Works matching AU Bornkamp, Bjoern

Results: 50

A New Comprehensive Approach to Assess the Probability of Success of Development Programs Before Pivotal Trials.

Published in:

Clinical Pharmacology & Therapeutics, 2022, v. 111, n. 5, p. 1050, doi. 10.1002/cpt.2488

By:

Hampson, Lisa V.;
Holzhauer, Björn;
Bornkamp, Björn;
Kahn, Joseph;
Lange, Markus R.;
Luo, Wen‐Lin;
Singh, Pritibha;
Ballerstedt, Steffen;
Cioppa, Giovanni Della

Publication type:

Article

G. Parmigiani and L. Inoue: Decision theory-principles and approaches.

Published in:

2011

By:

Bornkamp, Björn

Publication type:

Book Review

Anirban DasGupta: Asymptotic theory of statistics and probability.

Published in:

2010

By:

Bornkamp, Björn

Publication type:

Book Review

WATCH: A Workflow to Assess Treatment Effect Heterogeneity in Drug Development for Clinical Trial Sponsors.

Published in:

Pharmaceutical Statistics, 2025, v. 24, n. 2, p. 1, doi. 10.1002/pst.2463

By:

Sechidis, Konstantinos;
Sun, Sophie;
Chen, Yao;
Lu, Jiarui;
Zhang, Cong;
Baillie, Mark;
Ohlssen, David;
Vandemeulebroecke, Marc;
Hemmings, Rob;
Ruberg, Stephen;
Bornkamp, Björn

Publication type:

Article

Predicting subgroup treatment effects for a new study: Motivations, results and learnings from running a data challenge in a pharmaceutical corporation.

Published in:

Pharmaceutical Statistics, 2024, v. 23, n. 4, p. 495, doi. 10.1002/pst.2368

By:

Bornkamp, Björn;
Zaoli, Silvia;
Azzarito, Michela;
Martin, Ruvie;
Müller, Carsten Philipp;
Moloney, Conor;
Capestro, Giulia;
Ohlssen, David;
Baillie, Mark

Publication type:

Article

Interim decision making in seamless trial designs: An application in an adaptive dose‐finding study in a rare kidney disease.

Published in:

Pharmaceutical Statistics, 2024, v. 23, n. 1, p. 20, doi. 10.1002/pst.2335

By:

Papachristofi, Olympia;
Bornkamp, Björn;
Wright, Melanie;
Friede, Tim

Publication type:

Article

Sensitivity analyses for the principal ignorability assumption using multiple imputation.

Published in:

Pharmaceutical Statistics, 2023, v. 22, n. 1, p. 64, doi. 10.1002/pst.2260

By:

Wang, Craig;
Zhang, Yufen;
Mealli, Fabrizia;
Bornkamp, Björn

Publication type:

Article

Eliciting judgements about dependent quantities of interest: The SHeffield ELicitation Framework extension and copula methods illustrated using an asthma case study.

Published in:

Pharmaceutical Statistics, 2022, v. 21, n. 5, p. 1005, doi. 10.1002/pst.2212

By:

Holzhauer, Björn;
Hampson, Lisa V.;
Gosling, John Paul;
Bornkamp, Björn;
Kahn, Joseph;
Lange, Markus R.;
Luo, Wen‐Lin;
Brindicci, Caterina;
Lawrence, David;
Ballerstedt, Steffen;
O'Hagan, Anthony

Publication type:

Article

Improving the assessment of the probability of success in late stage drug development.

Published in:

Pharmaceutical Statistics, 2022, v. 21, n. 2, p. 439, doi. 10.1002/pst.2179

By:

Hampson, Lisa V.;
Bornkamp, Björn;
Holzhauer, Björn;
Kahn, Joseph;
Lange, Markus R.;
Luo, Wen‐Lin;
Cioppa, Giovanni Della;
Stott, Kelvin;
Ballerstedt, Steffen

Publication type:

Article

Identifying treatment effect heterogeneity in dose‐finding trials using Bayesian hierarchical models.

Published in:

Pharmaceutical Statistics, 2022, v. 21, n. 1, p. 17, doi. 10.1002/pst.2150

By:

Thomas, Marius;
Bornkamp, Björn;
Ickstadt, Katja

Publication type:

Article

Principal stratum strategy: Potential role in drug development.

