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Clearance of systemic hematologic tumors by venetoclax (Abt-199) and navitoclax.
Published in:
Pharmacology Research & Perspectives, 2015, v. 3, n. 5, p. 1, doi. 10.1002/prp2.178
By:
- Ackler, Scott;
- Oleksijew, Anatol;
- Chen, Jun;
- Chyla, Brenda J.;
- Clarin, Jerry;
- Foster, Kelly;
- McGonigal, Thomas;
- Mishra, Sasmita;
- Schlessinger, Sally;
- Smith, Morey L.;
- Tahir, Stephen K.;
- Leverson, Joel D.;
- Souers, Andrew J.;
- Boghaert, Erwin R.;
- Hickson, Jonathan
Publication type:
Article
Application of LDH assay for therapeutic efficacy evaluation of ex vivo tumor models.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-97894-0
By:
- Cox, Megan C.;
- Mendes, Rita;
- Silva, Fernanda;
- Mendes, Teresa F.;
- Zelaya-Lazo, Adelyn;
- Halwachs, Kathleen;
- Purkal, Julie J.;
- Isidro, Inês A.;
- Félix, Ana;
- Boghaert, Erwin R.;
- Brito, Catarina
Publication type:
Article
Reduction of translation initiation factor 4E decreases the malignancy of ras -transformed cloned rat embryo fibroblasts.
Published in:
International Journal of Cancer, 1995, v. 60, n. 2, p. 255, doi. 10.1002/ijc.2910600221
By:
- Graff, Jeremy R.;
- Boghaert, Erwin R.;
- De Benedetti, Arrigo;
- Tudor, Dianna L.;
- Zimmer, Constance C.;
- Chan, Shung Kai;
- Zimmer, Stephen G.
Publication type:
Article
Invasion by WC5 rat cerebellar cells is independent of RSV-induced changes in growth and adhesion.
Published in:
International Journal of Cancer, 1991, v. 49, n. 2, p. 239, doi. 10.1002/ijc.2910490217
By:
- Brady-Kalnay, Susann M.;
- Boghaert, Erwin R.;
- Zimmer, Stephen;
- Soll, David R.;
- Brackenbury, Robert
Publication type:
Article
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets.
Published in:
Nature Medicine, 2013, v. 19, n. 2, p. 202, doi. 10.1038/nm.3048
By:
- Souers, Andrew J;
- Leverson, Joel D;
- Boghaert, Erwin R;
- Ackler, Scott L;
- Catron, Nathaniel D;
- Chen, Jun;
- Dayton, Brian D;
- Ding, Hong;
- Enschede, Sari H;
- Fairbrother, Wayne J;
- Huang, David C S;
- Hymowitz, Sarah G;
- Jin, Sha;
- Khaw, Seong Lin;
- Kovar, Peter J;
- Lam, Lloyd T;
- Lee, Jackie;
- Maecker, Heather L;
- Marsh, Kennan C;
- Mason, Kylie D
Publication type:
Article
Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery.
Published in:
Scientific Reports, 2016, p. 28951, doi. 10.1038/srep28951
By:
- Stock, Kristin;
- Estrada, Marta F.;
- Vidic, Suzana;
- Gjerde, Kjersti;
- Rudisch, Albin;
- Santo, Vítor E.;
- Barbier, Michaël;
- Blom, Sami;
- Arundkar, Sharath C.;
- Selvam, Irwin;
- Osswald, Annika;
- Stein, Yan;
- Gruenewald, Sylvia;
- Brito, Catarina;
- van Weerden, Wytske;
- Rotter, Varda;
- Boghaert, Erwin;
- Oren, Moshe;
- Sommergruber, Wolfgang;
- Chong, Yolanda
Publication type:
Article
Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification.
