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Oncogenic EML4-ALK assemblies suppress growth factor perception and modulate drug tolerance.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-53451-7
By:
- Gonzalez-Martinez, David;
- Roth, Lee;
- Mumford, Thomas R.;
- Guan, Juan;
- Le, Anh;
- Doebele, Robert C.;
- Huang, Bo;
- Tulpule, Asmin;
- Niewiadomska-Bugaj, Magdalena;
- Bivona, Trever G.;
- Bugaj, Lukasz J.
Publication type:
Article
Emerging Targeted Therapies for the Treatment of Non-small Cell Lung Cancer.
Published in:
Current Oncology Reports, 2019, v. 21, n. 3, p. N.PAG, doi. 10.1007/s11912-019-0770-x
By:
- Halliday, Patrick R.;
- Blakely, Collin M.;
- Bivona, Trever G.
Publication type:
Article
Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca<sup>2+</sup> oscillations.
Published in:
EMBO Journal, 2004, v. 23, n. 8, p. 1749, doi. 10.1038/sj.emboj.7600197
By:
- Walker, Simon A.;
- Kupzig, Sabine;
- Bouyucef, Dalila;
- Davis, Louise C.;
- Tsuboi, Takashi;
- Bivona, Trever G.;
- Cozier, Gyles E.;
- Lockyer, Peter J.;
- Buckler, Alan;
- Rutter, Guy A.;
- Allen, Maxine J.;
- Philips, Mark R.;
- Cullen, Peter J.
Publication type:
Article
Mechanisms of Resistance to Epidermal Growth Factor Receptor Inhibitors and Novel Therapeutic Strategies to Overcome Resistance in NSCLC Patients.
Published in:
Chemotherapy Research & Practice, 2012, p. 1, doi. 10.1155/2012/817297
By:
- Lin, Luping;
- Bivona, Trever G.
Publication type:
Article
The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies.
Published in:
Nature Genetics, 2015, v. 47, n. 3, p. 250, doi. 10.1038/ng.3218
By:
- Lin, Luping;
- Chan, Elton;
- Olivas, Victor;
- Cade, Lindsay;
- Pazarentzos, Evangelos;
- Asthana, Saurabh;
- Neel, Dana;
- Yan, Jenny Jiacheng;
- Lu, Xinyuan;
- Pham, Luu;
- Wang, Mingxue M;
- Collisson, Eric A;
- Algazi, Alain;
- Bivona, Trever G;
- Muñoz-Couselo, Eva;
- Cortes, Javier;
- Frederick, Dennie T;
- Flaherty, Keith T;
- Cooper, Zachary A;
- Wargo, Jennifer A
Publication type:
Article
Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion.
Published in:
Journal of Cell Biology, 2004, v. 164, n. 3, p. 461, doi. 10.1083/jcb.200311093
By:
- Bivona, Trever G.;
- Wiener, Heidi H.;
- Ahearn, Ian M.;
- Silletti, Joseph;
- Chiu, Vi K.;
- Philips, Mark R.
Publication type:
Article
Personalized, Precision Lung Cancer Medicine through Integrated Genomic Analysis.
Published in:
Journal of OncoPathology, 2014, v. 2, n. 2, p. 43, doi. 10.13032/tjop.2052-5931.100083
By:
- Bivona, Trever G.
Publication type:
Article
Pathologic Complete Response to Neoadjuvant Crizotinib in a Lung Adenocarcinoma Patient With a MET Exon 14 Skipping Mutation.
Published in:
2019
By:
- Rotow, Julia K.;
- Woodard, Gavitt A.;
- Urisman, Anatoly;
- McCoach, Caroline E.;
- Bivona, Trever G.;
- Elicker, Brett M.;
- Jablons, David M.;
- Blakely, Collin M.
Publication type:
journal article
Neoadjuvant Oncogene-Targeted Therapy in Early Stage Non-Small-Cell Lung Cancer as a Strategy to Improve Clinical Outcome and Identify Early Mechanisms of Resistance.
