Works by Birrell, Mark A.

Results: 53

Bronchodilator activity of bitter tastants in human tissue.

Published in:

2011

By:

Belvisi, Maria G.;
Dale, Nicole;
Birrell, Mark A.;
Canning, Brendan J.

Publication type:

Letter

PI3Kγδ inhibition suppresses key disease features in a rat model of asthma.

Published in:

Respiratory Research, 2024, v. 25, n. 1, p. 1, doi. 10.1186/s12931-024-02814-1

By:

Pinkerton, James W.;
Preite, Silvia;
Piras, Antonio;
Zervas, Dimitrios;
Markou, Thomais;
Freeman, Mark S.;
Hofving, Tobias;
Ivarsson, Emil;
Bonvini, Sara J.;
Brailsford, Wayne;
Yrlid, Linda;
Belvisi, Maria G.;
Birrell, Mark A.

Publication type:

Article

Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids.

Published in:

BMC Genomics, 2007, v. 8, p. 1, doi. 10.1186/1471-2164-8-240

By:

Moschos, Sterghios A;
Williams, Andrew E;
Perry, Mark M;
Birrell, Mark A;
Belvisi, Maria G;
Lindsay, Mark A

Publication type:

Article

Role of the Inflammasome-Caspase1/11-IL-1/18 Axis in Cigarette Smoke Driven Airway Inflammation: An Insight into the Pathogenesis of COPD.

Published in:

PLoS ONE, 2014, v. 9, n. 11, p. 1, doi. 10.1371/journal.pone.0112829

By:

Eltom, Suffwan;
Belvisi, Maria G.;
Stevenson, Christopher S.;
Maher, Sarah A.;
Dubuis, Eric;
Fitzgerald, Kate A.;
Birrell, Mark A.

Publication type:

Article

Respiratory Infections Cause the Release of Extracellular Vesicles: Implications in Exacerbation of Asthma/COPD.

Published in:

PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0101087

By:

Eltom, Suffwan;
Dale, Nicole;
Raemdonck, Kristof R. G.;
Stevenson, Christopher S.;
Snelgrove, Robert J.;
Sacitharan, Pradeep K.;
Recchi, Chiara;
Wavre-Shapton, Silene;
McAuley, Daniel F.;
O'Kane, Cecilia;
Belvisi, Maria G.;
Birrell, Mark A.

Publication type:

Article

Cigarette Smoke Induced Airway Inflammation Is Independent of NF-κB Signalling.

Published in:

PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0054128

By:

Rastrick, Joseph M. D.;
Stevenson, Christopher S.;
Eltom, Suffwan;
Grace, Megan;
Davies, Meirion;
Kilty, Iain;
Evans, Steven M.;
Pasparakis, Manolis;
Catley, Matthew C.;
Lawrence, Toby;
Adcock, Ian M.;
Belvisi, Maria G.;
Birrell, Mark A.

Publication type:

Article

P2X7 Receptor and Caspase 1 Activation Are Central to Airway Inflammation Observed after Exposure to Tobacco Smoke.

Published in:

PLoS ONE, 2011, v. 6, n. 9, p. 1, doi. 10.1371/journal.pone.0024097

By:

Eltom, Suffwan;
Stevenson, Christopher S.;
Rastrick, Joseph;
Dale, Nicole;
Raemdonck, Kristof;
Wong, Sissie;
Catley, Matthew C.;
Belvisi, Maria G.;
Birrell, Mark A.

Publication type:

Article

Theobromine inhibits sensory nerve activation and cough.

Published in:

FASEB Journal, 2005, v. 19, n. 2, p. 231, doi. 10.1096/fj.04-1990fje

By:

Usmani, Omar S.;
Belvisi, Maria G.;
Patel, Hema J.;
Crispino, Natascia;
Birrell, Mark A.;
Korbonits, Márta;
Korbonits, Dezso;
Barnes, Peter J.

Publication type:

Article

Characterisation of a murine model of the late asthmatic response.

Published in:

2017

By:

Baker, Katie;
Raemdonck, Kristof;
Snelgrove, Robert J.;
Belvisi, Maria G.;
Birrell, Mark A.

Publication type:

journal article

Role of the ion channel, transient receptor potential cation channel subfamily V member 1 (TRPV1), in allergic asthma.

Published in:

2016

By:

Baker, Katie;
Raemdonck, Kristof;
Dekkak, Bilel;
Snelgrove, Robert J.;
Ford, John;
Shala, Fisnik;
Belvisi, Maria G.;
Birrell, Mark A.

Publication type:

journal article

CD4⁺ and CD8⁺ T cells play a central role in a HDM driven model of allergic asthma.

