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Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.
Published in:
Angewandte Chemie, 2019, v. 131, n. 2, p. 525, doi. 10.1002/ange.201810179
By:
- Vazquez‐Rodriguez, Saleta;
- Wright, Miranda;
- Rogers, Catherine M.;
- Cribbs, Adam P.;
- Velupillai, Srikannathasan;
- Philpott, Martin;
- Lee, Henry;
- Dunford, James E.;
- Huber, Kilian V. M.;
- Robers, Matthew B.;
- Vasta, James D.;
- Thezenas, Marie‐Laetitia;
- Bonham, Sarah;
- Kessler, Benedikt;
- Bennett, James;
- Fedorov, Oleg;
- Raynaud, Florence;
- Donovan, Adam;
- Blagg, Julian;
- Bavetsias, Vassilios
Publication type:
Article
Dynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single-Molecule Spectroscopy.
Published in:
Angewandte Chemie, 2017, v. 129, n. 38, p. 11567, doi. 10.1002/ange.201704654
By:
- Gilburt, James A. H.;
- Sarkar, Hajrah;
- Sheldrake, Peter;
- Blagg, Julian;
- Ying, Liming;
- Dodson, Charlotte A.
Publication type:
Article
Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.
Published in:
Angewandte Chemie International Edition, 2019, v. 58, n. 2, p. 515, doi. 10.1002/anie.201810179
By:
- Vazquez‐Rodriguez, Saleta;
- Wright, Miranda;
- Rogers, Catherine M.;
- Cribbs, Adam P.;
- Velupillai, Srikannathasan;
- Philpott, Martin;
- Lee, Henry;
- Dunford, James E.;
- Huber, Kilian V. M.;
- Robers, Matthew B.;
- Vasta, James D.;
- Thezenas, Marie‐Laetitia;
- Bonham, Sarah;
- Kessler, Benedikt;
- Bennett, James;
- Fedorov, Oleg;
- Raynaud, Florence;
- Donovan, Adam;
- Blagg, Julian;
- Bavetsias, Vassilios
Publication type:
Article
Dynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single-Molecule Spectroscopy.
Published in:
Angewandte Chemie International Edition, 2017, v. 56, n. 38, p. 11409, doi. 10.1002/anie.201704654
By:
- Gilburt, James A. H.;
- Sarkar, Hajrah;
- Sheldrake, Peter;
- Blagg, Julian;
- Ying, Liming;
- Dodson, Charlotte A.
Publication type:
Article
Donated chemical probes for open science.
Published in:
eLife, 2018, p. 1, doi. 10.7554/eLife.34311
By:
- MUÜLLER, SUSANNE;
- ACKLOO, SUZANNE;
- ARROWSMITH, CHERYL H.;
- BAUSER, MARCUS;
- BARYZA, JEREMY L.;
- BLAGG, JULIAN;
- BÖTTCHER, JARK;
- BOUNTRA, CHAS;
- BROWN, PETER J.;
- BUNNAGE, MARK E.;
- CARTER, ADRIAN J.;
- DAMERELL, DAVID;
- DÖTSCH, VOLKER;
- DREWRY, DAVID H.;
- EDWARDS, ALED M.;
- EDWARDS, JAMES;
- ELKINS, JON M.;
- FISCHER, CHRISTIAN;
- FRYE, STEPHEN V.;
- GOLLNER, ANDREAS
Publication type:
Article
Diverse Functionalization of Aurora-A Kinase at Specified Surface and Buried Sites by Native Chemical Modification.
Published in:
PLoS ONE, 2014, v. 9, n. 8, p. 1, doi. 10.1371/journal.pone.0103935
By:
- Rowan, Fiona;
- Richards, Meirion;
- Widya, Marcella;
- Bayliss, Richard;
- Blagg, Julian
Publication type:
Article
Fragment-Based Screening Maps Inhibitor Interactions in the ATP-Binding Site of Checkpoint Kinase 2.
