Works matching AU Biondi, Ricardo M.

Results: 27

Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA.

Published in:

EMBO Journal, 2000, v. 19, n. 5, p. 979, doi. 10.1093/emboj/19.5.979

By:

Biondi, Ricardo M.;
Cheung, Peter C. F.;
Casamayor, Antonio;
Deak, Maria;
Currie, Richard A.;
Alessi, Darion R.

Publication type:

Article

Identification of Key Phospholipids That Bind and Activate Atypical PKCs.

Published in:

Biomedicines, 2021, v. 9, n. 1, p. 45, doi. 10.3390/biomedicines9010045

By:

Velnati, Suresh;
Centonze, Sara;
Girivetto, Federico;
Capello, Daniela;
Biondi, Ricardo M.;
Bertoni, Alessandra;
Cantello, Roberto;
Ragnoli, Beatrice;
Malerba, Mario;
Graziani, Andrea;
Baldanzi, Gianluca

Publication type:

Article

Mutations in the MutSα interaction interface of MLH1 can abolish DNA mismatch repair.

Published in:

Nucleic Acids Research, 2006, v. 34, n. 22, p. 6574, doi. 10.1093/nar/gkl944

By:

Plotz, Guido;
Welsch, Christoph;
Giron-Monzon, Luis;
Friedhoff, Peter;
Albrecht, Mario;
Piiper, Albrecht;
Biondi, Ricardo M.;
Lengauer, Thomas;
Zeuzem, Stefan;
Raedle, Jochen

Publication type:

Article

Candida albicans Tpk1p and Tpk2p isoforms differentially regulate pseudohyphal development, biofilm structure, cell aggregation and adhesins expression.

Published in:

Yeast, 2011, v. 28, n. 4, p. 293, doi. 10.1002/yea.1839

By:

Giacometti, Romina;
Kronberg, Florencia;
Biondi, Ricardo M.;
Passeron, Susana

Publication type:

Article

Catalytic isoforms Tpk1 and Tpk2 of Candida albicans PKA have non-redundant roles in stress response and glycogen storage.

Published in:

Yeast, 2009, v. 26, n. 5, p. 273, doi. 10.1002/yea.1665

By:

Giacometti, Romina;
Kronberg, Florencia;
Biondi, Ricardo M.;
Passeron, Susana

Publication type:

Article

The PB1 and the ZZ domain of the autophagy receptor p62/SQSTM1 regulate the interaction of p62/SQSTM1 with the autophagosome protein LC3B.

Published in:

Protein Science: A Publication of the Protein Society, 2024, v. 33, n. 1, p. 1, doi. 10.1002/pro.4840

By:

Alcober‐Boquet, Lucia;
Zang, Tabea;
Pietsch, Larissa;
Suess, Evelyn;
Hartmann, Markus;
Proschak, Ewgenij;
Gross, Lissy Z. F.;
Sacerdoti, Mariana;
Zeuzem, Stefan;
Rogov, Vladimir V.;
Leroux, Alejandro E.;
Piiper, Albrecht;
Biondi, Ricardo M.

Publication type:

Article

Random insertion of GFP into the cAMP‐dependent protein kinase regulatory subunit fromDictyostelium discoideum.

Published in:

Nucleic Acids Research, 1998, v. 26, n. 21, p. 4946, doi. 10.1093/nar/26.21.4946

By:

Biondi, Ricardo M.;
Baehler, Pascal J.;
Reymond, Christophe D.;
Véron, Michel

Publication type:

Article

Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-39051-x

By:

González, Lorena;
Díaz, Lucía;
Pous, Joan;
Baginski, Blazej;
Duran-Corbera, Anna;
Scarpa, Margherita;
Brun-Heath, Isabelle;
Igea, Ana;
Martin-Malpartida, Pau;
Ruiz, Lidia;
Pallara, Chiara;
Esguerra, Mauricio;
Colizzi, Francesco;
Mayor-Ruiz, Cristina;
Biondi, Ricardo M.;
Soliva, Robert;
Macias, Maria J.;
Orozco, Modesto;
Nebreda, Angel R.

Publication type:

Article

Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1T315I and BCR-ABL1T315I-E255K.

