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Therapeutic strategies for identifying small molecules against prion diseases.
- Published in:
- Cell & Tissue Research, 2023, v. 392, n. 1, p. 337, doi. 10.1007/s00441-021-03573-x
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- Publication type:
- Article
Repurposing of Drugs Targeting YAP-TEAD Functions.
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- Cancers, 2018, v. 10, n. 9, p. 329, doi. 10.3390/cancers10090329
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- Publication type:
- Article
Small-Molecule Theranostic Probes: A Promising Future in Neurodegenerative Diseases.
- Published in:
- International Journal of Cell Biology, 2013, p. 1, doi. 10.1155/2013/150952
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- Publication type:
- Article
Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3β Inhibitors.
- Published in:
- Angewandte Chemie International Edition, 2015, v. 54, n. 5, p. 1578, doi. 10.1002/anie.201410456
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- Publication type:
- Article
Insight Into the Kinetic of Amyloid β (1-42) Peptide Self-Aggregation: Elucidation of Inhibitors' Mechanism of Action.
- Published in:
- ChemBioChem, 2007, v. 8, n. 17, p. 2152, doi. 10.1002/cbic.200700427
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- Publication type:
- Article
Fluorimetric Detection of Insulin Misfolding by Probes Derived from Functionalized Fluorene Frameworks.
- Published in:
- Molecules, 2024, v. 29, n. 6, p. 1196, doi. 10.3390/molecules29061196
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- Publication type:
- Article
The Use of Zidovudine Pharmacophore in Multi-Target-Directed Ligands for AIDS Therapy.
- Published in:
- Molecules, 2022, v. 27, n. 23, p. 8502, doi. 10.3390/molecules27238502
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- Publication type:
- Article
Cashew Nut Shell Liquid (CNSL) as a Source of Drugs for Alzheimer's Disease.
- Published in:
- Molecules, 2021, v. 26, n. 18, p. 5441, doi. 10.3390/molecules26185441
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- Publication type:
- Article
From Combinations to Single-Molecule Polypharmacology—Cromolyn-Ibuprofen Conjugates for Alzheimer's Disease.
- Published in:
- Molecules, 2021, v. 26, n. 4, p. 1112, doi. 10.3390/molecules26041112
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- Publication type:
- Article
Trypanocidal Activity of Quinoxaline 1,4 Di-N-oxide Derivatives as Trypanothione Reductase Inhibitors.
- Published in:
- Molecules, 2017, v. 22, n. 2, p. 220, doi. 10.3390/molecules22020220
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- Publication type:
- Article
Navigating the Chemical Space of Multitarget-Directed Ligands: From Hybrids to Fragments in Alzheimer’s Disease.
- Published in:
- Molecules, 2016, v. 21, n. 4, p. 466, doi. 10.3390/molecules21040466
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- Publication type:
- Article
PHENOTHIAZINE-TACRINE HETERODIMERS: PURSUING MULTITARGET DIRECTED APPROACH IN ALZHEIMER'S DISEASE.
- Published in:
- 2022
- By:
- Publication type:
- Abstract
FROM ACETYLCHOLINESTERASE INHIBITORS TO MULTI-TARGET-DIRECTED LIGANDS (MTDLs): A STEP FORWARD IN ALZHEIMER'S DISEASE DRUG DISCOVERY.
- Published in:
- Military Medical Science Letters / Vojenské zdravotnické Listy, 2018, v. 87, p. 69
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- Publication type:
- Article
DISCOVERY AND CHARACTERIZATION OF TACRINE/HUPRINE-TRYPTOPHAN HETERODIMERS AS NOVEL MULTIPOTENT COMPOUNDS AGAINST ALZHEIMER'S DISEASE.
- Published in:
- Military Medical Science Letters / Vojenské zdravotnické Listy, 2018, v. 87, p. 71
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- Publication type:
- Article
Polymethylene tetraamine backbone as template for the development of biologically active polyamines.
- Published in:
- Medicinal Research Reviews, 2003, v. 23, n. 2, p. 200, doi. 10.1002/med.10029
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- Publication type:
- Article
A Small Molecule Targeting the Multifactorial Nature of Alzheimer's Disease.
