Works matching AU Bettens, Karolien

Results: 26

A Phase Ia/b study of MEK1/2 inhibitor binimetinib with MET inhibitor crizotinib in patients with RAS mutant advanced colorectal cancer (MErCuRIC).

Published in:

BMC Cancer, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12885-025-14068-1

By:

Aroldi, Francesca;
Elez, Elena;
André, Thierry;
Perkins, Geraldine;
Prenen, Hans;
Popovici, Vlad;
Gallagher, Peter;
Houlden, Jennifer;
Collins, Linda;
Roberts, Corran;
Rolfo, Christian;
Di Nicolantonio, Federica;
Grayson, Margaret;
Boyd, Ruth;
Bettens, Karolien;
Delfavero, Jurgen;
Coyle, Victoria;
Lawler, Mark;
Khawaja, Hajrah;
Laurent-Puig, Pierre

Publication type:

Article

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.

Published in:

Nature Genetics, 2009, v. 41, n. 10, p. 1094, doi. 10.1038/ng.439

By:

Lambert, Jean-Charles;
Heath, Simon;
Even, Gael;
Campion, Dominique;
Sleegers, Kristel;
Hiltunen, Mikko;
Combarros, Onofre;
Zelenika, Diana;
Bullido, Maria J.;
Tavernier, Béatrice;
Letenneur, Luc;
Bettens, Karolien;
Berr, Claudine;
Pasquier, Florence;
Fiévet, Nathalie;
Barberger-Gateau, Pascale;
Engelborghs, Sebastiaan;
de Deyn, Peter;
Mateo, Ignacio;
Franck, Ana

Publication type:

Article

Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations.

Published in:

Molecular Neurodegeneration, 2015, v. 10, n. 1, p. 1, doi. 10.1186/s13024-015-0024-9

By:

Bettens, Karolien;
Vermeulen, Steven;
Van Cauwenberghe, Caroline;
Heeman, Bavo;
Asselbergh, Bob;
Robberecht, Caroline;
Engelborghs, Sebastiaan;
Vandenbulcke, Mathieu;
Vandenberghe, Rik;
De Deyn, Peter Paul;
Cruts, Marc;
Van Broeckhoven, Christine;
Sleegers, Kristel

Publication type:

Article

APP and BACE1 miRNA genetic variability has no major role in risk for Alzheimer disease.

Published in:

Human Mutation, 2009, v. 30, n. 8, p. 1207, doi. 10.1002/humu.21027

By:

Bettens, Karolien;
Brouwers, Nathalie;
Engelborghs, Sebastiaan;
Van Miegroet, Helen;
De Deyn, Peter P.;
Theuns, Jessie;
Sleegers, Kristel;
Van Broeckhoven, Christine

Publication type:

Article

No association between CALHM1 and risk for Alzheimer dementia in a Belgian population.

Published in:

Human Mutation, 2009, v. 30, n. 4, p. E570, doi. 10.1002/humu.20990

By:

Sleegers, Kristel;
Brouwers, Nathalie;
Bettens, Karolien;
Engelborghs, Sebastiaan;
van Miegroet, Helen;
De Deyn, Peter P;
Van Broeckhoven, Christine

Publication type:

Article

Common variation in GRB-associated Binding Protein 2 (GAB2) and increased risk for Alzheimer dementia.

Published in:

Human Mutation, 2009, v. 30, n. 2, p. E338, doi. 10.1002/humu.20909

By:

Sleegers, Kristel;
Bettens, Karolien;
Brouwers, Nathalie;
Engelborghs, Sebastiaan;
van Miegroet, Helen;
De Deyn, Peter P;
Van Broeckhoven, Christine

Publication type:

Article

SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population.

Published in:

Human Mutation, 2008, v. 29, n. 5, p. 769, doi. 10.1002/humu.20725

By:

Bettens, Karolien;
Brouwers, Nathalie;
Engelborghs, Sebastiaan;
De Deyn, Peter P.;
Van Broeckhoven, Christine;
Sleegers, Kristel

Publication type:

Article

Functional Changes in the Language Network in Response to Increased Amyloid β Deposition in Cognitively Intact Older Adults.

Published in:

Cerebral Cortex, 2016, v. 26, n. 1, p. 358, doi. 10.1093/cercor/bhu286

By:

Adamczuk, Katarzyna;
De Weer, An-Sofie;
Nelissen, Natalie;
Dupont, Patrick;
Sunaert, Stefan;
Bettens, Karolien;
Sleegers, Kristel;
Van Broeckhoven, Christine;
Van Laere, Koen;
Vandenberghe, Rik

Publication type:

Article

The CALHM1 P86L Polymorphism is a Genetic Modifier of Age at Onset in Alzheimer's Disease: a Meta-Analysis Study.