Published in:
2016
By:
- McCoach, Caroline E.;
- Bivona, Trever G.;
- Blakely, Collin M.;
- Doebele, Robert C.
Publication type:
journal article
Novel computational method for predicting polytherapy switching strategies to overcome tumor heterogeneity and evolution.
Published in:
Scientific Reports, 2017, p. 44206, doi. 10.1038/srep44206
By:
- Jonsson, Vanessa D.;
- Blakely, Collin M.;
- Lin, Luping;
- Asthana, Saurabh;
- Matni, Nikolai;
- Olivas, Victor;
- Pazarentzos, Evangelos;
- Gubens, Matthew A.;
- Bastian, Boris C.;
- Taylor, Barry S.;
- Doyle, John C.;
- Bivona, Trever G.
Publication type:
Article
Targeting AXL in NSCLC.
Published in:
Lung Cancer: Targets & Therapy, 2021, v. 12, p. 67, doi. 10.2147/LCTT.S305484
By:
- Zaman, Aubhishek;
- Bivona, Trever G
Publication type:
Article
AXL receptor tyrosine kinase as a therapeutic target in NSCLC.
Published in:
Lung Cancer: Targets & Therapy, 2015, v. 6, p. 27, doi. 10.2147/LCTT.S60438
By:
- Okimoto, Ross A.;
- Bivona, Trever G.
Publication type:
Article
AUY922 Effectively Overcomes MET- and AXL-Mediated Resistance to EGFR-TKI in Lung Cancer Cells.
Published in:
PLoS ONE, 2015, v. 10, n. 3, p. 1, doi. 10.1371/journal.pone.0119832
By:
- Choi, Yun Jung;
- Kim, Seon Ye;
- So, Kwang Sup;
- Baek, In-Jeoung;
- Kim, Woo Sung;
- Choi, Se Hoon;
- Lee, Jae Cheol;
- Bivona, Trever G.;
- Rho, Jin Kyung;
- Choi, Chang-Min
Publication type:
Article
Long Non-Coding RNAs as Emerging Targets in Lung Cancer.
Published in:
Cancers, 2023, v. 15, n. 12, p. 3135, doi. 10.3390/cancers15123135
By:
- Gencel-Augusto, Jovanka;
- Wu, Wei;
- Bivona, Trever G.
Publication type:
Article
Quantitative Framework for Bench-to-Bedside Cancer Research.
Published in:
Cancers, 2022, v. 14, n. 21, p. 5254, doi. 10.3390/cancers14215254
By:
- Zaman, Aubhishek;
- Bivona, Trever G.
Publication type:
Article
Targeting Oncogenic BRAF: Past, Present, and Future.
Published in:
Cancers, 2019, v. 11, n. 8, p. 1197, doi. 10.3390/cancers11081197
By:
- Zaman, Aubhishek;
- Wu, Wei;
- Bivona, Trever G.
Publication type:
Article
Non-Canonical Thinking for Targeting ALK-Fusion Onco-Proteins in Lung Cancer.
Published in:
Cancers, 2017, v. 9, n. 12, p. 164, doi. 10.3390/cancers9120164
By:
- Wei Wu;
- Haderk, Franziska;
- Bivona, Trever G.
Publication type:
Article
Digital multiplexed analysis of circular RNAs in FFPE and fresh non-small cell lung cancer specimens.
Published in:
Molecular Oncology, 2022, v. 16, n. 12, p. 2367, doi. 10.1002/1878-0261.13182
By:
- Pedraz-Valdunciel, Carlos;
- Giannoukakos, Stavros;
- Potie, Nicolas;
- Giménez-Capitán, Ana;
- Chung-Ying Huang;
- Hackenberg, Michael;
- Fernandez-Hilario, Alberto;
- Bracht, Jill;
- Filipska, Martyna;
- Aldeguer, Erika;
- Rodríguez, Sonia;
- Bivona, Trever G.;
- Warren, Sarah;
- Aguado, Cristina;
- Masaoki Ito;
- Aguilar-Hernández, Andrés;
- Molina-Vila, Miguel Angel;
- Rosell, Rafael
Publication type:
Article
DDX56 modulates post-transcriptional Wnt signaling through miRNAs and is associated with early recurrence in squamous cell lung carcinoma.
