Works by Bertin, John

Results: 29

<italic>t</italic>-BuOOH induces ferroptosis in human and murine cell lines.

Published in:

Archives of Toxicology, 2018, v. 92, n. 2, p. 759, doi. 10.1007/s00204-017-2066-y

By:

Wenz, Christine;
Faust, Dagmar;
Linz, Berenike;
Turmann, Christian;
Nikolova, Teodora;
Bertin, John;
Gough, Peter;
Wipf, Peter;
Schröder, Anna Sophia;
Krautwald, Stefan;
Dietrich, Cornelia

Publication type:

Article

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06155-8

By:

Taraborrelli, Lucia;
Peltzer, Nieves;
Montinaro, Antonella;
Kupka, Sebastian;
Rieser, Eva;
Hartwig, Torsten;
Sarr, Aida;
Darding, Maurice;
Draber, Peter;
Haas, Tobias L.;
Akarca, Ayse;
Marafioti, Teresa;
Pasparakis, Manolis;
Bertin, John;
Gough, Peter J.;
Bouillet, Philippe;
Strasser, Andreas;
Leverkus, Martin;
Silke, John;
Walczak, Henning

Publication type:

Article

Receptor-interacting protein 1 kinase inhibition therapeutically ameliorates experimental T cell-dependent colitis in mice.

Published in:

Cell Death & Disease, 2020, v. 11, n. 4, p. 1, doi. 10.1038/s41419-020-2423-2

By:

Gobbetti, Thomas;
Berger, Scott B.;
Fountain, Kathryn;
Slocombe, Tom;
Rowles, Alison;
Pearse, Gail;
Harada, Isobel;
Bertin, John;
Haynes, Andrea C.;
Beal, Allison M.

Publication type:

Article

RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function.

Published in:

Cell Death & Disease, 2017, v. 8, n. 2, p. e2588, doi. 10.1038/cddis.2017.20

By:

Hänggi, Kay;
Vasilikos, Lazaros;
Valls, Aida Freire;
Yerbes, Rosario;
Knop, Janin;
Spilgies, Lisanne M;
Rieck, Kristy;
Misra, Tvisha;
Bertin, John;
Gough, Peter J;
Schmidt, Thomas;
de Almodòvar, Carmen Ruiz;
Wong, W Wei-Lynn

Publication type:

Article

RIPK1 protects from TNF-α-mediated liver damage during hepatitis.

Published in:

Cell Death & Disease, 2016, v. 7, n. 11, p. e2462, doi. 10.1038/cddis.2016.362

By:

Filliol, Aveline;
Piquet-Pellorce, Claire;
Le Seyec, Jacques;
Farooq, Muhammad;
Genet, Valentine;
Lucas-Clerc, Catherine;
Bertin, John;
Gough, Peter J;
Dimanche-Boitrel, Marie-Thérèse;
Vandenabeele, Peter;
Bertrand, Mathieu JM;
Samson, Michel

Publication type:

Article

Kinase-independent function of RIP1, critical for mature T-cell survival and proliferation.

Published in:

Cell Death & Disease, 2016, v. 7, n. 9, p. e2379, doi. 10.1038/cddis.2016.307

By:

Dowling, John P;
Cai, Yubo;
Bertin, John;
Gough, Peter J;
Zhang, Jianke

Publication type:

Article

Respiratory Syncytial Virus Infection Promotes Necroptosis and HMGB1 Release by Airway Epithelial Cells.

Published in:

2020

By:

Simpson, Jennifer;
Zhixuan Loh;
Ullah, Md Ashik;
Lynch, Jason P.;
Werder, Rhiannon B.;
Collinson, Natasha;
Zhang, Vivian;
Dondelinger, Yves;
Bertrand, Mathieu J. M.;
Everard, Mark L.;
Blyth, Christopher C.;
Hartel, Gunter;
Van Oosterhout, Antoon J.;
Gough, Peter J.;
Bertin, John;
Upham, John W.;
Spann, Kirsten M.;
Phipps, Simon;
Loh, Zhixuan

Publication type:

journal article

NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens.

Published in:

Nature, 2012, v. 488, n. 7411, p. 389, doi. 10.1038/nature11250

By:

Anand, Paras K.;
Malireddi, R. K. Subbarao;
Lukens, John R.;
Vogel, Peter;
Bertin, John;
Lamkanfi, Mohamed;
Kanneganti, Thirumala-Devi

Publication type:

Article

Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin.