Published in:

Pharmaceutical Statistics, 2021, v. 20, n. 4, p. 737, doi. 10.1002/pst.2104

By:

Bornkamp, Björn;
Rufibach, Kaspar;
Lin, Jianchang;
Liu, Yi;
Mehrotra, Devan V.;
Roychoudhury, Satrajit;
Schmidli, Heinz;
Shentu, Yue;
Wolbers, Marcel

Publication type:

Article

Response to comments on Jaki et al., A proposal for a new PhD level curriculum on quantitative methods for drug development. Pharm Stat 17(5):593‐606, Sep/Oct 2018., DOI:https://doi.org/10.1002/pst.1873

Published in:

Pharmaceutical Statistics, 2019, v. 18, n. 3, p. 284, doi. 10.1002/pst.1942

By:

Jaki, Thomas;
Gordon, Allan;
Forster, Pamela;
Bijnens, Luc;
Bornkamp, Bjoern;
Brannath, Werner;
Fontana, Roberto;
Gasparini, Mauro;
Hampson, Lisa V.;
Jacobs, Tom;
Jones, Byron;
Paoletti, Xavier;
Posch, Martin;
Titman, Andrew;
Vonk, Richardus;
Koenig, Franz

Publication type:

Article

Model averaging for treatment effect estimation in subgroups.

Published in:

Pharmaceutical Statistics, 2017, v. 16, n. 2, p. 133, doi. 10.1002/pst.1796

By:

Bornkamp, Björn;
Ohlssen, David;
Magnusson, Baldur P.;
Schmidli, Heinz

Publication type:

Article

Characterization of dose-response for count data using a generalized MCP-Mod approach in an adaptive dose-ranging trial.

Published in:

Pharmaceutical Statistics, 2015, v. 14, n. 4, p. 359, doi. 10.1002/pst.1693

By:

Mercier, Francois;
Bornkamp, Bjoern;
Ohlssen, David;
Wallstroem, Erik

Publication type:

Article

Viewpoint: model selection uncertainty, pre-specification, and model averaging.

Published in:

Pharmaceutical Statistics, 2015, v. 14, n. 2, p. 79, doi. 10.1002/pst.1671

By:

Bornkamp, Björn

Publication type:

Article

A practical guide to Bayesian group sequential designs.

Published in:

Pharmaceutical Statistics, 2014, v. 13, n. 1, p. 71, doi. 10.1002/pst.1593

By:

Gsponer, Thomas;
Gerber, Florian;
Bornkamp, Björn;
Ohlssen, David;
Vandemeulebroecke, Marc;
Schmidli, Heinz

Publication type:

Article

Subgroup identification in dose-finding trials via model-based recursive partitioning.

Published in:

2018

By:

Thomas, Marius;
Bornkamp, Björn;
Seibold, Heidi

Publication type:

journal article

Model selection versus model averaging in dose finding studies.

Published in:

2016

By:

Schorning, Kirsten;
Bornkamp, Björn;
Bretz, Frank;
Dette, Holger

Publication type:

journal article

Model-based dose finding under model uncertainty using general parametric models.

Published in:

Statistics in Medicine, 2014, v. 33, n. 10, p. 1646, doi. 10.1002/sim.6052

By:

Pinheiro, José;
Bornkamp, Björn;
Glimm, Ekkehard;
Bretz, Frank

Publication type:

Article

On the efficiency of two-stage response-adaptive designs.

Published in:

Statistics in Medicine, 2013, v. 32, n. 10, p. 1646, doi. 10.1002/sim.5555

By:

Dette, Holger;
Bornkamp, Björn;
Bretz, Frank

Publication type:

Article

Exposure-response modelling approaches for determining optimal dosing rules in children.

Published in:

2020

By:

Wadsworth, Ian;
Hampson, Lisa V;
Bornkamp, Björn;
Jaki, Thomas

Publication type:

journal article

Testing multiple dose combinations in clinical trials.

Published in:

2020

By:

Saha, Saswati;
Brannath, Werner;
Bornkamp, Björn

Publication type:

journal article

Calculating quantiles of noisy distribution functions using local linear regressions.

Published in:

Computational Statistics, 2018, v. 33, n. 1, p. 487, doi. 10.1007/s00180-017-0736-0

By:

Bornkamp, Björn

Publication type:

Article

Stochastically ordered multiple regression.

Published in:

Biostatistics, 2010, v. 11, n. 3, p. 419, doi. 10.1093/biostatistics/kxq001

By:

Bornkamp, Björn;
Ickstadt, Katja;
Dunson, David

Publication type:

Article

A Note on B-Splines for Semiparametric Elicitation.

Published in:

American Statistician, 2009, v. 63, n. 4, p. 373, doi. 10.1198/tast.2009.08191

By:

Bornkamp, Björn;
Ickstadt, Katja

Publication type:

Article

Comparing algorithms for characterizing treatment effect heterogeneity in randomized trials.

