Works by Brandt, Roland

Results: 48

Towards mechanism-based tau-targeted therapies.

Published in:

Neural Regeneration Research, 2026, v. 21, n. 2, p. 687, doi. 10.4103/NRR.NRR-D-24-01240

By:

Bakota, Lidia;
Brandt, Roland

Publication type:

Article

Aortic valve endocarditis: the role of echocardiography.

Published in:

2013

By:

Brandt, Roland R.

Publication type:

Abstract

Microtubule Binding and Trapping at the Tip of Neurites Regulate Tau Motion in Living Neurons.

Published in:

Traffic, 2009, v. 10, n. 11, p. 1655, doi. 10.1111/j.1600-0854.2009.00977.x

By:

Weissmann, Carina;
Reyher, Hans-Jürgen;
Gauthier, Anne;
Steinhoff, Heinz-Jürgen;
Junge, Wolfgang;
Brandt, Roland

Publication type:

Article

Quantitative live cell imaging of a tauopathy model enables the identification of a polypharmacological drug candidate that restores physiological microtubule interaction.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-45851-6

By:

Pinzi, Luca;
Conze, Christian;
Bisi, Nicolo;
Torre, Gabriele Dalla;
Soliman, Ahmed;
Monteiro-Abreu, Nanci;
Trushina, Nataliya I.;
Krusenbaum, Andrea;
Dolouei, Maryam Khodaei;
Hellwig, Andrea;
Christodoulou, Michael S.;
Passarella, Daniele;
Bakota, Lidia;
Rastelli, Giulio;
Brandt, Roland

Publication type:

Article

Quantitative live cell imaging of a tauopathy model enables the identification of a polypharmacological drug candidate that restores physiological microtubule interaction.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-45851-6

By:

Pinzi, Luca;
Conze, Christian;
Bisi, Nicolo;
Torre, Gabriele Dalla;
Soliman, Ahmed;
Monteiro-Abreu, Nanci;
Trushina, Nataliya I.;
Krusenbaum, Andrea;
Dolouei, Maryam Khodaei;
Hellwig, Andrea;
Christodoulou, Michael S.;
Passarella, Daniele;
Bakota, Lidia;
Rastelli, Giulio;
Brandt, Roland

Publication type:

Article

Neuronal stress granules as dynamic microcompartments: current concepts and open questions.

Published in:

Biological Chemistry, 2023, v. 404, n. 5, p. 491, doi. 10.1515/hsz-2022-0302

By:

Söhnel, Anna-Carina;
Brandt, Roland

Publication type:

Article

The microtubule skeleton and the evolution of neuronal complexity in vertebrates.

Published in:

Biological Chemistry, 2019, v. 400, n. 9, p. 1163, doi. 10.1515/hsz-2019-0149

By:

Trushina, Nataliya I.;
Mulkidjanian, Armen Y.;
Brandt, Roland

Publication type:

Article

Microcompartments in the Drosophila heart and the mammalian brain: general features and common principles.

Published in:

Biological Chemistry, 2013, v. 394, n. 2, p. 217, doi. 10.1515/hsz-2012-0261

By:

Brandt, Roland;
Paululat, Achim

Publication type:

Article

Highlight: The physiology and dynamics of cellular microcompartments.

Published in:

Biological Chemistry, 2013, v. 394, n. 2, p. 149, doi. 10.1515/hsz-2012-0349

By:

Brandt, Roland;
Klare, Johann;
Steinhoff, Heinz-Jürgen;
Ungermann, Christian

Publication type:

Article

Live cell imaging of cytoskeletal dynamics in neurons using fluorescence photoactivation.

Published in:

Biological Chemistry, 2010, v. 391, n. 6, p. 639, doi. 10.1515/BC.2010.060

By:

Gauthier, Anne;
Brandt, Roland

Publication type:

Article

Multiple Episodes of a Transient Global Left Ventricular Dysfunction Reminiscent to Apical Ballooning.

Published in:

Cardiology, 2007, v. 108, n. 1, p. 1, doi. 10.1159/000095577

By:

Nef, Holger M.;
Möllmann, Helge;
Vogt, Achim;
Weber, Michael;
Deetjen, Anja;
Dill, Thorsten;
Brandt, Roland;
Hamm, Christian W.;
Elsässer, Albrecht

Publication type:

Article

Targeting microtubules in axonal re- and degeneration (Commentary on Li et al. (.

