Works by Brüne, Bernhard

Results: 160

S1PR4-dependent effects of Etrasimod on primary human myeloid immune cell activation.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1590816

By:

Sailer, Fiona K.;
Palmer, Megan A.;
Aliraj, Blerina;
Heering, Jan;
Brockmann, Andreas;
Elewa, Mohammed A. F.;
Röhrig, Aissa;
Proschak, Ewgenij;
Stepniak, Dariusz T.;
Ramsey, Simeon;
Brüne, Bernhard;
Weigert, Andreas

Publication type:

Article

Sulforaphane potentiates oxaliplatin-induced cell growth inhibition in colorectal cancer cells via induction of different modes of cell death.

Published in:

Cancer Chemotherapy & Pharmacology, 2011, v. 67, n. 5, p. 1167, doi. 10.1007/s00280-010-1413-y

By:

Kaminski, Bettina;
Weigert, Andreas;
Brüne, Bernhard;
Schumacher, Marco;
Wenzel, Uwe;
Steinhilber, Dieter;
Stein, Jürgen;
Ulrich, Sandra

Publication type:

Article

The G2A Receptor Controls Polarization of Macrophage by Determining Their Localization Within the Inflamed Tissue.

Published in:

Frontiers in Immunology, 2018, p. N.PAG, doi. 10.3389/fimmu.2018.02261

By:

Kern, Katharina;
Schäfer, Stephan M. G.;
Cohnen, Jennifer;
Pierre, Sandra;
Osthues, Tabea;
Tarighi, Neda;
Hohmann, Stefan;
Ferreiros, Nerea;
Brüne, Bernhard;
Weigert, Andreas;
Geisslinger, Gerd;
Sisignano, Marco;
Scholich, Klaus

Publication type:

Article

A Novel Function for 15-Lipoxygenases in Cholesterol Homeostasis and CCL17 Production in Human Macrophages.

Published in:

Frontiers in Immunology, 2018, p. N.PAG, doi. 10.3389/fimmu.2018.01906

By:

Snodgrass, Ryan G.;
Zezina, Ekaterina;
Namgaladze, Dmitry;
Gupta, Sahil;
Angioni, Carlo;
Geisslinger, Gerd;
Lütjohann, Dieter;
Brüne, Bernhard

Publication type:

Article

The zinc finger protein Gfi1 is implicated in the regulation of IgG2b production and the expression of Iγ2b germline transcripts.

Published in:

European Journal of Immunology, 2008, v. 38, n. 11, p. 3004, doi. 10.1002/eji.200838251

By:

Igwe, Emeka;
Kosan, Christian;
Khandanpour, Cyrus;
Sharif-Askari, Ehssan;
Brüne, Bernhard;
Möröy, Tarik

Publication type:

Article

Pharmacological Activation of p53 during Human Monocyte to Macrophage Differentiation Attenuates Their Pro-Inflammatory Activation by TLR4, TLR7 and TLR8 Agonists.

Published in:

Cancers, 2021, v. 13, n. 5, p. 958, doi. 10.3390/cancers13050958

By:

Namgaladze, Dmitry;
Brüne, Bernhard;
Upadhyay, Geeta

Publication type:

Article

Metabolic Plasticity Is an Essential Requirement of Acquired Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukemia.

Published in:

Cancers, 2020, v. 12, n. 11, p. 3443, doi. 10.3390/cancers12113443

By:

Mostazo, Miriam G. Contreras;
Kurrle, Nina;
Casado, Marta;
Fuhrmann, Dominik;
Alshamleh, Islam;
Häupl, Björn;
Martín-Sanz, Paloma;
Brüne, Bernhard;
Serve, Hubert;
Schwalbe, Harald;
Schnütgen, Frank;
Marin, Silvia;
Cascante, Marta

Publication type:

Article

MicroRNAs as Emerging Regulators of Signaling in the Tumor Microenvironment.

Published in:

Cancers, 2020, v. 12, n. 4, p. 911, doi. 10.3390/cancers12040911

By:

Syed, Shahzad Nawaz;
Brüne, Bernhard

Publication type:

Article

The Disturbed Iron Phenotype of Tumor Cells and Macrophages in Renal Cell Carcinoma Influences Tumor Growth.

Published in:

Cancers, 2020, v. 12, n. 3, p. 530, doi. 10.3390/cancers12030530

By:

Schnetz, Matthias;
Meier, Julia K.;
Rehwald, Claudia;
Mertens, Christina;
Urbschat, Anja;
Tomat, Elisa;
Akam, Eman A.;
Baer, Patrick;
Roos, Frederik C.;
Brüne, Bernhard;
Jung, Michaela

Publication type:

Article

Nitric oxide, oxidative stress, and apoptosis.

