Works by Brinton, Roberta Diaz

Results: 167

Sex-Related Differences in Brain Volumes and Cerebral Blood Flow Among Overweight and Obese Adults With Type 2 Diabetes: Exploratory Analyses From the Action for Health in Diabetes Brain Magnetic Resonance Imaging Study.

Published in:

2020

By:

Espeland, Mark A;
Hayden, Kathleen M;
Lockhart, Samuel N;
Yassine, Hussein N;
Hoscheidt, Siobhan;
Yasar, Sevil;
Luchsinger, Jose A;
Neiberg, Rebecca H;
Brinton, Roberta Diaz;
Carmichael, Owen;
Action for Health in Diabetes Brain Magnetic Resonance Imaging (Look AHEAD Brain) Research Group;
Diaz Brinton, Roberta

Publication type:

journal article

Impact of Type 2 Diabetes and Postmenopausal Hormone Therapy on Incidence of Cognitive Impairment in Older Women.

Published in:

2015

By:

Espeland, Mark A.;
Diaz Brinton, Roberta;
Hugenschmidt, Christina;
Manson, JoAnn E.;
Craft, Suzanne;
Yaffe, Kristine;
Weitlauf, Julie;
Vaughan, Leslie;
Johnson, Karen C.;
Padula, Claudia B.;
Jackson, Rebecca D.;
Resnick, Susan M.;
Brinton, Roberta Diaz;
WHIMS Study Group

Publication type:

journal article

Multisystem failure, tipping points, and risk of Alzheimer's disease.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2025, v. 21, n. 5, p. 1, doi. 10.1002/alz.70249

By:

Merlini, Simona;
Bedrick, Edward J.;
Brinton, Roberta Diaz;
Vitali, Francesca

Publication type:

Article

Sex and Race Differences in the Association Between Statin Use and the Incidence of Alzheimer Disease.

Published in:

JAMA Neurology, 2017, v. 74, n. 2, p. 225, doi. 10.1001/jamaneurol.2016.3783

By:

Zissimopoulos, Julie M.;
Barthold, Douglas;
Brinton, Roberta Diaz;
Joyce, Geoffrey

Publication type:

Article

Increased Alzheimer's risk during the menopause transition: A 3-year longitudinal brain imaging study.

Published in:

PLoS ONE, 2018, v. 13, n. 12, p. 1, doi. 10.1371/journal.pone.0207885

By:

Mosconi, Lisa;
Rahman, Aneela;
Diaz, Ivan;
Wu, Xian;
Scheyer, Olivia;
Hristov, Hollie Webb;
Vallabhajosula, Shankar;
Isaacson, Richard S.;
de Leon, Mony J.;
Brinton, Roberta Diaz

Publication type:

Article

Correction: Perimenopause and emergence of an Alzheimer's bioenergetic phenotype in brain and periphery.

Published in:

2018

By:

Mosconi, Lisa;
Berti, Valentina;
Quinn, Crystal;
McHugh, Pauline;
Petrongolo, Gabriella;
Osorio, Ricardo S.;
Connaughty, Christopher;
Pupi, Alberto;
Vallabhajosula, Shankar;
Isaacson, Richard S.;
de Leon, Mony J.;
Swerdlow, Russell H.;
Diaz Brinton, Roberta

Publication type:

Correction Notice

Medroxyprogesterone acetate exacerbates glutamate excitotoxicity.

Published in:

Gynecological Endocrinology, 2006, v. 22, n. 7, p. 355, doi. 10.1080/09513590600863337

By:

Nilsen, Jon;
Morales, Alison;
Brinton, Roberta Diaz

Publication type:

Article

Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-90084-y

By:

Mosconi, Lisa;
Berti, Valentina;
Dyke, Jonathan;
Schelbaum, Eva;
Jett, Steven;
Loughlin, Lacey;
Jang, Grace;
Rahman, Aneela;
Hristov, Hollie;
Pahlajani, Silky;
Andrews, Randolph;
Matthews, Dawn;
Etingin, Orli;
Ganzer, Christine;
de Leon, Mony;
Isaacson, Richard;
Brinton, Roberta Diaz

Publication type:

Article

Association between CNS-active drugs and risk of Alzheimer’s and age-related neurodegenerative diseases.