Published in:

European Journal of Neuroscience, 2017, v. 46, n. 1, p. 1647, doi. 10.1111/ejn.13615

By:

Brandt, Roland

Publication type:

Article

Evaluation and Elucidation of DNA-Containing Viologen Dendrimer Complex Formation.

Published in:

European Journal of Organic Chemistry, 2016, v. 2016, n. 10, p. 1897, doi. 10.1002/ejoc.201501485

By:

Bongard, Dirk;
Degefa, Tesfaye Hailu;
Schön, Peter;
Giese, Maria;
Brandt, Roland;
Walder, LorENz

Publication type:

Article

Tau Aggregation and Progressive Neuronal Degeneration in the Absence of Changes in Spine Density and Morphology after Targeted Expression of Alzheimer's Disease-Relevant Tau Constructs in Organotypic Hippocampal Slices.

Published in:

Journal of Neuroscience, 2006, v. 26, n. 22, p. 6103, doi. 10.1523/JNEUROSCI.4245-05.2006

By:

Shahani, Neelam;
Subramaniam, Srinivasa;
Wolf, Tobias;
Tackenberg, Christian;
Brandt, Roland

Publication type:

Article

Insulin-Like Growth Factor 1 Inhibits Extracellular Signal-Regulated Kinase to Promote Neuronal Survival via the Phosphatidylinositol 3-Kinase/Protein Kinase A/c-Raf Pathway.

Published in:

Journal of Neuroscience, 2005, v. 25, n. 11, p. 2838, doi. 10.1523/JNEUROSCI.5060-04.2005

By:

Subramaniam, Srinivasa;
Shahani, Neelam;
Strelau, Jens;
Laliberté, Christine;
Brandt, Roland;
Kaplan, David;
Unsicker, Klaus

Publication type:

Article

Regulation between O-GlcNAcylation and phosphorylation of neurofilament-M and their dysregulation in Alzheimer disease.

Published in:

FASEB Journal, 2008, v. 22, n. 1, p. 138, doi. 10.1096/fj.07-8309com

By:

Yanqiu Deng;
Bin Li;
Fei Liu;
Iqbal, Khalid;
Grundke-Iqbal, Inge;
Brandt, Roland;
Cheng-Xin Gong

Publication type:

Article

Intraoperative characterization of interventricular mechanical dyssynchrony using electroanatomic mapping system--a feasibility study.

Published in:

2012

By:

Sperzel J;
Brandt R;
Hou W;
Doelger A;
Zdarek J;
Rosenberg SP;
Ryu K;
Koh S;
Yang M;
Sperzel, Johannes;
Brandt, Roland;
Hou, Wenbo;
Doelger, Annette;
Zdarek, Jan;
Rosenberg, Stuart P;
Ryu, Kyungmoo;
Koh, Steve;
Yang, Michael

Publication type:

journal article

Intraoperative characterization of interventricular mechanical dyssynchrony using electroanatomic mapping system-a feasibility study.

Published in:

Journal of Interventional Cardiac Electrophysiology, 2012, v. 35, n. 2, p. 189, doi. 10.1007/s10840-012-9695-0

By:

Sperzel, Johannes;
Brandt, Roland;
Hou, Wenbo;
Doelger, Annette;
Zdarek, Jan;
Rosenberg, Stuart;
Ryu, Kyungmoo;
Koh, Steve;
Yang, Michael

Publication type:

Article

Bradycardia--Induced Polymorphic Ventricular Tachycardia After Atrioventricular Junction Ablation for Sinus Tachycardia-Induced Cardiomyopathy.

Published in:

Journal of Cardiovascular Electrophysiology, 1995, v. 6, n. 8, p. 630, doi. 10.1111/j.1540-8167.1995.tb00440.x

By:

Brandt, Roland R.;
Shen, Win-Kuang

Publication type:

Article

Tau Biology and Tau-Directed Therapies for Alzheimer's Disease.