Published in:

Kidney International Supplement, 2003, n. 84, p. 22, doi. 10.1046/j.1523-1755.63.s84.6.x

By:

Brüne, Bernhard;
Zhou, Jie;
Von Knethen, Andreas

Publication type:

Article

The iron load of lipocalin-2 (LCN-2) defines its pro-tumour function in clear-cell renal cell carcinoma.

Published in:

2020

By:

Rehwald, Claudia;
Schnetz, Matthias;
Urbschat, Anja;
Mertens, Christina;
Meier, Julia K.;
Bauer, Rebekka;
Baer, Patrick;
Winslow, Sofia;
Roos, Frederik C.;
Zwicker, Klaus;
Huard, Arnaud;
Weigert, Andreas;
Brüne, Bernhard;
Jung, Michaela

Publication type:

journal article

Douglas D. Thomas named next Editor-in-Chief of Biological Chemistry.

Published in:

Biological Chemistry, 2021, v. 402, n. 1, p. 3, doi. 10.1515/hsz-2020-0357

By:

Brüne, Bernhard

Publication type:

Article

Happy Birthday: Biological Chemistry is celebrating its 400th volume.

Published in:

Biological Chemistry, 2020, v. 401, n. 1, p. 1, doi. 10.1515/hsz-2019-0389

By:

Brüne, Bernhard

Publication type:

Article

S1PR4 is required for plasmacytoid dendritic cell differentiation.

Published in:

Biological Chemistry, 2015, v. 396, n. 6/7, p. 775, doi. 10.1515/hsz-2014-0271

By:

Dillmann, Christina;
Mora, Javier;
Olesch, Catherine;
Brüne, Bernhard;
Weigert, Andreas

Publication type:

Article

Betulinic acid suppresses NGAL-induced epithelial-to-mesenchymal transition in melanoma.

Published in:

Biological Chemistry, 2013, v. 394, n. 6, p. 773, doi. 10.1515/hsz-2013-0106

By:

Gheorgheosu, Dorina;
Jung, Michaela;
Ören, Bilge;
Schmid, Tobias;
Dehelean, Cristina;
Muntean, Danina;
Brüne, Bernhard

Publication type:

Article

The liaison between apoptotic cells and macrophages – the end programs the beginning.

Published in:

Biological Chemistry, 2009, v. 390, n. 5/6, p. 379, doi. 10.1515/BC.2009.048

By:

Weigert, Andreas;
Jennewein, Carla;
Brüne, Bernhard

Publication type:

Article

Phospholipase A-Modified Low-Density Lipoprotein Activates Liver X Receptor in Human Macrophages.

Published in:

Cell Biochemistry & Biophysics, 2012, v. 63, n. 2, p. 143, doi. 10.1007/s12013-012-9351-4

By:

Morbitzer, Daniel;
Namgaladze, Dmitry;
Brüne, Bernhard

Publication type:

Article

Tax1BP1 limits hepatic inflammation and reduces experimental hepatocarcinogenesis.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-73387-4

By:

Waidmann, Oliver;
Pleli, Thomas;
Weigert, Andreas;
Imelmann, Esther;
Kakoschky, Bianca;
Schmithals, Christian;
Döring, Claudia;
Frank, Matthias;
Longerich, Thomas;
Köberle, Verena;
Hansmann, Martin-Leo;
Brüne, Bernhard;
Zeuzem, Stefan;
Piiper, Albrecht;
Dikic, Ivan

Publication type:

Article

The influenza virus NS1A binding protein gene modulates macrophages response to cytokines and phagocytic potential in inflammation.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-72342-7

By:

Hotter, Georgina;
Mastora, Chrysoula;
Jung, Michaela;
Brüne, Bernhard;
Carbonell, Teresa;
Josa, Claudia;
Pérez-Calvo, Juan Ignacio;
Cruzado, Josep Maria;
Guiteras, Roser;
Sola, Anna

Publication type:

Article

Rapid glycolytic activation accompanying innate immune responses: mechanisms and function.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1180488

By:

Namgaladze, Dmitry;
Brüne, Bernhard

Publication type:

Article

Impact of ATP-citrate lyase catalytic activity and serine 455 phosphorylation on histone acetylation and inflammatory responses in human monocytic THP-1 cells.

