Works by Bers, Donald M.

Results: 100

Cardiomyocyte Na+ and Ca2+ mishandling drives vicious cycle involving CaMKII, ROS, and ryanodine receptors.

Published in:

Basic Research in Cardiology, 2021, v. 116, n. 1, p. 1, doi. 10.1007/s00395-021-00900-9

By:

Hegyi, Bence;
Pölönen, Risto‑Pekka;
Hellgren, Kim T.;
Ko, Christopher Y.;
Ginsburg, Kenneth S.;
Bossuyt, Julie;
Mercola, Mark;
Bers, Donald M.

Publication type:

Article

CaMKII and PKA-dependent phosphorylation co-regulate nuclear localization of HDAC4 in adult cardiomyocytes.

Published in:

Basic Research in Cardiology, 2021, v. 116, n. 1, p. 1, doi. 10.1007/s00395-021-00850-2

By:

Helmstadter, Kathryn G.;
Ljubojevic-Holzer, Senka;
Wood, Brent M.;
Taheri, Khanha D.;
Sedej, Simon;
Erickson, Jeffrey R.;
Bossuyt, Julie;
Bers, Donald M.

Publication type:

Article

Hyperglycemia regulates cardiac K+ channels via O-GlcNAc-CaMKII and NOX2-ROS-PKC pathways.

Published in:

Basic Research in Cardiology, 2020, v. 115, n. 6, p. 1, doi. 10.1007/s00395-020-00834-8

By:

Hegyi, Bence;
Borst, Johanna M.;
Bailey, Logan R. J.;
Shen, Erin Y.;
Lucena, Austen J.;
Navedo, Manuel F.;
Bossuyt, Julie;
Bers, Donald M.

Publication type:

Article

Upregulated Na/Ca exchange is involved in both contractile dysfunction and arrhythmogenesis in heart failure.

Published in:

Basic Research in Cardiology, 2002, v. 97, p. I36

By:

Bers, Donald M.;
Pogwizd, Steven M.;
Schlotthauer, Klaus

Publication type:

Article

Action potential duration determines sarcoplasmic reticulum Ca2+ reloading in mammalian ventricular myocytes.

Published in:

Journal of Physiology, 2004, v. 559, n. 2, p. 593, doi. 10.1113/jphysiol.2004.067959

By:

Bassani, Rosana A.;
Altamirano, Julio;
Puglisi, José L.;
Bers, Donald M.

Publication type:

Article

Modulation of excitation--contraction coupling by isoproterenol in cardiomyocytes with controlled SR Ca2+ load and Ca2+ current trigger.

Published in:

Journal of Physiology, 2004, v. 556, n. 2, p. 463, doi. 10.1113/jphysiol.2003.055384

By:

Ginsburg, Kenneth S.;
Bers, Donald M.

Publication type:

Article

Intracellular [Na+] and Na+ pump rate in rat and rabbit ventricular myocytes.

Published in:

Journal of Physiology, 2002, v. 539, n. 1, p. 133, doi. 10.1113/jphysiol.2001.012940

By:

Despa, Sanda;
Islam, Mohammed A.;
Pogwizd, Steven M.;
Bers, Donald M.

Publication type:

Article

A cardiac dihydropyridine receptor II-III loop peptide inhibits resting Ca2+ sparks in ferret ventricular myocytes.

Published in:

Journal of Physiology, 2001, v. 537, n. 1, p. 17, doi. 10.1111/j.1469-7793.2001.0017k.x

By:

Li, Yanxia;
Bers, Donald M.

Publication type:

Article

Ca2+ influx via the L-type Ca2+ channel during tail current and above current reversal potential in ferret ventricular myocytes.

Published in:

Journal of Physiology, 2000, v. 523, n. 1, p. 57, doi. 10.1111/j.1469-7793.2000.t01-2-00057.x

By:

Zhou, Zhuan;
Bers, Donald M.

Publication type:

Article

Cytosolic and mitochondrial Ca2+ signals in patch clamped mammalian ventricular myocytes.

Published in:

Journal of Physiology, 1998, v. 507, n. 2, p. 379, doi. 10.1111/j.1469-7793.1998.379bt.x

By:

Zhou, Zhuan;
Matlib, Mohammed A.;
Bers, Donald M.

Publication type:

Article

The effect of Ca2+-calmodulin-dependent protein kinase II on cardiac excitation-contraction coupling in ferret ventricular myocytes.