Published in:
Molecular Cancer, 2021, v. 20, n. 1, p. 1, doi. 10.1186/s12943-021-01403-w
By:
- Wu, Qingqing;
- Luo, Xiaoyang;
- Terp, Mikkel G.;
- Li, Qingrun;
- Li, Yuan;
- Shen, Lei;
- Chen, Ying;
- Jacobsen, Kirstine;
- Bivona, Trever G.;
- Chen, Haiquan;
- Zeng, Rong;
- Ditzel, Henrik J.
Publication type:
Article
FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR.
Published in:
Nature, 2011, v. 471, n. 7339, p. 523, doi. 10.1038/nature09870
By:
- Bivona, Trever G.;
- Hieronymus, Haley;
- Parker, Joel;
- Chang, Kenneth;
- Taron, Miquel;
- Rosell, Rafael;
- Moonsamy, Philicia;
- Dahlman, Kimberly;
- Miller, Vincent A.;
- Costa, Carlota;
- Hannon, Gregory;
- Sawyers, Charles L.
Publication type:
Article
Betacellulin drives therapy resistance in glioblastoma.
Published in:
Neuro-Oncology, 2020, v. 22, n. 4, p. 457, doi. 10.1093/neuonc/noz206
By:
- Fan, Qiwen;
- An, Zhenyi;
- Wong, Robyn A;
- Luo, Xujun;
- Lu, Edbert D;
- Baldwin, Albert;
- Mayekar, Manasi K;
- Haderk, Franziska;
- Shokat, Kevan M;
- Bivona, Trever G;
- Weiss, William A
Publication type:
Article
CIC-DUX4 oncoprotein drives sarcoma metastasis and tumorigenesis via distinct regulatory programs.
Published in:
2019
By:
- Okimoto, Ross A.;
- Wei Wu;
- Shigeki Nanjo;
- Olivas, Victor;
- Lin, Yone K.;
- Ponce, Rovingaile Kriska;
- Rieko Oyama;
- Tadashi Kondo;
- Bivona, Trever G.;
- Wu, Wei;
- Nanjo, Shigeki;
- Oyama, Rieko;
- Kondo, Tadashi
Publication type:
journal article
Membranes as messengers in T cell adhesion signaling.
Published in:
Nature Immunology, 2004, v. 5, n. 4, p. 363, doi. 10.1038/ni1057
By:
- Dustin, Michael L.;
- Philips, Mark R.;
- Bivona, Trever G.
Publication type:
Article
Current Landscape of Targeted Therapy in Lung Cancer.
Published in:
Clinical Pharmacology & Therapeutics, 2017, v. 102, n. 5, p. 757, doi. 10.1002/cpt.810
By:
- Mayekar, Manasi K.;
- Bivona, Trever G.
Publication type:
Article
Primary and metastatic tumors exhibit systems-level differences in dependence on mitochondrial respiratory function.
Published in:
PLoS Biology, 2022, v. 20, n. 9, p. 1, doi. 10.1371/journal.pbio.3001753
By:
- Bennett, Neal K.;
- Nakaoka, Hiroki J.;
- Laurent, Danny;
- Okimoto, Ross A.;
- Sei, Yoshitaka;
- Horvai, Andrew E.;
- Bivona, Trever G.;
- ten Hoeve, Johanna;
- Graeber, Thomas G.;
- Nakamura, Ken;
- Nakamura, Jean L.
Publication type:
Article
Phospholipase C? activates Ras on the Golgi apparatus by means of RasGRP1.
