Works matching AU Bräuner-Osborne, Hans

Results: 49

Novel approaches leading towards peptide GPCR de-orphanisation.

Published in:

2020

By:

Hauser, Alexander S.;
Gloriam, David E.;
Bräuner‐Osborne, Hans;
Foster, Simon R.;
Bräuner-Osborne, Hans

Publication type:

journal article

Differential G protein activation by the long and short isoforms of the dopamine D2 receptor.

Published in:

British Journal of Pharmacology, 2025, v. 182, n. 14, p. 3336, doi. 10.1111/bph.16388

By:

Reiner‐Link, David;
Madsen, Jakob Sture;
Gloriam, David E.;
Bräuner‐Osborne, Hans;
Hauser, Alexander S.

Publication type:

Article

Loss-of-function Thr347Ala Variant in the G Protein Subunit-Α11 Causes Familial Hypocalciuric Hypercalcemia 2.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2025, v. 110, n. 5, p. 1342, doi. 10.1210/clinem/dgae440

By:

Boisen, Ida Marie;
Du, Wei;
Juul, Anders;
Bräuner-Osborne, Hans;
Jensen, Anders A;
Jensen, Martin Blomberg

Publication type:

Article

The l-α-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in l-arginine-induced insulin release.

Published in:

Amino Acids, 2013, v. 44, n. 2, p. 383, doi. 10.1007/s00726-012-1341-8

By:

Smajilovic, Sanela;
Clemmensen, Christoffer;
Johansen, Lars;
Wellendorph, Petrine;
Holst, Jens;
Thams, Peter;
Ogo, Egbuna;
Bräuner-Osborne, Hans

Publication type:

Article

l-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances.

Published in:

Amino Acids, 2012, v. 43, n. 3, p. 1265, doi. 10.1007/s00726-011-1199-1

By:

Clemmensen, Christoffer;
Madsen, Andreas;
Smajilovic, Sanela;
Holst, Birgitte;
Bräuner-Osborne, Hans

Publication type:

Article

Structural insight to mutation effects uncover a common allosteric site in class C GPCRs.

Published in:

Bioinformatics, 2017, v. 33, n. 8, p. 1116, doi. 10.1093/bioinformatics/btw784

By:

Harpsøe, Kasper;
Boesgaard, Michael W.;
Munk, Christian;
Bräuner-Osborne, Hans;
Gloriam, David E.

Publication type:

Article

Structure–activity relationship of GPR15L peptide analogues and investigation of their interaction with the GPR15 receptor.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2023, v. 132, n. 6, p. 459, doi. 10.1111/bcpt.13861

By:

Deng, Yufang;
Perez Almeria, Claudia V.;
van Gijzel, Lieke;
Schaller, Kay;
Vedel, Line;
Gloriam, David E.;
Ulven, Trond;
Bräuner‐Osborne, Hans

Publication type:

Article

Delineation of the GPR15 receptor‐mediated Gα protein signalling profile in recombinant mammalian cells.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2022, v. 131, n. 2, p. 104, doi. 10.1111/bcpt.13738

By:

Deng, Yufang;
Moo, Ee Von;
Almería, Claudia Victoria Pérez;
Gentry, Patrick R.;
Vedel, Line;
Mathiesen, Jesper M.;
Bräuner‐Osborne, Hans

Publication type:

Article

Pharmacology and physiological function of the orphan GPRC6A receptor.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2020, v. 126, p. 77, doi. 10.1111/bcpt.13397

By:

Jørgensen, Christinna V.;
Bräuner‐Osborne, Hans

Publication type:

Article

Pharmacology and function of the orphan GPR139 G protein‐coupled receptor.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2020, v. 126, p. 35, doi. 10.1111/bcpt.13263

By:

Vedel, Line;
Nøhr, Anne Cathrine;
Gloriam, David E.;
Bräuner‐Osborne, Hans

Publication type:

Article

G protein‐coupled receptor pharmacology—The next generation.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2020, v. 126, p. 3, doi. 10.1111/bcpt.13291

By:

Bräuner‐Osborne, Hans;
Rosenkilde, Mette M.;
Gether, Ulrik;
Gloriam, David E.

Publication type:

Article

Enhanced agonist residence time, internalization rate and signalling of the GIP receptor variant [E354Q] facilitate receptor desensitization and long‐term impairment of the GIP system.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2020, v. 126, p. 122, doi. 10.1111/bcpt.13289

By:

Gabe, Maria Buur Nordskov;
van der Velden, Wijnand J. C.;
Gadgaard, Sarina;
Smit, Florent Xavier;
Hartmann, Bolette;
Bräuner‐Osborne, Hans;
Rosenkilde, Mette Marie

Publication type:

Article

Mutational Landscape of the Proglucagon-Derived Peptides.

