Works by Borysko, Petro

Results: 26

Fluorine‐Containing 6‐Azabicyclo[3.1.1]heptanes: Bicyclic Piperidine Analogs for Drug Discovery.

Published in:

European Journal of Organic Chemistry, 2025, v. 28, n. 17, p. 1, doi. 10.1002/ejoc.202500022

By:

Chernykh, Anton V.;
Liashuk, Oleksandr S.;
Hurieva, Anastasiia M.;
Lesyk, Dmytro;
Holota, Yuliia;
Borysko, Petro;
Shishkina, Svitlana V.;
Volochnyuk, Dmytro M.;
Grygorenko, Oleksandr O.

Publication type:

Article

Physicochemical and Biological Evaluation of gem‐Difluorinated Saturated Oxygen Heterocycles as Bioisosteres for Drug Discovery.

Published in:

Chemistry - A European Journal, 2025, v. 31, n. 10, p. 1, doi. 10.1002/chem.202404390

By:

Melnykov, Kostiantyn P.;
Liashuk, Oleksandr S.;
Holovach, Serhii;
Shatnia, Valeriia;
Horbenko, Artur;
Lesyk, Dmytro;
Melnyk, Varvara;
Skrypnik, Daniil;
Beshtynarska, Anna;
Borysko, Petro;
Viniichuk, Oleksandr;
Grygorenko, Oleksandr O.

Publication type:

Article

Front Cover: 3,3‐Difluorooxetane–A Versatile Functional Group for Bioisosteric Replacements in Drug Discovery (Chem. Eur. J. 72/2024).

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 72, p. 1, doi. 10.1002/chem.202487201

By:

Liashuk, Oleksandr S.;
Fedinchyk, Anastasiya;
Melnykov, Kostiantyn P.;
Herasymchuk, Maksym;
Alieksieieva, Diana;
Lesyk, Dmytro;
Bas, Yuliia P.;
Keda, Tetiana Ye.;
Yatsymyrskiy, Andriy V.;
Holota, Yuliia;
Borysko, Petro;
Yarmolchuk, Volodymyr S.;
Grygorenko, Oleksandr O.

Publication type:

Article

3,3‐Difluorooxetane–A Versatile Functional Group for Bioisosteric Replacements in Drug Discovery.

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 72, p. 1, doi. 10.1002/chem.202403277

By:

Liashuk, Oleksandr S.;
Fedinchyk, Anastasiya;
Melnykov, Kostiantyn P.;
Herasymchuk, Maksym;
Alieksieieva, Diana;
Lesyk, Dmytro;
Bas, Yuliia P.;
Keda, Tetiana Ye.;
Yatsymyrskiy, Andriy V.;
Holota, Yuliia;
Borysko, Petro;
Yarmolchuk, Volodymyr S.;
Grygorenko, Oleksandr O.

Publication type:

Article

Front Cover: Effect of gem‐Difluorination on the Key Physicochemical Properties Relevant to Medicinal Chemistry: The Case of Functionalized Cycloalkanes (Chem. Eur. J. 19/2022).

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 19, p. 1, doi. 10.1002/chem.202200746

By:

Holovach, Sergey;
Melnykov, Kostiantyn P.;
Skreminskiy, Artem;
Herasymchuk, Maksym;
Tavlui, Olha;
Aloshyn, Danylo;
Borysko, Petro;
Rozhenko, Alexander B.;
Ryabukhin, Sergey V.;
Volochnyuk, Dmitriy M.;
Grygorenko, Oleksandr O.

Publication type:

Article

Effect of gem‐Difluorination on the Key Physicochemical Properties Relevant to Medicinal Chemistry: The Case of Functionalized Cycloalkanes.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 19, p. 1, doi. 10.1002/chem.202200331

By:

Holovach, Sergey;
Melnykov, Kostiantyn P.;
Skreminskiy, Artem;
Herasymchuk, Maksym;
Tavlui, Olha;
Aloshyn, Danylo;
Borysko, Petro;
Rozhenko, Alexander B.;
Ryabukhin, Sergey V.;
Volochnyuk, Dmitriy M.;
Grygorenko, Oleksandr O.

Publication type:

Article

Spiro[3.3]heptane as a Saturated Benzene Bioisostere**.