- Published in:
- Angewandte Chemie International Edition, 2007, v. 46, n. 20, p. 3689, doi. 10.1002/anie.200700256
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- Publication type:
- Article
Lewis Acid-Catalyzed Generation of CC and CN Bonds on π-Deficient Heterocyclic Substrates.
- Published in:
- Advanced Synthesis & Catalysis, 2015, v. 357, n. 1, p. 185, doi. 10.1002/adsc.201400674
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- Publication type:
- Article
Synthetic polyamines: an overview of their multiple biological activities.
- Published in:
- Amino Acids, 2010, v. 38, n. 2, p. 383, doi. 10.1007/s00726-009-0430-9
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- Publication type:
- Article
Novel multifunctional tacrine–donepezil hybrids against Alzheimer's disease: Design synthesis and bioactivity studies.
- Published in:
- Archiv der Pharmazie, 2024, v. 357, n. 7, p. 1, doi. 10.1002/ardp.202300575
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- Publication type:
- Article
Naphthoquinone Derivatives Exert Their Antitrypanosomal Activity via a Multi-Target Mechanism.
- Published in:
- PLoS Neglected Tropical Diseases, 2013, v. 7, n. 1, p. 1, doi. 10.1371/journal.pntd.0002012
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- Publication type:
- Article
Quinone-Amino Acid Conjugates Targeting Leishmania Amino Acid Transporters.
- Published in:
- PLoS ONE, 2014, v. 9, n. 9, p. 1, doi. 10.1371/journal.pone.0107994
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- Publication type:
- Article
Pharmacological Characterization of Memoquin, a Multi-Target Compound for the Treatment of Alzheimer's Disease.
- Published in:
- PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0056870
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- Publication type:
- Article
Molecular basis for covalent inhibition of glyceraldehyde-3-phosphate dehydrogenase by a 2-phenoxy-1,4-naphthoquinone small molecule.
- Published in:
- Chemical Biology & Drug Design, 2017, v. 90, n. 2, p. 225, doi. 10.1111/cbdd.12941
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- Publication type:
- Article
Synthesis of New Lipoic Acid Conjugates and Evaluation of Their Free Radical Scavenging and Neuroprotective Activities.
- Published in:
- Chemical Biology & Drug Design, 2014, v. 83, n. 6, p. 688, doi. 10.1111/cbdd.12282
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- Publication type:
- Article
S4-04-04: Memoquin, a novel multifunctional compound for Alzheimer’s disease: An up-date on preclinical studies
- Published in:
- 2006
- By:
- Publication type:
- Abstract
S4-04-04: Memoquin, a novel multifunctional compound for Alzheimer’s disease: An up-date on preclinical studies
- Published in:
- 2006
- By:
- Publication type:
- Abstract
Phenothiazine‐based virtual screening, molecular docking, and molecular dynamics of new trypanothione reductase inhibitors of Trypanosoma cruzi.
- Published in:
- Molecular Informatics, 2023, v. 42, n. 10, p. 1, doi. 10.1002/minf.202300069
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- Publication type:
- Article
Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3β Inhibitors.
- Published in:
- Angewandte Chemie, 2015, v. 127, n. 5, p. 1598, doi. 10.1002/ange.201410456
- By:
- Publication type:
- Article
A perspective on multi-target drug discovery and design for complex diseases.
- Published in:
- Clinical & Translational Medicine, 2018, v. 7, n. 1, p. 1, doi. 10.1186/s40169-017-0181-2
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- Publication type:
- Article
Front Cover: Discovery of Sustainable Drugs for Neglected Tropical Diseases: Cashew Nut Shell Liquid (CNSL)‐Based Hybrids Target Mitochondrial Function and ATP Production in Trypanosoma brucei (ChemMedChem 6/2019).
- Published in:
- ChemMedChem, 2019, v. 14, n. 6, p. 613, doi. 10.1002/cmdc.201900135
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- Publication type:
- Article
Discovery of Sustainable Drugs for Neglected Tropical Diseases: Cashew Nut Shell Liquid (CNSL)‐Based Hybrids Target Mitochondrial Function and ATP Production in Trypanosoma brucei.