Published in:

Frontiers in Endocrinology, 2021, v. 12, p. 1, doi. 10.3389/fendo.2021.698511

By:

Lindquist, Peter;
Madsen, Jakob S.;
Bräuner-Osborne, Hans;
Rosenkilde, Mette M.;
Hauser, Alexander S.

Publication type:

Article

Transmembrane α-Helix 2 and 7 Are Important for Small Molecule-Mediated Activation of the GLP-1 Receptor.

Published in:

Pharmacology, 2011, v. 88, n. 5/6, p. 340, doi. 10.1159/000334338

By:

Rye Underwood, Christina;
Møller Knudsen, Sanne;
Schjellerup Wulff, Birgitte;
Bräuner-Osborne, Hans;
Lau, Jesper;
Knudsen, Lotte Bjerre;
Peters, Günther H.;
Reedtz-Runge, Steffen

Publication type:

Article

Design of Cyclopentaisoxazoline Amino Acids as Conformationally Constrained Agonists at Glutamate Receptors.

Published in:

European Journal of Organic Chemistry, 2003, v. 2003, n. 22, p. 4455, doi. 10.1002/ejoc.200300424

By:

Paola Conti;
Marco De Amici;
Giovanni Grazioso;
Gabriella Roda;
Tine B. Stensbøl;
Hans Bräuner-Osborne;
Ulf Madsen;
Lucio Toma;
Carlo De Micheli

Publication type:

Article

Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer.

Published in:

Scientific Reports, 2017, p. 46355, doi. 10.1038/srep46355

By:

Jacobsen, Stine Engesgaard;
Gether, Ulrik;
Bräuner-Osborne, Hans

Publication type:

Article

Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139.

Published in:

Scientific Reports, 2016, p. 36681, doi. 10.1038/srep36681

By:

Shehata, Mohamed A.;
Nøhr, Anne C.;
Lissa, Delphine;
Bisig, Christoph;
Isberg, Vignir;
Andersen, Kirsten B.;
Harpsøe, Kasper;
Björkling, Fredrik;
Bräuner-Osborne, Hans;
Gloriam, David E.

Publication type:

Article

Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors - A Structural Perspective of Ligands and Mutants.

Published in:

Scientific Reports, 2015, p. 13869, doi. 10.1038/srep13869

By:

Harpsøe, Kasper;
Isberg, Vignir;
Tehan, Benjamin G.;
Weiss, Dahlia;
Arsova, Angela;
Marshall, Fiona H.;
Bräuner-Osborne, Hans;
Gloriam, David E.

Publication type:

Article

Known regulators of nitric oxide synthase and arginase are agonists at the human G-protein-coupled receptor GPRC6A.

Published in:

British Journal of Pharmacology, 2006, v. 147, n. 8, p. 855, doi. 10.1038/sj.bjp.0706682

By:

Christiansen, Bolette;
Wellendorph, Petrine;
Bräuner-Osborne, Hans

Publication type:

Article

Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP.

Published in:

2003

By:

Mathiesen, Jesper Mosolff;
Svendsen, Nannette;
Brüuner-Osborne, Hans;
Thomsen, Christian;
Ramirez, M. Teresa;
Bräuner-Osborne, Hans

Publication type:

journal article

Functional pharmacology of cloned heterodimeric GABAB receptors expressed in mammalian cells.

Published in:

British Journal of Pharmacology, 1999, v. 128, n. 7, p. 1370, doi. 10.1038/sj.bjp.0702914

By:

Bräuner-Osborne, Hans;
Krogsgaard-Larsen, Povl

Publication type:

Article

Pharmacology of (S)-homoquisqualic acid and (S)-2-amino-5-phosphonopentanoic acid [(S)-AP5] at cloned metabotropic glutamate receptors.

Published in:

British Journal of Pharmacology, 1998, v. 123, n. 2, p. 269, doi. 10.1038/sj.bjp.0701616

By:

Bräuner-Osborne, Hans;
Krogsgaard-Larsen, Povl

Publication type:

Article

Synthesis of Novel N1-Substituted Bicyclic Pyrazole Amino Acids and Evaluation of Their Interaction with Glutamate Receptors.

