Works by Berninghausen, Otto

Results: 48

Mechanistic insights into Bcs1-mediated mitochondrial membrane translocation of the folded Rieske protein.

Published in:

EMBO Journal, 2025, v. 44, n. 13, p. 3720, doi. 10.1038/s44318-025-00459-4

By:

Rosales-Hernandez, Cristian;
Thoms, Matthias;
Berninghausen, Otto;
Becker, Thomas;
Beckmann, Roland

Publication type:

Article

SecM-Stalled Ribosomes Adopt an Altered Geometry at the Peptidyl Transferase Center.

Published in:

PLoS Biology, 2011, v. 9, n. 1, p. 1, doi. 10.1371/journal.pbio.1000581

By:

Bhushan, Shashi;
Hoffmann, Thomas;
Seidelt, Birgit;
Frauenfeld, Jens;
Mielke, Thorsten;
Berninghausen, Otto;
Wilson, Daniel N.;
Beckmann, Roland

Publication type:

Article

Promiscuous behaviour of archaeal ribosomal proteins: Implications for eukaryotic ribosome evolution.

Published in:

Nucleic Acids Research, 2013, v. 41, n. 2, p. 1284, doi. 10.1093/nar/gks1259

By:

Armache, Jean-Paul;
Anger, Andreas M.;
Márquez, Viter;
Franckenberg, Sibylle;
Fröhlich, Thomas;
Villa, Elizabeth;
Berninghausen, Otto;
Thomm, Michael;
Arnold, Georg J.;
Beckmann, Roland;
Wilson, Daniel N.

Publication type:

Article

Inhibition of SRP-dependent protein secretion by the bacterial alarmone (p)ppGpp.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28675-0

By:

Czech, Laura;
Mais, Christopher-Nils;
Kratzat, Hanna;
Sarmah, Pinku;
Giammarinaro, Pietro;
Freibert, Sven-Andreas;
Esser, Hanna Folke;
Musial, Joanna;
Berninghausen, Otto;
Steinchen, Wieland;
Beckmann, Roland;
Koch, Hans-Georg;
Bange, Gert

Publication type:

Article

A distinct assembly pathway of the human 39S late pre-mitoribosome.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-24818-x

By:

Cheng, Jingdong;
Berninghausen, Otto;
Beckmann, Roland

Publication type:

Article

Cecropins, antibacterial peptides from insects and mammals, are potently fungicidal against Candida albicans.

Published in:

Medical Microbiology & Immunology, 2001, v. 189, n. 3, p. 169, doi. 10.1007/s430-001-8025-x

By:

Andrä, Jörg;
Berninghausen, Otto;
Leippe, Matthias

Publication type:

Article

Parallel Structural Evolution of Mitochondrial Ribosomes and OXPHOS Complexes.

Published in:

Genome Biology & Evolution, 2015, v. 7, n. 5, p. 1235, doi. 10.1093/gbe/evv061

By:

van der Sluis, Eli O.;
Bauerschmitt, Heike;
Becker, Thomas;
Mielke, Thorsten;
Frauenfeld, Jens;
Berninghausen, Otto;
Neupert, Walter;
Herrmann, Johannes M.;
Beckmann, Roland

Publication type:

Article

Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes.

Published in:

PLoS Biology, 2020, v. 18, n. 7, p. 1, doi. 10.1371/journal.pbio.3000780

By:

Wells, Jennifer N.;
Buschauer, Robert;
Mackens-Kiani, Timur;
Best, Katharina;
Kratzat, Hanna;
Berninghausen, Otto;
Becker, Thomas;
Gilbert, Wendy;
Cheng, Jingdong;
Beckmann, Roland

Publication type:

Article

Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin 1.

Published in:

Journal of Cell Biology, 2006, v. 174, n. 3, p. 459, doi. 10.1083/jcb.200508170

By:

Deinhardt, Katrin;
Berninghausen, Otto;
Willison, Hugh J.;
Hopkins, Colin R.;
Schiavo, Giampietro

Publication type:

Article

Neurotrophins Redirect p75<sup>NTR</sup> from a Clathrin-Independent to a Clathrin-Dependent Endocytic Pathway Coupled to Axonal Transport.