- Published in:
- ChemMedChem, 2019, v. 14, n. 6, p. 621, doi. 10.1002/cmdc.201800790
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- Publication type:
- Article
Development of a Focused Library of Triazole‐Linked Privileged‐Structure‐Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections.
- Published in:
- ChemMedChem, 2018, v. 13, n. 7, p. 678, doi. 10.1002/cmdc.201700786
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- Publication type:
- Article
Multitarget Drug Discovery and Polypharmacology.
- Published in:
- 2016
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- Publication type:
- Editorial
Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer′s Disease.
- Published in:
- ChemMedChem, 2016, v. 11, n. 12, p. 1284, doi. 10.1002/cmdc.201600014
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- Publication type:
- Article
Novel Tacrine-Grafted Ugi Adducts as Multipotent Anti-Alzheimer Drugs: A Synthetic Renewal in Tacrine-Ferulic Acid Hybrids.
- Published in:
- ChemMedChem, 2015, v. 10, n. 3, p. 523, doi. 10.1002/cmdc.201402409
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- Publication type:
- Article
Toward the Development of Dual-Targeted Glyceraldehyde-3-phosphate Dehydrogenase/Trypanothione Reductase Inhibitors against Trypanosoma brucei and Trypanosoma cruzi.
- Published in:
- ChemMedChem, 2014, v. 9, n. 2, p. 371, doi. 10.1002/cmdc.201300399
- By:
- Publication type:
- Article
The Bivalent Ligand Approach as a Tool for Improving the in vitro Anti-Alzheimer Multitarget Profile of Dimebon.
- Published in:
- ChemMedChem, 2013, v. 8, n. 8, p. 1276, doi. 10.1002/cmdc.201300263
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- Publication type:
- Article
Remembering Marie Curie's Legacy.
- Published in:
- ChemMedChem, 2011, v. 6, n. 4, p. 575, doi. 10.1002/cmdc.201100083
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- Publication type:
- Article
Hybrid Lipoic Acid Derivatives to Attack Prion Disease on Multiple Fronts.
- Published in:
- ChemMedChem, 2011, v. 6, n. 4, p. 601, doi. 10.1002/cmdc.201100072
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- Publication type:
- Article
Corrigendum: Cover Picture: Discovery of a Class of Diketopiperazines as Antiprion Compounds (ChemMedChem 8/2010).
- Published in:
- ChemMedChem, 2010, v. 5, n. 9, p. 1414, doi. 10.1002/cmdc.201090039
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- Publication type:
- Article
A perspective on multi‐target drug discovery and design for complex diseases.
- Published in:
- Clinical & Translational Medicine, 2018, v. 7, n. 1, p. 1, doi. 10.1186/s40169-017-0181-2
- By:
- Publication type:
- Article
Click Chemistry and Targeted Degradation: A Winning Combination for Medicinal Chemists?
- Published in:
- ChemMedChem, 2023, v. 18, n. 20, p. 1, doi. 10.1002/cmdc.202300422
- By:
- Publication type:
- Article
Turning Donepezil into a Multi‐Target‐Directed Ligand through a Merging Strategy.
- Published in:
- ChemMedChem, 2021, v. 16, n. 1, p. 187, doi. 10.1002/cmdc.202000484
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- Publication type:
- Article
Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library.
- Published in:
- Pharmaceutics, 2022, v. 14, n. 2, p. 391, doi. 10.3390/pharmaceutics14020391
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- Publication type:
- Article
Design and In Vitro Study of a Dual Drug-Loaded Delivery System Produced by Electrospinning for the Treatment of Acute Injuries of the Central Nervous System.
- Published in:
- Pharmaceutics, 2021, v. 13, n. 6, p. 848, doi. 10.3390/pharmaceutics13060848
- By:
- Publication type:
- Article
In Vitro and In Silico Analysis of New n-Butyl and Isobutyl Quinoxaline-7-carboxylate 1,4-di- N -oxide Derivatives against Trypanosoma cruzi as Trypanothione Reductase Inhibitors.
- Published in:
- International Journal of Molecular Sciences, 2022, v. 23, n. 21, p. 13315, doi. 10.3390/ijms232113315
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- Publication type:
- Article