Published in:

Frontiers in Immunology, 2022, v. 13, p. 01, doi. 10.3389/fimmu.2022.906127

By:

Dominguez, Monica;
Truemper, Verena;
Mota, Ana Carolina;
Brüne, Bernhard;
Namgaladze, Dmitry

Publication type:

Article

Depletion of tristetraprolin in breast cancer cells increases interleukin-16 expression and promotes tumor infiltration with monocytes/macrophages.

Published in:

Carcinogenesis, 2013, v. 34, n. 4, p. 850, doi. 10.1093/carcin/bgs387

By:

Milke, Larissa;
Schulz, Kathrin;
Weigert, Andreas;
Sha, Weixiao;
Schmid, Tobias;
Brüne, Bernhard

Publication type:

Article

Inflammation-induced loss of Pdcd4 is mediated by phosphorylation-dependent degradation.

Published in:

Carcinogenesis, 2011, v. 32, n. 10, p. 1427, doi. 10.1093/carcin/bgr131

By:

Schmid, Tobias;
Bajer, Magdalena M.;
Blees, Johanna S.;
Eifler, Lisa K.;
Milke, Larissa;
Rübsamen, Daniela;
Schulz, Kathrin;
Weigert, Andreas;
Baker, Alyson R.;
Colburn, Nancy H.;
Brüne, Bernhard

Publication type:

Article

Knockout of HIF-1α in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses.

Published in:

Carcinogenesis, 2010, v. 31, n. 10, p. 1863, doi. 10.1093/carcin/bgq088

By:

Werno, Christian;
Menrad, Heidi;
Weigert, Andreas;
Dehne, Nathalie;
Goerdt, Sergij;
Schledzewski, Kai;
Kzhyshkowska, Julia;
Brüne, Bernhard

Publication type:

Article

HIF-1 and p53: communication of transcription factors under hypoxia.

Published in:

Journal of Cellular & Molecular Medicine, 2004, v. 8, n. 4, p. 423, doi. 10.1111/j.1582-4934.2004.tb00467.x

By:

Schmid, Tobias;
Zhou, Jie;
Brüne, Bernhard

Publication type:

Article

Tumour stroma-derived lipocalin-2 promotes breast cancer metastasis.

Published in:

Journal of Pathology, 2016, v. 239, n. 3, p. 274, doi. 10.1002/path.4724

By:

Ören, Bilge;
Urosevic, Jelena;
Mertens, Christina;
Mora, Javier;
Guiu, Marc;
Gomis, Roger R;
Weigert, Andreas;
Schmid, Tobias;
Grein, Stephan;
Brüne, Bernhard;
Jung, Michaela

Publication type:

Article

Sphingosine-1-phosphate signalling induces the production of Lcn-2 by macrophages to promote kidney regeneration.

Published in:

Journal of Pathology, 2011, v. 225, n. 4, p. 597, doi. 10.1002/path.2982

By:

Sola, Anna;
Weigert, Andreas;
Jung, Michaela;
Vinuesa, Eugenia;
Brecht, Kerstin;
Weis, Nicole;
Brüne, Bernhard;
Borregaard, Niels;
Hotter, Georgina

Publication type:

Article

Nitric oxide maintains endothelial redox homeostasis through PKM2 inhibition.

Published in:

EMBO Journal, 2019, v. 38, n. 17, p. N.PAG, doi. 10.15252/embj.2018100938

By:

Siragusa, Mauro;
Thöle, Janina;
Bibli, Sofia‐Iris;
Luck, Bert;
Loot, Annemarieke E;
Silva, Kevin;
Wittig, Ilka;
Heidler, Juliana;
Stingl, Heike;
Randriamboavonjy, Voahanginirina;
Kohlstedt, Karin;
Brüne, Bernhard;
Weigert, Andreas;
Fisslthaler, Beate;
Fleming, Ingrid

Publication type:

Article

Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2.

Published in:

FASEB Journal, 2011, v. 25, n. 7, p. 2408, doi. 10.1096/fj.10-179473

By:

Brecht, Kerstin;
Weigert, Andreas;
Jiong Hu;
Popp, Rüdiger;
Fisslthaler, Beate;
Korff, Thomas;
Fleming, Ingrid;
Geisslinger, Gerd;
Brüne, Bernhard

Publication type:

Article

Apoptotic cells induce arginase II in macrophages, thereby attenuating NO production.