Published in:
Nature, 2003, v. 424, n. 6949, p. 694, doi. 10.1038/nature01806
By:
- Bivona, Trever G.;
- Pérez de Castro, Ignacio;
- Ahearn, Ian M.;
- Grana, Theresa M.;
- Chiu, Vi K.;
- Lockyer, Peter J.;
- Cullen, Peter J.;
- Pellicer, Angel;
- Cox, Adrienne D.;
- Philips, Mark R.
Publication type:
Article
Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer.
Published in:
Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00963-0
By:
- Pengfei Ma;
- Yujie Fu;
- Mei-Chun Cai;
- Ying Yan;
- Ying Jing;
- Shengzhe Zhang;
- Minjiang Chen;
- Jie Wu;
- Ying Shen;
- Liang Zhu;
- Hong-Zhuan Chen;
- Wei-Qiang Gao;
- Mengzhao Wang;
- Zhenyu Gu;
- Bivona, Trever G.;
- Xiaojing Zhao;
- Guanglei Zhuang
Publication type:
Article
Convergent Akt activation drives acquired EGFR inhibitor resistance in lung cancer.
Published in:
Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00450-6
By:
- Jacobsen, Kirstine;
- Bertran-Alamillo, Jordi;
- Molina, Miguel Angel;
- Teixidó, Cristina;
- Karachaliou, Niki;
- Pedersen, Martin Haar;
- Castellví, Josep;
- Garzón, Mónica;
- Codony-Servat, Carles;
- Codony-Servat, Jordi;
- Giménez-Capitán, Ana;
- Drozdowskyj, Ana;
- Viteri, Santiago;
- Larsen, Martin R.;
- Lassen, Ulrik;
- Felip, Enriqueta;
- Bivona, Trever G.;
- Ditzel, Henrik J.;
- Rosell, Rafael
Publication type:
Article
Activating Mutations Cluster in the 'Molecular Brake' Regions of Protein Kinases and Do Not Associate with Conserved or Catalytic Residues.
Published in:
Human Mutation, 2014, v. 35, n. 3, p. 318, doi. 10.1002/humu.22493
By:
- Molina‐Vila, Miguel A.;
- Nabau‐Moretó, Nuria;
- Tornador, Cristian;
- Sabnis, Amit J.;
- Rosell, Rafael;
- Estivill, Xavier;
- Bivona, Trever G.;
- Marino‐Buslje, Cristina
Publication type:
Article
3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib.
Published in:
Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-04889-w
By:
- Meraz, Ismail M.;
- Majidi, Mourad;
- Fang, Bingliang;
- Meng, Feng;
- Gao, Lihui;
- Shao, RuPing;
- Song, Renduo;
- Li, Feng;
- Lissanu, Yonathan;
- Chen, Huiqin;
- Ha, Min Jin;
- Wang, Qi;
- Wang, Jing;
- Shpall, Elizabeth;
- Jung, Sung Yun;
- Haderk, Franziska;
- Gui, Philippe;
- Riess, Jonathan Wesley;
- Olivas, Victor;
- Bivona, Trever G.
Publication type:
Article
Author Correction: 3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib.
Published in:
Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-04979-9
By:
- Meraz, Ismail M.;
- Majidi, Mourad;
- Fang, Bingliang;
- Meng, Feng;
- Gao, Lihui;
- Shao, RuPing;
- Song, Renduo;
- Li, Feng;
- Lissanu, Yonathan;
- Chen, Huiqin;
- Ha, Min Jin;
- Wang, Qi;
- Wang, Jing;
- Shpall, Elizabeth;
- Jung, Sung Yun;
- Haderk, Franziska;
- Gui, Philippe;
- Riess, Jonathan Wesley;
- Olivas, Victor;
- Bivona, Trever G.
Publication type:
Article
3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib.