Published in:

Traffic, 2007, v. 8, n. 12, p. 1736, doi. 10.1111/j.1600-0854.2007.00645.x

By:

Deinhardt, Katrin;
Reversi, Alessandra;
Berninghausen, Otto;
Hopkins, Colin R.;
Schiavo, Giampietro

Publication type:

Article

Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2.

Published in:

Nature Communications, 2023, v. 14, p. 1, doi. 10.1038/s41467-023-38161-w

By:

Ikeuchi, Ken;
Ivic, Nives;
Buschauer, Robert;
Cheng, Jingdong;
Fröhlich, Thomas;
Matsuo, Yoshitaka;
Berninghausen, Otto;
Inada, Toshifumi;
Becker, Thomas;
Beckmann, Roland

Publication type:

Article

Structural basis for clearing of ribosome collisions by the RQT complex.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-36230-8

By:

Best, Katharina;
Ikeuchi, Ken;
Kater, Lukas;
Best, Daniel;
Musial, Joanna;
Matsuo, Yoshitaka;
Berninghausen, Otto;
Becker, Thomas;
Inada, Toshifumi;
Beckmann, Roland

Publication type:

Article

B. subtilis MutS2 splits stalled ribosomes into subunits without mRNA cleavage.

Published in:

EMBO Journal, 2024, v. 43, n. 4, p. 484, doi. 10.1038/s44318-023-00010-3

By:

Park, Esther N;
Mackens-Kiani, Timur;
Berhane, Rebekah;
Esser, Hanna;
Erdenebat, Chimeg;
Burroughs, A Maxwell;
Berninghausen, Otto;
Aravind, L;
Beckmann, Roland;
Green, Rachel;
Buskirk, Allen R

Publication type:

Article

Architecture of the active post‐translational Sec translocon.

Published in:

EMBO Journal, 2021, v. 40, n. 3, p. 1, doi. 10.15252/embj.2020105643

By:

Weng, Tsai‐Hsuan;
Steinchen, Wieland;
Beatrix, Birgitta;
Berninghausen, Otto;
Becker, Thomas;
Bange, Gert;
Cheng, Jingdong;
Beckmann, Roland

Publication type:

Article

A structural inventory of native ribosomal ABCE1‐43S pre‐initiation complexes.

Published in:

EMBO Journal, 2021, v. 40, n. 1, p. 1, doi. 10.15252/embj.2020105179

By:

Kratzat, Hanna;
Mackens‐Kiani, Timur;
Ameismeier, Michael;
Potocnjak, Mia;
Cheng, Jingdong;
Dacheux, Estelle;
Namane, Abdelkader;
Berninghausen, Otto;
Herzog, Franz;
Fromont‐Racine, Micheline;
Becker, Thomas;
Beckmann, Roland

Publication type:

Article

Molecular analysis of the ribosome recycling factor ABCE1 bound to the 30S post‐splitting complex.

Published in:

EMBO Journal, 2020, v. 39, n. 9, p. 1, doi. 10.15252/embj.2019103788

By:

Nürenberg‐Goloub, Elina;
Kratzat, Hanna;
Heinemann, Holger;
Heuer, André;
Kötter, Peter;
Berninghausen, Otto;
Becker, Thomas;
Tampé, Robert;
Beckmann, Roland

Publication type:

Article

Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts.

Published in:

EMBO Journal, 2020, v. 39, n. 3, p. N.PAG, doi. 10.15252/embj.2019103365

By:

Tesina, Petr;
Lessen, Laura N;
Buschauer, Robert;
Cheng, Jingdong;
Wu, Colin Chih‐Chien;
Berninghausen, Otto;
Buskirk, Allen R;
Becker, Thomas;
Beckmann, Roland;
Green, Rachel

Publication type:

Article

Structure of the Bacillus subtilis hibernating 100S ribosome reveals the basis for 70S dimerization.

