Works by Boletta, Alessandra

Results: 31

mTORC1-driven accumulation of the oncometabolite fumarate as a potential critical step in renal cancer progression.

Published in:

Molecular & Cellular Oncology, 2019, v. 6, n. 1, p. 1, doi. 10.1080/23723556.2018.1537709

By:

Drusian, Luca;
Boletta, Alessandra

Publication type:

Article

Role of the KEAP1-NRF2 Axis in Renal Cell Carcinoma.

Published in:

Cancers, 2020, v. 12, n. 11, p. 3458, doi. 10.3390/cancers12113458

By:

Clerici, Sara;
Boletta, Alessandra

Publication type:

Article

Targeting mitochondrial respiration and the BCL2 family in high‐grade MYC‐associated B‐cell lymphoma.

Published in:

Molecular Oncology, 2022, v. 16, n. 5, p. 1132, doi. 10.1002/1878-0261.13115

By:

Donati, Giulio;
Ravà, Micol;
Filipuzzi, Marco;
Nicoli, Paola;
Cassina, Laura;
Verrecchia, Alessandro;
Doni, Mirko;
Rodighiero, Simona;
Parodi, Federica;
Boletta, Alessandra;
Vellano, Christopher P.;
Marszalek, Joseph R.;
Draetta, Giulio F.;
Amati, Bruno

Publication type:

Article

Defective metabolism in polycystic kidney disease: potential for therapy and open questions.

Published in:

Nephrology Dialysis Transplantation, 2014, v. 29, n. 8, p. 1480, doi. 10.1093/ndt/gft521

By:

Rowe, Isaline;
Boletta, Alessandra

Publication type:

Article

Dissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways.

Published in:

Communications Biology, 2018, v. 1, n. 1, p. N.PAG, doi. 10.1038/s42003-018-0200-x

By:

Podrini, Christine;
Rowe, Isaline;
Pagliarini, Roberto;
Costa, Ana S. H.;
Chiaravalli, Marco;
Di Meo, Ivano;
Kim, Hyunho;
Distefano, Gianfranco;
Tiranti, Valeria;
Qian, Feng;
di Bernardo, Diego;
Frezza, Christian;
Boletta, Alessandra

Publication type:

Article

P-104: Targeting the mitochondrial protease CLPP in Multiple Myeloma.

Published in:

Clinical Lymphoma, Myeloma & Leukemia, 2021, v. 21, p. S95, doi. 10.1016/S2152-2650(21)02238-2

By:

Perini, Tommaso;
Oliva, Laura;
Materozzi, Maria;
Cassina, Laura;
Samur, Mehmet K.;
Orfanelli, Ugo;
Milan, Enrico;
Boletta, Alessandra;
Munshi, Nikhil C.;
Cenci, Simone

Publication type:

Article

Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium.

Published in:

Journal of Neuroscience, 2015, v. 35, n. 31, p. 11153, doi. 10.1523/JNEUROSCI.0686-15.2015

By:

Shinya Ohata;
Herranz-Pérez, Vicente;
Jin Nakatani;
Boletta, Alessandra;
García-Verdugo, José Manuel;
Álvarez-Buylla, Arturo

Publication type:

Article

A Regulatory Role of Polycystin-1 on Cystic Fibrosis Transmembrane Conductance Regulator Plasma Membrane Expression.

Published in:

Cellular Physiology & Biochemistry (Karger AG), 2006, v. 18, n. 1-3, p. 9, doi. 10.1159/000095133

By:

Ikeda, Masahiro;
Peying Fong;
Jie Cheng;
Boletta, Alessandra;
Feng Qian;
Xue-Mei Zhang;
Hui Cai;
Germino, Gregory G.;
Guggino, William B.

Publication type:

Article

Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy.