Published in:

Annals of Hematology, 2021, v. 100, n. 8, p. 2023, doi. 10.1007/s00277-020-04357-z

By:

Mian, Afsar Ali;
Haberbosch, Isabella;
Khamaisie, Hazem;
Agbarya, Abed;
Pietsch, Larissa;
Eshel, Elizabeh;
Najib, Dally;
Chiriches, Claudia;
Ottmann, Oliver Gerhard;
Hantschel, Oliver;
Biondi, Ricardo M.;
Ruthardt, Martin;
Mahajna, Jamal

Publication type:

Article

Depletion of yeast PDK1 orthologs triggers a stress-like transcriptional response.

Published in:

BMC Genomics, 2015, v. 16, n. 1, p. 1, doi. 10.1186/s12864-015-1903-8

By:

Pastor-Flores, Daniel;
Ferrer-Dalmau, Jofre;
Bahí, Anna;
Boleda, Martí;
Biondi, Ricardo M.;
Casamayor, Antonio

Publication type:

Article

Discovery of a Potent Allosteric Kinase Modulator by Combining Computational and Synthetic Methods.

Published in:

Angewandte Chemie, 2015, v. 127, n. 47, p. 14139, doi. 10.1002/ange.201506310

By:

Kroon, Edwin;
Schulze, Jörg O.;
Süß, Evelyn;
Camacho, Carlos J.;
Biondi, Ricardo M.;
Dömling, Alexander

Publication type:

Article

DNA mismatch repair activity of MutLα is regulated by CK2-dependent phosphorylation of MLH1 (S477).

Published in:

Molecular Carcinogenesis, 2018, v. 57, n. 12, p. 1723, doi. 10.1002/mc.22892

By:

Weßbecher, Isabel M.;
Hinrichsen, Inga;
Funke, Sebastian;
Oellerich, Thomas;
Plotz, Guido;
Zeuzem, Stefan;
Grus, Franz H.;
Biondi, Ricardo M.;
Brieger, Angela

Publication type:

Article

Phosphorylation-dependent signaling controls degradation of DNA mismatch repair protein PMS2.

Published in:

Molecular Carcinogenesis, 2017, v. 56, n. 12, p. 2663, doi. 10.1002/mc.22709

By:

Hinrichsen, Inga;
Weßbecher, Isabel M.;
Huhn, Meik;
Passmann, Sandra;
Zeuzem, Stefan;
Plotz, Guido;
Biondi, Ricardo M.;
Brieger, Angela

Publication type:

Article

Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation.

Published in:

EMBO Journal, 2007, v. 26, n. 9, p. 2251, doi. 10.1038/sj.emboj.7601682

By:

Hauge, Camilla;
Antal, Torben L;
Hirschberg, Daniel;
Doehn, Ulrik;
Thorup, Katrine;
Idrissova, Leila;
Hansen, Klaus;
Jensen, Ole N;
Jørgensen, Thomas J;
Biondi, Ricardo M;
Frödin, Morten

Publication type:

Article

Allosteric activation of the protein kinase PDK1 with low molecular weight compounds.

Published in:

EMBO Journal, 2006, v. 25, n. 23, p. 5469, doi. 10.1038/sj.emboj.7601416

By:

Engel, Matthias;
Hindie, Valerie;
Lopez-Garcia, Laura A.;
Stroba, Adriana;
Schaeffer, Francis;
Adrian, Iris;
Imig, Jochen;
Idrissova, Leila;
Nastainczyk, Wolfgang;
Zeuzem, Stefan;
Alzari, Pedro M.;
Hartmann, Rolf W.;
Piiper, Albrecht;
Biondi, Ricardo M.

Publication type:

Article

A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation.

Published in:

EMBO Journal, 2002, v. 21, n. 20, p. 5396, doi. 10.1093/emboj/cdf551

By:

Frödin, Morten;
Antal, Torben L.;
Dümmler, Bettina A.;
Jensen, Claus J.;
Deak, Maria;
Gammeltoft, Steen;
Biondi, Ricardo M.

Publication type:

Article

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site.

Published in:

EMBO Journal, 2002, v. 21, n. 16, p. 4219, doi. 10.1093/emboj/cdf437

By:

Biondi, Ricardo M.;
Komander, David;
Thomas, Christine C.;
Lizcano, Jose M.;
Deak, Maria;
Alessi, Dario R.;
Aalten, Daan M.F.Van

Publication type:

Article

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

Published in:

EMBO Journal, 2001, v. 20, n. 16, p. 4380, doi. 10.1093/emboj/20.16.4380

By:

Biondi, Ricardo M.;
Kieloch, Agnieszka;
Acurrie, Richard;
Deak, Maria;
Alessi, Dario R.