Published in:

Chemistry & Biodiversity, 2005, v. 2, n. 6, p. 748, doi. 10.1002/cbdv.200590052

By:

Conti, Paola;
Grazioso, Giovanni;
Joppolo di Ventimiglia, Samuele;
Pinto, Andrea;
Roda, Gabriella;
Madsen, Ulf;
Bräuner-Osborne, Hans;
Nielsen, Birgitte;
Costagli, Chiara;
Galli, Alessandro

Publication type:

Article

SYNTHESIS AND PHARMACOLOGICAL CHARACTERIZATION OF CERTAIN BACLOFEN ANALOGUES.

Published in:

Digest Journal of Nanomaterials & Biostructures (DJNB), 2013, v. 8, n. 1, p. 139

By:

ATTIA, MOHAMED I.;
HERDEIS, CLAUS;
BRÄUNER-OSBORNE, HANS

Publication type:

Article

mGluR5: Exploration of Orthosteric and Allosteric Ligand Binding Pockets and Their Applications to Drug Discovery.

Published in:

Neurochemical Research, 2014, v. 39, n. 10, p. 1862, doi. 10.1007/s11064-014-1248-8

By:

Mølck, Christina;
Harpsøe, Kasper;
Gloriam, David;
Mathiesen, Jesper;
Nielsen, Søren;
Bräuner-Osborne, Hans

Publication type:

Article

Pharmacological Identification of a Guanidine-Containing β-Alanine Analogue with Low Micromolar Potency and Selectivity for the Betaine/GABA Transporter 1 (BGT1).

Published in:

Neurochemical Research, 2014, v. 39, n. 10, p. 1988, doi. 10.1007/s11064-014-1336-9

By:

Al-Khawaja, Anas;
Petersen, Jette;
Damgaard, Maria;
Jensen, Mette;
Vogensen, Stine;
Lie, Maria;
Kragholm, Bolette;
Bräuner-Osborne, Hans;
Clausen, Rasmus;
Frølund, Bente;
Wellendorph, Petrine

Publication type:

Article

Introduction to Special Issue in Honor of Professor Povl Krogsgaard-Larsen.

Published in:

Neurochemical Research, 2014, v. 39, n. 10, p. 1845, doi. 10.1007/s11064-014-1408-x

By:

Bräuner-Osborne, Hans;
Schousboe, Arne

Publication type:

Article

Arrestin‐independent internalization of the GLP‐1 receptor is facilitated by a GRK, clathrin, and caveolae‐dependent mechanism.

Published in:

FEBS Journal, 2025, v. 292, n. 7, p. 1675, doi. 10.1111/febs.17338

By:

Moo, Ee Von;
Møller, Thor Christian;
Sørensen, Frederikke Astrid;
Inoue, Asuka;
Bräuner‐Osborne, Hans

Publication type:

Article

Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-73674-0

By:

Møller, Thor C.;
Pedersen, Mie F.;
van Senten, Jeffrey R.;
Seiersen, Sofie D.;
Mathiesen, Jesper M.;
Bouvier, Michel;
Bräuner-Osborne, Hans

Publication type:

Article

The Calcium-Sensing Receptor Is Essential for Calcium and Bicarbonate Sensitivity in Human Spermatozoa.

Published in:

2021

By:

Boisen, Ida Marie;
Rehfeld, Anders;
Mos, Iris;
Poulsen, Nadia Nicholine;
Nielsen, John Erik;
Schwarz, Peter;
Rejnmark, Lars;
Dissing, Steen;
Bach-Mortensen, Pernille;
Juul, Anders;
Bräuner-Osborne, Hans;
Lanske, Beate;
Blomberg Jensen, Martin

Publication type:

journal article

Heterozygous Mutation (Q459R) in the Calcium-Sensing Receptor Gene Causes Familial Hypocalciuric Hypercalcemia 1 (FHH1).

Published in:

2020

By:

Boisen, Ida Marie;
Mos, Iris;
Lerche-Black, Eva Merete;
Juul, Anders;
Bräuner-Osborne, Hans;
Blomberg Jensen, Martin

Publication type:

journal article

Specific γ-hydroxybutyrate-binding sites but loss of pharmacological effects of γ-hydroxybutyrate in GABAB(1)-deficient mice.