Published in:

Journal of Physiology, 1997, v. 501, n. 1, p. 17, doi. 10.1111/j.1469-7793.1997.017bo.x

By:

Li, Li;
Satoh, Hiroshi;
Ginsburg, Kenneth S.;
Bers, Donald M.

Publication type:

Article

Cardiac-specific Conditional Knockout of the 18-kDa Mitochondrial Translocator Protein Protects from Pressure Overload Induced Heart Failure.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-34451-2

By:

Thai, Phung N.;
Daugherty, Daniel J.;
Frederich, Bert J.;
Lu, Xiyuan;
Deng, Wenbin;
Bers, Donald M.;
Dedkova, Elena N.;
Schaefer, Saul

Publication type:

Article

S-nitrosylation of cardiac myocyte proteins may underlie sex differences in cardiac disease.

Published in:

Frontiers in Physiology, 2025, p. 1, doi. 10.3389/fphys.2025.1565917

By:

Asamudo, Esther U.;
Parackal, Raquel E.;
Erickson, Jeffrey R.;
Bers, Donald M.

Publication type:

Article

Beyond beta blockers.

Published in:

Nature Medicine, 2005, v. 11, n. 4, p. 379, doi. 10.1038/nm0405-379

By:

Bers, Donald M.

Publication type:

Article

Subcellular Propagation of Cardiomyocyte β-Adrenergic Activation of Calcium Uptake Involves Internal β-Receptors and AKAP7.

Published in:

Function, 2022, v. 3, n. 3, p. 1, doi. 10.1093/function/zqac020

By:

Shannon, Thomas R;
Bare, Dan J;
Van Dijk, Sabine;
Raofi, Shayan;
Huynh, Tiffany N-M;
Xiang, Yang K;
Bossuyt, Julie;
Dodge-Kafka, Kimberly L;
Ginsburg, Kenneth S;
Bers, Donald M

Publication type:

Article

Akt regulates L-type Ca2+ channel activity by modulating Cavα 1 protein stability.

Published in:

Journal of Cell Biology, 2009, v. 184, n. 6, p. 923, doi. 10.1083/jcb.200805063

By:

Catalucci, Daniele;
Deng-Hong Zhang;
DeSantiago, Jaime;
Aimond, Franck;
Barbara, Guillaume;
Chemin, Jean;
Bonci, Désiré;
Picht, Eckard;
Rusconi, Francesca;
Dalton, Nancy D.;
Peterson, Kirk L.;
Richard, Sylvain;
Bers, Donald M.;
Brown, Joan Heller;
Condorelli, Gianluigi

Publication type:

Article

Regulation of CaMKII signaling in cardiovascular disease.

Published in:

Frontiers in Pharmacology, 2015, p. 1, doi. 10.3389/fphar.2015.00178

By:

Mollova, Mariya Y.;
Katus, Hugo A.;
Backs, Johannes;
Santulli, Gaetano;
Bers, Donald M.

Publication type:

Article

CaMKII comes of age in cardiac health and disease.

Published in:

Frontiers in Pharmacology, 2014, v. 5, p. 1, doi. 10.3389/fphar.2014.00154

By:

Grandi, Eleonora;
Edwards, Andrew G.;
Herren, Anthony W.;
Bers, Donald M.

Publication type:

Article

Ca2+ current facilitation is CaMKII-dependent and has arrhythmogenic consequences.

Published in:

Frontiers in Pharmacology, 2014, v. 5, p. 1, doi. 10.3389/fphar.2014.00144

By:

Bers, Donald M.;
Morotti, Stefano;
Greenstein, Joseph L.;
Anderson, Mark Edward;
Grueter, Chad

Publication type:

Article

Mitochondrial Quality Control in Aging and Heart Failure: Influence of Ketone Bodies and Mitofusin-Stabilizing Peptides.

Published in:

Frontiers in Physiology, 2019, p. N.PAG, doi. 10.3389/fphys.2019.00382

By:

Thai, Phung N.;
Seidlmayer, Lea K.;
Miller, Charles;
Ferrero, Maura;
Dorn II, Gerald W.;
Schaefer, Saul;
Bers, Donald M.;
Dedkova, Elena N.

Publication type:

Article

Na+ transport in cardiac myocytes; Implications for excitation-contraction coupling.

Published in:

IUBMB Life, 2009, v. 61, n. 3, p. 215, doi. 10.1002/iub.163

By:

Bers, Donald M.;
Despa, Sanda

Publication type:

Article

Nitric Oxide-Dependent Activation of CaMKII Increases Diastolic Sarcoplasmic Reticulum Calcium Release in Cardiac Myocytes in Response to Adrenergic Stimulation.