Published in:

Nature Medicine, 2013, v. 19, n. 4, p. 488, doi. 10.1038/nm.3092

By:

Rowe, Isaline;
Chiaravalli, Marco;
Mannella, Valeria;
Ulisse, Valeria;
Quilici, Giacomo;
Pema, Monika;
Song, Xuewen W;
Xu, Hangxue;
Mari, Silvia;
Qian, Feng;
Pei, York;
Musco, Giovanna;
Boletta, Alessandra

Publication type:

Article

Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration

Published in:

BMC Cell Biology, 2015, v. 16, n. 1, p. 15, doi. 10.1186/s12860-015-0059-3

By:

Castelli, Maddalena;
De Pascalis, Chiara;
Distefano, Gianfranco;
Ducano, Nadia;
Oldani, Amanda;
Lanzetti, Letizia;
Boletta, Alessandra

Publication type:

Article

Novel Functional Complexity of Polycystin-1 by GPS Cleavage In Vivo: Role in Polycystic Kidney Disease.

Published in:

Molecular & Cellular Biology, 2014, v. 34, n. 17, p. 3341, doi. 10.1128/MCB.00687-14

By:

Kurbegovic, Almira;
Hyunho Kim;
Hangxue Xu;
Shengqiang Yu;
Cruanès, Julie;
Maser, Robin L.;
Boletta, Alessandra;
Trudel, Marie;
Feng Qian

Publication type:

Article

Polycystin-1 Regulates Actomyosin Contraction and the Cellular Response to Extracellular Stiffness.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-53061-0

By:

Nigro, Elisa Agnese;
Distefano, Gianfranco;
Chiaravalli, Marco;
Matafora, Vittoria;
Castelli, Maddalena;
Pesenti Gritti, Angela;
Bachi, Angela;
Boletta, Alessandra

Publication type:

Article

Mitochondria remodeling during endometrial stromal cell decidualization.

Published in:

Life Science Alliance, 2024, v. 7, n. 12, p. 1, doi. 10.26508/lsa.202402627

By:

Torre, Marco Dalla;
Pittari, Daniele;
Boletta, Alessandra;
Cassina, Laura;
Sitia, Roberto;
Anelli, Tiziana

Publication type:

Article

Double inhibition of cAMP and mTOR signalling may potentiate the reduction of cell growth in ADPKD cells.

Published in:

Clinical & Experimental Nephrology, 2017, v. 21, n. 2, p. 203, doi. 10.1007/s10157-016-1289-1

By:

Stephanis, Lucia;
Bonon, Anna;
Varani, Katia;
Lanza, Giovanni;
Gafà, Roberta;
Pinton, Paolo;
Pema, Monika;
Somlo, Stefan;
Boletta, Alessandra;
Aguiari, Gianluca

Publication type:

Article

Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents.

Published in:

Nature, 2000, v. 408, n. 6815, p. 990, doi. 10.1038/35050128

By:

Hanaoka, Kazushige;
Qian, Feng;
Boletta, Alessandra;
Bhunia, Anil K.;
Piontek, Klaus;
Tsiokas, Leonidas;
Sukhatme, Vikas P.;
Guggino, William B.;
Germino, Gregory G.

Publication type:

Article

mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex.

Published in:

Nature Communications, 2016, v. 7, n. 3, p. 10786, doi. 10.1038/ncomms10786

By:

Pema, Monika;
Drusian, Luca;
Chiaravalli, Marco;
Castelli, Maddalena;
Yao, Qin;
Ricciardi, Sara;
Somlo, Stefan;
Qian, Feng;
Biffo, Stefano;
Boletta, Alessandra

Publication type:

Article

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism.

Published in:

Nature Communications, 2014, v. 5, n. 11, p. 5482, doi. 10.1038/ncomms6482

By:

Kim, Hyunho;
Xu, Hangxue;
Yao, Qin;
Li, Weizhe;
Huang, Qiong;
Outeda, Patricia;
Cebotaru, Valeriu;
Chiaravalli, Marco;
Boletta, Alessandra;
Piontek, Klaus;
Germino, Gregory G.;
Weinman, Edward J.;
Watnick, Terry;
Qian, Feng

Publication type:

Article

Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesis.

