Therapy, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13195-024-01495-8

By:

Deckers, Kay;
Zwan, Marissa D.;
Soons, Lion M.;
Waterink, Lisa;
Beers, Sonja;
van Houdt, Sofie;
Stiensma, Berrit;
Kwant, Judy Z.;
Wimmers, Sophie C. P. M.;
Heutz, Rachel A. M.;
Claassen, Jurgen A. H. R.;
Oosterman, Joukje M.;
de Heus, Rianne A. A.;
van de Rest, Ondine;
Vermeiren, Yannick;
Voshaar, Richard C. Oude;
Smidt, Nynke;
Broersen, Laus M.;
Sikkes, Sietske A. M.;
Aarts, Esther

Publication type:

Article

Integrating a multimodal lifestyle intervention with medical food in prodromal Alzheimer's disease: the MIND-ADmini randomized controlled trial.

Published in:

Alzheimer's Research & Therapy, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13195-024-01468-x

By:

Thunborg, Charlotta;
Wang, Rui;
Rosenberg, Anna;
Sindi, Shireen;
Andersen, Pia;
Andrieu, Sandrine;
Broersen, Laus M.;
Coley, Nicola;
Couderc, Celine;
Duval, Celine Z.;
Faxen-Irving, Gerd;
Hagman, Göran;
Hallikainen, Merja;
Håkansson, Krister;
Kekkonen, Eija;
Lehtisalo, Jenni;
Levak, Nicholas;
Mangialasche, Francesca;
Pantel, Johannes;
Rydström, Anders

Publication type:

Article

Effects of Specific Multi-Nutrient Enriched Diets on Cerebral Metabolism, Cognition and Neuropathology in AβPPswe-PS1dE9 Mice.

Published in:

PLoS ONE, 2013, v. 8, n. 9, p. 1, doi. 10.1371/journal.pone.0075393

By:

Jansen, Diane;
Zerbi, Valerio;
Arnoldussen, Ilse A. C.;
Wiesmann, Maximilian;
Rijpma, Anne;
Fang, Xiaotian T.;
Dederen, Pieter J.;
Mutsaers, Martina P. C.;
Broersen, Laus M.;
Lütjohann, Dieter;
Miller, Malgorzata;
Joosten, Leo A. B.;
Heerschap, Arend;
Kiliaan, Amanda J.

Publication type:

Article

High Content Analysis of Hippocampal Neuron-Astrocyte Co-cultures Shows a Positive Effect of Fortasyn Connect on Neuronal Survival and Postsynaptic Maturation.

Published in:

Frontiers in Neuroscience, 2017, p. 1, doi. 10.3389/fnins.2017.00440

By:

van Deijk, Anne-Lieke F.;
Broersen, Laus M.;
Verkuyl, J. Martin;
Smit, August B.;
Verheijen, Mark H. G.

Publication type:

Article

Nutritional intake and adherence to dietary recommendation for patients with prodromal Alzheimers disease within a multimodal lifestyle trial.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.076524

By:

Levak, Nicholas;
Lehtisalo, Jenni;
Thunborg, Charlotta;
Westman, Eric;
Sindi, Shireen;
Rosenberg, Anna;
Andersen, Pia;
Andrieu, Sandrine;
Broersen, Laus M.;
Coley, Nicola;
Irving, Gerd Faxén;
Mangialasche, Francesca;
Pantel, Johannes;
Ngandu, Tiia;
Soininen, Hilkka;
Hartmann, Tobias;
Solomon, Alina;
Kivipelto, Miia

Publication type:

Article

Study Design of FINGER‐NL: a Multidomain Lifestyle Intervention in Dutch Older Adults to Maintain Optimal Cognitive Functioning.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 21, p. 1, doi. 10.1002/alz.078523

By:

Deckers, Kay;
Zwan, Marissa D.;
Soons, Lion M.;
Waterink, Lisa;
Beers, Sonja;
van Houdt, Sofie;
Meijer‐Krommenhoek, Yvonne;
van Pelt, Hilde;
Claassen, Jurgen A.H.R.;
Oosterman, Joukje M.;
de Heus, Rianne A.A.;
van de Rest, Ondine;
Smidt, Nynke;
Broersen, Laus M.;
Counotte, Danielle;
Sikkes, Sietske A.M.;
van Boxtel, Martin P.J.;
Aarts, Esther;
Köhler, Sebastian;
van der Flier, Wiesje M.