Publication type:

Article

Predicting protein targets for drug-like compounds using transcriptomics.

Published in:

PLoS Computational Biology, 2018, v. 14, n. 12, p. 1, doi. 10.1371/journal.pcbi.1006651

By:

Pabon, Nicolas A.;
Camacho, Carlos J.;
Xia, Yan;
Bar-Joseph, Ziv;
Estabrooks, Samuel K.;
Brodsky, Jeffrey L.;
Ye, Zhaofeng;
Herbrand, Amanda K.;
Süß, Evelyn;
Biondi, Ricardo M.;
Assimon, Victoria A.;
Gestwicki, Jason E.

Publication type:

Article

The choreography of protein kinase PDK1 and its diverse substrate dance partners.

Published in:

Biochemical Journal, 2023, v. 480, n. 19, p. 1503, doi. 10.1042/BCJ20220396

By:

Leroux, Alejandro E.;
Biondi, Ricardo M.

Publication type:

Article

Differential Stability of Cell-Free Circulating microRNAs: Implications for Their Utilization as Biomarkers.

Published in:

PLoS ONE, 2013, v. 8, n. 9, p. 1, doi. 10.1371/journal.pone.0075184

By:

Köberle, Verena;
Pleli, Thomas;
Schmithals, Christian;
Augusto Alonso, Eduardo;
Haupenthal, Jörg;
Bönig, Halvard;
Peveling-Oberhag, Jan;
Biondi, Ricardo M.;
Zeuzem, Stefan;
Kronenberger, Bernd;
Waidmann, Oliver;
Piiper, Albrecht

Publication type:

Article

InterAKTions with FKBPs - Mutational and Pharmacological Exploration.

Published in:

PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0057508

By:

Fabian, Anne-Katrin;
März, Andreas;
Neimanis, Sonja;
Biondi, Ricardo M.;
Kozany, Christian;
Hausch, Felix

Publication type:

Article

Alternative AKT2 splicing produces protein lacking the hydrophobic motif regulatory region.

Published in:

PLoS ONE, 2020, v. 15, n. 11, p. 1, doi. 10.1371/journal.pone.0242819

By:

Plotz, Guido;
Lopez-Garcia, Laura A.;
Brieger, Angela;
Zeuzem, Stefan;
Biondi, Ricardo M.

Publication type:

Article

ACE2, the Receptor that Enables Infection by SARS‐CoV‐2: Biochemistry, Structure, Allostery and Evaluation of the Potential Development of ACE2 Modulators.

Published in:

ChemMedChem, 2020, v. 15, n. 18, p. 1682, doi. 10.1002/cmdc.202000368

By:

Gross, Lissy Z. F.;
Sacerdoti, Mariana;
Piiper, Albrecht;
Zeuzem, Stefan;
Leroux, Alejandro E.;
Biondi, Ricardo M.

Publication type:

Article

Discovery of a Potent Allosteric Kinase Modulator by Combining Computational and Synthetic Methods.

Published in:

Angewandte Chemie International Edition, 2015, v. 54, n. 47, p. 13933, doi. 10.1002/anie.201506310

By:

Kroon, Edwin;
Schulze, Jörg O.;
Süß, Evelyn;
Camacho, Carlos J.;
Biondi, Ricardo M.;
Dömling, Alexander

Publication type:

Article

Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1.

Published in:

Nature Chemical Biology, 2009, v. 5, n. 10, p. 758, doi. 10.1038/nchembio.208

By:

Hindie, Valerie;
Stroba, Adriana;
Zhang, Hua;
Lopez-Garcia, Laura A.;
Idrissova, Leila;
Zeuzem, Stefan;
Hirschberg, Daniel;
Schaeffer, Francis;
Jørgensen, Thomas J. D.;
Engel, Matthias;
Alzari, Pedro M.;
Biondi, Ricardo M.

Publication type:

Article

Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors.

Published in:

Cellular Physiology & Biochemistry (Karger AG), 2018, v. 45, n. 6, p. 2516, doi. 10.1159/000488270

By:

Pleli, Thomas;
Mondorf, Antonia;
Ferreiros, Nerea;
Thomas, Dominique;
Dvorak, Karel;
Biondi, Ricardo M.;
Heringdorf, Dagmar Meyer zu;
Zeuzem, Stefan;
Geisslinger, Gerd;
Zimmermann, Herbert;
Waidmann, Oliver;
Piiper, Albrecht

Publication type:

Article