Published in:

Frontiers in Psychiatry, 2024, p. 1, doi. 10.3389/fpsyt.2024.1358568

By:

Cortes-Flores, Helena;
Torrandell-Haro, Georgina;
Brinton, Roberta Diaz

Publication type:

Article

Allopregnanolone Preclinical Acute Pharmacokinetic and Pharmacodynamic Studies to Predict Tolerability and Efficacy for Alzheimer’s Disease.

Published in:

PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0128313

By:

Irwin, Ronald W.;
Solinsky, Christine M.;
Loya, Carlos M.;
Salituro, Francesco G.;
Rodgers, Kathleen E.;
Bauer, Gerhard;
Rogawski, Michael A.;
Brinton, Roberta Diaz

Publication type:

Article

Early Decline in Glucose Transport and Metabolism Precedes Shift to Ketogenic System in Female Aging and Alzheimer's Mouse Brain: Implication for Bioenergetic Intervention.

Published in:

PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0079977

By:

Ding, Fan;
Yao, Jia;
Rettberg, Jamaica R.;
Chen, Shuhua;
Brinton, Roberta Diaz

Publication type:

Article

Ovariectomy Induces a Shift in Fuel Availability and Metabolism in the Hippocampus of the Female Transgenic Model of Familial Alzheimer's.

Published in:

PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0059825

By:

Ding, Fan;
Yao, Jia;
Zhao, Liqin;
Mao, Zisu;
Chen, Shuhua;
Brinton, Roberta Diaz

Publication type:

Article

Allopregnanolone Reinstates Tyrosine Hydroxylase Immunoreactive Neurons and Motor Performance in an MPTP-Lesioned Mouse Model of Parkinson's Disease.

Published in:

PLoS ONE, 2012, v. 7, n. 11, p. 1, doi. 10.1371/journal.pone.0050040

By:

Adeosun, Samuel O.;
Xu Hou;
Yun Jiao;
Baoying Zheng;
Henry, Sherry;
Hill, Rosanne;
Zhi He;
Pani, \Amar;
Kyle, Patrick;
Xiaoming Ou;
Mosley, Thomas;
Farley, Jerry M.;
Stockmeier, Craig;
Paul, Ian;
Bigler, Steven;
Brinton, Roberta Diaz;
Smeyne, Richard;
Jun Ming Wang

Publication type:

Article

A Dominant Negative ERβ Splice Variant Determines the Effectiveness of Early or Late Estrogen Therapy after Ovariectomy in Rats.

Published in:

PLoS ONE, 2012, v. 7, n. 3, p. 1, doi. 10.1371/journal.pone.0033493

By:

Wang, Jun Ming;
Hou, Xu;
Adeosun, Samuel;
Hill, Rosanne;
Henry, Sherry;
Paul, Ian;
Irwin, Ronald W.;
Ou, Xiao-Ming;
Bigler, Steven;
Stockmeier, Craig;
Brinton, Roberta Diaz;
Gomez-Sanchez, Elise

Publication type:

Article

Allopregnanolone Promotes Regeneration and Reduces β-Amyloid Burden in a Preclinical Model of Alzheimer's Disease.

Published in:

PLoS ONE, 2011, v. 6, n. 8, p. 1, doi. 10.1371/journal.pone.0024293

By:

Chen, Shuhua;
Wang, Jun Ming;
Irwin, Ronald W.;
Yao, Jia;
Liu, Lifei;
Brinton, Roberta Diaz

Publication type:

Article

2-Deoxy-D-Glucose Treatment Induces Ketogenesis, Sustains Mitochondrial Function, and Reduces Pathology in Female Mouse Model of Alzheimer's Disease.

Published in:

PLoS ONE, 2011, v. 6, n. 7, p. 1, doi. 10.1371/journal.pone.0021788

By:

Jia Yao;
Shuhua Chen;
Zisu Mao;
Cadenas, Enrique;
Brinton, Roberta Diaz

Publication type:

Article

The Neurosteroid Allopregnanolone Promotes Proliferation of Rodent and Human Neural Progenitor Cells and Regulates Cell-Cycle Gene and Protein Expression.