Published in:

EMBO Reports, 2005, v. 6, n. 12, p. 1201, doi. 10.1038/sj.embor.7400552

By:

Magalhaes, Joao Gamelas;
Philpott, Dana J.;
Nahori, Marie-Anne;
Jéhanno, Muguette;
Fritz, Joerg;
Le Bourhis, Lionel;
Viala, Jérôme;
Hugot, Jean-Pierre;
Giovannini, Marco;
Bertin, John;
Lepoivre, Michel;
Mengin-Lecreulx, Dominique;
Sansonetti, Philippe J.;
Girardin, Stephen E.

Publication type:

Article

CARD4/Nod1 mediates NF-?B and JNK activation by invasive Shigella flexneri.

Published in:

2001

By:

Girardin, Stephen E.;
Tournebize, Régis;
Marvis, Maria;
Page, Anne-Laure;
Li, Xiaoxia;
Stark, George R.;
Bertin, John;
Distefano, Peter S.;
Yaniv, Moshe;
Sansonetti, Philippe J.;
Philpott, Dana J.

Publication type:

Report

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis.

Published in:

Nature, 2014, v. 513, n. 7516, p. 95, doi. 10.1038/nature13706

By:

Takahashi, Nozomi;
Vereecke, Lars;
Bertrand, Mathieu J. M.;
Duprez, Linde;
Divert, Tatyana;
Sze, Mozes;
Gilbert, Barbara;
Kourula, Stephanie;
Goossens, Vera;
Lefebvre, Sylvie;
Declercq, Wim;
van Loo, Geert;
Berger, Scott B.;
Bertin, John;
Gough, Peter J.;
Gonçalves, Amanda;
Günther, Claudia;
Becker, Christoph;
Vandenabeele, Peter

Publication type:

Article

A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection.

Published in:

Science Immunology, 2021, v. 6, n. 59, p. 1, doi. 10.1126/sciimmunol.abi9002

By:

Humphries, Fiachra;
Shmuel-Galia, Liraz;
Jiang, Zhaozhao;
Wilson, Ruth;
Landis, Philip;
Ng, Sze-Ling;
Parsi, Krishna Mohan;
Maehr, Rene;
Cruz, John;
Morales, Angel;
Ramanjulu, Joshi M.;
Bertin, John;
Pesiridis, G. Scott;
Fitzgerald, Katherine A.

Publication type:

Article

Response to Inhibition of Receptor‐Interacting Protein Kinase 1 (RIPK1) in Active Plaque Psoriasis: A Randomized Placebo‐Controlled Study.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 108, n. 4, p. 808, doi. 10.1002/cpt.1852

By:

Weisel, Kathleen;
Berger, Scott;
Papp, Kim;
Maari, Catherine;
Krueger, James G.;
Scott, Nicola;
Tompson, Debra;
Wang, Susanne;
Simeoni, Monica;
Bertin, John;
Peter Tak, Paul

Publication type:

Article

Identification of an antibody-based immunoassay for measuring direct target binding of RIPK1 inhibitors in cells and tissues.

Published in:

Pharmacology Research & Perspectives, 2017, v. 5, n. 6, p. 1, doi. 10.1002/prp2.377

By:

Finger, Joshua N.;
Brusq, Jean‐Marie;
Campobasso, Nino;
Cook, Michael N.;
Deutsch, Jennifer;
Haag, Heather;
Harris, Philip A.;
Jenkins, Earl L.;
Joglekar, Devika;
Lich, John D.;
Maguire, Sean;
Nagilla, Rakesh;
Rivera, Elizabeth J.;
Sun, Helen;
Votta, Bartholomew J.;
Bertin, John;
Gough, Peter J.

Publication type:

Article

Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK1 inhibitor GSK2982772 in healthy volunteers.

Published in:

Pharmacology Research & Perspectives, 2017, v. 5, n. 6, p. 1, doi. 10.1002/prp2.365

By:

Weisel, Kathleen;
Scott, Nicola E.;
Tompson, Debra J.;
Votta, Bartholomew J.;
Madhavan, Sujith;
Povey, Kat;
Wolstenholme, Allen;
Simeoni, Monica;
Rudo, Todd;
Richards‐Peterson, Lauren;
Sahota, Tarjinder;
Wang, J. Gene;
Lich, John;
Finger, Joshua;
Verticelli, Adeline;
Reilly, Michael;
Gough, Peter J.;
Harris, Philip A.;
Bertin, John;
Wang, Mei‐Lun

Publication type:

Article

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3.