Published in:

PLoS ONE, 2014, v. 9, n. 2, p. 1, doi. 10.1371/journal.pone.0087495

By:

Curran, Jerry;
Tang, Lifei;
Roof, Steve R.;
Velmurugan, Sathya;
Millard, Ashley;
Shonts, Stephen;
Wang, Honglan;
Santiago, Demetrio;
Ahmad, Usama;
Perryman, Matthew;
Bers, Donald M.;
Mohler, Peter J.;
Ziolo, Mark T.;
Shannon, Thomas R.

Publication type:

Article

Formation of Spatially Discordant Alternans Due to Fluctuations and Diffusion of Calcium.

Published in:

PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0085365

By:

Sato, Daisuke;
Bers, Donald M.;
Shiferaw, Yohannes

Publication type:

Article

Nuclear Translocation of Cardiac G Protein-Coupled Receptor Kinase 5 Downstream of Select Gq-Activating Hypertrophic Ligands Is a Calmodulin-Dependent Process.

Published in:

PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0057324

By:

Gold, Jessica I.;
Martini, Jeffrey S.;
Hullmann, Jonathan;
Gao, Erhe;
Chuprun, J. Kurt;
Lee, Linda;
Tilley, Douglas G.;
Rabinowitz, Joseph E.;
Bossuyt, Julie;
Bers, Donald M.;
Koch, Walter J.

Publication type:

Article

Targets for therapy in sarcomeric cardiomyopathies.

Published in:

Cardiovascular Research, 2015, v. 105, n. 4, p. 457, doi. 10.1093/cvr/cvv023

By:

Tardiff, Jil C.;
Carrier, Lucie;
Bers, Donald M.;
Poggesi, Corrado;
Ferrantini, Cecilia;
Coppini, Raffaele;
Maier, Lars S.;
Ashrafian, Houman;
Huke, Sabine;
van der Velden, Jolanda

Publication type:

Article

Na+/K+-ATPase α2-isoform preferentially modulates Ca2+ transients and sarcoplasmic reticulum Ca2+ release in cardiac myocytes.

Published in:

Cardiovascular Research, 2012, v. 95, n. 4, p. 480, doi. 10.1093/cvr/cvs213

By:

Despa, Sanda;
Lingrel, Jerry B.;
Bers, Donald M.

Publication type:

Article

Minding the store of Ca2+ during ischaemia/reperfusion.

Published in:

2010

By:

Bers, Donald M.;
Ginsburg, Kenneth S.

Publication type:

Editorial

Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation–contraction coupling in the heart

Published in:

Cardiovascular Research, 2007, v. 73, n. 4, p. 631, doi. 10.1016/j.cardiores.2006.11.005

By:

Maier, Lars S.;
Bers, Donald M.

Publication type:

Article

Calmodulin and Ca2+/calmodulin kinases in the heart — Physiology and pathophysiology

Published in:

2007

By:

Maier, Lars S.;
Bers, Donald M.;
Brown, Joan Heller

Publication type:

Editorial

Differential distribution and regulation of mouse cardiac Na+/K+-ATPase α1 and α2 subunits in T-tubule and surface sarcolemmal membranes

Published in:

Cardiovascular Research, 2007, v. 73, n. 1, p. 92, doi. 10.1016/j.cardiores.2006.11.006

By:

Berry, Roger G.;
Despa, Sanda;
Fuller, William;
Bers, Donald M.;
Shattock, Michael J.

Publication type:

Article

Impaired relaxation in transgenic mice overexpressing junctin

Published in:

Cardiovascular Research, 2003, v. 59, n. 2, p. 369, doi. 10.1016/S0008-6363(03)00432-2

By:

Kirchhefer, Uwe;
Neumann, Joachim;
Bers, Donald M.;
Buchwalow, Igor B.;
Fabritz, Larissa;
Hanske, Gabriela;
Justus, Isabel;
Riemann, Burkhard;
Schmitz, Wilhelm;
Jones, Larry R.

Publication type:

Article

Sodium and the heart: a hidden key factor in cardiac regulation

Published in:

2003

By:

Pieske, Burkert;
Houser, Steven R.;
Hasenfuss, Gerd;
Bers, Donald M.