Published in:
2016
By:
- Jieyi Wang;
- Goetsch, Liliane;
- Tucker, Lora;
- Qian Zhang;
- Gonzalez, Alexandra;
- Vaidya, Kedar S.;
- Oleksijew, Anatol;
- Boghaert, Erwin;
- Minghao Song;
- Sokolova, Irina;
- Pestova, Ekaterina;
- Anderson, Mark;
- Pappano, William N.;
- Ansell, Peter;
- Bhathena, Anahita;
- Naumovski, Louie;
- Corvaia, Nathalie;
- Reilly, Edward B.;
- Wang, Jieyi;
- Zhang, Qian
Publication type:
journal article
CD20-specific antibody-targeted chemotherapy of non-Hodgkin’s B-cell lymphoma using calicheamicin-conjugated rituximab.
Published in:
Cancer Immunology, Immunotherapy, 2007, v. 56, n. 7, p. 1107, doi. 10.1007/s00262-006-0260-5
By:
- DiJoseph, John F.;
- Dougher, Maureen M.;
- Armellino, Douglas C.;
- Kalyandrug, Lyka;
- Kunz, Arthur;
- Boghaert, Erwin R.;
- Hamann, Philip R.;
- Damle, Nitin K.
Publication type:
Article
Antibody-targeted chemotherapy of B-cell lymphoma using calicheamicin conjugated to murine or humanized antibody against CD22.
Published in:
Cancer Immunology, Immunotherapy, 2005, v. 54, n. 1, p. 11, doi. 10.1007/s00262-004-0572-2
By:
- DiJoseph, John;
- Popplewell, Andrew;
- Tickle, Simon;
- Ladyman, Heather;
- Lawson, Alastair;
- Kunz, Arthur;
- Khandke, Kiran;
- Armellino, Douglas;
- Boghaert, Erwin;
- Hamann, Philip;
- Zinkewich-Peotti, Karen;
- Stephens, Sue;
- Weir, Neil;
- Damle, Nitin
Publication type:
Article
A "Prozone-Like" Effect Influences the Efficacy of the Monoclonal Antibody ABT-700 against the Hepatocyte Growth Factor Receptor.
Published in:
Pharmacology, 2017, v. 100, n. 5/6, p. 229, doi. 10.1159/000478663
By:
- Vaidya, Kedar S.;
- Oleksijew, anatol;
- Tucker, Lora a.;
- Pappano, William N.;
- anderson, Mark G.;
- Grinnell, Christine M.;
- Zhang, Qian;
- Heighton, Sarah J.;
- Mitten, Michael J.;
- Mishra, Sasmita;
- Palma, Joann P.;
- Wang, Jieyi;
- Reilly, Edward B.;
- Boghaert, Erwin R.
Publication type:
Article
Exploring Metabolic Signatures of Ex Vivo Tumor Tissue Cultures for Prediction of Chemosensitivity in Ovarian Cancer.
Published in:
Cancers, 2022, v. 14, n. 18, p. N.PAG, doi. 10.3390/cancers14184460
By:
- Mendes, Rita;
- Graça, Gonçalo;
- Silva, Fernanda;
- Guerreiro, Ana C. L.;
- Gomes-Alves, Patrícia;
- Serpa, Jacinta;
- Boghaert, Erwin R.;
- Alves, Paula M.;
- Félix, Ana;
- Brito, Catarina;
- Isidro, Inês A.
Publication type:
Article
Patient-Derived Explants of Colorectal Cancer: Histopathological and Molecular Analysis of Long-Term Cultures.
Published in:
Cancers, 2021, v. 13, n. 18, p. 4695, doi. 10.3390/cancers13184695
By:
- da Mata, Sara;
- Franchi-Mendes, Teresa;
- Abreu, Sofia;
- Filipe, Bruno;
- Morgado, Sónia;
- Mesquita, Marta;
- Albuquerque, Cristina;
- Fonseca, Ricardo;
- Santo, Vítor E.;
- Boghaert, Erwin R.;
- Rosa, Isadora;
- Brito, Catarina
Publication type:
Article
Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy.