Published in:
PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0065689
By:
- Silva-Santisteban, M. Cris;
- Westwood, Isaac M.;
- Boxall, Kathy;
- Brown, Nathan;
- Peacock, Sam;
- McAndrew, Craig;
- Barrie, Elaine;
- Richards, Meirion;
- Mirza, Amin;
- Oliver, Antony W.;
- Burke, Rosemary;
- Hoelder, Swen;
- Jones, Keith;
- Aherne, G. Wynne;
- Blagg, Julian;
- Collins, Ian;
- Garrett, Michelle D.;
- van Montfort, Rob L. M.
Publication type:
Article
Mechanism-Based Screen for G1/S Checkpoint Activators Identifies a Selective Activator of EIF2AK3/PERK Signalling.
Published in:
PLoS ONE, 2012, v. 7, n. 1, p. 1, doi. 10.1371/journal.pone.0028568
By:
- Stockwell, Simon R.;
- Platt, Georgina;
- Barrie, S. Elaine;
- Zoumpoulidou, Georgia;
- te Poele, Robert H.;
- Aherne, G. Wynne;
- Wilson, Stuart C.;
- Sheldrake, Peter;
- McDonald, Edward;
- Venet, Mathilde;
- Soudy, Christelle;
- Elustondo, Frédéric;
- Rigoreau, Laurent;
- Blagg, Julian;
- Workman, Paul;
- Garrett, Michelle D.;
- Mittnacht, Sibylle
Publication type:
Article
Analysis of water patterns in protein kinase binding sites.
Published in:
Proteins, 2011, v. 79, n. 7, p. 2109, doi. 10.1002/prot.23032
By:
- Barillari, Caterina;
- Duncan, Anna L.;
- Westwood, Isaac M.;
- Blagg, Julian;
- van Montfort, Rob L. M.
Publication type:
Article
Asymmetric Diels- Alder reactions: X-Ray crystal-structure analysis of [ N-(( E)-But-2-enoyl)bornane-10,2-sultam]tetrachlorotitanium.
Published in:
Helvetica Chimica Acta, 1989, v. 72, n. 1, p. 123, doi. 10.1002/hlca.19890720116
By:
- Oppolzer, Wolfgang;
- Rodriguez, Inès;
- Blagg, Julian;
- Bernardinelli, Gérald
Publication type:
Article
Role for the Histone Demethylase KDM4B in Rhabdomyosarcoma via CDK6 and CCNA2: Compensation by KDM4A and Apoptotic Response of Targeting Both KDM4B and KDM4A.
Published in:
Cancers, 2021, v. 13, n. 7, p. 1734, doi. 10.3390/cancers13071734
By:
- Walters, Zoë S.;
- Aladowicz, Ewa;
- Villarejo-Balcells, Barbara;
- Nugent, Gary;
- Selfe, Joanna L.;
- Eve, Paul;
- Blagg, Julian;
- Rossanese, Olivia;
- Shipley, Janet;
- Uren, Aykut
Publication type:
Article
Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor.
Published in:
Molecular Oncology, 2018, v. 12, n. 3, p. 287, doi. 10.1002/1878-0261.12148
By:
- Whittaker, Steven R.;
- Barlow, Clare;
- Martin, Mathew P.;
- Mancusi, Caterina;
- Wagner, Steve;
- Self, Annette;
- Barrie, Elaine;
- Te Poele, Robert;
- Sharp, Swee;
- Brown, Nathan;
- Wilson, Stuart;
- Jackson, Wayne;
- Fischer, Peter M.;
- Clarke, Paul A.;
- Walton, Michael I.;
- McDonald, Edward;
- Blagg, Julian;
- Noble, Martin;
- Garrett, Michelle D.;
- Workman, Paul
Publication type:
Article
Mapping the 3D structures of small molecule binding sites.
Published in:
Journal of Cheminformatics, 2016, v. 8, n. 1, p. 1, doi. 10.1186/s13321-016-0180-0
By:
- Meyers, Joshua;
- Brown, Nathan;
- Blagg, Julian
Publication type:
Article
Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy.
Published in:
2017
By:
- Faisal, Amir;
- Mak, Grace W Y;
- Gurden, Mark D;
- Xavier, Cristina P R;
- Anderhub, Simon J;
- Innocenti, Paolo;
- Westwood, Isaac M;
- Naud, Sébastien;
- Hayes, Angela;
- Box, Gary;
- Valenti, Melanie R;
- De Haven Brandon, Alexis K;
- O'Fee, Lisa;
- Schmitt, Jessica;
- Woodward, Hannah L;
- Burke, Rosemary;
- vanMontfort, Rob L M;
- Blagg, Julian;
- Raynaud, Florence I;
- Eccles, Suzanne A
Publication type:
journal article
Catalytic inhibition of KDM1A in Ewing sarcoma is insufficient as a therapeutic strategy.
