Works by Bottomley, Stephen P.

Results: 34

The REFOLD database: a tool for the optimization of protein expression and refolding.

Published in:

Nucleic Acids Research, 2006, v. 34, n. suppl 1, p. d207, doi. 10.1093/nar/gkj080

By:

Chow, Michelle K. M.;
Amin, Abdullah A.;
Fulton, Kate F.;
Fernando, Thushan;
Kamau, Lawrence;
Batty, Chris;
Louca, Michael;
Ho, Storm;
Whisstock, James C.;
Bottomley, Stephen P.;
Buckle, Ashley M.

Publication type:

Article

PFD: a database for the investigation of protein folding kinetics and stability.

Published in:

Nucleic Acids Research, 2005, v. 33, n. suppl 1, p. d279

By:

Fulton, Kate F.;
Devlin, Glyn L.;
Jodun, Rachel A.;
Silvestri, Linda;
Bottomley, Stephen P.;
Fersht, Alan R.;
Buckle, Ashley M.

Publication type:

Article

Multi-domain misfolding: understanding the aggregation pathway of polyglutamine proteins.

Published in:

PEDS: Protein Engineering, Design & Selection, 2009, v. 22, n. 8, p. 447, doi. 10.1093/protein/gzp033

By:

Saunders, Helen M.;
Bottomley, Stephen P.

Publication type:

Article

X-ray crystal structure of MENT: evidence for functional loop–sheet polymers in chromatin condensation.

Published in:

EMBO Journal, 2006, v. 25, n. 13, p. 3144, doi. 10.1038/sj.emboj.7601201

By:

McGowan, Sheena;
Buckle, Ashley M.;
Irving, James A.;
Ong, Poh Chee;
Bashtannyk-Puhalovich, Tanya A.;
Kan, Wan-Ting;
Henderson, Kate N.;
Bulynko, Yaroslava A.;
Popova, Evgenya Y.;
Smith, A. Ian;
Bottomley, Stephen P.;
Rossjohn, Jamie;
Grigoryev, Sergei A.;
Pike, Robert N.;
Whisstock, James C.

Publication type:

Article

Serpins in the Caenorhabditis elegans genome.

Published in:

Proteins, 1999, v. 36, n. 1, p. 31, doi. 10.1002/(SICI)1097-0134(19990701)36:1<31::AID-PROT3>3.0.CO;2-Q

By:

Whisstock, James C.;
Irving, James A.;
Bottomley, Stephen P.;
Pike, Robert N.;
Lesk, Arthur M.

Publication type:

Article

Crystallization and X-ray analysis of a single fab binding domain from protein L of Peptostreptococcus magnus.

Published in:

Proteins, 1995, v. 23, n. 4, p. 610, doi. 10.1002/prot.340230420

By:

Sohi, Maninder K.;
Wan, Tommy;
Sutton, Brian J.;
Atkinson, Tony;
Atkinson, Max A.;
Murphy, Jonathan P.;
Bottomley, Stephen P.;
Gore, Michael G.

Publication type:

Article

Dopamine promotes α-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway.

Published in:

FASEB Journal, 2005, v. 19, n. 10, p. 1377, doi. 10.1096/fj.04-3437fje

By:

Cappai, Roberto;
Leck, Su-Ling;
Tew, Deborah J.;
Williamson, Nicholas A.;
Smith, David P.;
Galatis, Denise;
Sharples, Robyn A.;
Curtain, Cyril C.;
Ali, Feda' E.;
Cherny, Robert A.;
Culvenor, Janetta G.;
Bottomley, Stephen P.;
Masters, Colin L.;
Barnham, Kevin J.;
Hill, Andrew F.

Publication type:

Article

Structural biology: Serpins' mystery solved.

Published in:

Nature, 2008, v. 455, n. 7217, p. 1189, doi. 10.1038/4551189a

By:

Whisstock, James C.;
Bottomley, Stephen P.

Publication type:

Article

The structural diversity in ?1-antitrypsin misfolding.

Published in:

EMBO Reports, 2011, v. 12, n. 10, p. 983, doi. 10.1038/embor.2011.187

By:

Bottomley, Stephen P

Publication type:

Article

The N terminus of the serpin, tengpin, functions to trap the metastable native state.

