Works by Bourguet, William

Results: 47

Author Correction: An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice.

Published in:

2025

By:

Wang, Xiaojuan;
Zhang, Guohui;
Bian, Zhiwei;
Chow, Vimanda;
Grimaldi, Marina;
Carivenc, Coralie;
Sirounian, Savannah;
Li, Hao;
Sladekova, Lucia;
Motta, Stefano;
Luperi, Yulia;
Gong, Yufeng;
Costello, Cait;
Li, Linhao;
Jachimowicz, Matthew;
Guo, Miao;
Hu, Shian;
Wilson, Derek;
Balaguer, Patrick;
Bourguet, William

Publication type:

Correction Notice

An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-56624-0

By:

Wang, Xiaojuan;
Zhang, Guohui;
Bian, Zhiwei;
Chow, Vimanda;
Grimaldi, Marina;
Carivenc, Coralie;
Sirounian, Savannah;
Li, Hao;
Sladekova, Lucia;
Motta, Stefano;
Luperi, Yulia;
Gong, Yufeng;
Costello, Cait;
Li, Linhao;
Jachimowicz, Matthew;
Guo, Miao;
Hu, Shian;
Wilson, Derek;
Balaguer, Patrick;
Bourguet, William

Publication type:

Article

Functional and Structural Study of the Amino Acid Substitution in a Novel Familial Androgen Receptor Mutation (W752G) Responsible for Complete Androgen Insensitivity Syndrome.

Published in:

Sexual Development, 2018, v. 12, n. 5, p. 218, doi. 10.1159/000491114

By:

Paris, Françoise;
Boulahtouf, abdelhay;
Kalfa, Nicolas;
Guibal, Marie P.;
Gaspari, Laura;
Servant, Nadège;
Bourguet, William;
Sultan, Charles;
Balaguer, Patrick

Publication type:

Article

A mutation mimicking ligand-induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers.

Published in:

EMBO Journal, 1997, v. 16, n. 18, p. 5697, doi. 10.1093/emboj/16.18.5697

By:

Vivat, Valerie;
Zechel, Christina;
Wurtz, Jean-Marie;
Bourguet, William;
Kagechika, Hiroyuki;
Umemiya, Hiroki;
Shudo, Koichi;
Moras, Dino;
Gronemeyer, Hinrich;
Chambon, Pierre

Publication type:

Article

2,4-Di-tert-butylphenol Induces Adipogenesis in Human Mesenchymal Stem Cells by Activating Retinoid X Receptors.

Published in:

Endocrinology, 2023, v. 164, n. 4, p. 1, doi. 10.1210/endocr/bqad021

By:

Ren, Xiao-Min;
Chang, Richard C;
Huang, Yikai;
Amato, Angélica Amorim;
Carivenc, Coralie;
Grimaldi, Marina;
Kuo, Yun;
Balaguer, Patrick;
Bourguet, William;
Blumberg, Bruce

Publication type:

Article

In Silico Predictions of Endocrine Disruptors Properties.

Published in:

Endocrinology, 2019, v. 160, n. 11, p. 2709, doi. 10.1210/en.2019-00382

By:

Schneider, Melanie;
Pons, Jean-Luc;
Labesse, Gilles;
Bourguet, William

Publication type:

Article

High Content Screening Using New U2OS Reporter Cell Models Identifies Harmol Hydrochloride as a Selective and Competitive Antagonist of the Androgen Receptor.

Published in:

Cells (2073-4409), 2020, v. 9, n. 6, p. 1469, doi. 10.3390/cells9061469

By:

Dellal, Hadjer;
Boulahtouf, Abdelhay;
Alaterre, Elina;
Cuenant, Alice;
Grimaldi, Marina;
Bourguet, William;
Gongora, Céline;
Balaguer, Patrick;
Pourquier, Philippe

Publication type:

Article

Regulation of RXR-RAR Heterodimers by RXR- and RAR-Specific Ligands and Their Combinations.

Published in:

Cells (2073-4409), 2019, v. 8, n. 11, p. 1392, doi. 10.3390/cells8111392

By:

le Maire, Albane;
Teyssier, Catherine;
Balaguer, Patrick;
Bourguet, William;
Germain, Pierre

Publication type:

Article

Exploring hydrophobic sites in proteins with xenon or krypton.