Published in:
Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-04889-w
By:
- Meraz, Ismail M.;
- Majidi, Mourad;
- Fang, Bingliang;
- Meng, Feng;
- Gao, Lihui;
- Shao, RuPing;
- Song, Renduo;
- Li, Feng;
- Lissanu, Yonathan;
- Chen, Huiqin;
- Ha, Min Jin;
- Wang, Qi;
- Wang, Jing;
- Shpall, Elizabeth;
- Jung, Sung Yun;
- Haderk, Franziska;
- Gui, Philippe;
- Riess, Jonathan Wesley;
- Olivas, Victor;
- Bivona, Trever G.
Publication type:
Article
A Case of Metastatic Atypical Neuroendocrine Tumor with ALK Translocation and Diffuse Brain Metastases.
Published in:
Oncologist, 2017, v. 22, n. 7, p. 768, doi. 10.1634/theoncologist.2017-0054
By:
- Wang, Victoria E.;
- Young, Lauren;
- Ali, Siraj;
- Miller, Vincent A.;
- Urisman, Anatoly;
- Wolfe, John;
- Bivona, Trever G.;
- Damato, Bertil;
- Fogh, Shannon;
- Bergsland, Emily K.
Publication type:
Article
Small-molecule targeted therapies induce dependence on DNA double-strand break repair in residual tumor cells.
Published in:
Science Translational Medicine, 2022, v. 14, n. 638, p. 1, doi. 10.1126/scitranslmed.abc7480
By:
- Ali, Moiez;
- Lu, Min;
- Ang, Hazel Xiaohui;
- Soderquist, Ryan S.;
- Eyler, Christine E.;
- Hutchinson, Haley M.;
- Glass, Carolyn;
- Bassil, Christopher F.;
- Lopez, Omar M.;
- Kerr, D. Lucas;
- Falcon, Christina J.;
- Yu, Helena A.;
- Hata, Aaron N.;
- Blakely, Collin M.;
- McCoach, Caroline E.;
- Bivona, Trever G.;
- Wood, Kris C.
Publication type:
Article
3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib.
Published in:
Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-04889-w
By:
- Meraz, Ismail M.;
- Majidi, Mourad;
- Fang, Bingliang;
- Meng, Feng;
- Gao, Lihui;
- Shao, RuPing;
- Song, Renduo;
- Li, Feng;
- Lissanu, Yonathan;
- Chen, Huiqin;
- Ha, Min Jin;
- Wang, Qi;
- Wang, Jing;
- Shpall, Elizabeth;
- Jung, Sung Yun;
- Haderk, Franziska;
- Gui, Philippe;
- Riess, Jonathan Wesley;
- Olivas, Victor;
- Bivona, Trever G.
Publication type:
Article
Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC.
Published in:
2017
By:
- Chaib, Imane;
- Karachaliou, Niki;
- Pilotto, Sara;
- Servat, Jordi Codony;
- Xueting Cai;
- Xuefei Li;
- Drozdowskyj, Ana;
- Servat, Carles Codony;
- Jie Yang;
- Chunping Hu;
- Cardona, Andres Felipe;
- Vivanco, Guillermo Lopez;
- Vergnenegre, Alain;
- Sanchez, Jose Miguel;
- Provencio, Mariano;
- Reguart, Noemi;
- Caicun Zhou;
- Peng Cao;
- Ma, Patrick C.;
- Bivona, Trever G.
Publication type:
journal article
Functional screening identifies aryl hydrocarbon receptor as suppressor of lung cancer metastasis.
Published in:
Oncogenesis, 2020, v. 9, n. 11, p. 1, doi. 10.1038/s41389-020-00286-8
By:
- Nothdurft, Silke;
- Thumser-Henner, Clotilde;
- Breitenbücher, Frank;
- Okimoto, Ross A.;
- Dorsch, Madeleine;
- Opitz, Christiane A.;
- Sadik, Ahmed;
- Esser, Charlotte;
- Hölzel, Michael;
- Asthana, Saurabh;
- Forster, Jan;
- Beisser, Daniela;
- Kalmbach, Sophie;
- Grüner, Barbara M.;
- Bivona, Trever G.;
- Schramm, Alexander;
- Schuler, Martin
Publication type:
Article

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