Published in:

EMBO Reports, 2007, v. 8, n. 7, p. 658, doi. 10.1038/sj.embor.7400986

By:

Zhang, Qingwei;
Buckle, Ashley M;
Law, Ruby H P;
Pearce, Mary C;
Cabrita, Lisa D;
Lloyd, Gordon J;
Irving, James A;
Smith, A Ian;
Ruzyla, Katya;
Rossjohn, Jamie;
Bottomley, Stephen P;
Whisstock, James C

Publication type:

Article

Serpin polymerization and its role in disease—The molecular basis of α1-antitrypsin deficiency.

Published in:

IUBMB Life, 2009, v. 61, n. 1, p. 1, doi. 10.1002/iub.127

By:

Knaupp, Anja S.;
Bottomley, Stephen P.

Publication type:

Article

Serpin polymerization and its role in disease—The molecular basis of α1-antitrypsin deficiency.

Published in:

IUBMB Life, 2009, v. 61, n. 1, p. spcone, doi. 10.1002/iub.173

By:

Knaupp, Anja S.;
Bottomley, Stephen P.

Publication type:

Article

The Role of Protein Misfolding in the Pathogenesis of Human Diseases.

Published in:

IUBMB Life, 2004, v. 56, n. 3, p. 119, doi. 10.1080/15216540410001674003

By:

Ellisdon, Andrew M.;
Bottomley, Stephen P.

Publication type:

Article

Serpins: Finely Balanced Conformational Traps .

Published in:

IUBMB Life, 2002, v. 54, n. 1, p. 1, doi. 10.1080/15216540213825

By:

Pike, Robert N.;
Bottomley, Stephen P.;
Irving, James A.;
Bird, Phillip I.;
Whisstock, James C.

Publication type:

Article

Blind Man's Bluff - Elaboration of Fragment Hits in the Absence of Structure for the Development of Antitrypsin Deficiency Inhibitors.

Published in:

Australian Journal of Chemistry, 2013, v. 66, n. 12, p. 1525, doi. 10.1071/CH13290

By:

Headey, Stephen J.;
Pearce, Mary C.;
Scanlon, Martin J.;
Bottomley, Stephen P.

Publication type:

Article

A family of E. coli expression vectors for laboratory scale and high throughput soluble protein production.

Published in:

BMC Biotechnology, 2006, v. 6, p. 1, doi. 10.1186/1472-6750-6-12

By:

Cabrita, Lisa D.;
Dai, Weiwen;
Bottomley, Stephen P.

Publication type:

Article

Amyloid Formation from an α-Helix Peptide Bundle Is Seeded by 310-Helix Aggregates.

Published in:

Chemistry - A European Journal, 2011, v. 17, n. 1, p. 151, doi. 10.1002/chem.201002500

By:

Singh, Yogendra;
Sharpe, Philip C.;
Hoang, Huy N.;
Lucke, Andrew J.;
McDowall, Alasdair W.;
Bottomley, Stephen P.;
Fairlie, David P.

Publication type:

Article

How do proteins avoid becoming too stable? Biophysical studies into metastable proteins.

Published in:

European Biophysics Journal, 2004, v. 33, n. 2, p. 83, doi. 10.1007/s00249-003-0356-1

By:

Cabrita, Lisa D.;
Bottomley, Stephen P.

Publication type:

Article

PolyQ: a database describing the sequence and domain context of polyglutamine repeats in proteins.

Published in:

Nucleic Acids Research, 2011, v. 39, n. suppl_1, p. D272, doi. 10.1093/nar/gkq1100

By:

Robertson, Amy L.;
Bate, Mark A.;
Androulakis, Steve G.;
Bottomley, Stephen P.;
Buckle, Ashley M.

Publication type:

Article

Smoothing a rugged protein folding landscape by sequence-based redesign.

Published in:

Scientific Reports, 2016, p. 33958, doi. 10.1038/srep33958

By:

Porebski, Benjamin T.;
Keleher, Shani;
Hollins, Jeffrey J.;
Nickson, Adrian A.;
Marijanovic, Emilia M.;
Borg, Natalie A.;
Costa, Mauricio G. S.;
Pearce, Mary A.;
Dai, Weiwen;
Zhu, Liguang;
Irving, James A.;
Hoke, David E.;
Kass, Itamar;
Whisstock, James C.;
Bottomley, Stephen P.;
Webb, Geoffrey I.;
McGowan, Sheena;
Buckle, Ashley M.