Published in:

Biometrical Journal, 2024, v. 66, n. 1, p. 1, doi. 10.1002/bimj.202100337

By:

Sun, Sophie;
Sechidis, Konstantinos;
Chen, Yao;
Lu, Jiarui;
Ma, Chong;
Mirshani, Ardalan;
Ohlssen, David;
Vandemeulebroecke, Marc;
Bornkamp, Björn

Publication type:

Article

A multiple comparison procedure for dose‐finding trials with subpopulations.

Published in:

Biometrical Journal, 2020, v. 62, n. 1, p. 53, doi. 10.1002/bimj.201800111

By:

Thomas, Marius;
Bornkamp, Björn;
Posch, Martin;
König, Franz

Publication type:

Article

Bayesian Biostatistics 2014 - Satellite conference of the International Biometric Conference.

Published in:

2015

By:

Held, Leonhard;
Bornkamp, Björn;
Müller, Peter

Publication type:

Editorial

Practical considerations for using functional uniform prior distributions for dose-response estimation in clinical trials.

Published in:

Biometrical Journal, 2014, v. 56, n. 6, p. 947, doi. 10.1002/bimj.201300138

By:

Bornkamp, Björn

Publication type:

Article

Phase II dose-response trials: A simulation study to compare analysis method performance under design considerations.

Published in:

Journal of Biopharmaceutical Statistics, 2017, v. 27, n. 5, p. 885, doi. 10.1080/10543406.2017.1293078

By:

Rekowski, Jan;
Köllmann, Claudia;
Bornkamp, Björn;
Ickstadt, Katja;
Scherag, André

Publication type:

Article

Innovative Approaches for Designing and Analyzing Adaptive Dose-Ranging Trials.

Published in:

Journal of Biopharmaceutical Statistics, 2007, v. 17, n. 6, p. 965, doi. 10.1080/10543400701643848

By:

Bornkamp, Björn;
Bretz, Frank;
Dmitrienko, Alex;
Enas, Greg;
Gaydos, Brenda;
Hsu, Chyi-Hung;
König, Franz;
Krams, Michael;
Liu, Qing;
Neuenschwander, Beat;
Parke, Tom;
Pinheiro, José;
Roy, Amit;
Sax, Rick;
Shen, Frank

Publication type:

Article

DESIGN AND ANALYSIS OF DOSE-FINDING STUDIES COMBINING MULTIPLE COMPARISONS AND MODELING PROCEDURES.

Published in:

Journal of Biopharmaceutical Statistics, 2006, v. 16, n. 5, p. 639, doi. 10.1080/10543400600860428

By:

Pinheiro, José;
Bornkamp, Björn;
Bretz, Frank

Publication type:

Article

Bayesian inference for a principal stratum estimand on recurrent events truncated by death.

Published in:

Biometrics, 2023, v. 79, n. 4, p. 3792, doi. 10.1111/biom.13831

By:

Lyu, Tianmeng;
Bornkamp, Björn;
Mueller‐Velten, Guenther;
Schmidli, Heinz

Publication type:

Article

Likelihood ratio tests for a dose-response effect using multiple nonlinear regression models.

Published in:

Biometrics, 2017, v. 73, n. 1, p. 197, doi. 10.1111/biom.12563

By:

Gutjahr, Georg;
Bornkamp, Björn

Publication type:

Article

Unimodal regression using Bernstein-Schoenberg splines and penalties.

Published in:

Biometrics, 2014, v. 70, n. 4, p. 783, doi. 10.1111/biom.12193

By:

Köllmann, Claudia;
Bornkamp, Björn;
Ickstadt, Katja

Publication type:

Article

Functional Uniform Priors for Nonlinear Modeling.

Published in:

Biometrics, 2012, v. 68, n. 3, p. 893, doi. 10.1111/j.1541-0420.2012.01747.x

By:

Bornkamp, Björn

Publication type:

Article

Bayesian Nonparametric Estimation of Continuous Monotone Functions with Applications to Dose–Response Analysis.

