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Identification of Effective Anticancer G-Quadruplex-Targeting Chemotypes through the Exploration of a High Diversity Library of Natural Compounds.
- Published in:
- Pharmaceutics, 2021, v. 13, n. 10, p. 1611, doi. 10.3390/pharmaceutics13101611
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- Publication type:
- Article
Therapeutic Use of G4-Ligands in Cancer: State-of-the-Art and Future Perspectives.
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- Pharmaceuticals (14248247), 2024, v. 17, n. 6, p. 771, doi. 10.3390/ph17060771
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- Publication type:
- Article
MiR‐182‐3p targets TRF2 and impairs tumor growth of triple‐negative breast cancer.
- Published in:
- EMBO Molecular Medicine, 2023, v. 15, n. 1, p. 1, doi. 10.15252/emmm.202216033
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- Publication type:
- Article
Anti‐tumoural activity of the G‐quadruplex ligand pyridostatin against BRCA1/2‐deficient tumours.
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- EMBO Molecular Medicine, 2022, v. 14, n. 3, p. 1, doi. 10.15252/emmm.202114501
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- Publication type:
- Article
BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity.
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- EMBO Molecular Medicine, 2017, v. 9, n. 10, p. 1398, doi. 10.15252/emmm.201607446
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- Publication type:
- Article
Selective Targeting of Cancer-Related G-Quadruplex Structures by the Natural Compound Dicentrine.
- Published in:
- International Journal of Molecular Sciences, 2023, v. 24, n. 4, p. 4070, doi. 10.3390/ijms24044070
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- Publication type:
- Article
Synthesis and Characterization of Bis-Triazolyl-Pyridine Derivatives as Noncanonical DNA-Interacting Compounds.
- Published in:
- International Journal of Molecular Sciences, 2021, v. 22, n. 21, p. 11959, doi. 10.3390/ijms222111959
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- Publication type:
- Article
Trifunctionalized Naphthalene Diimides and Dimeric Analogues as G-Quadruplex-Targeting Anticancer Agents Selected by Affinity Chromatography.
- Published in:
- International Journal of Molecular Sciences, 2020, v. 21, n. 6, p. 1964, doi. 10.3390/ijms21061964
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- Publication type:
- Article
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect.
- Published in:
- 2007
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- Publication type:
- journal article
SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage.
- Published in:
- Nucleic Acids Research, 2017, v. 45, n. 4, p. 1820, doi. 10.1093/nar/gkw1202
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- Publication type:
- Article
Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance.
- Published in:
- Nucleic Acids Research, 2016, v. 44, n. 4, p. 1579, doi. 10.1093/nar/gkv1122
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- Publication type:
- Article
A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds.
- Published in:
- Nucleic Acids Research, 2015, v. 43, n. 3, p. 1759, doi. 10.1093/nar/gkv006
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- Publication type:
- Article
Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis.
- Published in:
- Nucleic Acids Research, 2014, v. 42, n. 5, p. 2945, doi. 10.1093/nar/gkt1289
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- Publication type:
- Article
Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway.
- Published in:
- Nucleic Acids Research, 2009, v. 37, n. 16, p. 5353, doi. 10.1093/nar/gkp582
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- Publication type:
- Article
Emerging roles of telomeric chromatin alterations in cancer.
- Published in:
- Journal of Experimental & Clinical Cancer Research (17569966), 2019, v. 38, n. 1, p. N.PAG, doi. 10.1186/s13046-019-1030-5
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- Publication type:
- Article
Targeting <italic>KRAS</italic> in metastatic colorectal cancer: current strategies and emerging opportunities.
- Published in:
- Journal of Experimental & Clinical Cancer Research (17569966), 2018, v. 37, p. 1, doi. 10.1186/s13046-018-0719-1
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- Publication type:
- Article
Cancer cells induce immune escape via glycocalyx changes controlled by the telomeric protein TRF2.
- Published in:
- EMBO Journal, 2019, v. 38, n. 11, p. N.PAG, doi. 10.15252/embj.2018100012
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- Publication type:
- Article
Bcl-2 overexpression decreases BCNU sensitivity of a human glioblastoma line through enhancement of catalase activity.