Published in:

Journal of Neuroscience, 2005, v. 25, n. 19, p. 4706, doi. 10.1523/JNEUROSCI.4520-04.2005

By:

Jun Ming Wang;
Johnston, Patrick B.;
Ball, Bret Gene;
Diaz Brinton, Roberta

Publication type:

Article

Impact of fish oil supplementation on plasma levels of highly unsaturated fatty acid-containing lipid classes and molecular species in American football athletes.

Published in:

Nutrition & Metabolism, 2024, v. 21, n. 1, p. 1, doi. 10.1186/s12986-024-00815-x

By:

Mullins, Anne Veronica;
Snider, Justin M.;
Michael, Bryce;
Porter, Lydia Rose;
Brinton, Roberta Diaz;
Chilton, Floyd H.

Publication type:

Article

Selective estrogen receptor modulators (SERM) for the brain: Recent advances and remaining challenges for developing a NeuroSERM™.

Published in:

Drug Development Research, 2002, v. 56, n. 3, p. 380, doi. 10.1002/ddr.10090

By:

Brinton, Roberta Diaz

Publication type:

Article

Sex-specific associations of serum cortisol with brain biomarkers of Alzheimer's risk.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-56071-9

By:

Mosconi, Lisa;
Williams, Schantel;
Carlton, Caroline;
Zarate, Camila;
Boneu, Camila;
Fauci, Francesca;
Ajila, Trisha;
Nerattini, Matilde;
Jett, Steven;
Andy, Caroline;
Battista, Michael;
Pahlajani, Silky;
Osborne, Joseph;
Brinton, Roberta Diaz;
Dyke, Jonathan P.

Publication type:

Article

Combination therapies targeting AD risk factors delay cognitive decline over 10 years in Alzheimer's patient.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. S7, p. 1, doi. 10.1002/alz.093134

By:

Torrandell‐Haro, Georgina;
Shang, Yuan;
Vitali, Francesca;
Brinton, Roberta Diaz

Publication type:

Article

Impact of humanized APOE on brain volumetrics and white matter microstructure within a mouse model for Alzheimer's Disease.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. S2, p. 1, doi. 10.1002/alz.092751

By:

Bhattrai, Avnish;
Raikes, Adam C.;
McLean, John W.;
Wiegand, Jean‐Paul L.;
Brinton, Roberta Diaz

Publication type:

Article

Endocrinological aging drives alterations in white matter architecture: Evidence from a humanized APOE risk model of Alzheimer's disease.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. S2, p. 1, doi. 10.1002/alz.092658

By:

Raikes, Adam C.;
Bhattrai, Avnish;
Wang, Tian;
Brinton, Roberta Diaz

Publication type:

Article

Extended Exposure to Alzheimer's Risk Factors Increases Alzheimer's Diagnosis Risk Amplified in APOε4 Carriers: Implication for Delayed Onset of Alzheimer's Risk Factors.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. S2, p. 1, doi. 10.1002/alz.091806

By:

Merlini, Simona;
Vitali, Francesca;
Brinton, Roberta Diaz

Publication type:

Article

Midlife Neuroinflammatory Dynamics: The Emergence of Alzheimer's Disease Neuroimmune Profile in the Female Human Brain.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.093151

By:

Van Rossum, Hannah;
Shang, Yuan;
Brinton, Roberta Diaz

Publication type:

Article

APOEε4 Allele Modulates Region‐Specific Transcriptomic Changes in Epigenetic Control Pathways: Implications for Late‐Onset Alzheimer's Disease Risk.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.092722

By:

Delatorre, Nicole;
Van Rossum, Hannah;
Parker, Anna;
Brinton, Roberta Diaz

Publication type:

Article

CNS‐active drugs for neuropsychiatric disorders differentially modulate the risk of AD development.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.091759

By:

Cortes‐Flores, Helena;
Torrandell‐Haro, Georgina;
Brinton, Roberta Diaz

Publication type:

Article

Behavioral and metabolic profiles in an aged, humanized APP/APOE mouse model of Alzheimer's Disease risk.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.091716

By:

McLean, John W.;
Bhattrai, Avnish;
Brinton, Roberta Diaz

Publication type:

Article

Key role of ERβ in estrogenic regulation of neuronal mitochondrial function.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.086633

By:

Wang, Tian;
Mao, Zisu;
Chen, Shuhua;
Shang, Yuan;
McLean, John W.;
Stanton, James Brett;
Qi, Guoyuan;
Yin, Fei;
Brinton, Roberta Diaz

Publication type:

Article

Sex and APOE differences in Alzheimer's Disease‐On‐Ramp risk factor profiles: Are all risk factors for Alzheimer's Disease created equal?

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082316

By:

Merlini, Simona;
Vitali, Francesca;
Brinton, Roberta Diaz

Publication type:

Article

Computational identification of precision therapeutics for Alzheimer's disease specific to endocrine and APOE genotype status.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 21, p. 1, doi. 10.1002/alz.080506

By:

Vitali, Francesca;
Zhang, Jessica;
Wang, Tian;
Brinton, Roberta Diaz

Publication type:

Article

Development of a selective estrogen β‐receptor phytoestrogen formulation – PhytoSERM – for the reduction of Alzheimer's risk and relief of menopausal symptoms in women: a phase 2 randomized clinical trial framework.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 21, p. 1, doi. 10.1002/alz.080295

By:

Hernandez, Gerson D;
Lopez, Claudia M;
Raikes, Adam C.;
Matthews, Dawn C;
Mosconi, Lisa;
Brinton, Roberta Diaz

Publication type:

Article

The Antidepressant Therapy Selective Norepinephrine Reuptake Inhibitors (SNRIs) Reduces the Risk of Alzheimer's Disease.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 21, p. 1, doi. 10.1002/alz.080047

By:

Cortes‐Flores, Helena;
Torrandell‐Haro, Georgina;
Brinton, Roberta Diaz

Publication type:

Article

Sex differences in white matter bundle properties across menopausal transition states.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079940

By:

Raikes, Adam C.;
Dyke, Jonathan;
Jett, Steven;
Williams, Schantel;
Pahlajani, Silky;
Brinton, Roberta Diaz;
Mosconi, Lisa

Publication type:

Article

Correlational analysis of plasma metabolome and brain imaging in a humanized APOE mouse model.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080468

By:

Bhattrai, Avnish;
McLean, John W.;
Simmons, Hannah;
Raikes, Adam C.;
Wiegand, Jean‐Paul L.;
Kaddurah‐Daouk, Rima F.;
Brinton, Roberta Diaz

Publication type:

Article

Distinct immune signatures associated with sex and genotype in the 15m novel hAPP+hAPOE mouse risk model of Alzheimer's disease.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080139

By:

Delatorre, Nicole;
Van Rossum, Hannah;
Brinton, Roberta Diaz

Publication type:

Article

Plasma metabolomic profiles of aged, humanized APOE mice and behavioral correlates.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080101

By:

McLean, John W.;
Bhattrai, Avnish;
Simmons, Hannah;
Wiegand, Jean‐Paul L.;
Raikes, Adam C.;
Kaddurah‐Daouk, Rima F.;
Brinton, Roberta Diaz

Publication type:

Article

Statin therapy reduces the risk of AD: Clinic to bench translation for protective mechanism.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080504

By:

Torrandell‐Haro, Georgina;
Chen, Shuhua;
Brinton, Roberta Diaz

Publication type:

Article

Distinct immune signatures associated with sex and genotype in the 12m novel hAPP hAPOE mouse risk model of Alzheimer's disease.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080058

By:

Van Rossum, Hannah;
Delatorre, Nicole;
Brinton, Roberta Diaz

Publication type:

Article

Loss of Fatty Acid Degradation by Astrocytic Mitochondria as a Mechanism of Neuroinflammation and Neurodegeneration.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.076572