Published in:

2016

By:

Raemdonck, Kristof;
Baker, Katie;
Dale, Nicole;
Dubuis, Eric;
Shala, Fisnik;
Belvisi, Maria G.;
Birrell, Mark A.

Publication type:

journal article

TLR4 activation induces IL-1β release via an IPAF dependent but caspase 1/11/8 independent pathway in the lung.

Published in:

Respiratory Research, 2014, v. 15, n. 8, p. 1, doi. 10.1186/s12931-014-0087-0

By:

Eltom, Suffwan;
Belvisi, Maria G.;
Liang Yew-Booth;
Dekkak, Bilel;
Maher, Sarah A.;
Dubuis, Eric D.;
Jones, Victoria;
Fitzgerald, Kate A.;
Birrell, Mark A.

Publication type:

Article

Response to 'Effects of diesel exhaust particles on coagulation'.

Published in:

2017

By:

Smyth, Erica;
Solomon, Antonia;
Birrell, Mark A;
Smallwood, Miranda J;
Winyard, Paul G;
Tetley, Teresa D;
Emerson, Michael

Publication type:

Letter

Role of EP2 and EP4 receptors in airway microvascular leak induced by prostaglandin E2.

Published in:

2016

By:

Jones, Victoria C;
Birrell, Mark A;
Maher, Sarah A;
Griffiths, Mark;
Grace, Megan;
O'Donnell, Valerie B;
Clark, Stephen R;
Belvisi, Maria G

Publication type:

journal article

The role of adenylyl cyclase isoform 6 in β-adrenoceptor signalling in murine airways.

Published in:

2015

By:

Birrell, Mark A;
Bonvini, Sara J;
Wortley, Michael A;
Buckley, James;
Yew-Booth, Liang;
Maher, Sarah A;
Dale, Nicole;
Dubuis, Eric D;
Belvisi, Maria G

Publication type:

journal article

The role of adenylyl cyclase isoform 6 in β-adrenoceptor signalling in murine airways.

Published in:

British Journal of Pharmacology, 2015, v. 172, n. 1, p. 131, doi. 10.1111/bph.12905

By:

Birrell, Mark A;
Bonvini, Sara J;
Wortley, Michael A;
Buckley, James;
Yew ‐ Booth, Liang;
Maher, Sarah A;
Dale, Nicole;
Dubuis, Eric D;
Belvisi, Maria G

Publication type:

Article

Selectivity profiling of the novel EP2 receptor antagonist, PF-04418948, in functional bioassay systems: atypical affinity at the guinea pig EP2 receptor.

Published in:

British Journal of Pharmacology, 2013, v. 168, n. 1, p. 129, doi. 10.1111/j.1476-5381.2012.02088.x

By:

Birrell, Mark A;
Maher, Sarah A;
Buckley, James;
Dale, Nicole;
Bonvini, Sara;
Raemdonck, Kristof;
PullEN, Nick;
Giembycz, Mark A;
Belvisi, Maria G

Publication type:

Article

Selectivity profiling of the novel EP2 receptor antagonist, PF-04418948, in functional bioassay systems: atypical affinity at the guinea pig EP2 receptor.

Published in:

2013

By:

Birrell MA;
Maher SA;
Buckley J;
Dale N;
Bonvini S;
Raemdonck K;
Pullen N;
Giembycz MA;
Belvisi MG;
Birrell, Mark A;
Maher, Sarah A;
Buckley, James;
Dale, Nicole;
Bonvini, Sara;
Raemdonck, Kristof;
Pullen, Nick;
Giembycz, Mark A;
Belvisi, Maria G

Publication type:

journal article

At last, a truly selective EP₂ receptor antagonist.

Published in:

2011

By:

Birrell, Mark A;
Nials, Anthony T

Publication type:

journal article

Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking.

Published in:

Human Molecular Genetics, 2013, v. 22, n. 5, p. 843, doi. 10.1093/hmg/dds488

By:

Shenker, Natalie S.;
Polidoro, Silvia;
van Veldhoven, Karin;
Sacerdote, Carlotta;
Ricceri, Fulvio;
Birrell, Mark A.;
Belvisi, Maria G.;
Brown, Robert;
Vineis, Paolo;
Flanagan, James M.

Publication type:

Article

Protein Phosphatase 2A Reduces Cigarette Smoke-induced Cathepsin S and Loss of Lung Function.

