Works by Bradner, James

Results: 56
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    HDAC2 negatively regulates memory formation and synaptic plasticity.

    Published in:
    Nature, 2009, v. 459, n. 7243, p. 55, doi. 10.1038/nature07925
    By:
    • Guan, Ji-Song;
    • Haggarty, Stephen J.;
    • Giacometti, Emanuela;
    • Dannenberg, Jan-Hermen;
    • Joseph, Nadine;
    • Gao, Jun;
    • Nieland, Thomas J. F.;
    • Zhou, Ying;
    • Wang, Xinyu;
    • Mazitschek, Ralph;
    • Bradner, James E.;
    • DePinho, Ronald A.;
    • Jaenisch, Rudolf;
    • Tsai, Li-Huei
    Publication type:
    Article
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    Donor-recipient mismatch for common gene deletion polymorphisms in graft-versus-host disease.

    Published in:
    Nature Genetics, 2009, v. 41, n. 12, p. 1341, doi. 10.1038/ng.490
    By:
    • McCarroll, Steven A.;
    • Bradner, James E.;
    • Turpeinen, Hannu;
    • Volin, Liisa;
    • Martin, Paul J.;
    • Chilewski, Shannon D.;
    • Antin, Joseph H.;
    • Lee, Stephanie J.;
    • Ruutu, Tapani;
    • Storer, Barry;
    • Warren, Edus H.;
    • Bo Zhang;
    • Lue Ping Zhao;
    • Ginsburg, David;
    • Soiffer, Robert J.;
    • Partanen, Jukka;
    • Hansen, John A.;
    • Ritz, Jerome;
    • Palotie, Aarno;
    • Altshuler, David
    Publication type:
    Article
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    Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis.

    Published in:
    PLoS Pathogens, 2017, v. 13, n. 10, p. 1, doi. 10.1371/journal.ppat.1006668
    By:
    • Cheng, Jingwei;
    • Park, Donglim Esther;
    • Berrios, Christian;
    • White, Elizabeth A.;
    • Arora, Reety;
    • Yoon, Rosa;
    • Branigan, Timothy;
    • Xiao, Tengfei;
    • Westerling, Thomas;
    • Federation, Alexander;
    • Zeid, Rhamy;
    • Strober, Benjamin;
    • Swanson, Selene K.;
    • Florens, Laurence;
    • Bradner, James E.;
    • Brown, Myles;
    • Howley, Peter M.;
    • Padi, Megha;
    • Washburn, Michael P.;
    • DeCaprio, James A.
    Publication type:
    Article
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    HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1 histone methyltransferase.

    Published in:
    Science Translational Medicine, 2017, v. 9, n. 398, p. 1, doi. 10.1126/scitranslmed.aal5272
    By:
    • Chakraborty, Abhishek A.;
    • Eijiro Nakamura;
    • Jun Qi;
    • Creech, Amanda;
    • Jaffe, Jacob D.;
    • Paulk, Joshiawa;
    • Novak, Jesse S.;
    • Nagulapalli, Kshithija;
    • McBrayer, Samuel K.;
    • Cowley, Glenn S.;
    • Pineda, Javier;
    • Jiaxi Song;
    • Wang, Yaoyu E.;
    • Carr, Steven A.;
    • Root, David E.;
    • Signoretti, Sabina;
    • Bradner, James E.;
    • Kaelin Jr., William G.
    Publication type:
    Article
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    Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma.

    Published in:
    Science Translational Medicine, 2017, v. 9, n. 389, p. 1, doi. 10.1126/scitranslmed.aal2668
    By:
    • Manier, Salomon;
    • Huynh, Daisy;
    • Yu J. Shen;
    • Jia Zhou;
    • Yusufzai, Timur;
    • Salem, Karma Z.;
    • Ebright, Richard Y.;
    • Jiantao Shi;
    • Jihye Park;
    • Glavey, Siobhan V.;
    • Devine, William G.;
    • Chia-Jen Liu;
    • Leleu, Xavier;
    • Quesnel, Bruno;
    • Roche-Lestienne, Catherine;
    • Snyder, John K.;
    • Brown, Lauren E.;
    • Gray, Nathanael;
    • Bradner, James;
    • Whitesell, Luke
    Publication type:
    Article
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    Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome.

    Published in:
    Nature Communications, 2017, v. 8, n. 2, p. 14400, doi. 10.1038/ncomms14400
    By:
    • Cohen, Andrea J.;
    • Saiakhova, Alina;
    • Corradin, Olivia;
    • Luppino, Jennifer M.;
    • Lovrenert, Katreya;
    • Bartels, Cynthia F.;
    • Morrow, James J.;
    • Mack, Stephen C.;
    • Dhillon, Gursimran;
    • Beard, Lydia;
    • Myeroff, Lois;
    • Kalady, Matthew F.;
    • Willis, Joseph;
    • Bradner, James E.;
    • Keri, Ruth A.;
    • Berger, Nathan A.;
    • Pruett-Miller, Shondra M.;
    • Markowitz, Sanford D.;
    • Scacheri, Peter C.
    Publication type:
    Article
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    Combined autophagy and proteasome inhibition.

