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PHOCUS: A Phase 3, Randomized, Open-Label Study of Sequential Treatment with Pexa-Vec (JX-594) and Sorafenib in Patients with Advanced Hepatocellular Carcinoma.
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- Liver Cancer (2235-1795), 2024, v. 13, n. 3, p. 256, doi. 10.1159/000533650
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- Article
Development and applications of oncolytic Maraba virus vaccines.
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- Oncolytic Virotherapy, 2018, v. 7, p. 117, doi. 10.2147/OV.S154494
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Intrinsic and Tumor Microenvironment-Induced Metabolism Adaptations of T Cells and Impact on Their Differentiation and Function.
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- Frontiers in Immunology, 2016, p. 1, doi. 10.3389/fimmu.2016.00114
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Phase 1b Trial of Biweekly Intravenous Pexa-Vec (JX-594), an Oncolytic and Immunotherapeutic Vaccinia Virus in Colorectal Cancer.
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- Molecular Therapy, 2015, v. 23, n. 9, p. 1532, doi. 10.1038/mt.2015.109
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- Article
Complement Inhibition Prevents Oncolytic Vaccinia Virus Neutralization in Immune Humans and Cynomolgus Macaques.
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- Molecular Therapy, 2015, v. 23, n. 6, p. 1066, doi. 10.1038/mt.2015.49
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- Article
Phase 1 Study of Intratumoral Pexa-Vec (JX-594), an Oncolytic and Immunotherapeutic Vaccinia Virus, in Pediatric Cancer Patients.
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- Molecular Therapy, 2015, v. 23, n. 3, p. 602, doi. 10.1038/mt.2014.243
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- Article
First-in-man Study of Western Reserve Strain Oncolytic Vaccinia Virus: Safety, Systemic Spread, and Antitumor Activity.
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- Molecular Therapy, 2015, v. 23, n. 1, p. 202, doi. 10.1038/mt.2014.194
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- Article
The emerging therapeutic potential of the oncolytic immunotherapeutic Pexa-Vec (JX-594).
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- Oncolytic Virotherapy, 2015, v. 4, p. 25, doi. 10.2147/OV.S59640
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Going viral with cancer immunotherapy.
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- Nature Reviews Cancer, 2014, v. 14, n. 8, p. 559, doi. 10.1038/nrc3770
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- Article
Oncolytic virotherapy as emerging immunotherapeutic modality: potential of parvovirus H-1.
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- Frontiers in Oncology, 2014, v. 4, p. 1, doi. 10.3389/fonc.2014.00092
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Oncolytic and Immunotherapeutic Vaccinia Induces Antibody-Mediated Complement-Dependent Cancer Cell Lysis in Humans.
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- Science Translational Medicine, 2013, v. 5, n. 185, p. 1, doi. 10.1126/scitranslmed.3005361
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- Article
Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer.
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- Nature Medicine, 2013, v. 19, n. 3, p. 329, doi. 10.1038/nm.3089
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- Article
The Oncolytic Poxvirus JX-594 Selectively Replicates in and Destroys Cancer Cells Driven by Genetic Pathways Commonly Activated in Cancers.
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- Molecular Therapy, 2012, v. 20, n. 4, p. 749, doi. 10.1038/mt.2011.276
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- Article
A Mechanistic Proof-of-concept Clinical Trial With JX-594, a Targeted Multi-mechanistic Oncolytic Poxvirus, in Patients With Metastatic Melanoma.
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- Molecular Therapy, 2011, v. 19, n. 10, p. 1913, doi. 10.1038/mt.2011.132
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Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans.
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- Nature, 2011, v. 477, n. 7362, p. 99, doi. 10.1038/nature10358
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Sequential Therapy With JX-594, A Targeted Oncolytic Poxvirus, Followed by Sorafenib in Hepatocellular Carcinoma: Preclinical and Clinical Demonstration of Combination Efficacy.
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- Molecular Therapy, 2011, v. 19, n. 6, p. 1170, doi. 10.1038/mt.2011.39
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- Article
Targeting Tumor Vasculature With an Oncolytic Virus.
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- Molecular Therapy, 2011, v. 19, n. 5, p. 886, doi. 10.1038/mt.2011.26
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Enhancement of Vaccinia Virus Based Oncolysis with Histone Deacetylase Inhibitors.
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- PLoS ONE, 2010, v. 5, n. 12, p. 1, doi. 10.1371/journal.pone.0014462
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Efficacy and Safety/Toxicity Study of Recombinant Vaccinia Virus JX-594 in Two Immunocompetent Animal Models of Glioma.
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- Molecular Therapy, 2010, v. 18, n. 11, p. 1927, doi. 10.1038/mt.2010.183
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Translational control of the innate immune response through IRF-7.
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- Nature, 2008, v. 452, n. 7185, p. 323, doi. 10.1038/nature06730
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Targeted Inflammation During Oncolytic Virus Therapy Severely Compromises Tumor Blood Flow.
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- Molecular Therapy, 2007, v. 15, n. 9, p. 1686, doi. 10.1038/sj.mt.6300215
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- Article