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- Journal of Cellular Biochemistry, 2001, v. 83, n. 3, p. 473, doi. 10.1002/jcb.1245
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- Publication type:
- Article
The future of antisense therapy: combination with anticancer treatments.
- Published in:
- Oncogene, 2003, v. 22, n. 42, p. 6579, doi. 10.1038/sj.onc.1206812
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- Publication type:
- Article
Reconstitution of hTERT restores tumorigenicity in melanoma-derived c-Myc low-expressing clones.
- Published in:
- Oncogene, 2002, v. 21, n. 19, p. 3011, doi. 10.1038/sj.onc.1205415
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- Publication type:
- Article
BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors.
- Published in:
- Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-11048-5
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- Publication type:
- Article
Harnessing Omics Approaches on Advanced Preclinical Models to Discovery Novel Therapeutic Targets for the Treatment of Metastatic Colorectal Cancer.
- Published in:
- Cancers, 2020, v. 12, n. 7, p. 1830, doi. 10.3390/cancers12071830
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- Publication type:
- Article
TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells.
- Published in:
- Nature Cell Biology, 2013, v. 15, n. 7, p. 818, doi. 10.1038/ncb2774
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- Publication type:
- Article
Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities.
- Published in:
- Journal of Experimental & Clinical Cancer Research (17569966), 2014, v. 33, n. 1, p. 1, doi. 10.1186/s13046-014-0081-x
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- Publication type:
- Article
On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts.
- Published in:
- Journal of Experimental & Clinical Cancer Research (17569966), 2013, v. 32, n. 1, p. 1, doi. 10.1186/1756-9966-32-68
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- Publication type:
- Article
Encapsulation of c-myc antisense oligodeoxynucleotides in lipid particles improves antitumoral efficacy in vivo in a human melanoma line.
- Published in:
- Cancer Gene Therapy, 2001, v. 8, n. 6, p. 459, doi. 10.1038/sj.cgt.7700326
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- Publication type:
- Article
Dyads of G‐Quadruplex Ligands Triggering DNA Damage Response and Tumour Cell Growth Inhibition at Subnanomolar Concentration.
- Published in:
- Chemistry - A European Journal, 2019, v. 25, n. 47, p. 11085, doi. 10.1002/chem.201900766
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- Publication type:
- Article
In vivo administration of liposomal vincristine sensitizes drug-resistant human solid tumors.
- Published in:
- International Journal of Cancer, 2004, v. 110, n. 5, p. 767, doi. 10.1002/ijc.20174
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- Publication type:
- Article
α-tocopherol protects against cisplatin-induced toxicity without interfering with antitumor efficacy.
- Published in:
- International Journal of Cancer, 2003, v. 104, n. 2, p. 243, doi. 10.1002/ijc.10933
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- Publication type:
- Article
ZD1839 (IRESSA), an EGFR-selective tyrosine kinase inhibitor, enhances taxane activity in bcl-2 overexpressing, multidrug-resistant MCF-7 ADR human breast cancer cells.
- Published in:
- International Journal of Cancer, 2002, v. 98, n. 3, p. 463, doi. 10.1002/ijc.10230
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- Publication type:
- Article
bcl-2 over-expression enhances NF-κB activity and induces mmp-9 transcription in human MCF7.
- Published in:
- International Journal of Cancer, 2000, v. 86, n. 2, p. 188, doi. 10.1002/(SICI)1097-0215(20000415)86:2<188::AID-IJC7>3.0.CO;2-W
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- Publication type:
- Article
bcl-2 inhibits mitochondrial metabolism and lonidamine-induced apoptosis in adriamycin-resistant mcf7 cells.
- Published in:
- International Journal of Cancer, 1999, v. 82, n. 1, p. 125, doi. 10.1002/(SICI)1097-0215(19990702)82:1<125::AID-IJC21>3.0.CO;2-Q
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- Publication type:
- Article
Diagnosis and treatment of ALT tumors: is Trabectedin a new therapeutic option?