Publication type:

Article

The Z Mutation Alters the Global Structural Dynamics of α1-Antitrypsin.

Published in:

PLoS ONE, 2014, v. 9, n. 9, p. 1, doi. 10.1371/journal.pone.0102617

By:

Hughes, Victoria A.;
Meklemburg, Robert;
Bottomley, Stephen P.;
Wintrode, Patrick L.

Publication type:

Article

Conformational Behavior and Aggregation of Ataxin-3 in SDS.

Published in:

PLoS ONE, 2013, v. 8, n. 7, p. 1, doi. 10.1371/journal.pone.0069416

By:

Saunders, Helen M.;
Hughes, Victoria A.;
Cappai, Roberto;
Bottomley, Stephen P.

Publication type:

Article

The Roles of Helix I and Strand 5A in the Folding, Function and Misfolding of α1-Antitrypsin.

Published in:

PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0054766

By:

Knaupp, Anja S.;
Keleher, Shani;
Li Yang;
Weiwen Dai;
Bottomley, Stephen P.;
Pearce, Mary C.

Publication type:

Article

Conformational Change in the Chromatin Remodelling Protein MENT.

Published in:

PLoS ONE, 2009, v. 4, n. 3, p. 1, doi. 10.1371/journal.pone.0004727

By:

Poh Chee Ong;
Golding, Sarah J.;
Pearce, Mary C.;
Irving, James A.;
Grigoryev, Sergei A.;
Pike, Debbie;
Langendorf, Christopher G.;
Bashtannyk-Puhalovich, Tanya A.;
Bottomley, Stephen P.;
Whisstock, James C.;
Pike, Robert N.;
McGowan, Sheena

Publication type:

Article

The loss of tryptophan 194 in antichymotrypsin lowers the kinetic barrier to misfolding.

Published in:

FEBS Journal, 2007, v. 274, n. 14, p. 3622, doi. 10.1111/j.1742-4658.2007.05897.x

By:

Pearce, Mary C.;
Cabrita, Lisa D.;
Ellisdon, Andrew M.;
Bottomley, Stephen P.

Publication type:

Article

Serpins 2005 – fun between the β-sheets.

Published in:

FEBS Journal, 2005, v. 272, n. 19, p. 4868, doi. 10.1111/j.1742-4658.2005.04927.x

By:

Whisstock, James C.;
Bottomley, Stephen P.;
Bird, Phillip I.;
Pike, Robert N.;
Coughlin, Paul

Publication type:

Article

Prevention of Polymerization of M and Z α1-Antitrypsin (α1-AT) with Trimethylamine N-Oxide.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2001, v. 24, n. 6, p. 727, doi. 10.1165/ajrcmb.24.6.4407

By:

Devlin, Glyn L.;
Parfrey, Helen;
Tew, Deborah J.;
Lomas, David A.;
Bottomley, Stephen P.

Publication type:

Article

Flanking domain stability modulates the aggregation kinetics of a polyglutamine disease protein.

Published in:

Protein Science: A Publication of the Protein Society, 2011, v. 20, n. 10, p. 1675, doi. 10.1002/pro.698

By:

Saunders, Helen M.;
Gilis, Dimitri;
Rooman, Marianne;
Dehouck, Yves;
Robertson, Amy L.;
Bottomley, Stephen P.

Publication type:

Article

Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding.

Published in:

Protein Science: A Publication of the Protein Society, 2008, v. 17, n. 12, p. 2127, doi. 10.1110/ps.037234.108

By:

Pearce, Mary C.;
Morton, Craig J.;
Feil, Susanne C.;
Hansen, Guido;
Adams, Julian J.;
Parker, Michael W.;
Bottomley, Stephen P.

Publication type:

Article

Enhancing the stability and solubility of TEV protease using in silico design.

Published in:

Protein Science: A Publication of the Protein Society, 2007, v. 16, n. 11, p. 2360, doi. 10.1110/ps.072822507

By:

Cabrita, Lisa D.;
Gilis, Dimitri;
Robertson, Amy L.;
Dehouck, Yves;
Rooman, Marianne;
Bottomley, Stephen P.

Publication type:

Article

The human serpin proteinase inhibitor-9 self-associates at physiological temperatures.