Published in:

Proteins, 1998, v. 30, n. 1, p. 61, doi. 10.1002/(SICI)1097-0134(19980101)30:1<61::AID-PROT6>3.0.CO;2-N

By:

Prangé, Thierry;
Schiltz, Marc;
Pernot, Lucile;
Colloc'h, Nathalie;
Longhi, Sonia;
Bourguet, William;
Fourme, Roger

Publication type:

Article

A two‐in‐one expression construct for biophysical and structural studies of the human pregnane X receptor ligand‐binding domain, a pharmaceutical and environmental target.

Published in:

Acta Crystallographica: Section F, Structural Biology Communications, 2025, v. 81, n. 3, p. 85, doi. 10.1107/S2053230X2500069X

By:

Carivenc, Coralie;
Laconde, Guillaume;
Blanc, Pauline;
Amblard, Muriel;
Bourguet, William;
Delfosse, Vanessa

Publication type:

Article

A revisited version of the apo structure of the ligand‐binding domain of the human nuclear receptor retinoic X receptor α.

Published in:

Acta Crystallographica: Section F, Structural Biology Communications, 2019, v. 75, n. 2, p. 98, doi. 10.1107/S2053230X18018022

By:

Eberhardt, Jérôme;
McEwen, Alastair G.;
Bourguet, William;
Moras, Dino;
Dejaegere, Annick

Publication type:

Article

Reporter cell lines for the characterization of the interactions between human nuclear receptors and endocrine disruptors.

Published in:

Frontiers in Endocrinology, 2015, v. 6, p. 1, doi. 10.3389/fendo.2015.00062

By:

Grimaldi, Marina;
Boulahtouf, Abdelhay;
Delfosse, Vanessa;
Thouennon, Erwan;
Bourguet, William;
Balaguer, Patrick

Publication type:

Article

The Human Mixed Lineage Leukemia 5 (MLL5), a Sequentially and Structurally Divergent SET Domain-Containing Protein with No Intrinsic Catalytic Activity.

Published in:

PLoS ONE, 2016, v. 11, n. 11, p. 1, doi. 10.1371/journal.pone.0165139

By:

Mas-y-Mas, Sarah;
Barbon, Marta;
Teyssier, Catherine;
Déméné, Hélène;
Carvalho, João E.;
Bird, Louise E.;
Lebedev, Andrey;
Fattori, Juliana;
Schubert, Michael;
Dumas, Christian;
Bourguet, William;
le Maire, Albane

Publication type:

Article

Peroxisome proliferator‐activated receptor gamma‐ligand‐binding domain mutations associated with familial partial lipodystrophy type 3 disrupt human trophoblast fusion and fibroblast migration.

Published in:

Journal of Cellular & Molecular Medicine, 2020, v. 24, n. 13, p. 7660, doi. 10.1111/jcmm.15401

By:

Shoaito, Hussein;
Chauveau, Sabine;
Gosseaume, Camille;
Bourguet, William;
Vigouroux, Corinne;
Vatier, Camille;
Pienkowski, Catherine;
Fournier, Thierry;
Degrelle, Séverine A.

Publication type:

Article

The GOLIATH Project: Towards an Internationally Harmonised Approach for Testing Metabolism Disrupting Compounds.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 10, p. 3480, doi. 10.3390/ijms21103480

By:

Legler, Juliette;
Zalko, Daniel;
Jourdan, Fabien;
Jacobs, Miriam;
Fromenty, Bernard;
Balaguer, Patrick;
Bourguet, William;
Munic Kos, Vesna;
Nadal, Angel;
Beausoleil, Claire;
Cristobal, Susana;
Remy, Sylvie;
Ermler, Sibylle;
Margiotta-Casaluci, Luigi;
Griffin, Julian L.;
Blumberg, Bruce;
Chesné, Christophe;
Hoffmann, Sebastian;
Andersson, Patrik L.;
Kamstra, Jorke H.

Publication type:

Article

A structural perspective on nuclear receptors as targets of environmental compounds.

Published in:

Acta Pharmacologica Sinica, 2015, v. 36, n. 1, p. 88, doi. 10.1038/aps.2014.133

By:

Delfosse, Vanessa;
Maire, Albane le;
Balaguer, Patrick;
Bourguet, William

Publication type:

Article

Activation of RXR–PPAR heterodimers by organotin environmental endocrine disruptors.

Published in:

EMBO Reports, 2009, v. 10, n. 4, p. 367, doi. 10.1038/embor.2009.8

By:

le Maire, Albane;
Grimaldi, Marina;
Roecklin, Dominique;
Dagnino, Sonia;
Vivat-Hannah, Valérie;
Balaguer, Patrick;
Bourguet, William

Publication type:

Article

Structural and Functional Specialization of OSBP-Related Proteins.

