Works by Brewitz, Lennart

Results: 24

Human Oxygenase Variants Employing a Single Protein FeII Ligand Are Catalytically Active.

Published in:

Angewandte Chemie, 2021, v. 133, n. 26, p. 14778, doi. 10.1002/ange.202103711

By:

Brasnett, Amelia;
Pfeffer, Inga;
Brewitz, Lennart;
Chowdhury, Rasheduzzaman;
Nakashima, Yu;
Tumber, Anthony;
McDonough, Michael A.;
Schofield, Christopher J.

Publication type:

Article

Innenrücktitelbild: Achiral Trisubstituted Thioureas as Secondary Ligands to CuI Catalysts: Direct Catalytic Asymmetric Addition of α‐Fluoronitriles to Imines (Angew. Chem. 9/2019).

Published in:

Angewandte Chemie, 2019, v. 131, n. 9, p. 2931, doi. 10.1002/ange.201814446

By:

Balaji, Pandur Venkatesan;
Brewitz, Lennart;
Kumagai, Naoya;
Shibasaki, Masakatsu

Publication type:

Article

Achiral Trisubstituted Thioureas as Secondary Ligands to CuI Catalysts: Direct Catalytic Asymmetric Addition of α‐Fluoronitriles to Imines.

Published in:

Angewandte Chemie, 2019, v. 131, n. 9, p. 2670, doi. 10.1002/ange.201812673

By:

Balaji, Pandur Venkatesan;
Brewitz, Lennart;
Kumagai, Naoya;
Shibasaki, Masakatsu

Publication type:

Article

Human prolyl hydroxylase domain 2 reacts with O2 and 2-oxoglutarate to enable formation of inactive Fe(III).2OG.hypoxia-inducible-factor α complexes.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-75761-y

By:

Fiorini, Giorgia;
Marshall, Stephen A.;
Figg Jr., William D.;
Myers, William K.;
Brewitz, Lennart;
Schofield, Christopher J.

Publication type:

Article

2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26673-2

By:

Nakashima, Yu;
Brewitz, Lennart;
Tumber, Anthony;
Salah, Eidarus;
Schofield, Christopher J.

Publication type:

Article

Cyclic β²,³-amino acids improve the serum stability of macrocyclic peptide inhibitors targeting the SARS-CoV-2 main protease.

Published in:

Bulletin of the Chemical Society of Japan, 2024, v. 97, n. 5, p. 1, doi. 10.1093/bulcsj/uoae018

By:

Takashi Miura;
Malla, Tika R.;
Brewitz, Lennart;
Tumber, Anthony;
Salah, Eidarus;
Kang Ju Lee;
Naohiro Terasaka;
Owen, C. David;
Damerell, Claire Strain;
Lukacik, Petra;
Walsh, Martin A.;
Akane Kawamura;
Schofield, Christopher J.;
Takayuki Katoh;
Hiroaki Suga

Publication type:

Article

Structural and Computational Investigation of Intramolecular N···H Interactions in α- and β-Fluorinated 7-Azaindoline Amides.

Published in:

European Journal of Organic Chemistry, 2018, v. 2018, n. 6, p. 714, doi. 10.1002/ejoc.201701083

By:

Brewitz, Lennart;
Noda, Hidetoshi;
Kumagai, Naoya;
Shibasaki, Masakatsu

Publication type:

Article

Human Oxygenase Variants Employing a Single Protein FeII Ligand Are Catalytically Active.

Published in:

Angewandte Chemie International Edition, 2021, v. 60, n. 26, p. 14657, doi. 10.1002/anie.202103711

By:

Brasnett, Amelia;
Pfeffer, Inga;
Brewitz, Lennart;
Chowdhury, Rasheduzzaman;
Nakashima, Yu;
Tumber, Anthony;
McDonough, Michael A.;
Schofield, Christopher J.

Publication type:

Article

Inside Back Cover: Achiral Trisubstituted Thioureas as Secondary Ligands to CuI Catalysts: Direct Catalytic Asymmetric Addition of α‐Fluoronitriles to Imines (Angew. Chem. Int. Ed. 9/2019).

Published in:

Angewandte Chemie International Edition, 2019, v. 58, n. 9, p. 2905, doi. 10.1002/anie.201814446

By:

Balaji, Pandur Venkatesan;
Brewitz, Lennart;
Kumagai, Naoya;
Shibasaki, Masakatsu

Publication type:

Article

Achiral Trisubstituted Thioureas as Secondary Ligands to CuI Catalysts: Direct Catalytic Asymmetric Addition of α‐Fluoronitriles to Imines.