Published in:

Biometrics, 2009, v. 65, n. 1, p. 198, doi. 10.1111/j.1541-0420.2008.01060.x

By:

Bornkamp, Björn;
Ickstadt, Katja

Publication type:

Article

Nonlinear mixed‐effects modeling as a method for causal inference to predict exposures under desired within‐subject dose titration schemes.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2025, v. 14, n. 1, p. 68, doi. 10.1002/psp4.13239

By:

Bartels, Christian;
Scauda, Martina;
Coello, Neva;
Dumortier, Thomas;
Bornkamp, Björn;
Moffa, Giusi

Publication type:

Article

A framework to guide dose & regimen strategy for clinical drug development.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 11, p. 1276, doi. 10.1002/psp4.12701

By:

Sander, Oliver;
Magnusson, Baldur;
Ludwig, Inga;
Jullion, Astrid;
Meille, Christophe;
Lorand, Daniel;
Bornkamp, Björn;
Hinder, Markus;
Kovacs, Steven J.;
Looby, Michael

Publication type:

Article

Estimands—What they are and why they are important for pharmacometricians.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 4, p. 279, doi. 10.1002/psp4.12617

By:

Akacha, Mouna;
Bartels, Christian;
Bornkamp, Björn;
Bretz, Frank;
Coello, Neva;
Dumortier, Thomas;
Looby, Michael;
Sander, Oliver;
Schmidli, Heinz;
Steimer, Jean‐Louis;
Vong, Camille

Publication type:

Article

A Longitudinal Item Response Theory Model to Characterize Cognition Over Time in Elderly Subjects.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2017, v. 6, n. 9, p. 635, doi. 10.1002/psp4.12219

By:

Vandemeulebroecke, Marc;
Bornkamp, Björn;
Krahnke, Tillmann;
Mielke, Johanna;
Monsch, Andreas;
Quarg, Peter

Publication type:

Article

Closed MCP‐Mod for Pairwise Comparisons of Several Doses With a Control.

Published in:

Statistics in Medicine, 2025, v. 44, n. 10-12, p. 1, doi. 10.1002/sim.70124

By:

Koenig, Franz;
Krasnozhon, Sergey;
Bornkamp, Bjoern;
Bretz, Frank;
Glimm, Ekkehard;
Graf, Alexandra;
Xi, Dong

Publication type:

Article

Randomization‐Based Inference for MCP‐Mod.

Published in:

Statistics in Medicine, 2025, v. 44, n. 10-12, p. 1, doi. 10.1002/sim.70092

By:

Pin, Lukas;
Sverdlov, Oleksandr;
Bretz, Frank;
Bornkamp, Björn

Publication type:

Article

Connecting Instrumental Variable methods for causal inference to the Estimand Framework.

Published in:

Statistics in Medicine, 2021, v. 40, n. 25, p. 5605, doi. 10.1002/sim.9143

By:

Bowden, Jack;
Bornkamp, Björn;
Glimm, Ekkehard;
Bretz, Frank

Publication type:

Article

Comment: Comparison With Iterated Laplace Approximation.

Published in:

2012

By:

Bornkamp, Björn

Publication type:

Opinion

Approximating Probability Densities by Iterated Laplace Approximations.

Published in:

Journal of Computational & Graphical Statistics, 2011, v. 20, n. 3, p. 656, doi. 10.1198/jcgs.2011.10099

By:

Bornkamp, Björn

Publication type:

Article

Conditional and Unconditional Treatment Effects in Randomized Clinical Trials: Estimands, Estimation, and Interpretation.

Published in:

Statistics in Biopharmaceutical Research, 2024, v. 16, n. 3, p. 371, doi. 10.1080/19466315.2023.2292774

By:

Wei, Jiawei;
Xu, Jiajun;
Bornkamp, Björn;
Lin, Ray;
Tian, Hong;
Xi, Dong;
Zhang, Xin;
Zhao, Ziqiang;
Roychoudhury, Satrajit

Publication type:

Article

On Identification of the Principal Stratum Effect in Patients Who Would Comply If Treated.

Published in:

2021

By:

Dukes, Oliver;
Van Lancker, Kelly;
Bornkamp, Björn;
Heinzmann, Dominik;
Rufibach, Kaspar;
Wolbers, Marcel

Publication type:

Letter

Estimating the Treatment Effect in a Subgroup Defined by an Early Post-Baseline Biomarker Measurement in Randomized Clinical Trials With Time-To-Event Endpoint.

Published in:

Statistics in Biopharmaceutical Research, 2020, v. 12, n. 1, p. 19, doi. 10.1080/19466315.2019.1575280

By:

Bornkamp, Björn;
Bermann, Georgina

Publication type:

Article

Comparing Approaches to Treatment Effect Estimation for Subgroups in Clinical Trials.

Published in:

Statistics in Biopharmaceutical Research, 2017, v. 9, n. 2, p. 160, doi. 10.1080/19466315.2016.1251490

By:

Thomas, Marius;
Bornkamp, Björn

Publication type:

Article