    Published in:
    Autophagy, 2014, v. 10, n. 8, p. 1380, doi. 10.4161/auto.29264
    By:
    • Vogl, Dan T.;
    • Stadtmauer, Edward A.;
    • Kay-See Tan;
    • Heitjan, Daniel F.;
    • Davis, Lisa E.;
    • Pontiggia, Laura;
    • Rangwala, Reshma;
    • Shengfu Piao;
    • Yunyoung C. Chang;
    • Scott, Emma C.;
    • Paul, Thomas M.;
    • Nichols, Charles W.;
    • Porter, David L.;
    • Kaplan, Janeen;
    • Mallon, Gayle;
    • Bradner, James E.;
    • Amaravadi, Ravi K.
    Publication type:
    Article
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    A toolbox for class I HDACs reveals isoform specific roles in gene regulation and protein acetylation.

    Published in:
    PLoS Genetics, 2022, v. 18, n. 8, p. 1, doi. 10.1371/journal.pgen.1010376
    By:
    • Hess, Lena;
    • Moos, Verena;
    • Lauber, Arnel A.;
    • Reiter, Wolfgang;
    • Schuster, Michael;
    • Hartl, Natascha;
    • Lackner, Daniel;
    • Boenke, Thorina;
    • Koren, Anna;
    • Guzzardo, Paloma M.;
    • Gundacker, Brigitte;
    • Riegler, Anna;
    • Vician, Petra;
    • Miccolo, Claudia;
    • Leiter, Susanna;
    • Chandrasekharan, Mahesh B.;
    • Vcelkova, Terezia;
    • Tanzer, Andrea;
    • Jun, Jun Qi;
    • Bradner, James
    Publication type:
    Article
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    Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands.

    Published in:
    Angewandte Chemie, 2017, v. 129, n. 21, p. 5832, doi. 10.1002/ange.201611281
    By:
    • Remillard, David;
    • Buckley, Dennis L.;
    • Paulk, Joshiawa;
    • Brien, Gerard L.;
    • Sonnett, Matthew;
    • Seo, Hyuk ‐ Soo;
    • Dastjerdi, Shiva;
    • Wühr, Martin;
    • Dhe ‐ Paganon, Sirano;
    • Armstrong, Scott A.;
    • Bradner, James E.
    Publication type:
    Article
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    The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation.

    Published in:
    Journal of Cellular Physiology, 2015, v. 230, n. 11, p. 2683, doi. 10.1002/jcp.24991
    By:
    • Wu, Qiong;
    • Madany, Pasil;
    • Akech, Jacqueline;
    • Dobson, Jason R.;
    • Douthwright, Stephen;
    • Browne, Gillian;
    • Colby, Jennifer L.;
    • Winter, Georg E.;
    • Bradner, James E.;
    • Pratap, Jitesh;
    • Sluder, Greenfield;
    • Bhargava, Rohit;
    • Chiosea, Simion I.;
    • van Wijnen, Andre J.;
    • Stein, Janet L.;
    • Stein, Gary S.;
    • Lian, Jane B.;
    • Nickerson, Jeffrey A.;
    • Imbalzano, Anthony N.
    Publication type:
    Article
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    Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules.

    Published in:
    Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-18377-w
    By:
    • Nabet, Behnam;
    • Ferguson, Fleur M.;
    • Seong, Bo Kyung A.;
    • Kuljanin, Miljan;
    • Leggett, Alan L.;
    • Mohardt, Mikaela L.;
    • Robichaud, Amanda;
    • Conway, Amy S.;
    • Buckley, Dennis L.;
    • Mancias, Joseph D.;
    • Bradner, James E.;
    • Stegmaier, Kimberly;
    • Gray, Nathanael S.
    Publication type:
    Article
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    An epigenomic approach to therapy for tamoxifen-resistant breast cancer.

    Published in:
    Cell Research, 2014, v. 24, n. 7, p. 809, doi. 10.1038/cr.2014.71
    By:
    • Feng, Qin;
    • Zhang, Zheng;
    • Shea, Martin J;
    • Creighton, Chad J;
    • Coarfa, Cristian;
    • Hilsenbeck, Susan G;
    • Lanz, Rainer;
    • He, Bin;
    • Wang, Lei;
    • Fu, Xiaoyong;
    • Nardone, Agostina;
    • Song, Yongcheng;
    • Bradner, James;
    • Mitsiades, Nicholas;
    • Mitsiades, Constantine S;
    • Osborne, C Kent;
    • Schiff, Rachel;
    • O'Malley, Bert W
    Publication type:
    Article
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    RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia.

    Published in:
    Nature, 2011, v. 478, n. 7370, p. 524, doi. 10.1038/nature10334
    By:
    • Zuber, Johannes;
    • Shi, Junwei;
    • Wang, Eric;
    • Rappaport, Amy R.;
    • Herrmann, Harald;
    • Sison, Edward A.;
    • Magoon, Daniel;
    • Qi, Jun;
    • Blatt, Katharina;
    • Wunderlich, Mark;
    • Taylor, Meredith J.;
    • Johns, Christopher;
    • Chicas, Agustin;
    • Mulloy, James C.;
    • Kogan, Scott C.;
    • Brown, Patrick;
    • Valent, Peter;
    • Bradner, James E.;
    • Lowe, Scott W.;
    • Vakoc, Christopher R.
    Publication type:
    Article
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    Direct inhibition of the NOTCH transcription factor complex.