Published in:

FASEB Journal, 2007, v. 21, n. 11, p. 2704, doi. 10.1096/fj.06-7815com

By:

Johann, Axel M.;
Barra, Vera;
Kuhn, Anne-Marie;
Weigert, Andreas;
Von Knethen, Andreas;
Brüne, Bernhard

Publication type:

Article

A23187, ionomycin and thapsigargin upregulate mRNA of HIF-1α via endoplasmic reticulum stress rather than a rise in intracellular calcium.

Published in:

Journal of Cellular Physiology, 2008, v. 215, n. 3, p. 708, doi. 10.1002/jcp.21351

By:

Werno, Christian;
Jie Zhou;
Brüne, Bernhard

Publication type:

Article

Sphingosine-1-Phosphate and Macrophage Biology—How the Sphinx Tames the Big Eater.

Published in:

Frontiers in Immunology, 2019, p. 1, doi. 10.3389/fimmu.2019.01706

By:

Weigert, Andreas;
Olesch, Catherine;
Brüne, Bernhard

Publication type:

Article

Prodromal sensory neuropathy in Pink1−/−SNCAA53T double mutant Parkinson mice.

Published in:

Neuropathology & Applied Neurobiology, 2021, v. 47, n. 7, p. 1060, doi. 10.1111/nan.12734

By:

Valek, Lucie;
Tran, Bao;
Wilken‐Schmitz, Annett;
Trautmann, Sandra;
Heidler, Juliana;
Schmid, Tobias;
Brüne, Bernhard;
Thomas, Dominique;
Deller, Thomas;
Geisslinger, Gerd;
Auburger, Georg;
Tegeder, Irmgard

Publication type:

Article

p53 accumulation in apoptotic macrophages is an energy demanding process that precedes cytochrome c release in response to nitric oxide.

Published in:

Oncogene, 1999, v. 18, n. 47, p. 6403, doi. 10.1038/sj.onc.1203058

By:

Brockhaus, Florian;
Brüne, Bernhard

Publication type:

Article

Etoposide and cisplatin induced apoptosis in activated RAW 264.7 macrophages is attenuated by cAMP-induced gene expression.

Published in:

Oncogene, 1998, v. 17, n. 3, p. 387, doi. 10.1038/sj.onc.1201926

By:

von Knethen, Andreas;
Lotero, Alfredo;
Brüne, Bernhard

Publication type:

Article

Intracellular Iron Chelation Modulates the Macrophage Iron Phenotype with Consequences on Tumor Progression.

Published in:

PLoS ONE, 2016, v. 11, n. 11, p. 1, doi. 10.1371/journal.pone.0166164

By:

Mertens, Christina;
Akam, Eman Abureida;
Rehwald, Claudia;
Brüne, Bernhard;
Tomat, Elisa;
Jung, Michaela

Publication type:

Article

Diaryl Disulfides as Novel Stabilizers of Tumor Suppressor Pdcd4.

Published in:

PLoS ONE, 2016, v. 11, n. 3, p. 1, doi. 10.1371/journal.pone.0151643

By:

Schmid, Tobias;
Blees, Johanna S.;
Bajer, Magdalena M.;
Wild, Janine;
Pescatori, Luca;
Cuzzucoli Crucitti, Giuliana;
Scipione, Luigi;
Costi, Roberta;
Henrich, Curtis J.;
Brüne, Bernhard;
Colburn, Nancy H.;
Di Santo, Roberto

Publication type:

Article

Peroxisome proliferator-activated receptor γ-induced T cell apoptosis reduces survival during polymicrobial sepsis.

Published in:

2011

By:

Schmidt MV;
Paulus P;
Kuhn AM;
Weigert A;
Morbitzer V;
Zacharowski K;
Kempf VA;
Brüne B;
von Knethen A;
Schmidt, Martina Victoria;
Paulus, Patrick;
Kuhn, Anne-Marie;
Weigert, Andreas;
Morbitzer, Virginie;
Zacharowski, Kai;
Kempf, Volkhard A J;
Brüne, Bernhard;
von Knethen, Andreas

Publication type:

journal article

Peroxisome Proliferator-activated Receptor γ-induced T Cell Apoptosis Reduces Survival during Polymicrobial Sepsis.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2011, v. 184, n. 1, p. 64, doi. 10.1164/rccm.201010-1585OC

By:

Schmidt, Martina Victoria;
Paulus, Patrick;
Kuhn, Anne-Marie;
Weigert, Andreas;
Morbitzer, Virginie;
Zacharowski, Kai;
Kempf, Volkhard A. J.;
Brüne, Bernhard;
von Knethen, Andreas

Publication type:

Article

Inhibition of macrophage fatty acid β-oxidation exacerbates palmitate-induced inflammatory and endoplasmic reticulum stress responses.