Publication type:

Editorial

Stretch-dependent slow force response in isolated rabbit myocardium is Na+ dependent

Published in:

Cardiovascular Research, 2003, v. 57, n. 4, p. 1052, doi. 10.1016/S0008-6363(02)00830-1

By:

von Lewinski, Dirk;
Stumme, Burkhard;
Maier, Lars S.;
Luers, Claus;
Bers, Donald M.;
Pieske, Burkert

Publication type:

Article

Intracellular Na in animal models of hypertrophy and heart failure: contractile function and arrhythmogenesis

Published in:

Cardiovascular Research, 2003, v. 57, n. 4, p. 887, doi. 10.1016/S0008-6363(02)00735-6

By:

Pogwizd, Steven M.;
Sipido, Karin R.;
Verdonck, Fons;
Bers, Donald M.

Publication type:

Article

Intracellular Na+ regulation in cardiac myocytes

Published in:

Cardiovascular Research, 2003, v. 57, n. 4, p. 897, doi. 10.1016/S0008-6363(02)00656-9

By:

Bers, Donald M.;
Barry, William H.;
Despa, Sanda

Publication type:

Article

Ca channels in cardiac myocytes: structure and function in Ca influx and intracellular Ca release.

Published in:

Cardiovascular Research, 1999, v. 42, n. 2, p. 339, doi. 10.1016/S0008-6363(99)00038-3

By:

Bers, Donald M;
Perez-Reyes, Edward

Publication type:

Article

α‐Actinin‐1 promotes activity of the L‐type Ca2+ channel Cav1.2.

Published in:

EMBO Journal, 2020, v. 39, n. 18, p. 1, doi. 10.15252/embj.2020106171

By:

Turner, Matthew;
Anderson, David E;
Bartels, Peter;
Nieves‐Cintron, Madeline;
Coleman, Andrea M;
Henderson, Peter B;
Man, Kwun Nok Mimi;
Tseng, Pang‐Yen;
Yarov‐Yarovoy, Vladimir;
Bers, Donald M;
Navedo, Manuel F;
Horne, Mary C;
Ames, James B;
Hell, Johannes W

Publication type:

Article

α‐Actinin‐1 promotes activity of the L‐type Ca2+ channel Cav1.2.

Published in:

EMBO Journal, 2020, v. 39, n. 5, p. 1, doi. 10.15252/embj.2019102622

By:

Turner, Matthew;
Anderson, David E;
Bartels, Peter;
Nieves‐Cintron, Madeline;
Coleman, Andrea M;
Henderson, Peter B;
Man, Kwun Nok Mimi;
Tseng, Pang‐Yen;
Yarov‐Yarovoy, Vladimir;
Bers, Donald M;
Navedo, Manuel F;
Horne, Mary C;
Ames, James B;
Hell, Johannes W

Publication type:

Article

Mechanochemotransduction During Cardiomyocyte Contraction Is Mediated by Localized Nitric Oxide Signaling.

Published in:

Science Signaling, 2014, v. 7, n. 317, p. 1, doi. 10.1126/scisignal.2005046

By:

Zhong Jian;
Huilan Han;
Tieqiao Zhang;
Puglisi, Jose;
Izu, Leighton T.;
Shaw, John A.;
Ekama Onofiok;
Erickson, Jeffery R.;
Yi-Je Chen;
Horvath, Balazs;
Shimkunas, Rafael;
Wenwu Xiao;
Yuanpei Li;
Tingrui Pan;
Chan, James;
Banyasz, Tamas;
Tardiff, Jil C.;
Nipavan Chiamvimonvat;
Bers, Donald M.;
Lam, Kit S.

Publication type:

Article

Decreased cardiac L-type Ca2+ channel activity induces hypertrophy and heart failure in mice.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 280, doi. 10.1172/JCI58227

By:

Goonasekera, Sanjeewa A.;
Hammer, Karin;
Auger-Messier, Mannix;
Bodi, Ilona;
Xiongwen Chen;
Hongyu Zhang;
Reiken, Steven;
Elrod, John W.;
Correll, Robert N.;
York, Allen J.;
Sargent, Michelle A.;
Hofmann, Franz;
Moosmang, Sven;
Marks, Andrew R.;
Houser, Steven R.;
Bers, Donald M.;
Molkentin, Jeffery D.

Publication type:

Article

Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels.

Published in:

2006

By:

Wagner, Stefan;
Dybkova, Nataliya;
Rasenack, Eva C. L.;
Jacobshagen, Claudius;
Fabritz, Larissa;
Kirchhof, Paulus;
Maier, Sebastian K. G.;
Tong Zhang;
Hasenfuss, Gerd;
Brown, Joan Heller;
Bers, Donald M.;
Maier, Lars S.;
Zhang, Tong

Publication type:

journal article

Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling.