Published in:

Nature Communications, 2013, v. 4, n. 10, p. 2658, doi. 10.1038/ncomms3658

By:

Castelli, Maddalena;
Boca, Manila;
Chiaravalli, Marco;
Ramalingam, Harini;
Rowe, Isaline;
Distefano, Gianfranco;
Carroll, Thomas;
Boletta, Alessandra

Publication type:

Article

Deciphering Variability of PKD1 and PKD2 in an Italian Cohort of 643 Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD).

Published in:

Scientific Reports, 2016, p. 30850, doi. 10.1038/srep30850

By:

Carrera, Paola;
Calzavara, Silvia;
Magistroni, Riccardo;
den Dunnen, Johan T.;
Rigo, Francesca;
Stenirri, Stefania;
Testa, Francesca;
Messa, Piergiorgio;
Cerutti, Roberta;
Scolari, Francesco;
Izzi, Claudia;
Edefonti, Alberto;
Negrisolo, Susanna;
Benetti, Elisa;
Alibrandi, Maria Teresa Sciarrone;
Manunta, Paolo;
Boletta, Alessandra;
Ferrari, Maurizio

Publication type:

Article

Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1.

Published in:

Human Molecular Genetics, 2012, v. 21, n. 26, p. 5456, doi. 10.1093/hmg/dds391

By:

Foy, Rebecca L.;
Chitalia, Vipul C.;
Panchenko, Maria V.;
Zeng, Liling;
Lopez, Delia;
Lee, Jean W.;
Rana, Shaunak V.;
Boletta, Alessandra;
Qian, Feng;
Tsiokas, Leonidas;
Piontek, Klaus B.;
Germino, Gregory G.;
Zhou, Mina I.;
Cohen, Herbert T.

Publication type:

Article

Melanin-like nanoparticles as a potential novel therapeutic approach in ADPKD.

Published in:

EMBO Molecular Medicine, 2025, v. 17, n. 1, p. 6, doi. 10.1038/s44321-024-00173-4

By:

Cassina, Laura;
Boletta, Alessandra

Publication type:

Article

Inhibition of asparagine synthetase effectively retards polycystic kidney disease progression.

Published in:

EMBO Molecular Medicine, 2024, v. 16, n. 6, p. 1379, doi. 10.1038/s44321-024-00071-9

By:

Clerici, Sara;
Podrini, Christine;
Stefanoni, Davide;
Distefano, Gianfranco;
Cassina, Laura;
Steidl, Maria Elena;
Tronci, Laura;
Canu, Tamara;
Chiaravalli, Marco;
Spies, Daniel;
Bell 3rd, Thomas A;
Costa, Ana SH;
Esposito, Antonio;
D'Alessandro, Angelo;
Frezza, Christian;
Bachi, Angela;
Boletta, Alessandra

Publication type:

Article

Oxidative stress enhances the therapeutic action of a respiratory inhibitor in MYC‐driven lymphoma.

Published in:

EMBO Molecular Medicine, 2023, v. 15, n. 6, p. 1, doi. 10.15252/emmm.202216910

By:

Donati, Giulio;
Nicoli, Paola;
Verrecchia, Alessandro;
Vallelonga, Veronica;
Croci, Ottavio;
Rodighiero, Simona;
Audano, Matteo;
Cassina, Laura;
Ghsein, Aya;
Binelli, Giorgio;
Boletta, Alessandra;
Mitro, Nico;
Amati, Bruno

Publication type:

Article

Nephrocystin-1 Forms a Complex with Polycystin-1 via a Polyproline Motif/SH3 Domain Interaction and Regulates the Apoptotic Response in Mammals.