Published in:

Angewandte Chemie International Edition, 2019, v. 58, n. 9, p. 2644, doi. 10.1002/anie.201812673

By:

Balaji, Pandur Venkatesan;
Brewitz, Lennart;
Kumagai, Naoya;
Shibasaki, Masakatsu

Publication type:

Article

Cover Feature: (2R,3S)‐3,4,4,4‐Tetrafluorovaline: A Fluorinated Bioisostere of Isoleucine (Eur. J. Org. Chem. 13/2020).

Published in:

European Journal of Organic Chemistry, 2020, v. 2020, n. 13, p. 1918, doi. 10.1002/ejoc.202000326

By:

Brewitz, Lennart;
Noda, Hidetoshi;
Kumagai, Naoya;
Shibasaki, Masakatsu

Publication type:

Article

(2R,3S)‐3,4,4,4‐Tetrafluorovaline: A Fluorinated Bioisostere of Isoleucine.

Published in:

European Journal of Organic Chemistry, 2020, v. 2020, n. 11, p. 1745, doi. 10.1002/ejoc.202000109

By:

Brewitz, Lennart;
Noda, Hidetoshi;
Kumagai, Naoya;
Shibasaki, Masakatsu

Publication type:

Article

Formal Total Synthesis of the Algal Toxin (−)-Polycavernoside A.

Published in:

Chemistry - A European Journal, 2013, v. 19, n. 14, p. 4532, doi. 10.1002/chem.201204551

By:

Brewitz, Lennart;
Llaveria, Josep;
Yada, Akira;
Fürstner, Alois

Publication type:

Article

Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis.

Published in:

eLife, 2022, p. 1, doi. 10.7554/eLife.69348

By:

Brereton, Christopher J.;
Liudi Yao;
Davies, Elizabeth R.;
Yilu Zhou;
Vukmirovic, Milica;
Bell, Joseph A.;
Siyuan Wang;
Ridley, Robert A.;
Dean, Lareb S. N.;
Andriotis, Orestis G.;
Conforti, Franco;
Brewitz, Lennart;
Mohammed, Soran;
Wallis, Timothy;
Tavassoli, Ali;
Ewing, Rob M.;
Alzetani, Aiman;
Marshall, Benjamin G.;
Fletcher, Sophie V.;
Thurner, Philipp J.

Publication type:

Article

Author Correction: Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors.

Published in:

2020

By:

Brewitz, Lennart;
Tumber, Anthony;
Pfeffer, Inga;
McDonough, Michael A.;
Schofield, Christopher J.

Publication type:

Correction Notice

Author Correction: Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors.

Published in:

2020

By:

Brewitz, Lennart;
Tumber, Anthony;
Pfeffer, Inga;
McDonough, Michael A.;
Schofield, Christopher J.

Publication type:

Correction Notice

Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-65123-9

By:

Brewitz, Lennart;
Tumber, Anthony;
Pfeffer, Inga;
McDonough, Michael A.;
Schofield, Christopher J.

Publication type:

Article

Publisher Correction: Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19.

Published in:

2021

By:

Redhead, Martin A.;
Owen, C. David;
Brewitz, Lennart;
Collette, Amelia H.;
Lukacik, Petra;
Strain-Damerell, Claire;
Robinson, Sean W.;
Collins, Patrick M.;
Schäfer, Philipp;
Swindells, Mark;
Radoux, Chris J.;
Hopkins, Iva Navratilova;
Fearon, Daren;
Douangamath, Alice;
von Delft, Frank;
Malla, Tika R.;
Vangeel, Laura;
Vercruysse, Thomas;
Thibaut, Jan;
Leyssen, Pieter

Publication type:

Correction Notice

Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-92416-4

By:

Redhead, Martin A.;
Owen, C. David;
Brewitz, Lennart;
Collette, Amelia H.;
Lukacik, Petra;
Strain-Damerell, Claire;
Robinson, Sean W.;
Collins, Patrick M.;
Schäfer, Philipp;
Swindells, Mark;
Radoux, Chris J.;
Hopkins, Iva Navratilova;
Fearon, Daren;
Douangamath, Alice;
von Delft, Frank;
Malla, Tika R.;
Vangeel, Laura;
Vercruysse, Thomas;
Thibaut, Jan;
Leyssen, Pieter

Publication type:

Article

Crystallographic and Selectivity Studies on the Approved HIF Prolyl Hydroxylase Inhibitors Desidustat and Enarodustat.

Published in:

ChemMedChem, 2024, v. 19, n. 24, p. 1, doi. 10.1002/cmdc.202400504

By:

Corner, Thomas P.;
Salah, Eidarus;
Tumber, Anthony;
Kaur, Samanpreet;
Nakashima, Yu;
Allen, Mark D.;
Schnaubelt, Lara I.;
Fiorini, Giorgia;
Brewitz, Lennart;
Schofield, Christopher J.

Publication type:

Article

Mass Spectrometric Assays Reveal Discrepancies in Inhibition Profiles for the SARS‐CoV‐2 Papain‐Like Protease.

