Works by Biernat, Jacek

Results: 43

Faltungszustand des Proteins Tau bei Bindung an Mikrotubuli.

Published in:

Angewandte Chemie, 2015, v. 127, n. 35, p. 10488, doi. 10.1002/ange.201501714

By:

Kadavath, Harindranath;
Jaremko, Mariusz;
Jaremko, Łukasz;
Biernat, Jacek;
Mandelkow, Eckhard;
Zweckstetter, Markus

Publication type:

Article

Mechanismus der Phenothiazin-induzierten Hemmung der Tau-Aggregation.

Published in:

Angewandte Chemie, 2013, v. 125, n. 12, p. 3596, doi. 10.1002/ange.201208290

By:

Akoury, Elias;
Pickhardt, Marcus;
Gajda, Michal;
Biernat, Jacek;
Mandelkow, Eckhard;
Zweckstetter, Markus

Publication type:

Article

Die dynamische Struktur von Tau-Filamenten.

Published in:

Angewandte Chemie, 2011, v. 123, n. 48, p. 11723, doi. 10.1002/ange.201105493

By:

Bibow, Stefan;
Mukrasch, Marco D.;
Chinnathambi, Subashchandrabose;
Biernat, Jacek;
Griesinger, Christian;
Mandelkow, Eckhard;
Zweckstetter, Markus

Publication type:

Article

Rhodanine-Based Tau Aggregation Inhibitors in Cell Models of Tauopathy.

Published in:

Angewandte Chemie International Edition, 2007, v. 46, n. 48, p. 9215, doi. 10.1002/anie.200704051

By:

Bulic, Bruno;
Pickhardt, Marcus;
Khlistunova, Inna;
Biernat, Jacek;
Mandelkow, Eva-Maria;
Mandelkow, Eckhard;
Waldmann, Herbert

Publication type:

Article

Structural Principles of Tau and the Paired Helical Filaments of Alzheimer’s Disease.

Published in:

Brain Pathology, 2007, v. 17, n. 1, p. 83, doi. 10.1111/j.1750-3639.2007.00053.x

By:

Mandelkow, Eckhard;
von Bergen, Martin;
Biernat, Jacek;
Mandelkow, Eva-Maria

Publication type:

Article

Imbalance of Hsp70 family variants fosters tau accumulation.

Published in:

FASEB Journal, 2013, v. 27, n. 4, p. 1450, doi. 10.1096/fj.12-220889

By:

Jinwal, Umesh K.;
Akoury, Elias;
Abisambra, Jose F.;
O'Leary III, John C.;
Thompson, Andrea D.;
Blair, Laura J.;
Ying Jin;
Bacon, Justin;
Nordhues, Bryce A.;
Cockman, Matthew;
Zhang, Juan;
Pengfei Li;
Bo Zhang;
Borysov, Sergiy;
Uversky, Vladimir N.;
Biernat, Jacek;
Mandelkow, Eckhard;
Gestwicki, Jason E.;
Zweckstetter, Markus;
Dickey, Chad A.

Publication type:

Article

Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06880-0

By:

Oroz, Javier;
Chang, Bliss J.;
Wysoczanski, Piotr;
Lee, Chung-Tien;
Pérez-Lara, Ángel;
Chakraborty, Pijush;
Hofele, Romina V.;
Baker, Jeremy D.;
Blair, Laura J.;
Biernat, Jacek;
Urlaub, Henning;
Mandelkow, Eckhard;
Dickey, Chad A.;
Zweckstetter, Markus

Publication type:

Article

Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-02230-8

By:

Fontela, Yunior Cabrales;
Kadavath, Harindranath;
Biernat, Jacek;
Riedel, Dietmar;
Mandelkow, Eckhard;
Zweckstetter, Markus

Publication type:

Article

A novel mechanism for axonal sorting of tau protein: A retrograde barrier at the axon initial segment

Published in:

2011

By:

Mandelkow, Eckhard;
Li, Xiaoyu;
Marx, Alexander;
Mandelkow, Eva;
Biernat, Jacek

Publication type:

Abstract

P2-138: Prevention of tau aggregation in vitro and in cells by low molecular weight compounds derived from phenylthiazolyl-hydrazide or rhodanine core structures

Published in:

2008

By:

Pickhardt, Marcus;
Bulic, Bruno;
Larbig, Gregor;
Coksezen, Atilla;
Biernat, Jacek;
Khlistunova, Inna;
Mandelkow, Eva-Maria;
Schmidt, Boris;
Waldmann, Herbert;
Meyer, Bernd;
Mandelkow, Eckhard

Publication type:

Abstract

P2-126: Stepwise proteolysis liberates tau fragments that nucleate the aggregation of tau and tau-dependent toxicity in a neuronal cell model

Published in:

2008

By:

Wang, Yipeng;
Biernat, Jacek;
Pickhardt, Marcus;
Mandelkow, Eckhard;
Mandelkow, Eva-Maria

Publication type:

Abstract

O4-01-02: Neurofibrillary tangles and neuronal loss in an inducible transgenic mouse model expressing a mutant repeat domain of tau

Published in:

2008

By:

Nissen, Astrid;
Mocanu, Magdalena;
Eckermann, Katrin;
Khlistunova, Inna;
Biernat, Jacek;
Drexler, Dagmar;
Petrova, Olga;
Zhou, Lepu;
Rune, Gabriele;
Mandelkow, Eva-Maria

Publication type:

Abstract

P3-303: Inhibition of tau aggregation and disaggregation of PHFs by low MW compounds in vitro and in cells

Published in:

2006

By:

Pickhardt, Marcus;
Gazova, Zuzana;
von Bergen, Martin;
Biernat, Jacek;
Khlistunova, Inna;
Wang, Yi-Peng;
Hascher, Antje;
Mandelkow, Eva-Maria;
Mandelkow, Eckhard

Publication type:

Abstract

P2-047: Inducible cell model of tauopathy expressing full-length tau

Published in:

2006

By:

Wang, Yipeng;
Khlistunova, Inna;
Biernat, Jacek;
Pickhardt, Marcus;
von Bergen, Martin;
Mandelkow, Eckhard;
Mandelkow, Eva Maria

Publication type:

Abstract

P2-044: Inducible cell models of tauopathy show that tau aggregation is toxic to cells, but tau pathology can be reversed

Published in:

2006

By:

Biernat, Jacek;
Khlistunova, Inna;
Wang, Yipeng;
Pickhardt, Marcus;
Gazova, Zuzana;
Mandelkow, Eva Maria

Publication type:

Abstract

P1-085: Neurofibrilary tangle formation and neuronal loss in an inducible transgenic mouse model expressing 4R repeat tau domain with DelK280 mutation

Published in:

2006

By:

Mocanu, Magdalena M.;
Nissen, Astrid;
Eckermann, Katrin;
Khlistunova, Inna;
Biernat, Jacek;
Schonig, Kai;
Bujard, Hermann;
Haemisch, Andreas;
Rune, Gabriele;
Mandelkow, Eva Maria

Publication type:

Abstract

O2-04-04: Formation of tau pathology in transgenic mice conditionally expressing human tau with delK280 mutation impairs synaptic plasticity in hippocampal neurons

Published in:

2006

By:

Eckermann, Katrin;
Khlistunova, Inna;
Biernat, Jacek;
Mocanu, Magdalena;
Schönig, Kai;
Bujard, Hermann;
Haemisch, Andreas;
Rune, Gabriele;
Zhou, Lepu;
Alzheimer, Christian;
Mandelkow, Eva-Maria

Publication type:

Abstract

P3-303: Inhibition of tau aggregation and disaggregation of PHFs by low MW compounds in vitro and in cells

Published in:

2006

By:

Pickhardt, Marcus;
Gazova, Zuzana;
von Bergen, Martin;
Biernat, Jacek;
Khlistunova, Inna;
Wang, Yi-Peng;
Hascher, Antje;
Mandelkow, Eva-Maria;
Mandelkow, Eckhard

Publication type:

Abstract

P2-047: Inducible cell model of tauopathy expressing full-length tau

Published in:

2006

By:

Wang, Yipeng;
Khlistunova, Inna;
Biernat, Jacek;
Pickhardt, Marcus;
von Bergen, Martin;
Mandelkow, Eckhard;
Mandelkow, Eva Maria

Publication type:

Abstract

P2-044: Inducible cell models of tauopathy show that tau aggregation is toxic to cells, but tau pathology can be reversed

Published in:

2006

By:

Biernat, Jacek;
Khlistunova, Inna;
Wang, Yipeng;
Pickhardt, Marcus;
Gazova, Zuzana;
Mandelkow, Eva Maria

Publication type:

Abstract

P1-085: Neurofibrilary tangle formation and neuronal loss in an inducible transgenic mouse model expressing 4R repeat tau domain with DelK280 mutation

Published in:

2006

By:

Mocanu, Magdalena M.;
Nissen, Astrid;
Eckermann, Katrin;
Khlistunova, Inna;
Biernat, Jacek;
Schonig, Kai;
Bujard, Hermann;
Haemisch, Andreas;
Rune, Gabriele;
Mandelkow, Eva Maria

Publication type:

Abstract

O2-04-04: Formation of tau pathology in transgenic mice conditionally expressing human tau with delK280 mutation impairs synaptic plasticity in hippocampal neurons

Published in:

2006

By:

Eckermann, Katrin;
Khlistunova, Inna;
Biernat, Jacek;
Mocanu, Magdalena;
Schönig, Kai;
Bujard, Hermann;
Haemisch, Andreas;
Rune, Gabriele;
Zhou, Lepu;
Alzheimer, Christian;
Mandelkow, Eva-Maria

Publication type:

Abstract

Structural Polymorphism of 441-Residue Tau at Single Residue Resolution.

Published in:

PLoS Biology, 2009, v. 7, n. 2, p. e1000034, doi. 10.1371/journal.pbio.1000034

By:

Mukrasch, Marco D.;
Bibow, Stefan;
Korukottu, Jegannath;
Jeganathan, Sadasivam;
Biernat, Jacek;
Griesinger, Christian;
Mandelkow, Eckhard;
Zweckstetter, Markus

Publication type:

Article

Lipid membrane templated misfolding and self-assembly of intrinsically disordered tau protein.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-70208-6

By:

Majewski, Jaroslaw;
Jones, Emmalee M.;
Vander Zanden, Crystal M.;
Biernat, Jacek;
Mandelkow, Eckhard;
Chi, Eva Y.

Publication type:

Article

Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity.

Published in:

Human Molecular Genetics, 2012, v. 21, n. 16, p. 3587, doi. 10.1093/hmg/dds190

By:

Fatouros, Chronis;
Pir, Ghulam Jeelani;
Biernat, Jacek;
Koushika, Sandhya Padmanabhan;
Mandelkow, Eckhard;
Mandelkow, Eva-Maria;
Schmidt, Enrico;
Baumeister, Ralf

Publication type:

Article

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases.

Published in:

Human Molecular Genetics, 2012, v. 21, n. 15, p. 3500, doi. 10.1093/hmg/dds161

By:

Coppola, Giovanni;
Chinnathambi, Subashchandrabose;
Lee, Jason JiYong;
Dombroski, Beth A.;
Baker, Matt C.;
Soto-Ortolaza, Alexandra I.;
Lee, Suzee E.;
Klein, Eric;
Huang, Alden Y.;
Sears, Renee;
Lane, Jessica R.;
Karydas, Anna M.;
Kenet, Robert O.;
Biernat, Jacek;
Wang, Li-San;
Cotman, Carl W.;
DeCarli, Charles S.;
Levey, Allan I.;
Ringman, John M.;
Mendez, Mario F.