Published in:

Angewandte Chemie, 2024, v. 136, n. 9, p. 1, doi. 10.1002/ange.202316557

By:

Prysiazhniuk, Kateryna;
Datsenko, Oleksandr P.;
Polishchuk, Oleksandr;
Shulha, Stanislav;
Shablykin, Oleh;
Nikandrova, Yelyzaveta;
Horbatok, Kateryna;
Bodenchuk, Iryna;
Borysko, Petro;
Shepilov, Dmytro;
Pishel, Iryna;
Kubyshkin, Vladimir;
Mykhailiuk, Pavel K.

Publication type:

Article

Hydroaminoalkyl Functionalization of Pyrimidin‐2(1H)‐ones by Visible Light Organophotocatalysis: A Radical Approach to Biginelli‐Type Dihydropyrimidines.

Published in:

Advanced Synthesis & Catalysis, 2023, v. 365, n. 20, p. 3484, doi. 10.1002/adsc.202300781

By:

Lukianov, Oleh;
Tkachuk, Viktor;
Shishkina, Svitlana;
Lachmann, Leonid;
Vadzyuk, Olga;
Borysko, Petro;
Kovalskyy, Dmytro;
Gillaizeau, Isabelle;
Sukach, Volodymyr

Publication type:

Article

Screening of benzenesulfonamide in combination with chemically diverse fragments against carbonic anhydrase by differential scanning fluorimetry.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2020, v. 35, n. 1, p. 306, doi. 10.1080/14756366.2019.1698562

By:

Krasavin, Mikhail;
Kalinin, Stanislav;
Zozulya, Sergey;
Gryniukova, Anastasiia;
Borysko, Petro;
Angeli, Andrea;
Supuran, Claudiu T.

Publication type:

Article

Further validation of strecker-type α-aminonitriles as a new class of potent human carbonic anhydrase II inhibitors: hit expansion within the public domain using differential scanning fluorimetry leads to chemotype refinement.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2020, v. 35, n. 1, p. 165, doi. 10.1080/14756366.2019.1693556

By:

Krasavin, Mikhail;
Kalinin, Stanislav;
Zozulya, Sergey;
Griniukova, Anastasia;
Borysko, Petro;
Angeli, Andrea;
Supuran, Claudiu T.

Publication type:

Article

Discovery of Strecker-type α-aminonitriles as a new class of human carbonic anhydrase inhibitors using differential scanning fluorimetry.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2016, v. 31, n. 6, p. 1707, doi. 10.3109/14756366.2016.1156676

By:

Krasavin, Mikhail;
Stavniichuk, Roman;
Zozulya, Sergey;
Borysko, Petro;
Vullo, Daniela;
Supuran, Claudiu T.

Publication type:

Article

Difluoromethyl Nitrile Oxide (CF<sub>2</sub>HCNO): A Neglected Chemical Reagent.

Published in:

European Journal of Organic Chemistry, 2017, v. 2017, n. 27, p. 3935, doi. 10.1002/ejoc.201700764

By:

Khutorianskyi, Andrii;
Chalyk, Bohdan;
Borysko, Petro;
Kondratiuk, Anna;
Mykhailiuk, Pavel K.

Publication type:

Article

2‐Oxabicyclo[2.1.1]hexanes: Synthesis, Properties, and Validation as Bioisosteres of ortho‐ and meta‐Benzenes.

Published in:

Angewandte Chemie International Edition, 2024, v. 63, n. 19, p. 1, doi. 10.1002/anie.202319831

By:

Levterov, Vadym V.;
Panasiuk, Yaroslav;
Shablykin, Oleh;
Stashkevych, Oleksandr;
Sahun, Kateryna;
Rassokhin, Artur;
Sadkova, Iryna;
Lesyk, Dmytro;
Anisiforova, Anna;
Holota, Yuliia;
Borysko, Petro;
Bodenchuk, Iryna;
Voloshchuk, Nataliya M.;
Mykhailiuk, Pavel K.

Publication type:

Article

Spiro[3.3]heptane as a Saturated Benzene Bioisostere**.

Published in:

Angewandte Chemie International Edition, 2024, v. 63, n. 9, p. 1, doi. 10.1002/anie.202316557

By:

Prysiazhniuk, Kateryna;
Datsenko, Oleksandr P.;
Polishchuk, Oleksandr;
Shulha, Stanislav;
Shablykin, Oleh;
Nikandrova, Yelyzaveta;
Horbatok, Kateryna;
Bodenchuk, Iryna;
Borysko, Petro;
Shepilov, Dmytro;
Pishel, Iryna;
Kubyshkin, Vladimir;
Mykhailiuk, Pavel K.