Published in:

Nature, 2006, v. 440, n. 7081, p. 233, doi. 10.1038/nature04517

By:

Kanneganti, Thirumala-Devi;
Özören, Nesrin;
Body-Malapel, Mathilde;
Amer, Amal;
Park, Jong-Hwan;
Franchi, Luigi;
Whitfield, Joel;
Barchet, Winfried;
Colonna, Marco;
Vandenabeele, Peter;
Bertin, John;
Coyle, Anthony;
Grant, Ethan P.;
Akira, Shizuo;
Núñez, Gabriel

Publication type:

Article

MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses.

Published in:

PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0127083

By:

Yu, Jong W.;
Hoffman, Sandy;
Beal, Allison M.;
Dykon, Angela;
Ringenberg, Michael A.;
Hughes, Anna C.;
Dare, Lauren;
Anderson, Amber D.;
Finger, Joshua;
Kasparcova, Viera;
Rickard, David;
Berger, Scott B.;
Ramanjulu, Joshi;
Emery, John G.;
Gough, Peter J.;
Bertin, John;
Foley, Kevin P.

Publication type:

Article

Identification of Selective Small Molecule Inhibitors of the Nucleotide-Binding Oligomerization Domain 1 (NOD1) Signaling Pathway.

Published in:

PLoS ONE, 2014, v. 9, n. 5, p. 1, doi. 10.1371/journal.pone.0096737

By:

Rickard, David J.;
Sehon, Clark A.;
Kasparcova, Viera;
Kallal, Lorena A.;
Haile, Pamela A.;
Zeng, Xin;
Montoute, Monica N.;
Poore, Derek D.;
Li, Hu;
Wu, Zining;
Eidam, Patrick M.;
Emery, John G.;
Marquis, Robert W.;
Gough, Peter J.;
Bertin, John

Publication type:

Article

Pathogen Sensing Pathways in Human Embryonic Stem Cell Derived-Endothelial Cells: Role of NOD1 Receptors.

Published in:

PLoS ONE, 2014, v. 9, n. 4, p. 1, doi. 10.1371/journal.pone.0091119

By:

Reed, Daniel M.;
Foldes, Gabor;
Gatheral, Timothy;
Paschalaki, Koralia E.;
Lendvai, Zsuzsanna;
Bagyura, Zsolt;
Nemeth, Tamas;
Skopal, Judit;
Merkely, Bela;
Telcian, Aurica G.;
Gogsadze, Leila;
Edwards, Michael R.;
Gough, Peter J.;
Bertin, John;
Johnston, Sebastian L.;
Harding, Sian E.;
Mitchell, Jane A.

Publication type:

Article

Identification of Benzimidazole Diamides as Selective Inhibitors of the Nucleotide-Binding Oligomerization Domain 2 (NOD2) Signaling Pathway.

Published in:

PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0069619

By:

Rickard, David J.;
Sehon, Clark A.;
Kasparcova, Viera;
Kallal, Lorena A.;
Zeng, Xin;
Montoute, Monica N.;
Chordia, Tushar;
Poore, Derek D.;
Li, Hu;
Wu, Zining;
Eidam, Patrick M.;
Haile, Pamela A.;
Yu, Jong;
Emery, John G.;
Marquis, Robert W.;
Gough, Peter J.;
Bertin, John

Publication type:

Article

A Key Role for the Endothelium in NOD1 Mediated Vascular Inflammation: Comparison to TLR4 Responses.

Published in:

PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0042386

By:

Gatheral, Timothy;
Reed, Daniel M.;
Moreno, Laura;
Gough, Peter J.;
Votta, Bart J.;
Sehon, Clark A.;
Rickard, David J.;
Bertin, John;
Lim, Eric;
Nicholson, Andrew G.;
Mitchell, Jane A.;
Bozza, Patricia T.

Publication type:

Article

Protective Effects of Necrostatin-1 in Acute Pancreatitis: Partial Involvement of Receptor Interacting Protein Kinase 1.