Published in:

ChemMedChem, 2022, v. 17, n. 9, p. 1, doi. 10.1002/cmdc.202200016

By:

Brewitz, Lennart;
Kamps, Jos J. A. G.;
Lukacik, Petra;
Strain‐Damerell, Claire;
Zhao, Yilin;
Tumber, Anthony;
Malla, Tika R.;
Orville, Allen M.;
Walsh, Martin A.;
Schofield, Christopher J.

Publication type:

Article

Structure‐Activity Studies Reveal Scope for Optimisation of Ebselen‐Type Inhibition of SARS‐CoV‐2 Main Protease.

Published in:

ChemMedChem, 2022, v. 17, n. 4, p. 1, doi. 10.1002/cmdc.202100582

By:

Thun‐Hohenstein, Siegfried T. D.;
Suits, Timothy F.;
Malla, Tika R.;
Tumber, Anthony;
Brewitz, Lennart;
Choudhry, Hani;
Salah, Eidarus;
Schofield, Christopher J.

Publication type:

Article

Synthesis of Novel Pyridine‐Carboxylates as Small‐Molecule Inhibitors of Human Aspartate/Asparagine‐β‐Hydroxylase.

Published in:

ChemMedChem, 2020, v. 15, n. 13, p. 1139, doi. 10.1002/cmdc.202000147

By:

Brewitz, Lennart;
Tumber, Anthony;
Thalhammer, Armin;
Salah, Eidarus;
Christensen, Kirsten E.;
Schofield, Christopher J.

Publication type:

Article

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-12711-7

By:

Pfeffer, Inga;
Brewitz, Lennart;
Krojer, Tobias;
Jensen, Sacha A.;
Kochan, Grazyna T.;
Kershaw, Nadia J.;
Hewitson, Kirsty S.;
McNeill, Luke A.;
Kramer, Holger;
Münzel, Martin;
Hopkinson, Richard J.;
Oppermann, Udo;
Handford, Penny A.;
McDonough, Michael A.;
Schofield, Christopher J.

Publication type:

Article

Works by Brewitz, Lennart

Human Oxygenase Variants Employing a Single Protein Fe<sup>II</sup> Ligand Are Catalytically Active.

Innenrücktitelbild: Achiral Trisubstituted Thioureas as Secondary Ligands to Cu<sup>I</sup> Catalysts: Direct Catalytic Asymmetric Addition of α‐Fluoronitriles to Imines (Angew. Chem. 9/2019).

Achiral Trisubstituted Thioureas as Secondary Ligands to Cu<sup>I</sup> Catalysts: Direct Catalytic Asymmetric Addition of α‐Fluoronitriles to Imines.

Human prolyl hydroxylase domain 2 reacts with O<sub>2</sub> and 2-oxoglutarate to enable formation of inactive Fe(III).2OG.hypoxia-inducible-factor α complexes.

2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases.

Cyclic β²,³-amino acids improve the serum stability of macrocyclic peptide inhibitors targeting the SARS-CoV-2 main protease.

Structural and Computational Investigation of Intramolecular N···H Interactions in α- and β-Fluorinated 7-Azaindoline Amides.

Human Oxygenase Variants Employing a Single Protein Fe<sup>II</sup> Ligand Are Catalytically Active.

Inside Back Cover: Achiral Trisubstituted Thioureas as Secondary Ligands to Cu<sup>I</sup> Catalysts: Direct Catalytic Asymmetric Addition of α‐Fluoronitriles to Imines (Angew. Chem. Int. Ed. 9/2019).

Achiral Trisubstituted Thioureas as Secondary Ligands to Cu<sup>I</sup> Catalysts: Direct Catalytic Asymmetric Addition of α‐Fluoronitriles to Imines.

Cover Feature: (2R,3S)‐3,4,4,4‐Tetrafluorovaline: A Fluorinated Bioisostere of Isoleucine (Eur. J. Org. Chem. 13/2020).

(2R,3S)‐3,4,4,4‐Tetrafluorovaline: A Fluorinated Bioisostere of Isoleucine.

Formal Total Synthesis of the Algal Toxin (−)-Polycavernoside A.

Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis.

Author Correction: Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors.

Author Correction: Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors.

Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors.

Publisher Correction: Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19.

Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19.

Crystallographic and Selectivity Studies on the Approved HIF Prolyl Hydroxylase Inhibitors Desidustat and Enarodustat.

Mass Spectrometric Assays Reveal Discrepancies in Inhibition Profiles for the SARS‐CoV‐2 Papain‐Like Protease.

Structure‐Activity Studies Reveal Scope for Optimisation of Ebselen‐Type Inhibition of SARS‐CoV‐2 Main Protease.

Synthesis of Novel Pyridine‐Carboxylates as Small‐Molecule Inhibitors of Human Aspartate/Asparagine‐β‐Hydroxylase.

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern.