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MEK inhibitors for neurofibromatosis type 1 manifestations: Clinical evidence and consensus.
- Published in:
- Neuro-Oncology, 2022, v. 24, n. 11, p. 1845, doi. 10.1093/neuonc/noac165
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- Publication type:
- Article
Inhibition of Bromodomain and Extra Terminal (BET) Domain Activity Modulates the IL-23R/IL-17 Axis and Suppresses Acute Graft- Versus -Host Disease.
- Published in:
- Frontiers in Oncology, 2021, v. 11, p. 1, doi. 10.3389/fonc.2021.760789
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- Article
Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model.
- Published in:
- Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-11674-z
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- Article
PLX9486 shows anti-tumor efficacy in patient-derived, tyrosine kinase inhibitor-resistant KIT-mutant xenograft models of gastrointestinal stromal tumors.
- Published in:
- Clinical & Experimental Medicine, 2019, v. 19, n. 2, p. 201, doi. 10.1007/s10238-018-0541-2
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- Article
KRAS insertion mutations are oncogenic and exhibit distinct functional properties.
- Published in:
- Nature Communications, 2016, v. 7, n. 2, p. 10647, doi. 10.1038/ncomms10647
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- Article
The transcription cofactor c-JUN mediates phenotype switching and BRAF inhibitor resistance in melanoma.
- Published in:
- Science Signaling, 2015, v. 8, n. 390, p. 1, doi. 10.1126/scisignal.aab1111
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- Article
Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition.
- Published in:
- BMC Cancer, 2015, v. 15, n. 1, p. 1, doi. 10.1186/s12885-015-1377-8
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- Article
Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition.
- Published in:
- 2015
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- Publication type:
- journal article
PLC-γ and PI3K Link Cytokines to ERK Activation in Hematopoietic Cells with Normal and Oncogenic Kras.
- Published in:
- Science Signaling, 2013, v. 6, n. 304, p. 1, doi. 10.1126/scisignal.2004125
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- Article
Drug discovery: Pocket of opportunity.
- Published in:
- Nature, 2013, v. 503, n. 7477, p. 475, doi. 10.1038/nature12835
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- Article
Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy.
- Published in:
- Pigment Cell & Melanoma Research, 2013, v. 26, n. 6, p. 845, doi. 10.1111/pcmr.12148
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- Publication type:
- Article
Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition.
- Published in:
- Acta Neuropathologica, 2013, v. 125, n. 1, p. 159, doi. 10.1007/s00401-012-1056-7
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- Publication type:
- Article
Vemurafenib: the first drug approved for BRAF-mutant cancer.
- Published in:
- Nature Reviews Drug Discovery, 2012, v. 11, n. 11, p. 873, doi. 10.1038/nrd3847
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- Publication type:
- Article
Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation.
- Published in:
- 2011
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- Publication type:
- journal article
Interrogating the kinome.
- Published in:
- Nature Biotechnology, 2011, v. 29, n. 11, p. 981, doi. 10.1038/nbt.2021
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- Publication type:
- Article
The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis.
- Published in:
- Nephrology Dialysis Transplantation, 2011, v. 26, n. 11, p. 3458, doi. 10.1093/ndt/gfr432
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- Publication type:
- Article
Report from the Fifth National Cancer Institute Mouse Models of Human Cancers Consortium Nervous System Tumors Workshop.
- Published in:
- Neuro-Oncology, 2011, v. 13, n. 7, p. 692, doi. 10.1093/neuonc/nor080
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- Publication type:
- Article
Optimizing targeted therapeutic development: Analysis of a colorectal cancer patient population with the BRAF.
- Published in:
- International Journal of Cancer, 2011, v. 128, n. 9, p. 2075, doi. 10.1002/ijc.25555
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- Publication type:
- Article
Targeting BRAF<sup>V600E</sup> with PLX4720 Displays Potent Antimigratory and Anti-invasive Activity in Preclinical Models of Human Thyroid Cancer.
- Published in:
- Oncologist, 2011, v. 16, n. 3, p. 296, doi. 10.1634/theoncologist.2010-0317
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- Publication type:
- Article
PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas.
- Published in:
- Pigment Cell & Melanoma Research, 2010, v. 23, n. 6, p. 820, doi. 10.1111/j.1755-148X.2010.00763.x
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- Publication type:
- Article
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma.
- Published in:
- Nature, 2010, v. 467, n. 7315, p. 596, doi. 10.1038/nature09454
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- Publication type:
- Article
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.
- Published in:
- Nature, 2010, v. 464, n. 7287, p. 427, doi. 10.1038/nature08902
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- Publication type:
- Article
Cytostatic Activity of Adenosine Triphosphate-Competitive Kinase Inhibitors in BRAF Mutant Thyroid Carcinoma Cells.
- Published in:
- Journal of Clinical Endocrinology & Metabolism, 2010, v. 95, n. 1, p. 450, doi. 10.1210/jc.2009-0373
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- Publication type:
- Article
Hyperactive Ras in developmental disorders and cancer.
- Published in:
- 2007
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- Correction notice
PPAR Pan Agonist Induces Body Weight Loss Through Induction of Satiety.
- Published in:
- Diabetes, 2007, v. 56, p. A338
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- Publication type:
- Article
Hyperactive Ras in developmental disorders and cancer.
- Published in:
- Nature Reviews Cancer, 2007, v. 7, n. 4, p. 295, doi. 10.1038/nrc2109
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- Publication type:
- Article
Sending out an SOS.
- Published in:
- Nature Genetics, 2007, v. 39, n. 1, p. 8, doi. 10.1038/ng0107-8
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- Publication type:
- Article
Corrigendum: Germline KRAS mutations cause Noonan syndrome.
- Published in:
- 2006
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- Publication type:
- Correction notice
Germline KRAS mutations cause Noonan syndrome.
- Published in:
- Nature Genetics, 2006, v. 38, n. 3, p. 331, doi. 10.1038/ng1748
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- Publication type:
- Article
A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design.
- Published in:
- Nature Biotechnology, 2005, v. 23, n. 2, p. 201, doi. 10.1038/nbt1059
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- Publication type:
- Article
The Mechanism of Action of Phenylalanine Hydroxylase.
- Published in:
- Annals of the New York Academy of Sciences, 1986, v. 471, n. 1, p. 226, doi. 10.1111/j.1749-6632.1986.tb48038.x
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- Publication type:
- Article