Publication type:

Article

Spiro[3.3]heptane as a Saturated Benzene Bioisostere**.

Published in:

Angewandte Chemie International Edition, 2024, v. 63, n. 9, p. 1, doi. 10.1002/anie.202316557

By:

Prysiazhniuk, Kateryna;
Datsenko, Oleksandr P.;
Polishchuk, Oleksandr;
Shulha, Stanislav;
Shablykin, Oleh;
Nikandrova, Yelyzaveta;
Horbatok, Kateryna;
Bodenchuk, Iryna;
Borysko, Petro;
Shepilov, Dmytro;
Pishel, Iryna;
Kubyshkin, Vladimir;
Mykhailiuk, Pavel K.

Publication type:

Article

"Angular" Spirocyclic Azetidines: Synthesis, Characterization, and Evaluation in Drug Discovery.

Published in:

Angewandte Chemie, 2025, v. 137, n. 7, p. 1, doi. 10.1002/ange.202418850

By:

Kirichok, Alexander A.;
Tkachuk, Hennadii;
Levchenko, Kostiantyn;
Granat, Dmitry;
Yegorova, Tetyana;
Lesyk, Dmytro;
Anisiforova, Anna;
Holota, Yuliia;
Zomchak, Viktoriia;
Bodenchuk, Iryna;
Kosach, Viktoriia;
Borysko, Petro;
Korzh, Rodion A.;
Al‐Maali, Galeb;
Kubyshkin, Vladimir;
Rzepa, Henry S.;
Mykhailiuk, Pavel K.

Publication type:

Article

2‐Oxabicyclo[2.1.1]hexanes: Synthesis, Properties, and Validation as Bioisosteres of ortho‐ and meta‐Benzenes.

Published in:

Angewandte Chemie, 2024, v. 136, n. 19, p. 1, doi. 10.1002/ange.202319831

By:

Levterov, Vadym V.;
Panasiuk, Yaroslav;
Shablykin, Oleh;
Stashkevych, Oleksandr;
Sahun, Kateryna;
Rassokhin, Artur;
Sadkova, Iryna;
Lesyk, Dmytro;
Anisiforova, Anna;
Holota, Yuliia;
Borysko, Petro;
Bodenchuk, Iryna;
Voloshchuk, Nataliya M.;
Mykhailiuk, Pavel K.

Publication type:

Article

A prospective compound screening contest identified broader inhibitors for Sirtuin 1.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-55069-y

By:

Chiba, Shuntaro;
Ohue, Masahito;
Gryniukova, Anastasiia;
Borysko, Petro;
Zozulya, Sergey;
Yasuo, Nobuaki;
Yoshino, Ryunosuke;
Ikeda, Kazuyoshi;
Shin, Woong-Hee;
Kihara, Daisuke;
Iwadate, Mitsuo;
Umeyama, Hideaki;
Ichikawa, Takaaki;
Teramoto, Reiji;
Hsin, Kun-Yi;
Gupta, Vipul;
Kitano, Hiroaki;
Sakamoto, Mika;
Higuchi, Akiko;
Miura, Nobuaki

Publication type:

Article

2-Oxabicyclo[2.2.2]octane as a new bioisostere of the phenyl ring.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-41298-3

By:

Levterov, Vadym V.;
Panasiuk, Yaroslav;
Sahun, Kateryna;
Stashkevych, Oleksandr;
Badlo, Valentyn;
Shablykin, Oleh;
Sadkova, Iryna;
Bortnichuk, Lina;
Klymenko-Ulianov, Oleksii;
Holota, Yuliia;
Lachmann, Leonid;
Borysko, Petro;
Horbatok, Kateryna;
Bodenchuk, Iryna;
Bas, Yuliia;
Dudenko, Dmytro;
Mykhailiuk, Pavel K.

Publication type:

Article

IN SEARCH FOR SELECTIVE ACE2 BINDING CHEMICAL PROBES.