Published in:

2006

By:

Wu, Xu;
Zhang, Tong;
Bossuyt, Julie;
Li, Xiaodong;
McKinsey, Timothy A;
Dedman, John R;
Olson, Eric N;
Chen, Ju;
Brown, Joan Heller;
Bers, Donald M

Publication type:

journal article

Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling.

Published in:

Journal of Clinical Investigation, 2006, v. 116, n. 3, p. 675, doi. 10.1172/JCI27374

By:

Xu Wu;
Tong Zhang;
Bossuyt, Julie;
Xiaodong Li;
McKinsey, Timothy A.;
Dedman, John R.;
Olson, Eric N.;
Ju Chen;
Brown, Joan Heller;
Bers, Donald M.

Publication type:

Article

Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients.

Published in:

European Heart Journal, 2019, v. 40, n. 45, p. 3685, doi. 10.1093/eurheartj/ehz326

By:

Wu, Haodi;
Yang, Huaxiao;
Rhee, June-Wha;
Zhang, Joe Z;
Lam, Chi Keung;
Sallam, Karim;
Chang, Alex C Y;
Ma, Ning;
Lee, Jaecheol;
Zhang, Hao;
Blau, Helen M;
Bers, Donald M;
Wu, Joseph C

Publication type:

Article

How does β-adrenergic signalling affect the transitions from ventricular tachycardia to ventricular fibrillation?

Published in:

EP: Europace, 2014, v. 16, n. 3, p. 452, doi. 10.1093/europace/eut412

By:

Xie, Yuanfang;
Grandi, Eleonora;
Bers, Donald M.;
Sato, Daisuke

Publication type:

Article

Disease-associated mutations in Niemann-Pick type C1 alter ER calcium signaling and neuronal plasticity.

Published in:

Journal of Cell Biology, 2019, v. 218, n. 12, p. 4141, doi. 10.1083/jcb.201903018

By:

Tiscione, Scott A.;
Vivas, Oscar;
Ginsburg, Kenneth S.;
Bers, Donald M.;
Ory, Daniel S.;
Santana, Luis F.;
Dixon, Rose E.;
Dickson, Eamonn J.

Publication type:

Article

Molecular and cellular neurocardiology in heart disease.

Published in:

Journal of Physiology, 2025, v. 603, n. 7, p. 1689, doi. 10.1113/JP284739

By:

Habecker, Beth A.;
Bers, Donald M.;
Birren, Susan J.;
Chang, Rui;
Herring, Neil;
Kay, Matthew W.;
Li, Dan;
Mendelowitz, David;
Mongillo, Marco;
Montgomery, Johanna M.;
Ripplinger, Crystal M.;
Tampakakis, Emmanouil;
Winbo, Annika;
Zaglia, Tania;
Zeltner, Nadja;
Paterson, David J.

Publication type:

Article

Diversity of cells and signals in the cardiovascular system.

Published in:

Journal of Physiology, 2023, v. 601, n. 13, p. 2547, doi. 10.1113/JP284011

By:

Grandi, Eleonora;
Navedo, Manuel F.;
Saucerman, Jeffrey J.;
Bers, Donald M.;
Chiamvimonvat, Nipavan;
Dixon, Rose E.;
Dobrev, Dobromir;
Gomez, Ana M.;
Harraz, Osama F.;
Hegyi, Bence;
Jones, David K.;
Krogh‐Madsen, Trine;
Murfee, Walter Lee;
Nystoriak, Matthew A.;
Posnack, Nikki G.;
Ripplinger, Crystal M.;
Veeraraghavan, Rengasayee;
Weinberg, Seth

Publication type:

Article

Nitrosylation of cardiac CaMKII at Cys290 mediates mechanical afterload‐induced increases in Ca2+ transient and Ca2+ sparks.

Published in:

Journal of Physiology, 2022, v. 600, n. 22, p. 4865, doi. 10.1113/JP283427

By:

Alim, Chidera C.;
Ko, Christopher Y.;
Mira Hernandez, Juliana;
Shen, Erin Y.;
Baidar, Sonya;
Chen‐Izu, Ye;
Bers, Donald M.;
Bossuyt, Julie

Publication type:

Article

Increasing SERCA function promotes initiation of calcium sparks and breakup of calcium waves.

Published in:

Journal of Physiology, 2021, v. 599, n. 13, p. 3267, doi. 10.1113/JP281579

By:

Sato, Daisuke;
Uchinoumi, Hitoshi;
Bers, Donald M.

Publication type:

Article