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Engineering multicellular living systems—a Keystone Symposia report.
Published in:
Annals of the New York Academy of Sciences, 2022, v. 1518, n. 1, p. 183, doi. 10.1111/nyas.14896
By:
- Cable, Jennifer;
- Arlotta, Paola;
- Parker, Kevin Kit;
- Hughes, Alex J.;
- Goodwin, Katharine;
- Mummery, Christine L.;
- Kamm, Roger D.;
- Engle, Sandra J.;
- Tagle, Danilo A.;
- Boj, Sylvia F.;
- Stanton, Alice E.;
- Morishita, Yoshihiro;
- Kemp, Melissa L.;
- Norfleet, Dennis A.;
- May, Elebeoba E.;
- Lu, Aric;
- Bashir, Rashid;
- Feinberg, Adam W.;
- Hull, Sarah M.;
- Gonzalez, Anjelica L.
Publication type:
Article
Correction: The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/β-Catenin Coactivators Essential for Intestinal Homeostasis.
Published in:
PLoS Biology, 2017, v. 15, n. 2, p. 1, doi. 10.1371/journal.pbio.1002596
By:
- Mahmoudi, Tokameh;
- Boj, Sylvia F.;
- Hatzis, Pantelis;
- Li, Vivian S. W.;
- Taouatas, Nadia;
- Vries, Robert G. J.;
- Teunissen, Hans;
- Begthel, Harry;
- Korving, Jeroen;
- Mohammed, Shabaz;
- Heck, Albert J. R.;
- Clevers, Hans
Publication type:
Article
Preclinical models of pancreatic ductal adenocarcinoma.
Published in:
Journal of Pathology, 2016, v. 238, n. 2, p. 197, doi. 10.1002/path.4651
By:
- Hwang, Chang-Il;
- Boj, Sylvia F;
- Clevers, Hans;
- Tuveson, David A
Publication type:
Article
RNF43 truncations trap CK1 to drive niche‐independent self‐renewal in cancer.
Published in:
EMBO Journal, 2020, v. 39, n. 18, p. 1, doi. 10.15252/embj.2019103932
By:
- Spit, Maureen;
- Fenderico, Nicola;
- Jordens, Ingrid;
- Radaszkiewicz, Tomasz;
- Lindeboom, Rik GH;
- Bugter, Jeroen M;
- Cristobal, Alba;
- Ootes, Lars;
- van Osch, Max;
- Janssen, Eline;
- Boonekamp, Kim E;
- Hanakova, Katerina;
- Potesil, David;
- Zdrahal, Zbynek;
- Boj, Sylvia F;
- Medema, Jan Paul;
- Bryja, Vitezslav;
- Koo, Bon‐Kyoung;
- Vermeulen, Michiel;
- Maurice, Madelon M
Publication type:
Article
Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma.
Published in:
eLife, 2021, p. 1, doi. 10.7554/eLife.60747
By:
- De Crignis, Elisa;
- Hossain, Tanvir;
- Romal, Shahla;
- Carofiglio, Fabrizia;
- Moulos, Panagiotis;
- Khalid, Mir Mubashir;
- Rao, Shringar;
- Bazrafshan, Ameneh;
- Verstegen, Monique M. A.;
- Pourfarzad, Farzin;
- Koutsothanassis, Christina;
- Gehart, Helmuth;
- Tsung Wai Kan;
- Palstra, Robert-Jan;
- Boucher, Charles;
- IJzermans, Jan N. M.;
- Huch, Meritxell;
- Boj, Sylvia F.;
- Vries, Robert;
- Clevers, Hans
Publication type:
Article
Mismatch Repair Status in Patient-Derived Colorectal Cancer Organoids Does Not Affect Intrinsic Tumor Cell Sensitivity to Systemic Therapy.
Published in:
Cancers, 2021, v. 13, n. 21, p. 5434, doi. 10.3390/cancers13215434
By:
- Küçükköse, Emre;
- Wensink, G. Emerens;
- Roelse, Celine M.;
- van Schelven, Susanne J.;
- Raats, Daniëlle A. E.;
- Boj, Sylvia F.;
- Koopman, Miriam;
- Laoukili, Jamila;
- Roodhart, Jeanine M. L.;
- Kranenburg, Onno
Publication type:
Article
EuroDia: a beta-cell gene expression resource.
Published in:
Database: The Journal of Biological Databases & Curation, 2010, v. 2010, p. 1, doi. 10.1093/database/baq024
By:
- Liechti, Robin;
- Csárdi, Gábor;
- Bergmann, Sven;
- Schütz, Frédéric;
- Sengstag, Thierry;
- Boj, Sylvia F.;
- Servitja, Joan-Marc;
- Ferrer, Jorge;
- Van Lommel, Leentje;
- Schuit, Frans;
- Klinger, Sonia;
- Thorens, Bernard;
- Naamane, Najib;
- Eizirik, Decio L.;
- Marselli, Lorella;
- Bugliani, Marco;
- Marchetti, Piero;
- Lucas, Stephanie;
- Holm, Cecilia;
- Jongeneel, C. Victor
Publication type:
Article
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis.
Published in:
EMBO Journal, 2013, v. 32, n. 20, p. 2708, doi. 10.1038/emboj.2013.204
By:
- Huch, Meritxell;
- Bonfanti, Paola;
- Boj, Sylvia F;
- Sato, Toshiro;
- Loomans, Cindy J M;
- van de Wetering, Marc;
- Sojoodi, Mozhdeh;
- Li, Vivian S W;
- Schuijers, Jurian;
- Gracanin, Ana;
- Ringnalda, Femke;
- Begthel, Harry;
- Hamer, Karien;
- Mulder, Joyce;
- van Es, Johan H;
- de Koning, Eelco;
- Vries, Robert G J;
- Heimberg, Harry;
- Clevers, Hans
Publication type:
Article
Rationale and design of the HIT-CF organoid study: stratifying cystic fibrosis patients based on intestinal organoid response to different CFTR-modulators.
Published in:
Translational Medicine Communications, 2020, v. 5, n. 1, p. 1, doi. 10.1186/s41231-020-00060-3
By:
- van Mourik, Peter;
- Michel, Sabine;
- Vonk, Annelotte M.;
- Beekman, Jeffrey M.;
- van der Ent, Cornelis K.;
- on behalf of the HIT-CF consortium;
- De Keyser, Hilde;
- Lammertyn, Elise;
- van Koningsbruggen-Rietschel, Silke;
- Naehrlich, Lutz;
- Pool, Judith;
- van de Craen, Marc;
- Aguilera, Begoña;
- Pott, Johanna;
- Vries, Rob G. J.;
- Boj, Sylvia F.;
- De Boeck, Kris;
- Vermeulen, François;
- Ramalho, Anabela S.;
- Silva, Iris A. L.
Publication type:
Article
A Novel--192c/g Mutation in the Proximal P2 Promoter of the Hepatocyte Nuclear Factor-4α Gene (HNF4A) Associates With Late-Onset Diabetes.
Published in:
Diabetes, 2006, v. 55, n. 6, p. 1869, doi. 10.2337/db05-1684
By:
- Ek, Jakob;
- Hansen, Sara P.;
- Lajer, Maria;
- Nicot, Carine;
- Boesgaard, Trine W.;
- Pruhova, Stepanka;
- Johansen, Anders;
- Albrechtsen, Anders;
- Yderstræde, Knud;
- Lauenborg, Jeannet;
- Parrizas, Marcelina;
- Boj, Sylvia F.;
- Jørgensen, Torben;
- Borch-Johnsen, Knut;
- Damm, Peter;
- Ferrer, Jorge;
- Lebl, Jan;
- Pedersen, Oluf;
- Hansen, Torben
Publication type:
Article
The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/β- Catenin Coactivators Essential for Intestinal Homeostasis.
Published in:
PLoS Biology, 2010, v. 8, n. 11, p. 1, doi. 10.1371/journal.pbio.1000539
By:
- Mahmoudi, Tokameh;
- Boj, Sylvia F.;
- Hatzis, Pantelis;
- Li, Vivian S. W.;
- Taouatas, Nadia;
- Vries, Robert G. J.;
- Teunissen, Hans;
- Begthel, Harry;
- Korving, Jeroen;
- Mohammed, Shabaz;
- Heck, Albert J. R.;
- Clevers, Hans
Publication type:
Article
In vitro expansion of single Lgr5<sup>+</sup> liver stem cells induced by Wnt-driven regeneration.
Published in:
Nature, 2013, v. 494, n. 7436, p. 247, doi. 10.1038/nature11826
By:
- Huch, Meritxell;
- Dorrell, Craig;
- Boj, Sylvia F.;
- van Es, Johan H.;
- Li, Vivian S. W.;
- van de Wetering, Marc;
- Sato, Toshiro;
- Hamer, Karien;
- Sasaki, Nobuo;
- Finegold, Milton J.;
- Haft, Annelise;
- Vries, Robert G.;
- Grompe, Markus;
- Clevers, Hans
Publication type:
Article
Patient-derived organoids as a predictive biomarker for treatment response in cancer patients.
Published in:
NPJ Precision Oncology, 2021, v. 5, n. 1, p. 1, doi. 10.1038/s41698-021-00168-1
By:
- Wensink, G. Emerens;
- Elias, Sjoerd G.;
- Mullenders, Jasper;
- Koopman, Miriam;
- Boj, Sylvia F.;
- Kranenburg, Onno W.;
- Roodhart, Jeanine M. L.
Publication type:
Article
Organoids as a biomarker for personalized treatment in metastatic colorectal cancer: drug screen optimization and correlation with patient response.
Published in:
Journal of Experimental & Clinical Cancer Research (17569966), 2024, v. 43, n. 1, p. 1, doi. 10.1186/s13046-024-02980-6
By:
- Smabers, Lidwien P.;
- Wensink, Emerens;
- Verissimo, Carla S.;
- Koedoot, Esmee;
- Pitsa, Katerina-Chara;
- Huismans, Maarten A.;
- Higuera Barón, Celia;
- Doorn, Mayke;
- Valkenburg-van Iersel, Liselot B.;
- Cirkel, Geert A.;
- Brousali, Anneta;
- Overmeer, René;
- Koopman, Miriam;
- Braat, Manon N.;
- Penning de Vries, Bas;
- Elias, Sjoerd G.;
- Vries, Robert G.;
- Kranenburg, Onno;
- Boj, Sylvia F.;
- Roodhart, Jeanine M.
Publication type:
Article
G970R‐CFTR Mutation (c.2908G>C) Results Predominantly in a Splicing Defect.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 2, p. 656, doi. 10.1111/cts.12927
By:
- Fidler, Meredith C.;
- Buckley, Alexandra;
- Sullivan, James C.;
- Statia, Marvin;
- Boj, Sylvia F.;
- Vries, Robert G. J.;
- Munck, Anne;
- Higgins, Mark;
- Moretto Zita, Matteo;
- Negulescu, Paul;
- Goor, Fredrick;
- De Boeck, Kris
Publication type:
Article
Epistasis of Transcriptomes Reveals Synergism between Transcriptional Activators Hnf1α and Hnf4α.
Published in:
PLoS Genetics, 2010, v. 6, n. 5, p. 1, doi. 10.1371/journal.pgen.1000970
By:
- Boj, Sylvia F.;
- Petrov, Dimitri;
- Ferrer, Jorge
Publication type:
Article
Generation and initial characterization of novel tumour organoid models to study human pancreatic cancer‐induced cachexia.
Published in:
Journal of Cachexia, Sarcopenia & Muscle, 2020, v. 11, n. 6, p. 1509, doi. 10.1002/jcsm.12627
By:
- Vaes, Rianne D.W.;
- Dijk, David P.J.;
- Welbers, Tessa T.J.;
- Blok, Marinus J.;
- Aberle, Merel R.;
- Heij, Lara;
- Boj, Sylvia F.;
- Olde Damink, Steven W.M.;
- Rensen, Sander S.
Publication type:
Article
Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas.
Published in:
Human Molecular Genetics, 2003, v. 12, n. 24, p. 3307, doi. 10.1093/hmg/ddg355
By:
- Maestro, Miguel A.;
- Boj, Sylvia F.;
- Luco, Reini F.;
- Pierreux, Christophe E.;
- Cabedo, Judit;
- Servitja, Joan M.;
- German, Michael S.;
- Rousseau, Guy G.;
- Lemaigre, Frédéric P.;
- Ferrer, Jorge
Publication type:
Article
Long-term culture, genetic manipulation and xenotransplantation of human normal and breast cancer organoids.
Published in:
Nature Protocols, 2021, v. 16, n. 4, p. 1936, doi. 10.1038/s41596-020-00474-1
By:
- Dekkers, Johanna F.;
- van Vliet, Esmée J.;
- Sachs, Norman;
- Rosenbluth, Jennifer M.;
- Kopper, Oded;
- Rebel, Heggert G.;
- Wehrens, Ellen J.;
- Piani, Carol;
- Visvader, Jane E.;
- Verissimo, Carla S.;
- Boj, Sylvia F.;
- Brugge, Joan S.;
- Clevers, Hans;
- Rios, Anne C.
Publication type:
Article
Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene.
Published in:
2007
By:
- Pearson, Ewan R.;
- Boj, Sylvia F.;
- Steele, Anna M.;
- Barrett, Timothy;
- Stals, Karen;
- Shield, Julian P.;
- Ellard, Sian;
- Ferrer, Jorge;
- Hattersley, Andrew T.
Publication type:
journal article
Functional targets of the monogenic diabetes transcription factors HNF-1alpha and HNF-4alpha are highly conserved between mice and humans.
Published in:
2009
By:
- Boj SF;
- Servitja JM;
- Martin D;
- Rios M;
- Talianidis I;
- Guigo R;
- Ferrer J;
- Boj, Sylvia F;
- Servitja, Joan Marc;
- Martin, David;
- Rios, Martin;
- Talianidis, Iannis;
- Guigo, Roderic;
- Ferrer, Jorge
Publication type:
journal article
Functional Targets of the Monogenic Diabetes Transcription Factors HNF-1α and HNF-4α Are Highly Conserved Between Mice and Humans.
Published in:
Diabetes, 2009, v. 58, n. 5, p. 1245, doi. 10.2337/db08-0812
By:
- Boj, Sylvia F.;
- Servitja, Joan Marc;
- Martin, David;
- Rios, Martin;
- Talianidis, Iannis;
- Guigo, Roderic;
- Ferrer, Jorge
Publication type:
Article

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