Published in:

2019

By:

Doherty, Declan F;
Nath, Sridesh;
Poon, Justin;
Foronjy, Robert F;
Ohlmeyer, Michael;
Dabo, Abdoulaye J;
Salathe, Matthias;
Birrell, Mark;
Belvisi, Maria;
Baumlin, Nathalie;
Kim, Michael D;
Weldon, Sinéad;
Taggart, Clifford;
Geraghty, Patrick

Publication type:

journal article

Downregulation of MicroRNA-126 Augments DNA Damage Response in Cigarette Smokers and Patients with Chronic Obstructive Pulmonary Disease.

Published in:

2018

By:

Paschalaki, Koralia E.;
Zampetaki, Anna;
Baker, Jonathan R.;
Birrell, Mark A.;
Starke, Richard D.;
Belvisi, Maria G.;
Donnelly, Louise E.;
Mayr, Manuel;
Randi, Anna M.;
Barnes, Peter J.

Publication type:

journal article

XEN-D0501, a Novel Transient Receptor Potential Vanilloid 1 Antagonist, Does Not Reduce Cough in Patients with Refractory Cough.

Published in:

2017

By:

Belvisi, Maria G.;
Birrell, Mark A.;
Wortley, Michael A.;
Maher, Sarah A.;
Satia, Imran;
Badri, Huda;
Holt, Kimberley;
Round, Patrick;
McGarvey, Lorcan;
Ford, John;
Smith, Jaclyn A.

Publication type:

journal article

Neurophenotypes in Airway Diseases. Insights from Translational Cough Studies.

Published in:

2016

By:

Belvisi, Maria G.;
Birrell, Mark A.;
Khalid, Saifudin;
Wortley, Michael A.;
Dockry, Rachel;
Coote, Julie;
Holt, Kimberley;
Dubuis, Eric;
Kelsall, Angela;
Maher, Sarah A.;
Bonvini, Sara;
Woodcock, Ashley;
Smith, Jaclyn A.

Publication type:

journal article

TRPA1 agonists evoke coughing in guinea pig and human volunteers.

Published in:

2009

By:

Birrell MA;
Belvisi MG;
Grace M;
Sadofsky L;
Faruqi S;
Hele DJ;
Maher SA;
Freund-Michel V;
Morice AH;
Birrell, Mark A;
Belvisi, Maria G;
Grace, Megan;
Sadofsky, Laura;
Faruqi, Shoaib;
Hele, David J;
Maher, Sarah A;
Freund-Michel, Véronique;
Morice, Alyn H

Publication type:

journal article

Prostaglandin E2 mediates cough via the EP3 receptor: implications for future disease therapy.

Published in:

2009

By:

Maher SA;
Birrell MA;
Belvisi MG;
Maher, Sarah A;
Birrell, Mark A;
Belvisi, Maria G

Publication type:

journal article

In vivo bioimaging with tissue-specific transcription factor activated luciferase reporters.

Published in:

Scientific Reports, 2015, p. 11842, doi. 10.1038/srep11842

By:

Buckley, Suzanne M. K.;
Delhove, Juliette M. K. M.;
Perocheau, Dany P.;
Karda, Rajvinder;
Rahim, Ahad A.;
Howe, Steven J.;
Ward, Natalie J.;
Birrell, Mark A.;
Belvisi, Maria G.;
Arbuthnot, Patrick;
Johnson, Mark R.;
Waddington, Simon N.;
McKay, Tristan R.

Publication type:

Article

TRP Channel Antagonists as Potential Antitussives.

Published in:

Lung (0341-2040), 2012, v. 190, n. 1, p. 11, doi. 10.1007/s00408-011-9322-3

By:

Grace, Megan;
Dubuis, Eric;
Birrell, Mark;
Belvisi, Maria

Publication type:

Article

Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation.

Published in:

2003

By:

Patel, Hema J.;
Birrell, Mark A.;
Crispino, Natascia;
Hele, David J.;
Venkatesan, Priya;
Barnes, Peter J.;
Yacoub, Magdi H.;
Belvisi, Maria G.

Publication type:

journal article

Functional characterization and biomarker identification in the Brown Norway model of allergic airway inflammation.

Published in:

British Journal of Pharmacology, 2002, v. 137, n. 2, p. 263, doi. 10.1038/sj.bjp.0704865

By:

Underwood, Stephen L.;
Haddad, El-Bdaoui;
Birrell, Mark A.;
McCluskie, Kerryn;
Pecoraro, Michaela;
Dabrowski, Dominika;
Webber, Stephen E.;
Foster, Martyn L.;
Belvisi, Maria G.

Publication type:

Article

Effect of dopamine receptor agonists on sensory nerve activity: possible therapeutic targets for the treatment of asthma and COPD.