Published in:

European Journal of Neuroscience, 2003, v. 18, n. 10, p. 2722, doi. 10.1111/j.1460-9568.2003.03013.x

By:

Kaupmann, Klemens;
Cryan, John F.;
Wellendorph, Petrine;
Mombereau, Cedric;
Sansig, Gilles;
Klebs, Klaus;
Schmutz, Markus;
Froestl, Wolfgang;
Van Der Putten, Herman;
Mosbacher, Johannes;
Bräuner‐Osborne, Hans;
Waldmeier, Peter;
Bettler, Bernhard

Publication type:

Article

Phenylacetic acids and the structurally related non-steroidal anti-inflammatory drug diclofenac bind to specific γ-hydroxybutyric acid sites in rat brain.

Published in:

Fundamental & Clinical Pharmacology, 2009, v. 23, n. 2, p. 207, doi. 10.1111/j.1472-8206.2008.00664.x

By:

Wellendorph, Petrine;
Høg, Signe;
Skonberg, Christian;
Bräuner-Osborne, Hans

Publication type:

Article

Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors.

Published in:

Nature Communications, 2012, v. 3, n. 12, p. 1329, doi. 10.1038/ncomms2339

By:

Rossol, Manuela;
Pierer, Matthias;
Raulien, Nora;
Quandt, Dagmar;
Meusch, Undine;
Rothe, Kathrin;
Schubert, Kristin;
Schöneberg, Torsten;
Schaefer, Michael;
Krügel, Ute;
Smajilovic, Sanela;
Bräuner-Osborne, Hans;
Baerwald, Christoph;
Wagner, Ulf

Publication type:

Article

Metabolic and skeletal homeostasis are maintained in full locus GPRC6A knockout mice.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-41921-8

By:

Jørgensen, Christinna V.;
Gasparini, Sylvia J.;
Tu, Jinwen;
Zhou, Hong;
Seibel, Markus J.;
Bräuner-Osborne, Hans

Publication type:

Article

G Protein-Coupled Receptor Signaling Analysis Using Homogenous Time-Resolved Förster Resonance Energy Transfer (HTRF®) Technology.

Published in:

International Journal of Molecular Sciences, 2014, v. 15, n. 2, p. 2554, doi. 10.3390/ijms15022554

By:

Nørskov-Lauritsen, Lenea;
Thomsen, Alex Rojas Bie;
Bräuner-Osborne, Hans

Publication type:

Article

GABAB-Agonistic Activity of Certain Baclofen Homologues.

Published in:

Molecules, 2013, v. 18, n. 9, p. 10266, doi. 10.3390/molecules180910266

By:

Attia, Mohamed I.;
Herdeis, Claus;
Bräuner-Osborne, Hans

Publication type:

Article

Rigid nonproteinogenic cyclic amino acids as ligands for glutamate receptors: trans-Tris(homoglutamic) acids.

Published in:

Chirality, 2005, v. 17, n. 2, p. 99, doi. 10.1002/chir.20110

By:

Meyer, Udo;
Bisel, Philippe;
Bräuner-Osborne, Hans;
Madsen, Ulf;
Höfner, Georg;
Wanner, Klaus Th.;
Frahm, August Wilhelm

Publication type:

Article

Synthesis, theoretical and structural analyses, and enantiopharmacology of 3‐carboxy homologs of AMPAThis work was supported by grants from the Lundbeck Foundation, the Danish Medical Research Council, and the Danish Natural Science Research Council

Published in:

Chirality, 2004, v. 16, n. 7, p. 452

By:

Lotte Brehm;
Jeremy R. Greenwood;
Frank A. Sløk;
Mai Marie Holm;
Birgitte Nielsen;
Ulla Geneser;
Tine B. Stensbøl;
Hans Bräuner‐Osborne;
Mikael Begtrup;
Jan Egebjerg;
Povl Krogsgaard‐Larsen

Publication type:

Article

Glutamate receptor ligands: Synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs.

Published in:

Chirality, 2002, v. 14, n. 4, p. 351, doi. 10.1002/chir.10104

By:

Guldbrandt, Mette;
Johansen, Tommy N.;
Frydenvang, Karla;
Bräuner-Osborne, Hans;
Stensbøl, Tine B.;
Nielsen, Birgitte;
Karla, Rolf;
Santi, Flavio;
Krogsgaard-Larsen, Povl;
Madsen, Ulf

Publication type:

Article

Robust GLP-1 secretion by basic L-amino acids does not require the GPRC6A receptor.