Published in:
Science Translational Medicine, 2015, v. 7, n. 279, p. 1, doi. 10.1126/scitranslmed.aaa4642
By:
- Leverson, Joel D.;
- Phillips, Darren C.;
- Mitten, Michael J.;
- Boghaert, Erwin R.;
- Diaz, Dolores;
- Tahir, Stephen K.;
- Belmont, Lisa D.;
- Nimmer, Paul;
- Yu Xiao;
- Xiaoju Max Ma;
- Lowes, Kym N.;
- Kovar, Peter;
- Jun Chen;
- Sha Jin;
- Smith, Morey;
- Xue, John;
- Haichao Zhang;
- Oleksijew, Anatol;
- Magoc, Terrance J.;
- Vaidya, Kedar S.
Publication type:
Article
Determination of pharmacokinetic values of calicheamicin-antibody conjugates in mice by plasmon resonance analysis of small (5 μl) blood samples.
Published in:
Cancer Chemotherapy & Pharmacology, 2008, v. 61, n. 6, p. 1027, doi. 10.1007/s00280-007-0560-2
By:
- Boghaert, Erwin R.;
- Khandke, Kiran M.;
- Sridharan, Latha;
- Dougher, Maureen;
- DiJoseph, John F.;
- Kunz, Arthur;
- Hamann, Philip R.;
- Moran, Justin;
- Chaudhary, Inder;
- Damle, Nitin K.
Publication type:
Article
Patient-derived ovarian cancer explants: preserved viability and histopathological features in long-term agitation-based cultures.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-76291-z
By:
- Abreu, Sofia;
- Silva, Fernanda;
- Mendes, Rita;
- Mendes, Teresa F.;
- Teixeira, Marta;
- Santo, Vítor E.;
- Boghaert, Erwin R.;
- Félix, Ana;
- Brito, Catarina
Publication type:
Article
Genetic biomarkers of sensitivity and resistance to venetoclax monotherapy in patients with relapsed acute myeloid leukemia.
Published in:
American Journal of Hematology, 2018, v. 93, n. 8, p. E202, doi. 10.1002/ajh.25146
By:
- Chyla, Brenda;
- Daver, Naval;
- Doyle, Kelly;
- McKeegan, Evelyn;
- Huang, Xin;
- Ruvolo, Vivian;
- Wang, Zixing;
- Chen, Ken;
- Souers, Andrew;
- Leverson, Joel;
- Potluri, Jalaja;
- Boghaert, Erwin;
- Bhathena, Anahita;
- Konopleva, Marina;
- Popovic, Relja
Publication type:
Article
Butyrate Alters the Expression and Activity of Cell Cycle Components in Anaplastic Thyroid Carcinoma Cells.
Published in:
Thyroid, 2001, v. 11, n. 1, p. 21, doi. 10.1089/10507250150500621
By:
- Greenberg, Victoria L.;
- Williams, Jennifer M.;
- Boghaert, Erwin;
- Mendenhall, Michael;
- Ain, Kenneth B.;
- Zimmer, Stephen G.
Publication type:
Article
Synergistic therapeutic benefit by combining the antibody drug conjugate, depatux-m with temozolomide in pre-clinical models of glioblastoma with overexpression of EGFR.
Published in:
Journal of Neuro-Oncology, 2021, v. 152, n. 2, p. 233, doi. 10.1007/s11060-021-03703-z
By:
- Vaidya, Kedar S.;
- Mitten, Michael J.;
- Zelaya-Lazo, Adelyn L.;
- Oleksijew, Anatol;
- Alvey, Cory;
- Falls, Hugh D.;
- Mishra, Sasmita;
- Palma, Joann;
- Ansell, Peter;
- Phillips, Andrew C.;
- Reilly, Edward B.;
- Anderson, Mark;
- Boghaert, Erwin R.
Publication type:
Article
Drug screening in 3D in vitro tumor models: overcoming current pitfalls of efficacy read-outs.
Published in:
Biotechnology Journal, 2017, v. 12, n. 1, p. n/a, doi. 10.1002/biot.201600505
By:
- Santo, Vítor E.;
- Rebelo, Sofia P.;
- Estrada, Marta F.;
- Alves, Paula M.;
- Boghaert, Erwin;
- Brito, Catarina
Publication type:
Article

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