Published in:

Drugs, 2016, v. 76, n. 3, p. 301, doi. 10.1007/s40265-015-0529-0

By:

Bakota, Lidia;
Brandt, Roland

Publication type:

Article

Much More Than a Cytoskeletal Protein: Physiological and Pathological Functions of the Non-microtubule Binding Region of Tau.

Published in:

Frontiers in Neurology, 2020, v. 11, p. N.PAG, doi. 10.3389/fneur.2020.590059

By:

Brandt, Roland;
Trushina, Nataliya I.;
Bakota, Lidia

Publication type:

Article

Identification of Nucleoside Analogs as Inducers of Neuronal Differentiation in a Human Reporter Cell Line and Adult Stem Cells.

Published in:

Chemical Biology & Drug Design, 2015, v. 86, n. 2, p. 129, doi. 10.1111/cbdd.12488

By:

Raasch, Katharina;
Malecki, Edith;
Siemann, Maria;
Martinez, Malayko M.;
Heinisch, Jürgen J.;
Müller, Janine;
Bakota, Lidia;
Kaltschmidt, Christian;
Kaltschmidt, Barbara;
Rosemeyer, Helmut;
Brandt, Roland

Publication type:

Article

Analysis of photoactivatable tau proteins in living cells.

Published in:

2007

By:

Weissmann, Carina;
Hillje, Anna;
Reyher, Hans-Jürgen;
Steinhoff, Heinz-Jürgen;
Brandt, Roland

Publication type:

Abstract

Pseudohyperphosphorylation of tau is sufficient to induce aberrant sprouting and activation of ERK1/2 in transgenic mice.

Published in:

2007

By:

Hundelt, Monika;
Selle, Karolin;
Kosfeld, Anne;
Fath, Thomas;
Schultz, Christian;
Götz, Jürgen;
Von Engelhardt, Jacob;
Monyer, Hannah;
Brandt, Roland

Publication type:

Abstract

The transition of microglia to a ramified phenotype is associated with the formation of stable acetylated and detyrosinated microtubules.

Published in:

Glia (0894-1491), 1996, v. 18, n. 2, p. 129, doi. 10.1002/(SICI)1098-1136(199610)18:2<129::AID-GLIA5>3.0.CO;2-W

By:

Ilschner, Susanne;
Brandt, Roland

Publication type:

Article

Phosphorylation of native and truncated isoforms of protein τ by the double-stranded DNA-dependent protein kinase (DNA-PK) shows that the primary phosphorylation sites are localized between amino acid residues 212-231 of the longest τ.

Published in:

IUBMB Life, 1996, v. 40, n. 1, p. 21, doi. 10.1080/15216549600201492

By:

Wu, Joseph M.;
Chen, Yuping;
Hsieh, Tze-chen;
Brandt, Roland;
Lee, Gloria

Publication type:

Article

Presence of C-type natriuretic peptide in human kidney and urine.

Published in:

Kidney International, 1994, v. 46, n. 3, p. 744, doi. 10.1038/ki.1994.329

By:

Mattingly, Michael T.;
Brandt, Roland R.;
Heublein, Denise M.;
Chi-Ming Wei;
Nir, Amiram;
Burnett Jr., John C.

Publication type:

Article

Contractile response and mitral regurgitation after temporary interruption of long-term cardiac resynchronization therapy.

Published in:

European Heart Journal, 2006, v. 27, n. 2, p. 187, doi. 10.1093/eurheartj/ehi558

By:

Brandt, Roland R.;
Reiner, Christian;
Arnold, Roman;
Sperzel, Johannes;
Pitschner, Heinz F.;
Hamm, Christian W.

Publication type:

Article

Relation of N-terminal pro B-type natriuretic peptide to progression of aortic valve disease.

Published in:

European Heart Journal, 2005, v. 26, n. 10, p. 1023, doi. 10.1093/eurheartj/ehi236

By:

Weber, Michael;
Arnold, Roman;
Rau, Matthias;
Elsaesser, Albrecht;
Brandt, Roland;
Mitrovic, Veselin;
Hamm, Christian

Publication type:

Article

Cytoskeletal mechanisms of neuronal degeneration.