Published in:

Diabetes, Obesity & Metabolism, 2017, v. 19, n. 4, p. 599, doi. 10.1111/dom.12845

By:

Clemmensen, Christoffer;
Jørgensen, Christinna V.;
Smajilovic, Sanela;
Bräuner‐Osborne, Hans

Publication type:

Article

Structure–Activity Relationship Studies of the Natural Product Gq/11 Protein Inhibitor YM‐254890.

Published in:

ChemMedChem, 2019, v. 14, n. 8, p. 865, doi. 10.1002/cmdc.201900018

By:

Xiong, Xiao‐Feng;
Zhang, Hang;
Boesgaard, Michael W.;
Underwood, Christina R.;
Bräuner‐Osborne, Hans;
Strømgaard, Kristian

Publication type:

Article

Cover Picture: Structure-Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM-254890, Targeting the Gq Protein (ChemMedChem 11/2017).

Published in:

ChemMedChem, 2017, v. 12, n. 11, p. 785, doi. 10.1002/cmdc.201700313

By:

Zhang, Hang;
Xiong, Xiao-Feng;
Boesgaard, Michael W.;
Underwood, Christina R.;
Bräuner-Osborne, Hans;
Strømgaard, Kristian

Publication type:

Article

Structure-Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM-254890, Targeting the Gq Protein.

Published in:

ChemMedChem, 2017, v. 12, n. 11, p. 830, doi. 10.1002/cmdc.201700155

By:

Zhang, Hang;
Xiong, Xiao-Feng;
Boesgaard, Michael W.;
Underwood, Christina R.;
Bräuner-Osborne, Hans;
Strømgaard, Kristian

Publication type:

Article

Structure-Activity Relationships for Negative Allosteric mGluR5 Modulators.

Published in:

ChemMedChem, 2012, v. 7, n. 3, p. 440, doi. 10.1002/cmdc.201100578

By:

Kaae, Birgitte H.;
Harpsøe, Kasper;
Kvist, Trine;
Mathiesen, Jesper M.;
Mølck, Christina;
Gloriam, David;
Jimenez, Hermogenes N.;
Uberti, Michelle A.;
Nielsen, Søren M.;
Nielsen, Birgitte;
Bräuner-Osborne, Hans;
Sauerberg, Per;
Clausen, Rasmus P.;
Madsen, Ulf

Publication type:

Article

Novel 3-Carboxy- and 3-Phosphonopyrazoline Amino Acids as Potent and Selective NMDA Receptor Antagonists: Design, Synthesis, and Pharmacological Characterization.

Published in:

ChemMedChem, 2010, v. 5, n. 9, p. 1465, doi. 10.1002/cmdc.201000184

By:

Conti, Paola;
Pinto, Andrea;
Tamborini, Lucia;
Madsen, Ulf;
Nielsen, Birgitte;
Bräuner-Osborne, Hans;
Hansen, Kasper B.;
Landucci, Elisa;
Pellegrini-Giampietro, Domenico E.;
De Sarro, Giovambattista;
Donato Di Paola, Eugenio;
De Micheli, Carlo

Publication type:

Article

Synthesis of Conformationally Constrained Glutamic Acid Homologues and Investigation of Their Pharmacological Profiles.

Published in:

ChemMedChem, 2007, v. 2, n. 11, p. 1639, doi. 10.1002/cmdc.200700118

By:

Conti, Paola;
Pinto, Andrea;
Tamborini, Lucia;
Grazioso, Giovanni;
De Sarro, Giovambattista;
Bräuner-Osborne, Hans;
Szabo, Geza;
Gábor Hársing, László;
De Micheli, Carlo

Publication type:

Article

Endocytic proteins mediating GPR15 receptor internalization provide insight into the underlying mechanisms.

Published in:

FEBS Letters, 2023, v. 597, n. 11, p. 1528, doi. 10.1002/1873-3468.14622

By:

Deng, Yufang;
Moo, Ee Von;
Inoue, Asuka;
Bräuner‐Osborne, Hans

Publication type:

Article

The GABAB1a Isoform Mediates Heterosynaptic Depression at Hippocampal Mossy Fiber Synapses.

Published in:

Journal of Neuroscience, 2009, v. 29, n. 5, p. 1414, doi. 10.1523/JNEUROSCI.3697-08.2009

By:

Guetg, Nicole;
Seddik, Riad;
Vigot, Réjan;
Turecek, Rostislav;
Gassmann, Martin;
Vogt, Kaspar E.;
Bräuner-Osborne, Hans;
Shigemoto, Ryuichi;
Kretz, Oliver;
Frotscher, Michael;
Kulik, Ákos;
Bettler, Bernhard

Publication type:

Article