Published in:

Protein Science: A Publication of the Protein Society, 2004, v. 13, n. 7, p. 1859, doi. 10.1110/ps.04715304

By:

Benning, Lauren N.;
Whisstock, James C.;
Sun, Jiuru;
Bird, Phillip I.;
Bottomley, Stephen P.

Publication type:

Article

The role of strand 1 of the C β-sheet in the structure and function of α1-antitrypsin.

Published in:

Protein Science: A Publication of the Protein Society, 2001, v. 10, n. 12, p. 2518, doi. 10.1110/ps.ps.24101

By:

Bottomley, Stephen P.;
Lawrenson, Isobel D.;
Tew, Deborah;
Dai, Weiwen;
Whisstock, James C.;
Pike, Robert N.

Publication type:

Article

Cleaved antitrypsin polymers at atomic resolution.

Published in:

Protein Science: A Publication of the Protein Society, 2000, v. 9, n. 2, p. 417

By:

DUNSTONE, MICHELLE A.;
DAI, WEIWEN;
WHISSTOCK, JAMES C.;
ROSSJOHN, JAMIE;
PIKE, ROBERT N.;
FEIL, SUSANNE C.;
LE BONNIEC, BERNARD F.;
PARKER, MICHAEL W.;
BOTTOMLEY, STEPHEN P.

Publication type:

Article

The matrix refolded.

Published in:

2005

By:

Buckle, Ashley M.;
Devlin, Glyn L.;
Jodun, Rachel A.;
Fulton, Kate F.;
Faux, Noel;
Whisstock, James C.;
Bottomley, Stephen P.

Publication type:

Letter

Works by Bottomley, Stephen P.

The REFOLD database: a tool for the optimization of protein expression and refolding.

PFD: a database for the investigation of protein folding kinetics and stability.

Multi-domain misfolding: understanding the aggregation pathway of polyglutamine proteins.

X-ray crystal structure of MENT: evidence for functional loop–sheet polymers in chromatin condensation.

Serpins in the Caenorhabditis elegans genome.

Crystallization and X-ray analysis of a single fab binding domain from protein L of Peptostreptococcus magnus.

Dopamine promotes α-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway.

Structural biology: Serpins' mystery solved.

The structural diversity in ?<sub>1</sub>-antitrypsin misfolding.

The N terminus of the serpin, tengpin, functions to trap the metastable native state.

Serpin polymerization and its role in disease—The molecular basis of α<sub>1</sub>-antitrypsin deficiency.

Serpin polymerization and its role in disease—The molecular basis of α<sub>1</sub>-antitrypsin deficiency.

The Role of Protein Misfolding in the Pathogenesis of Human Diseases.

Serpins: Finely Balanced Conformational Traps .

Blind Man's Bluff - Elaboration of Fragment Hits in the Absence of Structure for the Development of Antitrypsin Deficiency Inhibitors.

A family of E. coli expression vectors for laboratory scale and high throughput soluble protein production.

Amyloid Formation from an α-Helix Peptide Bundle Is Seeded by 3<sub>10</sub>-Helix Aggregates.

How do proteins avoid becoming too stable? Biophysical studies into metastable proteins.

PolyQ: a database describing the sequence and domain context of polyglutamine repeats in proteins.

Smoothing a rugged protein folding landscape by sequence-based redesign.

The Z Mutation Alters the Global Structural Dynamics of α<sub>1</sub>-Antitrypsin.

Conformational Behavior and Aggregation of Ataxin-3 in SDS.

The Roles of Helix I and Strand 5A in the Folding, Function and Misfolding of α<sub>1</sub>-Antitrypsin.

Conformational Change in the Chromatin Remodelling Protein MENT.

The loss of tryptophan 194 in antichymotrypsin lowers the kinetic barrier to misfolding.

Serpins 2005 – fun between the β-sheets.

Prevention of Polymerization of M and Z α<sub>1</sub>-Antitrypsin (α<sub>1</sub>-AT) with Trimethylamine N-Oxide.

Flanking domain stability modulates the aggregation kinetics of a polyglutamine disease protein.

Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding.

Enhancing the stability and solubility of TEV protease using in silico design.

The human serpin proteinase inhibitor-9 self-associates at physiological temperatures.

The role of strand 1 of the C β-sheet in the structure and function of α<sub>1</sub>-antitrypsin.

Cleaved antitrypsin polymers at atomic resolution.

The matrix refolded.