Published in:

Contact (25152564), 2020, v. 3, p. 1, doi. 10.1177/2515256420946627

By:

Delfosse, Vanessa;
Bourguet, William;
Drin, Guillaume

Publication type:

Article

Structural and Functional Specialization of OSBP-Related Proteins.

Published in:

Contact (25152564), 2020, v. 3, p. 1, doi. 10.1177/2515256420946627

By:

Delfosse, Vanessa;
Bourguet, William;
Drin, Guillaume

Publication type:

Article

Pathophysiology of Androgen Insensitivity Syndromes: Molecular and Structural Approaches of Natural and Engineered Androgen Receptor Mutations at Amino Acid 743.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2002, v. 87, n. 12, p. 5793, doi. 10.1210/jc.2002-020491

By:

POUJOL, NICOLAS;
LUMBROSO, SERGE;
TÉ ROUANNE, BÉATRICE;
LOBACCARO, JEAN-MARC A.;
BOURGUET, WILLIAM;
SULTAN, CHARLES

Publication type:

Article

Functional analyses of phosphatidylserine/PI(4)P exchangers with diverse lipid species and membrane contexts reveal unanticipated rules on lipid transfer.

Published in:

BMC Biology, 2021, v. 19, n. 1, p. 1, doi. 10.1186/s12915-021-01183-1

By:

Ikhlef, Souade;
Lipp, Nicolas-Frédéric;
Delfosse, Vanessa;
Fuggetta, Nicolas;
Bourguet, William;
Magdeleine, Maud;
Drin, Guillaume

Publication type:

Article

Towards accurate high-throughput ligand affinity prediction by exploiting structural ensembles, docking metrics and ligand similarity.

Published in:

Bioinformatics, 2020, v. 36, n. 1, p. 160, doi. 10.1093/bioinformatics/btz538

By:

Schneider, Melanie;
Pons, Jean-Luc;
Bourguet, William;
Labesse, Gilles

Publication type:

Article

An integrated structure- and system-based framework to identify new targets of metabolites and known drugs.

Published in:

Bioinformatics, 2015, v. 31, n. 24, p. 3922, doi. 10.1093/bioinformatics/btv477

By:

Naveed, Hammad;
Hameed, Umar S.;
Harrus, Deborah;
Bourguet, William;
Arold, Stefan T.;
Xin Gao

Publication type:

Article

Pyrazine Arotinoids with Inverse Agonist Activities on the Retinoid and Rexinoid Receptors.

Published in:

ChemBioChem, 2009, v. 10, n. 7, p. 1252, doi. 10.1002/cbic.200900030

By:

García, José;
Khanwalkar, Harshal;
Pereira, Raquel;
Erb, Cathie;
Voegel, Johannes J.;
Collette, Pascal;
Mauvais, Pascale;
Bourguet, William;
Gronemeyer, Hinrich;
de Lera, Ángel R.

Publication type:

Article

Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha.

Published in:

Nature, 1995, v. 375, n. 6530, p. 377, doi. 10.1038/375377a0

By:

Bourguet, William;
Ruff, Marc

Publication type:

Article

Characterization of Novel Ligands of ERα, Erβ, and PPARγ: The Case of Halogenated Bisphenol A and Their Conjugated Metabolites.

Published in:

Toxicological Sciences, 2011, v. 122, n. 2, p. 372, doi. 10.1093/toxsci/kfr132

By:

Riu, Anne;
le Maire, Albane;
Grimaldi, Marina;
Audebert, Marc;
Hillenweck, Anne;
Bourguet, William;
Balaguer, Patrick;
Zalko, Daniel

Publication type:

Article

Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers.

Published in:

Journal of Cell Biology, 2011, v. 195, n. 6, p. 965, doi. 10.1083/jcb.201104062

By:

de Saint-Jean, Maud;
Delfosse, Vanessa;
Douguet, Dominique;
Chicanne, Gaëtan;
Payrastre, Bernard;
Bourguet, William;
Antonny, Bruno;
Drin, Guillaume

Publication type:

Article

Two Novel Cases of Resistance to Thyroid Hormone Due to THRA Mutation.