Published in:

British Journal of Pharmacology, 2002, v. 136, n. 4, p. 620, doi. 10.1038/sj.bjp.0704758

By:

Birrell, Mark A.;
Crispino, Natascia;
Hele, David J.;
Patel, Hema J.;
Yacoub, Magdi H.;
Barnes, Peter J.;
Belvisi, Maria G.

Publication type:

Article

Evidence that the anti-spasmogenic effect of the β-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinase.

Published in:

British Journal of Pharmacology, 2001, v. 133, n. 8, p. 1201, doi. 10.1038/sj.bjp.0704213

By:

Spicuzza, Lucia;
Belvisi, Maria G;
Birrell, Mark A;
Barnes, Peter J;
Hele, David J;
Giembycz, Mark A

Publication type:

Article

Role of p38 MAP kinase in LPS-induced airway inflammation in the rat.

Published in:

British Journal of Pharmacology, 2001, v. 132, n. 8, p. 1715, doi. 10.1038/sj.bjp.0704022

By:

Haddad, El-Bdaoui;
Birrell, Mark;
McCluskie, Kerryn;
Ling, Andrea;
Webber, Stephen E;
Foster, Martyn L;
Belvisi, Maria G

Publication type:

Article

Chronic systemic administration of salmeterol to rats promotes pulmonary β2-adrenoceptor desensitization and down-regulation of Gsα.

Published in:

British Journal of Pharmacology, 2001, v. 132, n. 6, p. 1261, doi. 10.1038/sj.bjp.0703946

By:

Finney, Paul A;
Donnelly, Louise E;
Belvisi, Maria G;
Chuang, Tsu-Tshen;
Birrell, Mark;
Harris, Andrew;
Mak, Judith C W;
Scorer, Carol;
Barnes, Peter J;
Adcock, Ian M;
Giembycz, Mark A

Publication type:

Article

Mediator involvement in antigen-induced bronchospasm and microvascular leakage in the airways of ovalbumin sensitized Brown Norway rats.

Published in:

British Journal of Pharmacology, 2001, v. 132, n. 2, p. 481, doi. 10.1038/sj.bjp.0703847

By:

Hele, Dave J;
Birrell, Mark A;
Webber, Stephen E;
Foster, Martyn L;
Belvisi, Maria G

Publication type:

Article

Effect of endothelin antagonists, including the novel ET(A) receptor antagonist LBL 031, on endothelin-1 and lipopolysaccharide-induced microvascular leakage in rat airways.

Published in:

2000

By:

Hele, Dave J;
Birrell, Mark A;
Webber, Stephen E;
Foster, Martyn L;
Belvisi, Maria G;
Hele, D J;
Birrell, M A;
Webber, S E;
Foster, M L;
Belvisi, M G

Publication type:

journal article

Characterization of the effects of cannabinoids on guinea-pig tracheal smooth muscle tone: role in the modulation of acetylcholine release from parasympathetic nerves.

Published in:

2000

By:

Spicuzza, Lucia;
Haddad, El-Bdaoui;
Birrell, Mark;
Ling, Andrea;
Clarke, Deborah;
Venkatesan, Priya;
Barnes, Peter J;
Belvisi, Maria G;
Spicuzza, L;
Haddad, E B;
Birrell, M;
Ling, A;
Clarke, D;
Venkatesan, P;
Barnes, P J;
Belvisi, M G

Publication type:

journal article

Iκ-B Kinase-2 Inhibitor Blocks Inflammation in Human Airway Smooth Muscle and a Rat Model of Asthma.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2005, v. 172, n. 8, p. 962, doi. 10.1164/rccm.200412-1647OC

By:

Birrell, Mark A.;
Hardaker, Elizabeth;
Wong, Sissie;
McCluskie, Kerryn;
Catley, Matthew;
De Alba, Jorge;
Newton, Robert;
Haj-Yahia, Saleem;
Pun, K. Tao;
Watts, Clarissa J.;
Shaw, Robert J.;
Savage, Tony J.;
Belvisi, Maria G.

Publication type:

Article

Steroid-resistant Inflammation in a Rat Model of Chronic Obstructive Pulmonary Disease Is Associated with a Lack of Nuclear Factor-κB Pathway Activation.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2005, v. 172, n. 1, p. 74, doi. 10.1164/rccm.200409-1257OC

By:

Birrell, Mark A.;
Wong, Sissie;
Hele, David J.;
McCluskie, Kerryn;
Hardaker, Elizabeth;
Belvisi, Maria G.

Publication type:

Article

Dissociation by steroids of eosinophilic inflammation from airway hyperresponsiveness in murine airways.

Published in:

2003

By:

Birrell, Mark A.;
Battram, Cliff H.;
Woodman, Paul;
McCluskie, Kerryn;
Belvisi, Maria G.