Published in:

Cells (2073-4409), 2021, v. 10, n. 5, p. 1035, doi. 10.3390/cells10051035

By:

Ouyang, Yulin;
Wen, Li;
Armstrong, Jane A.;
Chvanov, Michael;
Latawiec, Diane;
Cai, Wenhao;
Awais, Mohammad;
Mukherjee, Rajarshi;
Huang, Wei;
Gough, Peter J.;
Bertin, John;
Tepikin, Alexei V.;
Sutton, Robert;
Criddle, David N.;
Bultynck, Geert;
Tikkanen, Ritva

Publication type:

Article

Inhibition of Bcl10-mediated activation of NF-κB by BinCARD, a Bcl10-interacting CARD protein

Published in:

FEBS Letters, 2004, v. 578, n. 3, p. 239, doi. 10.1016/j.febslet.2004.10.094

By:

Woo, Ha-Na;
Hong, Gil-Sun;
Jun, Joon-Il;
Cho, Dong-Hyung;
Hyun-WooChoi;
Lee, Ho-June;
Chung, Chul-Woong;
Kim, In-Ki;
Jo, Dong-Gyu;
Pyo, Jong-Ok;
Bertin, John;
Jung, Yong-Keun

Publication type:

Article

Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-κB and caspase-1

Published in:

FEBS Letters, 2002, v. 530, n. 1-3, p. 73, doi. 10.1016/S0014-5793(02)03416-6

By:

Grenier, Jill M.;
Wang, Lin;
Manji, Gulam A.;
Huang, Waan-Jeng;
Al-Garawi, Amal;
Kelly, Roxanne;
Carlson, Adam;
Merriam, Sarah;
Lora, Jose M.;
Briskin, Michael;
DiStefano, Peter S.;
Bertin, John

Publication type:

Article

Necroptosis Is Active in Children With Inflammatory Bowel Disease and Contributes to Heighten Intestinal Inflammation.

Published in:

American Journal of Gastroenterology (Springer Nature), 2014, v. 109, n. 2, p. 279, doi. 10.1038/ajg.2013.403

By:

Pierdomenico, Maria;
Negroni, Anna;
Stronati, Laura;
Vitali, Roberta;
Prete, Enrica;
Bertin, John;
Gough, Peter J;
Aloi, Marina;
Cucchiara, Salvatore

Publication type:

Article

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages.

Published in:

Nature Immunology, 2006, v. 7, n. 6, p. 576, doi. 10.1038/ni1346

By:

Franchi, Luigi;
Amer, Amal;
Body-Malapel, Mathilde;
Kanneganti, Thirumala-Devi;
Özören, Nesrin;
Jagirdar, Rajesh;
Inohara, Naohiro;
Vandenabeele, Peter;
Bertin, John;
Coyle, Anthony;
Grant, Ethan P;
Núñez, Gabriel

Publication type:

Article

Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island.

Published in:

Nature Immunology, 2004, v. 5, n. 11, p. 1166, doi. 10.1038/ni1131

By:

Viala, Jérôme;
Chaput, Catherine;
Boneca, Ivo G.;
Cardona, Ana;
Girardin, Stephen E.;
Moran, Anthony P.;
Athman, Rafika;
Mémet, Sylvie;
Huerre, Michel R.;
Coyle, Anthony J.;
Distefano, Peter S.;
Sansonetti, Philippe J.;
Labigne, Agnès;
Bertin, John;
Philpott, Dana J.;
Ferrero, Richard L.

Publication type:

Article

A requirement for CARMA1 in TCR-induced NF-?B activation.

Published in:

Nature Immunology, 2002, v. 3, n. 9, p. 830, doi. 10.1038/ni824

By:

Wang, Donghai;
You, Yun;
Case, Sara M.;
McAllister-Lucas, Linda M.;
Wang, Lin;
DiStefano, Peter S.;
Nunez, Gabriel;
Bertin, John;
Lin, Xin

Publication type:

Article

Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28745-3

By:

Triantafilou, Martha;
Ramanjulu, Joshi;
Booty, Lee M.;
Jimenez-Duran, Gisela;
Keles, Hakan;
Saunders, Ken;
Nevins, Neysa;
Koppe, Emma;
Modis, Louise K.;
Pesiridis, G. Scott;
Bertin, John;
Triantafilou, Kathy

Publication type:

Article