Published in:

Diabetologia, 2014, v. 57, n. 5, p. 1067, doi. 10.1007/s00125-014-3173-4

By:

Namgaladze, Dmitry;
Lips, Sebastian;
Leiker, Thomas;
Murphy, Robert;
Ekroos, Kim;
Ferreiros, Nerea;
Geisslinger, Gerd;
Brüne, Bernhard

Publication type:

Article

Cholesterol metabolism in the regulation of inflammatory responses.

Published in:

Frontiers in Pharmacology, 2023, v. 14, p. 1, doi. 10.3389/fphar.2023.1121819

By:

Bauer, Rebekka;
Brüne, Bernhard;
Schmid, Tobias

Publication type:

Article

Editorial: Resolution of inflammation: Mechanisms, mediators and biomarkers: Volume II.

Published in:

Frontiers in Pharmacology, 2022, v. 13, p. 01, doi. 10.3389/fphar.2022.1100420

By:

Patrignani, Paola;
Brüne, Bernhard;
Steinhilber, Dieter

Publication type:

Article

Arachidonate 15-lipoxygenase type B: Regulation, function, and its role in pathophysiology.

Published in:

Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.1042420

By:

Benatzy, Yvonne;
Palmer, Megan A.;
Brüne, Bernhard

Publication type:

Article

Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-08989-2

By:

Frank, Ann-Christin;
Ebersberger, Stefanie;
Fink, Annika F.;
Lampe, Sebastian;
Weigert, Andreas;
Schmid, Tobias;
Ebersberger, Ingo;
Syed, Shahzad Nawaz;
Brüne, Bernhard

Publication type:

Article

Co-delivery of carbonic anhydrase IX inhibitor and doxorubicin as a promising approach to address hypoxia-induced chemoresistance.

Published in:

Drug Delivery, 2022, v. 29, n. 1, p. 2072, doi. 10.1080/10717544.2022.2092234

By:

Amin, Muhammad Umair;
Ali, Sajid;
Ali, Muhammad Yasir;
Fuhrmann, Dominik C.;
Tariq, Imran;
Seitz, Benjamin S.;
Preis, Eduard;
Brüßler, Jana;
Brüne, Bernhard;
Bakowsky, Udo

Publication type:

Article

Macrophages attenuate the transcription of CYP1A1 in breast tumor cells and enhance their proliferation.

Published in:

PLoS ONE, 2019, v. 14, n. 01, p. 1, doi. 10.1371/journal.pone.0209694

By:

Winslow, Sofia;
Scholz, Anica;
Rappl, Peter;
Brauß, Thilo F.;
Mertens, Christina;
Jung, Michaela;
Weigert, Andreas;
Brüne, Bernhard;
Schmid, Tobias

Publication type:

Article

Peroxisome proliferator-activated receptor γ (PPARγ) and sepsis.

Published in:

Archivum Immunologiae & Therapiae Experimentalis, 2007, v. 55, n. 1, p. 19, doi. 10.1007/s00005-007-0005-y

By:

Knethen, Andreas;
Soller, Mathias;
Brüne, Bernhard

Publication type:

Article

Inactivation of Tristetraprolin in Chronic Hypoxia Provokes the Expression of Cathepsin B.

Published in:

Molecular & Cellular Biology, 2015, v. 35, n. 3, p. 619, doi. 10.1128/MCB.01034-14

By:

Fuhrmann, Dominik C.;
Tausendschön, Michaela;
Wittig, Ilka;
Steger, Mirco;
Ding, Martina G.;
Schmid, Tobias;
Dehne, Nathalie;
Brüne, Bernhard

Publication type:

Article

Murine Alox8 versus the human ALOX15B ortholog: differences and similarities.

Published in:

Pflügers Archiv: European Journal of Physiology, 2024, v. 476, n. 12, p. 1817, doi. 10.1007/s00424-024-02961-w

By:

Palmer, Megan A.;
Benatzy, Yvonne;
Brüne, Bernhard

Publication type:

Article

Attenuation of p53 expression and Bax down-regulation during phorbol ester mediated inhibition of apoptosis.

Published in:

British Journal of Pharmacology, 1997, v. 121, n. 4, p. 625, doi. 10.1038/sj.bjp.0701156

By:

Meßmer, Udo K.;
Brüne, Bernhard

Publication type:

Article