Published in:

Thyroid, 2020, v. 30, n. 8, p. 1217, doi. 10.1089/thy.2019.0602

By:

le Maire, Albane;
Bouhours-Nouet, Natacha;
Soamalala, Jessica;
Mirebeau-Prunier, Delphine;
Paloni, Matteo;
Guee, Laura;
Heron, Delphine;
Mignot, Cyril;
Illouz, Frédéric;
Joubert, Florence;
Briet, Claire;
Rodien, Patrice;
Bourguet, William;
Flamant, Frédéric;
Guyot, Romain

Publication type:

Article

Pathological Interactions Between Mutant Thyroid Hormone Receptors and Corepressors and Their Modulation by a Thyroid Hormone Analogue with Therapeutic Potential.

Published in:

Thyroid, 2018, v. 28, n. 12, p. 1708, doi. 10.1089/thy.2017.0551

By:

Harrus, Déborah;
Déméné, Hélène;
Vasquez, Edwin;
Boulahtouf, Abdelhay;
Germain, Pierre;
Figueira, Ana Carolina;
Privalsky, Martin L.;
Bourguet, William;
le Maire, Albane

Publication type:

Article

Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.

Published in:

Nature Communications, 2016, v. 7, n. 9, p. 12777, doi. 10.1038/ncomms12777

By:

Ahmed-Belkacem, Abdelhakim;
Colliandre, Lionel;
Ahnou, Nazim;
Nevers, Quentin;
Gelin, Muriel;
Bessin, Yannick;
Brillet, Rozenn;
Cala, Olivier;
Douguet, Dominique;
Bourguet, William;
Krimm, Isabelle;
Pawlotsky, Jean-Michel;
Guichou, Jean- François

Publication type:

Article

Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds.

Published in:

Nature Communications, 2015, v. 6, n. 9, p. 8089, doi. 10.1038/ncomms9089

By:

Delfosse, Vanessa;
Dendele, Béatrice;
Huet, Tiphaine;
Grimaldi, Marina;
Boulahtouf, Abdelhay;
Gerbal-Chaloin, Sabine;
Beucher, Bertrand;
Roecklin, Dominique;
Muller, Christina;
Rahmani, Roger;
Cavaillès, Vincent;
Daujat-Chavanieu, Martine;
Vivat, Valérie;
Pascussi, Jean-Marc;
Balaguer, Patrick;
Bourguet, William

Publication type:

Article

A Comparative Study of Human and Zebrafish Pregnane X Receptor Activities of Pesticides and Steroids Using In Vitro Reporter Gene Assays.

Published in:

Frontiers in Endocrinology, 2021, v. 11, p. N.PAG, doi. 10.3389/fendo.2021.665521

By:

Creusot, Nicolas;
Garoche, Clémentine;
Grimaldi, Marina;
Boulahtouf, Abdelhay;
Chiavarina, Barbara;
Bourguet, William;
Balaguer, Patrick

Publication type:

Article

Allosteric Effects Govern Nuclear Receptor Action: DNA Appears as a Player.

Published in:

Science Signaling, 2009, v. 2, n. 73, p. 1, doi. 10.1126/scisignal.273pe34

By:

Gronemeyer, Hinrich;
Bourguet, William

Publication type:

Article

Structural and Functional Profiling of Environmental Ligands for Estrogen Receptors.

Published in:

Environmental Health Perspectives, 2014, v. 122, n. 12, p. 1306, doi. 10.1289/ehp.1408453

By:

Delfosse, Vanessa;
Grimaldi, Marina;
Cavaillès, Vincent;
Balaguer, Patrick;
Bourguet, William

Publication type:

Article

Peroxisome Proliferator-Activated Receptor ã Is a Target for Halogenated Analogs of Bisphenol A.

Published in:

Environmental Health Perspectives, 2011, v. 119, n. 9, p. 1227, doi. 10.1289/ehp.1003328

By:

Riu, Anne;
Grimaldi, Marina;
le Maire, Albane;
Bey, Gilbert;
Phillips, Kevinps;
Boulahtouf, Abdelhay;
Perdu, Elisabeth;
Zalko, Daniel;
Bourguet, William;
Balaguer, Patrick

Publication type:

Article

L'association fait le poison.

Published in:

Médecine Sciences, 2016, v. 32, n. 4, p. 326, doi. 10.1051/medsci/20163204005

By:

Delfosse, Vanessa;
Balaguer, Patrick;
Bourguet, William

Publication type:

Article

Vers des bisphénols sans effets hormonaux.

Published in:

Médecine Sciences, 2013, v. 29, n. 1, p. 14, doi. 10.1051/medsci/2013291004

By:

Balaguer, Patrick;
Delfosse, Vanessa;
Grimaldi, Marina;
Bourguet, William

Publication type:

Article

Estrogen-related receptor γ is an in vivo receptor of bisphenol A.