Published in:

Cell & Tissue Research, 2001, v. 305, n. 2, p. 255, doi. 10.1007/s004410000334

By:

Brandt, Roland

Publication type:

Article

The frontotemporal dementia mutation R406W blocks tau's interaction with the membrane in an annexin A2-dependent manner.

Published in:

Journal of Cell Biology, 2011, v. 192, n. 4, p. 647, doi. 10.1083/jcb.201007161

By:

Gauthier-Kemper, Anne;
Weissmann, Carina;
Golovyashkina, Nataliya;
Sebö-Lemke, Zsofia;
Drewes, Gerard;
Gerke, Volker;
Heinisch, Jürgen J.;
Brandt, Roland

Publication type:

Article

Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice.

Published in:

Translational Psychiatry, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41398-018-0327-z

By:

Schob, Claudia;
Morellini, Fabio;
Ohana, Ora;
Bakota, Lidia;
Hrynchak, Mariya V.;
Brandt, Roland;
Brockmann, Marco D.;
Cichon, Nicole;
Hartung, Henrike;
Hanganu-Opatz, Ileana L.;
Kraus, Vanessa;
Scharf, Sarah;
Herrmans-Borgmeyer, Irm;
Schweizer, Michaela;
Kuhl, Dietmar;
Wöhr, Markus;
Vörckel, Karl J.;
Calzada-Wack, Julia;
Fuchs, Helmut;
Gailus-Durner, Valérie

Publication type:

Article

Identification of MINUS, a small polypeptide that functions as a microtubule nucleation suppressor.

Published in:

EMBO Journal, 1999, v. 18, n. 3, p. 565, doi. 10.1093/emboj/18.3.565

By:

Fanara, Patrizia;
Oback, Björn;
Ashman, Keith;
Podtelejnikov, Alexandre;
Brandt, Roland

Publication type:

Article

Echocardiographic assessment of mitral regurgitation: discussion of practical and methodologic aspects of severity quantification to improve diagnostic conclusiveness.

Published in:

Clinical Research in Cardiology, 2021, v. 110, n. 11, p. 1704, doi. 10.1007/s00392-021-01841-y

By:

Hagendorff, Andreas;
Knebel, Fabian;
Helfen, Andreas;
Stöbe, Stephan;
Haghi, Dariush;
Ruf, Tobias;
Lavall, Daniel;
Knierim, Jan;
Altiok, Ertunc;
Brandt, Roland;
Merke, Nicolas;
Ewen, Sebastian

Publication type:

Article

Single-molecule imaging reveals dynamic biphasic partition of RNA-binding proteins in stress granules.

Published in:

Journal of Cell Biology, 2018, v. 217, n. 4, p. 1303, doi. 10.1083/jcb.201709007

By:

Niewidok, Benedikt;
Igaev, Maxim;
Pereira da Graca, Abel;
Strassner, Andre;
Lenzen, Christine;
Brandt, Roland;
Richter, Christian P.;
Piehler, Jacob;
Kurre, Rainer

Publication type:

Article

Microtubule dynamics and the neurodegenerative triad of Alzheimer's disease: The hidden connection.

Published in:

Journal of Neurochemistry, 2017, v. 143, n. 4, p. 409, doi. 10.1111/jnc.14011

By:

Brandt, Roland;
Bakota, Lidia

Publication type:

Article

Triple mammalian/yeast/bacterial shuttle vectors for single and combined Lentivirus- and Sindbis virus-mediated infections of neurons.

Published in:

Molecular Genetics & Genomics, 2012, v. 287, n. 4, p. 313, doi. 10.1007/s00438-012-0680-1

By:

Bakota, Lidia;
Brandt, Roland;
Heinisch, Jürgen

Publication type:

Article

Funktionen des Zytoskeletts bei der Entwicklung von Nervenzellen.

Published in:

Neuroforum, 2001, v. 7, n. 2, p. 47, doi. 10.1515/nf-2001-0204

By:

Brandt, Roland

Publication type:

Article

Divergent Pathways Mediate Spine Alterations and Cell Death Induced by Amyloid-ß, Wild-Type Tau, and R406W Tau.