    Published in:
    Nature, 2009, v. 462, n. 7270, p. 182, doi. 10.1038/nature08543
    By:
    • Moellering, Raymond E.;
    • Cornejo, Melanie;
    • Davis, Tina N.;
    • Bianco, Cristina Del;
    • Aster, Jon C.;
    • Blacklow, Stephen C.;
    • Kung, Andrew L.;
    • Gilliland, D. Gary;
    • Verdine, Gregory L.;
    • Bradner, James E.
    Publication type:
    Article
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    MELK is not necessary for the proliferation of basal-like breast cancer cells.

    Published in:
    eLife, 2017, p. 1, doi. 10.7554/eLife.26693
    By:
    • Hai-Tsang Huang;
    • Hyuk-Soo Seo;
    • Tinghu Zhang;
    • Yubao Wang;
    • Baishan Jiang;
    • Qing Li;
    • Buckley, Dennis L.;
    • Nabet, Behnam;
    • Roberts, Justin M.;
    • Paulk, Joshiawa;
    • Dastjerdi, Shiva;
    • Winter, Georg E.;
    • McLauchlan, Hilary;
    • Moran, Jennifer;
    • Bradner, James E.;
    • Eck, Michael J.;
    • Dhe-Paganon, Sirano;
    • Zhao, Jean J.;
    • Gray, Nathanael S.
    Publication type:
    Article
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    Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands.

    Published in:
    Angewandte Chemie International Edition, 2017, v. 56, n. 21, p. 5738, doi. 10.1002/anie.201611281
    By:
    • Remillard, David;
    • Buckley, Dennis L.;
    • Paulk, Joshiawa;
    • Brien, Gerard L.;
    • Sonnett, Matthew;
    • Seo, Hyuk‐Soo;
    • Dastjerdi, Shiva;
    • Wühr, Martin;
    • Dhe‐Paganon, Sirano;
    • Armstrong, Scott A.;
    • Bradner, James E.
    Publication type:
    Article
    46

    Erratum: Notch inhibition allows oncogene-independent generation of iPS cells.

    Published in:
    Nature Chemical Biology, 2014, v. 10, n. 12, p. 1074, doi. 10.1038/nchembio1214-1074b
    By:
    • Ichida, Justin K;
    • W, Julia T C;
    • Williams, Luis A;
    • Carter, Ava C;
    • Shi, Yingxiao;
    • Moura, Marcelo T;
    • Ziller, Michael;
    • Singh, Sean;
    • Amabile, Giovanni;
    • Bock, Christoph;
    • Umezawa, Akihiro;
    • Rubin, Lee L;
    • Bradner, James E;
    • Akutsu, Hidenori;
    • Meissner, Alexander;
    • Eggan, Kevin
    Publication type:
    Article
    47

    Erratum: Notch inhibition allows oncogene-independent generation of iPS cells.

    Published in:
    Nature Chemical Biology, 2014, v. 10, n. 12, p. 1074, doi. 10.1038/nchembio1214-1074c
    By:
    • Ichida, Justin K;
    • W, Julia T C;
    • Williams, Luis A;
    • Carter, Ava C;
    • Shi, Yingxiao;
    • Moura, Marcelo T;
    • Ziller, Michael;
    • Singh, Sean;
    • Amabile, Giovanni;
    • Bock, Christoph;
    • Umezawa, Akihiro;
    • Rubin, Lee L;
    • Bradner, James E;
    • Akutsu, Hidenori;
    • Meissner, Alexander;
    • Eggan, Kevin
    Publication type:
    Article
    48

    Notch inhibition allows oncogene-independent generation of iPS cells.

    Published in:
    Nature Chemical Biology, 2014, v. 10, n. 8, p. 632, doi. 10.1038/nchembio.1552
    By:
    • Ichida, Justin K;
    • T C W, Julia;
    • Williams, Luis A;
    • Carter, Ava C;
    • Shi, Yingxiao;
    • Moura, Marcelo T;
    • Ziller, Michael;
    • Singh, Sean;
    • Amabile, Giovanni;
    • Bock, Christoph;
    • Umezawa, Akihiro;
    • Rubin, Lee L;
    • Bradner, James E;
    • Akutsu, Hidenori;
    • Meissner, Alexander;
    • Eggan, Kevin
    Publication type:
    Article
    49

    Chemical phylogenetics of histone deacetylases.

    Published in:
    Nature Chemical Biology, 2010, v. 6, n. 3, p. 238, doi. 10.1038/nchembio.313
    By:
    • Bradner, James E.;
    • West, Nathan;
    • Grachan, Melissa L.;
    • Greenberg, Edward F.;
    • Haggarty, Stephen J.;
    • Warnow, Tandy;
    • Mazitschek, Ralph
    Publication type:
    Article
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