Publication type:

Article

MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1.

Published in:

EMBO Journal, 2003, v. 22, n. 19, p. 5090, doi. 10.1093/emboj/cdg447

By:

Timm, Thomas;
Xiao-Yu Li;
Biernat, Jacek;
Jiao, Jian;
Mandelkow, Eckhard;
Vandekerckhove, Joel;
Mandelkow, Eva-Maria

Publication type:

Article

Low-Power Solid-State NMR Experiments for Resonance Assignment under Fast Magic-Angle Spinning.

Published in:

ChemPhysChem, 2009, v. 10, n. 13, p. 2205, doi. 10.1002/cphc.200900439

By:

Vijayan, Vinesh;
Demers, Jean-Philippe;
Biernat, Jacek;
Mandelkow, Eckhard;
Becker, Stefan;
Lange, Adam

Publication type:

Article

Die krankheitsassoziierte Tau‐Phosphorylierung behindert die Tubulinpolymerisation in Tau‐Kondensaten.

Published in:

Angewandte Chemie, 2021, v. 133, n. 2, p. 737, doi. 10.1002/ange.202011157

By:

Savastano, Adriana;
Flores, David;
Kadavath, Harindranath;
Biernat, Jacek;
Mandelkow, Eckhard;
Zweckstetter, Markus

Publication type:

Article

Der Bindungsmodus eines Tau‐Peptids mit Tubulin.

Published in:

Angewandte Chemie, 2018, v. 130, n. 12, p. 3301, doi. 10.1002/ange.201712089

By:

Kadavath, Harindranath;
Cabrales Fontela, Yunior;
Jaremko, Mariusz;
Jaremko, Łukasz;
Overkamp, Kerstin;
Biernat, Jacek;
Mandelkow, Eckhard;
Zweckstetter, Markus

Publication type:

Article

Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00480-0

By:

Ambadipudi, Susmitha;
Biernat, Jacek;
Riedel, Dietmar;
Mandelkow, Eckhard;
Zweckstetter, Markus

Publication type:

Article

Inhibition of APP Trafficking by Tau Protein Does Not Increase the Generation of Amyloid-β Peptides.

Published in:

Traffic, 2006, v. 7, n. 7, p. 873, doi. 10.1111/j.1600-0854.2006.00434.x

By:

Goldsbury, Claire;
Mocanu, Maria-Magdalena;
Thies, Edda;
Kaether, Christoph;
Haass, Christian;
Keller, Patrick;
Biernat, Jacek;
Mandelkow, Eckhard;
Mandelkow, Eva-Maria

Publication type:

Article

Lysine/RNA-interactions drive and regulate biomolecular condensation.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-10792-y

By:

Ukmar-Godec, Tina;
Hutten, Saskia;
Grieshop, Matthew P.;
Rezaei-Ghaleh, Nasrollah;
Cima-Omori, Maria-Sol;
Biernat, Jacek;
Mandelkow, Eckhard;
Söding, Johannes;
Dormann, Dorothee;
Zweckstetter, Markus

Publication type:

Article

Disease‐Associated Tau Phosphorylation Hinders Tubulin Assembly within Tau Condensates.

Published in:

Angewandte Chemie International Edition, 2021, v. 60, n. 2, p. 726, doi. 10.1002/anie.202011157

By:

Savastano, Adriana;
Flores, David;
Kadavath, Harindranath;
Biernat, Jacek;
Mandelkow, Eckhard;
Zweckstetter, Markus

Publication type:

Article

The Binding Mode of a Tau Peptide with Tubulin.

Published in:

Angewandte Chemie International Edition, 2018, v. 57, n. 12, p. 3246, doi. 10.1002/anie.201712089

By:

Kadavath, Harindranath;
Cabrales fontela, Yunior;
Jaremko, Mariusz;
Jaremko, Łukasz;
Overkamp, Kerstin;
Biernat, Jacek;
Mandelkow, Eckhard;
Zweckstetter, Markus

Publication type:

Article

FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments.