Published in:

Journal of Neuroscience, 2009, v. 29, n. 46, p. 14439, doi. 10.1523/JNEUROSCI.3590-09.2009

By:

Tackenberg, Christian;
Brandt, Roland

Publication type:

Article

Neurotrophins Differentially Regulate the Survival and Morphological Complexity of Human CNS Model Neurons.

Published in:

Journal of Neurochemistry, 1999, v. 73, n. 1, p. 139, doi. 10.1046/j.1471-4159.1999.0730139.x

By:

Piontek, Jörg;
Chen, Chi Chiung;
Kempf, Martina;
Brandt, Roland

Publication type:

Article

The Balance Between τ Protein's Microtubule Growth and Nucleation Activities: Implications for the Formation of Axonal Microtubules.

Published in:

Journal of Neurochemistry, 1993, v. 61, n. 3, p. 997, doi. 10.1111/j.1471-4159.1993.tb03613.x

By:

Brandt, Roland;
Lee, Gloria

Publication type:

Article

The Evolution of Tau Phosphorylation and Interactions.

Published in:

Frontiers in Aging Neuroscience, 2019, p. 1, doi. 10.3389/fnagi.2019.00256

By:

Trushina, Nataliya I.;
Bakota, Lidia;
Mulkidjanian, Armen Y.;
Brandt, Roland

Publication type:

Article

Why kiss‐and‐hop explains that tau does not stabilize microtubules and does not interfere with axonal transport (at physiological conditions).

Published in:

Cytoskeleton, 2024, v. 81, n. 1, p. 47, doi. 10.1002/cm.21787

By:

Bakota, Lidia;
Brandt, Roland

Publication type:

Article

Region-specific dendritic simplification induced by Aβ, mediated by tau via dysregulation of microtubule dynamics: a mechanistic distinct event from other neurodegenerative processes.

Published in:

Molecular Neurodegeneration, 2015, v. 10, p. 1, doi. 10.1186/s13024-015-0049-0

By:

Golovyashkina, Nataliya;
Penazzi, Lorène;
Ballatore, Carlo;
Smith III, Amos B.;
Bakota, Lidia;
Brandt, Roland

Publication type:

Article

Herpes simplex virus-mediated expression of the axonal protein tau in human model neurons (NT2-N cells).

Published in:

Microscopy Research & Technique, 2000, v. 48, n. 2, p. 85, doi. 10.1002/(SICI)1097-0029(20000115)48:2<85::AID-JEMT4>3.0.CO;2-O

By:

Fath, Thomas;
Eidenmüller,, Jochen;
Maas, Thorsten;
Brandt, Roland

Publication type:

Article

Histology and histochemistry of axonal growth.

Published in:

Microscopy Research & Technique, 2000, v. 48, n. 1, p. 1, doi. 10.1002/(SICI)1097-0029(20000101)48:1<1::AID-JEMT1>3.0.CO;2-T

By:

Brandt, Roland

Publication type:

Article

Inverse and distinct modulation of tau-dependent neurodegeneration by presenilin 1 and amyloid-β in cultured cortical neurons: evidence that tau phosphorylation is the limiting factor in amyloid-β-induced cell death.

Published in:

Journal of Neurochemistry, 2007, v. 101, n. 5, p. 1303, doi. 10.1111/j.1471-4159.2006.04435.x

By:

Leschik, Julia;
Welzel, Alfred;
Weissmann, Carina;
Eckert, Anne;
Brandt, Roland

Publication type:

Article

Cerebrospinal fluid-based kinetic biomarkers of axonal transport in monitoring neurodegeneration.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 9, p. 3159, doi. 10.1172/JCI64575

By:

Fanara, Patrizia;
Wong, Po-Yin A.;
Husted, Kristofor H.;
Shanshan Liu;
Liu, Victoria M.;
Kohlstaedt, Lori A.;
Riiff, Timothy;
Protasio, Joan C.;
Boban, Drina;
Killion, Salena;
Killian, Maudi;
Epling, Lorrie;
Sinclair, Elisabeth;
Peterson, Julia;
Price, Richard W.;
Cabin, Deborah E.;
Nussbaum, Robert L.;
Brühmann, Jörg;
Brandt, Roland;
Christine, Chadwick W.

Publication type:

Article