Published in:
2019
By:
- Romo‐Morales, Antonio;
- Aladowicz, Ewa;
- Blagg, Julian;
- Gatz, Susanne A.;
- Shipley, Janet M.;
- Romo-Morales, Antonio
Publication type:
journal article
Corrigendum: The promise and peril of chemical probes.
Published in:
Nature Chemical Biology, 2015, v. 11, n. 11, p. 887, doi. 10.1038/nchembio1115-887c
By:
- Arrowsmith, Cheryl H;
- Audia, James E;
- Austin, Christopher;
- Baell, Jonathan;
- Bennett, Jonathan;
- Blagg, Julian;
- Bountra, Chas;
- Brennan, Paul E;
- Brown, Peter J;
- Bunnage, Mark E;
- Buser-Doepner, Carolyn;
- Campbell, Robert M;
- Carter, Adrian J;
- Cohen, Philip;
- Copeland, Robert A;
- Cravatt, Ben;
- Dahlin, Jayme L;
- Dhanak, Dashyant;
- Edwards, Aled M;
- Frederiksen, Mathias
Publication type:
Article
The promise and peril of chemical probes.
Published in:
Nature Chemical Biology, 2015, v. 11, n. 8, p. 536, doi. 10.1038/nchembio.1867
By:
- Arrowsmith, Cheryl H;
- Audia, James E;
- Austin, Christopher;
- Baell, Jonathan;
- Bennett, Jonathan;
- Blagg, Julian;
- Bountra, Chas;
- Brennan, Paul E;
- Brown, Peter J;
- Bunnage, Mark E;
- Buser-Doepner, Carolyn;
- Campbell, Robert M;
- Carter, Adrian J;
- Cohen, Philip;
- Copeland, Robert A;
- Cravatt, Ben;
- Dahlin, Jayme L;
- Dhanak, Dashyant;
- Edwards, Aled M;
- Frye, Stephen V
Publication type:
Article
Evaluation of germline BMP4 mutation as a cause of colorectal cancer.
Published in:
Human Mutation, 2011, v. 32, n. 1, p. E1928, doi. 10.1002/humu.21376
By:
- Lubbe, Steven J.;
- Pittman, Alan M.;
- Matijssen, Cornelis;
- Twiss, Philip;
- Olver, Bianca;
- Lloyd, Amy;
- Qureshi, Mobshra;
- Brown, Nathan;
- Nye, Emma;
- Stamp, Gordon;
- Blagg, Julian;
- Houlston, Richard S.
Publication type:
Article
Cancer Epigenetics: Biomolecular Therapeutics for Human Cancer. Edited by Antonio Giordano and Marcella Macaluso.
Published in:
ChemMedChem, 2013, v. 8, n. 6, p. 1014, doi. 10.1002/cmdc.201300152
By:
- Blagg, Julian
Publication type:
Article
A public-private partnership to unlock the untargeted kinome.
Published in:
Nature Chemical Biology, 2012, v. 9, n. 1, p. 3, doi. 10.1038/nchembio.1113
By:
- Knapp, Stefan;
- Arruda, Paulo;
- Blagg, Julian;
- Burley, Stephen;
- Drewry, David H;
- Edwards, Aled;
- Fabbro, Doriano;
- Gillespie, Paul;
- Gray, Nathanael S;
- Kuster, Bernhard;
- Lackey, Karen E;
- Mazzafera, Paulo;
- Tomkinson, Nicholas C O;
- Willson, Timothy M;
- Workman, Paul;
- Zuercher, William J
Publication type:
Article
Epigenetics: Targeting leukemia on the DOT.
Published in:
Nature Chemical Biology, 2011, v. 7, n. 10, p. 663, doi. 10.1038/nchembio.661
By:
- Travers, Jon;
- Blagg, Julian;
- Workman, Paul
Publication type:
Article

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