Published in:

FASEB Journal, 2014, v. 28, n. 7, p. 3124, doi. 10.1096/fj.13-240465

By:

Tohmé, Marie;
Prud'homme, Sophie M.;
Boulahtouf, Abdel;
Samarut, Eric;
Brunet, Frédéric;
Bernard, Laure;
Bourguet, William;
Gibert, Yami;
Balaguer, Patrick;
Laudet, Vincent

Publication type:

Article

A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 7, p. 801, doi. 10.1038/nsmb.1855

By:

le Maire, Albane;
Teyssier, Catherine;
Erb, Cathie;
Grimaldi, Marina;
Alvarez, Susana;
de Lera, Angel R.;
Balaguer, Patrick;
Gronemeyer, Hinrich;
Royer, Catherine A;
Germain, Pierre;
Bourguet, William

Publication type:

Article

Development of new approach methods for the identification and characterization of endocrine metabolic disruptors--a PARC project.

Published in:

Frontiers in Toxicology, 2024, p. 1, doi. 10.3389/ftox.2023.1212509

By:

Braeuning, Albert;
Balaguer, Patrick;
Bourguet, William;
Carreras-Puigvert, Jordi;
Feiertag, Katreece;
Kamstra, Jorke H.;
Knapen, Dries;
Lichtenstein, Dajana;
Marx-Stoelting, Philip;
Rietdijk, Jonne;
Schubert, Kristin;
Spjuth, Ola;
Stinckens, Evelyn;
Thedieck, Kathrin;
van den Boom, Rik;
Vergauwen, Lucia;
von Bergen, Martin;
Wewer, Neele;
Zalko, Daniel

Publication type:

Article

Design of selective nuclear receptor modulators: RAR and RXR as a case study.

Published in:

Nature Reviews Drug Discovery, 2007, v. 6, n. 10, p. 811, doi. 10.1038/nrd2398

By:

de Lera, Angel R.;
Bourguet, William;
Altucci, Lucia;
Gronemeyer, Hinrich

Publication type:

Article

An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor β (RARβ, NR1B2) Selective Agonist.

Published in:

PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0123195

By:

Nadendla, Eswarkumar;
Teyssier, Catherine;
Delfosse, Vanessa;
Vivat, Valérie;
Krishnasamy, Gunasekaran;
Gronemeyer, Hinrich;
Bourguet, William;
Germain, Pierre

Publication type:

Article

A structural view of nuclear hormone receptor: endocrine disruptor interactions.

Published in:

Cellular & Molecular Life Sciences, 2010, v. 67, n. 8, p. 1219, doi. 10.1007/s00018-009-0249-2

By:

le Maire, Albane;
Bourguet, William;
Balaguer, Patrick

Publication type:

Article

Reporter cell lines to evaluate the selectivity of chemicals for human and zebrafish estrogen and peroxysome proliferator activated γ receptors.

Published in:

Frontiers in Cellular Neuroscience, 2015, p. 1, doi. 10.3389/fnins.2015.00212

By:

Grimaldi, Marina;
Boulahtouf, Abdelhay;
Thouennon, Erwan;
Balaguer, Patrick;
Delfosse, Vanessa;
Bourguet, William

Publication type:

Article

Separation of Retinoid X Receptor Homo- and Heterodimerization Functions.

Published in:

Molecular & Cellular Biology, 2003, v. 23, n. 21, p. 7678, doi. 10.1128/MCB.23.21.7678-7688.2003

By:

Vivat-Hannah, Valerie;
Bourguet, William;
Gottardis, Marco;
Gronemeyer, Hinrich

Publication type:

Article

Ligands and DNA in the allosteric control of retinoid receptors function.

Published in:

Essays in Biochemistry, 2021, v. 65, n. 6, p. 887, doi. 10.1042/EBC20200168

By:

Germain, Pierre;
Rochel, Natacha;
Bourguet, William

Publication type:

Article

Insights into the activation mechanism of human estrogen-related receptor γ by environmental endocrine disruptors.

Published in:

Cellular & Molecular Life Sciences, 2019, v. 76, n. 23, p. 4769, doi. 10.1007/s00018-019-03129-x

By:

Thouennon, Erwan;
Delfosse, Vanessa;
Bailly, Rémy;
Blanc, Pauline;
Boulahtouf, Abdelhay;
Grimaldi, Marina;
Barducci, Alessandro;
Bourguet, William;
Balaguer, Patrick

Publication type:

Article