Published in:

Journal of Alzheimer's Disease, 2010, v. 22, n. 1, p. 247, doi. 10.3233/JAD-2010-100933

By:

Lambert, Jean-Charles;
Sleegers, Kristel;
González-Pérez, Antonio;
Ingelsson, Martin;
Beecham, Gary W.;
Hiltunen, Mikko;
Combarros, Onofre;
Bullido, Maria J.;
Brouwers, Nathalie;
Bettens, Karolien;
Berr, Claudine;
Pasquier, Florence;
Richard, Florence;
DeKosky, Steven T.;
Hannequin, Didier;
Haines, Jonathan L.;
Tognoni, Gloria;
Fiévet, Nathalie;
Dartigues, Jean-François;
Tzourio, Christophe

Publication type:

Article

Contribution of TARDBP to Alzheimer's Disease Genetic Etiology.

Published in:

Journal of Alzheimer's Disease, 2010, v. 21, n. 2, p. 423, doi. 10.3233/JAD-2010-100198

By:

Brouwers, Nathalie;
Bettens, Karolien;
Gijselinck, Ilse;
Engelborghs, Sebastiaan;
Pickut, Barbara A.;
Van Miegroet, Helen;
Montoya, Ana Gil;
Mattheijssens, Maria;
Peeters, Karin;
De Deyn, Peter P.;
Cruts, Marc;
Sleegers, Kristel;
Van Broeckhoven, Christine

Publication type:

Article

Follow-Up Study of Susceptibility Loci for Alzheimer's Disease and Onset Age Identified by Genome-Wide Association.

Published in:

Journal of Alzheimer's Disease, 2010, v. 19, n. 4, p. 1169, doi. 10.3233/JAD-2010-1310

By:

Bettens, Karolien;
Brouwers, Nathalie;
Van Miegroet, Helen;
Gil, Ana;
Engelborghs, Sebastiaan;
De Deyn, Peter P.;
Vandenberghe, Rik;
Van Broeckhoven, Christine;
Sleegers, Kristel

Publication type:

Article

A Study of the SORL1 Gene in Alzheimer's Disease and Cognitive Function.

Published in:

Journal of Alzheimer's Disease, 2009, v. 18, n. 1, p. 51, doi. 10.3233/JAD-2009-1137

By:

Fan Liu;
Ikram, M. Arfan;
Janssens, A. Cecile J. W.;
Schuur, Maaike;
De Koning, Inge;
Isaacs, Aaron;
Struchalin, Maksim;
Uitterlinden, Andre G.;
Den Dunnen, Johan T.;
Sleegers, Kristel;
Bettens, Karolien;
Van Broeckhoven, Christine;
Van Swieten, John;
Hofman, Albert;
Oostra, Ben A.;
Aulchenko, Yurii S.;
Breteler, Monique M. B.;
Van Duijn, Cornelia M.

Publication type:

Article

A 22-single nucleotide polymorphism Alzheimer's disease risk score correlates with family history, onset age, and cerebrospinal fluid Aβ42.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 12, p. 1452, doi. 10.1016/j.jalz.2015.02.013

By:

Sleegers, Kristel;
Bettens, Karolien;
De Roeck, Arne;
Van Cauwenberghe, Caroline;
Cuyvers, Elise;
Verheijen, Jan;
Struyfs, Hanne;
Van Dongen, Jasper;
Vermeulen, Steven;
Engelborghs, Sebastiaan;
Vandenbulcke, Mathieu;
Vandenberghe, Rik;
De Deyn, Peter Paul;
Van Broeckhoven, Christine

Publication type:

Article

The identification of high-penetrant loss-of-function mutations in abca7 in Alzheimer’s disease.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P854, doi. 10.1016/j.jalz.2015.08.022

By:

Cuyvers, Elise;
De Roeck, Arne;
Van den Bossche, Tobi;
Van Cauwenberghe, Caroline;
Bettens, Karolien;
Vermeulen, Steven;
Mattheijssens, Maria;
Peeters, Karin;
Engelborghs, Sebastiaan;
Vandenbulcke, Mathieu;
Vandenberghe, Rik;
De Deyn, Peter P.;
Van Broeckhoven, Christine;
Sleegers, Kristel

Publication type:

Article

Targeted re-sequencing of sorl1 in early-onset Alzheimer’s dementia: The european early onset dementia consortium.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P253, doi. 10.1016/j.jalz.2015.07.484

By:

Sleegers, Kristel;
Verheijen, Jan;
Zee, Julie van der;
Bettens, Karolien;
Engelborghs, Sebastiaan;
Vandenbulcke, Mathieu;
Sanchez-Valle, Raquel;
Benussi, Luisa;
de Mendonça, Alexandre;
Pastor, Pau;
Graff, Caroline;
Borroni, Barbara;
Vandenberghe, Rik;
De Deyn, Peter P.;
Van Broeckhoven, Christine

Publication type:

Article

Analysis of sqstm1 in patients with early-onset alzheimer's disease.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2014, v. 10, p. P135, doi. 10.1016/j.jalz.2014.04.077

By:

Cuyvers, Elise;
Bettens, Karolien;
Engelborghs, Sebastiaan;
Vandenbulcke, Mathieu;
Merlin, Céline;
Dillen, Lubina;
Mattheijssens, Maria;
Peeters, Karin;
Cras, Patrick;
Vandenberghe, Rik R.;
De Deyn, Peter;
van der Zee, Julie;
Van Broeckhoven, Christine;
Sleegers, Kristel

Publication type:

Article

Genetic association and interaction of Alzheimer's risk genes CLU, CR1, BIN1, PICALM and MS4A in a Flanders-Belgian cohort

Published in:

2012

By:

Bettens, Karolien;
Van Cauwenberghe, Caroline;
Cuyvers, Elise;
Le Bastard, Nathalie;
Engelborghs, Sebastiaan;
Vandenberghe, Rik;
De Deyn, Peter;
Van Broeckhoven, Christine;
Sleegers, Kristel

Publication type:

Abstract

Meta-Analysis of Rare CLU Variants Shows Association With Alzheimer's Risk and Calls Attention To The CLU Beta-Subunit

Published in:

2011

By:

Bettens, Karolien;
Brouwers, Nathalie;
Engelborghs, Sebastiaan;
Lambert, Jean-Charles;
Vandenberghe, Rik;
Pasquier, Florence;
De Deyn, Peter;
Amouyel, Philippe;
Van Broeckhoven, Christine;
Sleegers, Kristel

Publication type:

Abstract

Risk For Alzheimer's Associated With A Copy Number Variation In The Complement Receptor 1 Increasing C3b/C4b Binding Sites

Published in:

2011

By:

Brouwers, Nathalie;
Van Cauwenberghe, Caroline;
Engelborghs, Sebastiaan;
Lambert, Jean-Charles;
Bettens, Karolien;
Le Bastard, Nathalie;
Pasquier, Florence;
Vandenberghe, Rik;
De Deyn, Peter;
Cruts, Marc;
Amouyel, Philippe;
Sleegers, Kristel;
Van Broeckhoven, Christine

Publication type:

Abstract

Meta-analysis of the association between SORL1 variants and Alzheimer's disease

Published in:

2010

By:

Reitz, Christiane;
Cheng, Rong;
Rogaeva, Ekaterina;
Lee, Joseph;
Tokuhiro, Shinya;
Bettens, Karolien;
Sleegers, Kristel;
Tan, Eng King;
Kimura, Ryo;
Shibata, Nobuto;
Kamboh, Ilyas M.;
Prince, Jonathan;
Maier, Wolfgang;
Riemenschneider, Matthias;
Owen, Michael;
Harold, Denise;
Hollingworth, Paul;
Cellini, Elena;
Pericak-Vance, Margaret A.;
Younkin, Steven

Publication type:

Abstract

In-depth molecular genetic analysis of CLU in Alzheimer's disease

Published in:

2010

By:

Bettens, Karolien;
Brouwers, Nathalie;
Gil, Ana;
Van Miegroet, Helen;
Engelborghs, Sebastiaan;
De Deyn, Peter P.;
Vandenberghe, Rik;
Sleegers, Kristel;
Van Broeckhoven, Christine

Publication type:

Abstract

APP and BACE1 miRNA genetic variability in risk for Alzheimer's disease

Published in:

2009

By:

Bettens, Karolien;
Brouwers, Nathalie;
Van Miegroet, Helen;
Engelborghs, Sebastiaan;
De Deyn, Peter;
Theuns, Jessie;
Sleegers, Kristel;
Van Broeckhoven, Christine

Publication type:

Abstract

Novel APP mutation p.E682K at the β’ processing site is associated with early-onset Alzheimer's disease

Published in:

2009

By:

Brouwers, Nathalie;
Vandenberghe, Rik;
Bettens, Karolien;
Van den Broeck, Marleen;
Brys, Jolien;
Van Miegroet, Helen;
Sleegers, Kristel;
Van Broeckhoven, Christine

Publication type:

Abstract

P3-266: GAB2 and risk for Alzheimer's dementia in a Belgian population

Published in:

2008

By:

Sleegers, Kristel;
Bettens, Karolien;
Engelborghs, Sebastiaan;
Brouwers, Nathalie;
van Miegroet, Helen;
De Deyn, Peter P.;
Van Broeckhoven, Christine

Publication type:

Abstract

P3-202: The neuronal sorting receptor SORL1 is genetically associated with increased risk for late-onset Alzheimer's disease in the Belgian population

Published in:

2008

By:

Bettens, Karolien;
Brouwers, Nathalie;
Engelborghs, Sebastiaan;
De Deyn, Peter;
Van Broeckhoven, Christine;
Sleegers, Kristel

Publication type:

Abstract

Current status on Alzheimer disease molecular genetics: from past, to present, to future.

Published in:

Human Molecular Genetics, 2010, v. 19, n. R1, p. R4, doi. 10.1093/hmg/ddq142

By:

Bettens, Karolien;
Sleegers, Kristel;
Van Broeckhoven, Christine

Publication type:

Article