- Published in:
- Journal of Experimental & Clinical Cancer Research (17569966), 2017, v. 36, p. 1, doi. 10.1186/s13046-017-0657-3
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- Publication type:
- Article
Patient-derived xenografts: a relevant preclinical model for drug development.
- Published in:
- Journal of Experimental & Clinical Cancer Research (17569966), 2016, v. 35, p. 1, doi. 10.1186/s13046-016-0462-4
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- Publication type:
- Article
Therapeutic integration of c-myc and bcl-2 antisense molecules with docetaxel in a preclinical model of hormone-refractory prostate cancer.
- Published in:
- Prostate, 2007, v. 67, n. 13, p. 1475, doi. 10.1002/pros.20636
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- Publication type:
- Article
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells.
- Published in:
- Cell Death & Disease, 2018, v. 9, n. 10, p. 1, doi. 10.1038/s41419-018-1065-0
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- Publication type:
- Article
Electroporation increases antitumoral efficacy of the bcl-2 antisense G3139 and chemotherapy in a human melanoma xenograft.
- Published in:
- 2011
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- Publication type:
- journal article
Anacardic acid and thyroid hormone enhance cardiomyocytes production from undifferentiated mouse ES cells along functionally distinct pathways.
- Published in:
- Endocrine (1355008X), 2016, v. 53, n. 3, p. 681, doi. 10.1007/s12020-015-0751-2
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- Publication type:
- Article
Antisense clusterin oligodeoxynucleotides increase the response of HER-2 gene amplified breast cancer cells to Trastuzumab.
- Published in:
- Journal of Cellular Physiology, 2005, v. 204, n. 2, p. 463, doi. 10.1002/jcp.20295
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- Publication type:
- Article
Unlocking the potential of protein-derived peptides to target G-quadruplex DNA: from recognition to anticancer activity.
- Published in:
- Nucleic Acids Research, 2024, v. 52, n. 12, p. 6748, doi. 10.1093/nar/gkae471
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- Publication type:
- Article
Insights into telomeric G-quadruplex DNA recognition by HMGB1 protein.
- Published in:
- Nucleic Acids Research, 2019, v. 47, n. 18, p. 9950, doi. 10.1093/nar/gkz727
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- Publication type:
- Article
AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance.
- Published in:
- PLoS Genetics, 2015, v. 11, n. 6, p. 1, doi. 10.1371/journal.pgen.1005167
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- Publication type:
- Article
BRCA2 Deletion Induces Alternative Lengthening of Telomeres in Telomerase Positive Colon Cancer Cells.
- Published in:
- Genes, 2019, v. 10, n. 9, p. 697, doi. 10.3390/genes10090697
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- Publication type:
- Article
Inside Cover: Looking for Efficient G-Quadruplex Ligands: Evidence for Selective Stabilizing Properties and Telomere Damage by Drug-Like Molecules (ChemMedChem 4/2015).
- Published in:
- ChemMedChem, 2015, v. 10, n. 4, p. 586, doi. 10.1002/cmdc.201590008
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- Publication type:
- Article
Looking for Efficient G-Quadruplex Ligands: Evidence for Selective Stabilizing Properties and Telomere Damage by Drug-Like Molecules.
- Published in:
- ChemMedChem, 2015, v. 10, n. 4, p. 640, doi. 10.1002/cmdc.201402552
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- Publication type:
- Article
Aromatic Core Extension in the Series of N-Cyclic Bay-Substituted Perylene G-Quadruplex Ligands: Increased Telomere Damage, Antitumor Activity, and Strong Selectivity for Neoplastic over Healthy Cells.
- Published in:
- ChemMedChem, 2012, v. 7, n. 12, p. 2144, doi. 10.1002/cmdc.201200348
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- Publication type:
- Article
Drug repositioning strategy for the identification of novel telomere‐damaging agents: A role for NAMPT inhibitors.
- Published in:
- Aging Cell, 2023, v. 22, n. 11, p. 1, doi. 10.1111/acel.13944
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- Publication type:
- Article