Published in:

PLoS ONE, 2010, v. 5, n. 9, p. 1, doi. 10.1371/journal.pone.0012719

By:

Wodarczyk, Claas;
Distefano, Gianfranco;
Rowe, Isaline;
Gaetani, Massimiliano;
Bricoli, Barbara;
Muorah, Mordi;
Spitaleri, Andrea;
Mannella, Valeria;
Ricchiuto, Piero;
Pema, Monika;
Castelli, Maddalena;
Casanova, Ariel E.;
Mollica, Luca;
Banzi, Manuela;
Boca, Manila;
Antignac, Corinne;
Saunier, Sophie;
Musco, Giovanna;
Boletta, Alessandra

Publication type:

Article

Identification of a Polycystin-1 Cleavage Product, P100, That Regulates Store Operated Ca<sup>2+</sup> Entry through Interactions with STIM1.

Published in:

PLoS ONE, 2010, v. 5, n. 8, p. 1, doi. 10.1371/journal.pone.0012305

By:

Woodward, Owen M.;
Yun Li;
Shengqiang Yu;
Greenwell, Patrick;
Wodarczyk, Claas;
Boletta, Alessandra;
Guggino, William B.;
Feng Qian

Publication type:

Article

A Novel Mouse Model Reveals that Polycystin-1 Deficiency in Ependyma and Choroid Plexus Results in Dysfunctional Cilia and Hydrocephalus.

Published in:

PLoS ONE, 2009, v. 4, n. 9, p. 1, doi. 10.1371/journal.pone.0007137

By:

Wodarczyk, Claas;
Rowe, Isaline;
Chiaravalli, Marco;
Pema, Monika;
Feng Qian;
Boletta, Alessandra

Publication type:

Article

Polycystin-1 Is Required for Stereocilia Structure But Not for Mechanotransduction in Inner Ear Hair Cells.

Published in:

Journal of Neuroscience, 2011, v. 31, n. 34, p. 12251, doi. 10.1523/JNEUROSCI.6531-10.2011

By:

Steigelman, Katherine A.;
Lelli, Andrea;
Xudong Wu;
Jiangang Gao;
Lin, Susan;
Piontek, Klaus;
Wodarczyk, Claas;
Boletta, Alessandra;
Hyunho Kim;
Feng Qian;
Germino, Gregory;
Géléoc, Gwenaélle S. G.;
Holt, Jeffrey R.;
Jian Zuo

Publication type:

Article

Role of the Polycystins in Cell Migration, Polarity, and Tissue Morphogenesis.

Published in:

Cells (2073-4409), 2015, v. 4, n. 4, p. 687, doi. 10.3390/cells4040687

By:

Nigro, Elisa Agnese;
Castelli, Maddalena;
Boletta, Alessandra

Publication type:

Article

Polycystin-1 Regulates Extracellular Signal-Regulated Kinase-Dependent Phosphorylation of Tuberin To Control Cell Size through mTOR and Its Downstream Effectors S6K and 4EBP1.

Published in:

Molecular & Cellular Biology, 2009, v. 29, n. 9, p. 2359, doi. 10.1128/MCB.01259-08

By:

Distefano, Gianfranco;
Boca, Manila;
Rowe, Isaline;
Wodarczyk, Claas;
Li Ma;
Piontek, Klaus B.;
Germino, Gregory G.;
Pandolfi, Pier Paolo;
Boletta, Alessandra

Publication type:

Article

Increased mitochondrial fragmentation in polycystic kidney disease acts as a modifier of disease progression.

Published in:

FASEB Journal, 2020, v. 34, n. 5, p. 6493, doi. 10.1096/fj.201901739RR

By:

Cassina, Laura;
Chiaravalli, Marco;
Boletta, Alessandra

Publication type:

Article

Defective glycolysis and the use of 2-deoxy- d-glucose in polycystic kidney disease: from animal models to humans.

Published in:

Journal of Nephrology (JNonline), 2017, v. 30, n. 4, p. 511, doi. 10.1007/s40620-017-0395-9

By:

Magistroni, Riccardo;
Boletta, Alessandra

Publication type:

Article