Publication type:

Article

Multimodal preventive trial for Alzheimer's disease (MIND‐ADMINI): Pilot trial progress and results.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.056105

By:

Kivipelto, Miia;
Sindi, Shireen;
Thunborg, Charlotta;
Rosenberg, Anna;
Coley, Nicola;
Andrieu, Sandrine;
Broersen, Laus M;
Hartmann, Tobias;
Solomon, Alina;
Soininen, Hilkka

Publication type:

Article

Study design of FINGER‐NL: A multidomain lifestyle intervention in Dutch older adults to prevent cognitive decline.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.055136

By:

Zwan, Marissa D.;
Deckers, Kay;
Claassen, Jurgen A.H.R.;
Oosterman, Joukje M.;
de Heus, Rianne A.A.;
van de Rest, Ondine;
de Groot, Lisette C.P.G.M.;
Smidt, Nynke;
Broersen, Laus M.;
Counotte, Danielle;
Sikkes, Sietske A.M.;
van Boxtel, Martin P.J.;
Aarts, Esther;
van der Flier, Wiesje M;
Koehler, Sebastian

Publication type:

Article

P2‐016: EXPLORING THE EFFECT OF SOUVENAID ON CEREBRAL GLUCOSE METABOLISM IN EARLY ALZHEIMER'S DISEASE.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P576, doi. 10.1016/j.jalz.2019.06.1238

By:

Briels, Casper T.;
Scheltens, Nienke M.E.;
Yaqub, Maqsood M.;
Barkhof, Frederik;
Boellaard, Ronald;
van der Flier, Wiesje M.;
Schwarte, Lothar A.;
Teunissen, Charlotte E.;
Broersen, Laus M.;
Van Berckel, Bart N.M.;
Scheltens, Philip

Publication type:

Article

P2‐472: PHOSPHATIDYLCHOLINE‐DHA: WHERE MODIFIABLE LIFESTYLE FACTORS AND AD PATHOLOGY CONVERGE.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P904, doi. 10.1016/j.jalz.2018.06.1165

By:

de Wilde, Martijn C.;
Girault, Elodie;
van Wijk, Nick;
Broersen, Laus M.;
Attali, Amos

Publication type:

Article

SYNAPTIC MEMBRANE SYNTHESIS IN RATS IS INCREASED BY DIETARY SUPPLEMENTATION WITH URIDINE AND DOCOSAHEXAENOIC ACID AND DEPENDS ON ANTIOXIDANT SUPPLEMENTATION.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P780, doi. 10.1016/j.jalz.2016.06.1565

By:

van Wijk, Nick;
Turkyilmaz, Mesut;
Sevinc, Cansu;
de Wilde, Martijn C.;
Sijben, John W.C.;
Broersen, Laus M.;
Cansev, Mehmet

Publication type:

Article

A COMBINATION OF DIETARY PRECURSORS AND COFACTORS FOR MEMBRANE SYNTHESIS ENHANCES NEURITE OUTGROWTH IN VITRO.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P619, doi. 10.1016/j.jalz.2016.06.1233

By:

Savelkoul, Paul J.M.;
Kuipers, Almar A.M.;
Lotstra, Susanne J.;
Verkuyl, Martin J.M.;
Groenendijk, Martine;
de Wilde, Martijn C.;
Broersen, Laus M.

Publication type:

Article

Anti-inflammatory effects of rice bran components.

Published in:

Nutrition Reviews, 2018, v. 76, n. 5, p. 372, doi. 10.1093/nutrit/nuy011

By:

Kurtys, Ewelina;
Eisel, Ulrich L M;
Hageman, Robert J J;
Verkuyl, J Martin;
Broersen, Laus M;
Dierckx, Rudi A J O;
Vries, Erik F J de

Publication type:

Article

High-Throughput Analysis of Astrocyte Cultures Shows Prevention of Reactive Astrogliosis by the Multi-Nutrient Combination Fortasyn Connect.

Published in:

Cells (2073-4409), 2022, v. 11, n. 9, p. N.PAG, doi. 10.3390/cells11091428

By:

Badia-Soteras, Aina;
de Vries, Janneke;
Dykstra, Werner;
Broersen, Laus M.;
Verkuyl, Jan Martin;
Smit, August B.;
Verheijen, Mark H. G.

Publication type:

Article

Dietary Crude Lecithin Increases Systemic Availability of Dietary Docosahexaenoic Acid with Combined Intake in Rats.

Published in:

Lipids, 2016, v. 51, n. 7, p. 833, doi. 10.1007/s11745-016-4139-8

By:

Wijk, Nick;
Balvers, Martin;
Cansev, Mehmet;
Maher, Timothy J.;
Sijben, John W. C.;
Broersen, Laus M.

Publication type:

Article