Works by Brock, William J.

Results: 11

Developing a pragmatic consensus procedure supporting the ICH S1B(R1) weight of evidence carcinogenicity assessment.

Published in:

Frontiers in Toxicology, 2024, p. 1, doi. 10.3389/ftox.2024.1370045

By:

Bassan, Arianna;
Steigerwalt, Ronald;
Keller, Douglas;
Beilke, Lisa;
Bradley, Paul M.;
Bringezu, Frank;
Brock, William J.;
Burns-Naas, Leigh Ann;
Chambers, Jon;
Cross, Kevin;
Dorato, Michael;
Elespuru, Rosalie;
Fuhrer, Douglas;
Hal, Frances;
Hartke, Jim;
Jahnke, Gloria D.;
Kluxen, Felix M.;
McDuffie, Eric;
Schmidt, Friedemann;
Valentin, Jean-Pierre

Publication type:

Article

Need for Dedicated Equipment?

Published in:

Pharmazeutische Industrie (Pharmind), 2014, v. 76, n. 5, p. 718

By:

Hildebrandt, Knut;
Steines, Stephan A.;
Brock, William J.

Publication type:

Article

Quantitative Systems Toxicology Modeling Predicts that Reduced Biliary Efflux Contributes to Tolvaptan Hepatotoxicity.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 2, p. 433, doi. 10.1002/cpt.2007

By:

Beaudoin, James J.;
Brock, William J.;
Watkins, Paul B.;
Brouwer, Kim L. R.

Publication type:

Article

Inhalation toxicity and genotoxicity of hydrochlorofluorocarbon (HCFC)-225ca and HCFC-225cb.

Published in:

Journal of Applied Toxicology, 1999, v. 19, n. 2, p. 101, doi. 10.1002/(SICI)1099-1263(199903/04)19:2<101::AID-JAT546>3.0.CO;2-R

By:

William J. Brock;
Seiji Shin-Ya;
George M. Rusch;
Colin J. Hardy;
Henry J. Trochimowicz

Publication type:

Article

Inhibition of Human Hepatic Bile Acid Transporters by Tolvaptan and Metabolites: Contributing Factors to Drug-Induced Liver Injury?

Published in:

Toxicological Sciences, 2016, v. 149, n. 1, p. 237, doi. 10.1093/toxsci/kfv231

By:

Slizgi, Jason R.;
Yang Lu;
Brouwer, Kenneth R.;
Claire, Robert L. St.;
Freeman, Kimberly M.;
Pan, Maxwell;
Brock, William J.;
Brouwer, Kim L. R.

Publication type:

Article

miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model.

Published in:

Toxicological Sciences, 2018, v. 161, n. 1, p. 149, doi. 10.1093/toxsci/kfx206

By:

Mosedale, Merrie;
Eaddy, J Scott;
Trask, O Joseph;
Holman, Natalie S;
Wolf, Kristina K;
LeCluyse, Edward;
Ware, Brenton R;
Khetani, Salman R;
Lu, Jingtao;
Brock, William J

Publication type:

Article

Candidate Risk Factors and Mechanisms for Tolvaptan-Induced Liver Injury Are Identified Using a Collaborative Cross Approach.

Published in:

Toxicological Sciences, 2017, v. 156, n. 2, p. 438, doi. 10.1093/toxsci/kfw269

By:

Mosedale, Merrie;
Yunjung Kim;
Brock, William J.;
Roth, Sharin E.;
Wiltshire, Tim;
Eaddy, J. Scott;
Keele, Gregory R.;
Corty, Robert W.;
Yuying Xie;
Valdar, William;
Watkins, Paul B.

Publication type:

Article

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors.

Published in:

Toxicological Sciences, 2017, v. 155, n. 1, p. 61, doi. 10.1093/toxsci/kfw193

By:

Woodhead, Jeffrey L.;
Brock, William J.;
Roth, Sharin E.;
Shoaf, Susan E.;
Brouwer, Kim L. R.;
Church, Rachel;
Grammatopoulos, Tom N.;
Stiles, Linsey;
Siler, Scott Q.;
Howell, Brett A.;
Mosedale, Merrie;
Watkins, Paul B.;
Shoda, Lisl K. M.

Publication type:

Article

Efruxifermin, a long‐acting Fc‐fusion FGF21 analogue, reduces body weight gain but does not increase sympathetic tone or urine volume in Sprague Dawley rats.

Published in:

British Journal of Pharmacology, 2022, v. 179, n. 7, p. 1384, doi. 10.1111/bph.15725

By:

Tillman, Erik J.;
Brock, William J.;
Rolph, Tim

Publication type:

Article

SETTING SAFE ACUTE EXPOSURE LIMITS FOR HALON REPLACEMENT CHEMICALS USING PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING.

Published in:

Inhalation Toxicology, 2000, v. 12, n. 8, p. 751, doi. 10.1080/08958370050085174

By:

Vinegar, Allen;
Jepson, Gary W.;
Cisneros, Mark;
Rubenstein, Reva;
Brock, William J.

Publication type:

Article

Introduction to the WEEL values of selected fluorocarbons.

Published in:

Toxicology & Industrial Health, 2019, v. 35, n. 3, p. 177, doi. 10.1177/0748233719825532

By:

Brock, William J.

Publication type:

Article