Published in:

Molecular Neurodegeneration, 2020, v. 15, n. 1, p. 1, doi. 10.1186/s13024-020-00389-1

By:

Kaniyappan, Senthilvelrajan;
Tepper, Katharina;
Biernat, Jacek;
Chandupatla, Ram Reddy;
Hübschmann, Sabrina;
Irsen, Stephan;
Bicher, Sandra;
Klatt, Christoph;
Mandelkow, Eva-Maria;
Mandelkow, Eckhard

Publication type:

Article

Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer.

Published in:

Protein Science: A Publication of the Protein Society, 2016, v. 25, n. 5, p. 1010, doi. 10.1002/pro.2911

By:

Akoury, Elias;
Mukrasch, Marco D.;
Biernat, Jacek;
Tepper, Katharina;
Ozenne, Valery;
Mandelkow, Eckhard;
Blackledge, Martin;
Zweckstetter, Markus

Publication type:

Article

Folding of the Tau Protein on Microtubules.

Published in:

Angewandte Chemie International Edition, 2015, v. 54, n. 35, p. 10347, doi. 10.1002/anie.201501714

By:

Kadavath, Harindranath;
Jaremko, Mariusz;
Jaremko, Łukasz;
Biernat, Jacek;
Mandelkow, Eckhard;
Zweckstetter, Markus

Publication type:

Article

Mechanistic Basis of Phenothiazine-Driven Inhibition of Tau Aggregation.

Published in:

Angewandte Chemie International Edition, 2013, v. 52, n. 12, p. 3511, doi. 10.1002/anie.201208290

By:

Akoury, Elias;
Pickhardt, Marcus;
Gajda, Michal;
Biernat, Jacek;
Mandelkow, Eckhard;
Zweckstetter, Markus

Publication type:

Article

The Dynamic Structure of Filamentous Tau.

Published in:

Angewandte Chemie International Edition, 2011, v. 50, n. 48, p. 11520, doi. 10.1002/anie.201105493

By:

Bibow, Stefan;
Mukrasch, Marco D.;
Chinnathambi, Subashchandrabose;
Biernat, Jacek;
Griesinger, Christian;
Mandelkow, Eckhard;
Zweckstetter, Markus

Publication type:

Article

The Potential for ß-Structure in the Repeat Domain of Tau Protein Determines Aggregation, Synaptic Decay, Neuronal Loss, and Coassembly with Endogenous Tau in Inducible Mouse Models of Tauopathy.

Published in:

Journal of Neuroscience, 2008, v. 28, n. 3, p. 737, doi. 10.1523/JNEUROSCI.2824-07.2008

By:

Mocanu, Maria-Magdalena;
Nissen, Astrid;
Eckermann, Katrin;
Khlistunova, Inna;
Biernat, Jacek;
Drexler, Dagmar;
Petrova, Olga;
Schönig, Kai;
Bujard, Hermann;
Mandelkow, Eckhard;
Lepu Zhou;
Rune, Gabriele;
Mandelkow, Eva-Maria

Publication type:

Article

Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin.

Published in:

EMBO Journal, 2013, v. 32, n. 22, p. 2920, doi. 10.1038/emboj.2013.207

By:

Zempel, Hans;
Luedtke, Julia;
Kumar, Yatender;
Biernat, Jacek;
Dawson, Hana;
Mandelkow, Eckhard;
Mandelkow, Eva‐Maria

Publication type:

Article

Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration.

Published in:

EMBO Journal, 2011, v. 30, n. 23, p. 4825, doi. 10.1038/emboj.2011.376

By:

Li, Xiaoyu;
Kumar, Yatender;
Zempel, Hans;
Mandelkow, Eva-Maria;
Biernat, Jacek;
Mandelkow, Eckhard

Publication type:

Article