By:

Mi, Yashi;
Qi, Guoyuan;
Vitali, Francesca;
Shang, Yuan;
Raikes, Adam C.;
Wang, Tian;
Jin, Yan;
Brinton, Roberta Diaz;
Gu, Haiwei;
Yin, Fei

Publication type:

Article

Statin responder analysis for precision prevention of Alzheimer's Disease.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 11, p. 1, doi. 10.1002/alz.068305

By:

Torrandell‐Haro, Georgina;
Branigan, Gregory L;
Rodgers, Kathleen E.;
Brinton, Roberta Diaz

Publication type:

Article

In‐season docosahexaenoic acid supplementation does not prevent white matter damage during a single American football season: Implications for neurodegeneration prevention.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 11, p. 1, doi. 10.1002/alz.065751

By:

Raikes, Adam C.;
Hernandez, Gerson D;
Mullins, Veronica A.;
Wang, Yiwei;
Lopez, Claudia M;
Killgore, William D. S.;
Chilton, Floyd;
Brinton, Roberta Diaz

Publication type:

Article

Allopregnanolone as a Regenerative Therapeutic for Alzheimer's Disease: Phase 2 proof‐of‐concept clinical trial using hippocampal volume as a surrogate endpoint.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 10, p. 1, doi. 10.1002/alz.068251

By:

Hernandez, Gerson D;
Lopez, Claudia M;
Raikes, Adam C.;
Rodgers, Kathleen E.;
Matthews, Dawn C;
Cutter, Gary R;
Schneider, Lon S.;
Brinton, Roberta Diaz

Publication type:

Article

Translational potential of JAX humanized APOE mice: trajectories of resilient versus susceptible aging by sex and weight.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 5, p. 1, doi. 10.1002/alz.068242

By:

Vitali, Francesca;
Wiegand, Jean‐Paul L.;
Tucker, Allan;
Merlini, Simona;
Brinton, Roberta Diaz

Publication type:

Article

Translational potential of JAX humanized APOE mice: Hippocampal volume decline in very old mice.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 5, p. 1, doi. 10.1002/alz.068141

By:

Raikes, Adam C.;
Bhattrai, Avnish;
McLean, John W.;
Wiegand, Jean‐Paul L.;
Brinton, Roberta Diaz

Publication type:

Article

Translational potential of JAX humanized APOE mice: Metabolism and body composition in very old mice.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 5, p. 1, doi. 10.1002/alz.068128

By:

Bhattrai, Avnish;
McLean, John W.;
Raikes, Adam C.;
Wiegand, Jean‐Paul L.;
Skopp, Stacy M;
Brinton, Roberta Diaz

Publication type:

Article

Translational potential of JAX humanized APOE mice: Peripheral biomarkers of pathology.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 5, p. 1, doi. 10.1002/alz.067815

By:

McLean, John W.;
Reyes‐Reyes, Elsa M.;
Bhattrai, Avnish;
Wiegand, Jean‐Paul L.;
Raikes, Adam C.;
Rodgers, Kathleen E.;
Brinton, Roberta Diaz

Publication type:

Article

Translational potential of JAX humanized APOE mice: Peripheral interferon gamma induces systemic immuno‐metabolic dysfunction.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.068655

By:

Van Rossum, Hannah;
Delatorre, Nicole;
Mishra, Aarti;
Bhattrai, Avnish;
Raikes, Adam C.;
Rodgers, Kathleen E.;
Brinton, Roberta Diaz

Publication type:

Article

Translational potential of JAX humanized‐APOE mice: Building the foundation for translational validity by applying human clinical trial principles.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.068036

By:

Wiegand, Jean‐Paul L.;
Skopp, Stacy M;
Brinton, Roberta Diaz

Publication type:

Article

Translational potential of JAX humanized‐APOE mice model: Accelerated midlife endocrine aging in hAPOEε4/4 females.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.067969

By:

Wang, Tian;
Mao, Zisu;
Delatorre, Nicole;
Wiegand, Jean‐Paul L.;
Brinton, Roberta Diaz

Publication type:

Article