Publication type:

journal article

Lung-resident eosinophils represent a distinct regulatory eosinophil subset.

Published in:

2016

By:

Mesnil, Claire;
Raulier, Stéfanie;
Paulissen, Geneviève;
Xue Xiao;
Birrell, Mark A.;
Pirottin, Dimitri;
Janss, Thibaut;
Starkl, Philipp;
Ramery, Eve;
Henket, Monique;
Schleich, Florence N.;
Radermecker, Marc;
Thielemans, Kris;
Gillet, Laurent;
Thiry, Marc;
Belvisi, Maria G.;
Louis, Renaud;
Desmet, Christophe;
Marichal, Thomas;
Bureau, Fabrice

Publication type:

journal article

Impact of tobacco-smoke on key signaling pathways in the innate immune response in lung macrophages.

Published in:

Journal of Cellular Physiology, 2008, v. 214, n. 1, p. 27, doi. 10.1002/jcp.21158

By:

Birrell, Mark A.;
Wong, Sissie;
Catley, Matthew C.;
Belvisi, Maria G.

Publication type:

Article

New Advances and Potential Therapies for the Treatment of Asthma.

Published in:

BioDrugs, 2004, v. 18, n. 4, p. 211, doi. 10.2165/00063030-200418040-00001

By:

Belvisi, Maria G.;
Hele, David J.;
Birrell, Mark A.

Publication type:

Article

Phagocytosis-dependent activation of a TLR9- BTK-calcineurin- NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus.

Published in:

EMBO Molecular Medicine, 2015, v. 7, n. 3, p. 240, doi. 10.15252/emmm.201404556

By:

Herbst, Susanne;
Shah, Anand;
Mazon Moya, Maria;
Marzola, Vanessa;
Jensen, Barbara;
Reed, Anna;
Birrell, Mark A;
Saijo, Shinobu;
Mostowy, Serge;
Shaunak, Sunil;
Armstrong‐James, Darius

Publication type:

Article

APREPITANT FOR THE TREATMENT OF COUGH IN LUNG CANCER: A RANDOMISED PLACEBO-CONTROLLED TRIAL.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2021, v. 203, n. 6, p. E1

By:

Smith, Jaclyn A;
Harle, Amélie;
Dockry, Rachel;
Holt, Kimberley;
Russell, Philip;
Molassioti, Alexander;
Yorke, Janelle;
Robinson, Ryan;
Birrell, Mark A.;
Belvisi, Maria G.;
Blackhall, Fiona

Publication type:

Article

Aprepitant for Cough in Lung Cancer. A Randomized Placebo-controlled Trial and Mechanistic Insights.

Published in:

2021

By:

Smith, Jaclyn A.;
Harle, Am´elie;
Dockry, Rachel;
Holt, Kimberley;
Russell, Philip;
Molassiotis, Alex;
Yorke, Janelle;
Robinson, Ryan;
Birrell, Mark A.;
Belvisi, Maria G.;
Blackhall, Fiona;
Harle, Amélie

Publication type:

journal article

Targeting TRP channels for chronic cough: from bench to bedside.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2015, v. 388, n. 4, p. 401, doi. 10.1007/s00210-014-1082-1

By:

Bonvini, Sara;
Birrell, Mark;
Smith, Jaclyn;
Belvisi, Maria

Publication type:

Article

Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death.

Published in:

Nature Communications, 2016, v. 7, n. 11, p. 13292, doi. 10.1038/ncomms13292

By:

Thurston, Teresa L. M.;
Matthews, Sophie A.;
Jennings, Elliott;
Alix, Eric;
Shao, Feng;
Shenoy, Avinash R.;
Birrell, Mark A.;
Holden, David W.

Publication type:

Article

A Single 9-Colour Flow Cytometric Method to Characterise Major Leukocyte Populations in the Rat: Validation in a Model of LPS-Induced Pulmonary Inflammation.

Published in:

PLoS ONE, 2016, v. 11, n. 1, p. 1, doi. 10.1371/journal.pone.0142520

By:

Barnett-Vanes, Ashton;
Sharrock, Anna;
Birrell, Mark A.;
Rankin, Sara

Publication type:

Article

A role for Rab27 in neutrophil chemotaxis and lung recruitment.

Published in:

BMC Cell Biology, 2014, v. 15, n. 1, p. 2, doi. 10.1186/s12860-014-0039-z

By:

Singh, Rajesh K.;
Furze, Rebecca C.;
Birrell, Mark A.;
Rankin, Sara M.;
Hume, Alistair N.;
Seabra, Miguel C.

Publication type:

Article