Published in:

Physiological Journal / Fiziologichnyi Zhurnal, 2022, v. 68, p. 58

By:

Rayevsky, Alex V.;
Poturai, Andrii S.;
Kravets, Iryna O.;
Pashenko, Alexander E.;
Borisova, Tatiana A.;
Tolstanova, Ganna M.;
Volochnyuk, Dmitriy M.;
Borysko, Petro O.;
Vadzyuk, Olga B.;
Alieksieieva, Diana O.;
Zabolotna, Yuliana;
Horvath, Dragos;
Ryabukhin, Sergey V.;
Varnek, Alexandre

Publication type:

Article

Cover Feature: Synthesis of Multifunctional Spirocyclic Azetidines and Their Application in Drug Discovery (Chem. Eur. J. 21/2018).

Published in:

Chemistry - A European Journal, 2018, v. 24, n. 21, p. 5398, doi. 10.1002/chem.201800624

By:

Kirichok, Alexander A.;
Shton, Irina O.;
Pishel, Irina M.;
Zozulya, Sergey A.;
Borysko, Petro O.;
Kubyshkin, Vladimir;
Zaporozhets, Olha A.;
Tolmachev, Andrei A.;
Mykhailiuk, Pavel K.

Publication type:

Article

Synthesis of Multifunctional Spirocyclic Azetidines and Their Application in Drug Discovery.

Published in:

Chemistry - A European Journal, 2018, v. 24, n. 21, p. 5444, doi. 10.1002/chem.201800193

By:

Kirichok, Alexander A.;
Shton, Irina O.;
Pishel, Irina M.;
Zozulya, Sergey A.;
Borysko, Petro O.;
Kubyshkin, Vladimir;
Zaporozhets, Olha A.;
Tolmachev, Andrei A.;
Mykhailiuk, Pavel K.

Publication type:

Article

Anticancer activity features of imidazole-based ionic liquids and lysosomotropic detergents: in silico and in vitro studies.

Published in:

Molecular Diversity, 2024, v. 28, n. 6, p. 3817, doi. 10.1007/s11030-023-10779-4

By:

Gryniukova, Anastasiia;
Borysko, Petro;
Myziuk, Iryna;
Alieksieieva, Diana;
Hodyna, Diana;
Semenyuta, Ivan;
Kovalishyn, Vasyl;
Metelytsia, Larysa;
Rogalsky, Sergiy;
Tcherniuk, Sergey

Publication type:

Article

In Vitro Evaluation of In Silico Screening Approaches in Search for Selective ACE2 Binding Chemical Probes.

Published in:

Molecules, 2022, v. 27, n. 17, p. 5400, doi. 10.3390/molecules27175400

By:

Rayevsky, Alexey V.;
Poturai, Andrii S.;
Kravets, Iryna O.;
Pashenko, Alexander E.;
Borisova, Tatiana A.;
Tolstanova, Ganna M.;
Volochnyuk, Dmitriy M.;
Borysko, Petro O.;
Vadzyuk, Olga B.;
Alieksieieva, Diana O.;
Zabolotna, Yuliana;
Klimchuk, Olga;
Horvath, Dragos;
Marcou, Gilles;
Ryabukhin, Sergey V.;
Varnek, Alexandre

Publication type:

Article

SAR by Space: Enriching Hit Sets from the Chemical Space.

Published in:

Molecules, 2019, v. 24, n. 17, p. 3096, doi. 10.3390/molecules24173096

By:

Klingler, Franca-Maria;
Gastreich, Marcus;
Grygorenko, Oleksandr O.;
Savych, Olena;
Borysko, Petro;
Griniukova, Anastasia;
Gubina, Kateryna E.;
Lemmen, Christian;
Moroz, Yurii S.;
Muñoz-Torrero, Diego;
Luque, F. Javier;
Pastor-Anglada, Marçal

Publication type:

Article

"Angular" Spirocyclic Azetidines: Synthesis, Characterization, and Evaluation in Drug Discovery.

Published in:

Angewandte Chemie International Edition, 2025, v. 64, n. 7, p. 1, doi. 10.1002/anie.202418850

By:

Kirichok, Alexander A.;
Tkachuk, Hennadii;
Levchenko, Kostiantyn;
Granat, Dmitry;
Yegorova, Tetyana;
Lesyk, Dmytro;
Anisiforova, Anna;
Holota, Yuliia;
Zomchak, Viktoriia;
Bodenchuk, Iryna;
Kosach, Viktoriia;
Borysko, Petro;
Korzh, Rodion A.;
Al‐Maali, Galeb;
Kubyshkin, Vladimir;
Rzepa, Henry S.;
Mykhailiuk, Pavel K.

Publication type:

Article