Published in:

EMBO Journal, 2017, v. 36, n. 14, p. 2061, doi. 10.15252/embj.201696189

By:

Beckert, Bertrand;
Abdelshahid, Maha;
Schäfer, Heinrich;
Steinchen, Wieland;
Arenz, Stefan;
Berninghausen, Otto;
Beckmann, Roland;
Bange, Gert;
Turgay, Kürşad;
Wilson, Daniel N

Publication type:

Article

Membrane lipid composition protects Entamoeba histolytica from self-destruction by its pore-forming toxins

Published in:

FEBS Letters, 2004, v. 564, n. 1/2, p. 109, doi. 10.1016/S0014-5793(04)00324-2

By:

Andrä, Jörg;
Berninghausen, Otto;
Leippe, Matthias

Publication type:

Article

Structure of the Bacillus subtilis 70S ribosome reveals the basis for species-specific stalling.

Published in:

Nature Communications, 2015, v. 6, n. 4, p. 6941, doi. 10.1038/ncomms7941

By:

Sohmen, Daniel;
Chiba, Shinobu;
Shimokawa-Chiba, Naomi;
Innis, C. Axel;
Berninghausen, Otto;
Beckmann, Roland;
Ito, Koreaki;
Wilson, Daniel N.

Publication type:

Article

Visualization of a polytopic membrane protein during SecY-mediated membrane insertion.

Published in:

Nature Communications, 2014, v. 5, n. 6, p. 4103, doi. 10.1038/ncomms5103

By:

Bischoff, Lukas;
Wickles, Stephan;
Berninghausen, Otto;
van der Sluis, Eli O.;
Beckmann, Roland

Publication type:

Article

60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein particle.

Published in:

Nature Communications, 2014, v. 5, n. 3, p. 3491, doi. 10.1038/ncomms4491

By:

Leidig, Christoph;
Thoms, Matthias;
Holdermann, Iris;
Bradatsch, Bettina;
Berninghausen, Otto;
Bange, Gert;
Sinning, Irmgard;
Hurt, Ed;
Beckmann, Roland

Publication type:

Article

Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide.

Published in:

Nature Communications, 2014, v. 5, n. 3, p. 3501, doi. 10.1038/ncomms4501

By:

Arenz, Stefan;
Ramu, Haripriya;
Gupta, Pulkit;
Berninghausen, Otto;
Beckmann, Roland;
Vázquez-Laslop, Nora;
Mankin, Alexander S.;
Wilson, Daniel N.

Publication type:

Article

nucleoplasmic phase of pre-40S formation prior to nuclear export.

Published in:

Nucleic Acids Research, 2022, v. 50, n. 20, p. 11924, doi. 10.1093/nar/gkac961

By:

Cheng, Jingdong;
Lau, Benjamin;
Thoms, Matthias;
Ameismeier, Michael;
Berninghausen, Otto;
Hurt, Ed;
Beckmann, Roland

Publication type:

Article

In vitro structural maturation of an early stage pre-40S particle coupled with U3 snoRNA release and central pseudoknot formation.

Published in:

Nucleic Acids Research, 2022, v. 50, n. 20, p. 11916, doi. 10.1093/nar/gkac910

By:

Cheng, Jingdong;
La Venuta, Giuseppe;
Lau, Benjamin;
Berninghausen, Otto;
Beckmann, Roland;
Hurt, Ed

Publication type:

Article

Structural basis of l-tryptophan-dependent inhibition of release factor 2 by the TnaC arrest peptide.

Published in:

Nucleic Acids Research, 2021, v. 49, n. 16, p. 9539, doi. 10.1093/nar/gkab665

By:

Su, Ting;
Kudva, Renuka;
Becker, Thomas;
Buschauer, Robert;
Komar, Tobias;
Berninghausen, Otto;
von Heijne, Gunnar;
Cheng, Jingdong;
Beckmann, Roland

Publication type:

Article

The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis.

Published in:

Nucleic Acids Research, 2016, v. 44, n. 13, p. 6471, doi. 10.1093/nar/gkw470

By:

Arenz, Stefan;
Abdelshahid, Maha;
Sohmen, Daniel;
Payoe, Roshani;
Starosta, Agata L.;
Berninghausen, Otto;
Hauryliuk, Vasili;
Beckmann, Roland;
Wilson, Daniel N.

Publication type:

Article

Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome.

Published in:

Nucleic Acids Research, 2016, v. 44, n. 4, p. 1944, doi. 10.1093/nar/gkv1517

By:

Schmidt, Christian;
Becker, Thomas;
Heuer, Andrè;
Braunger, Katharina;
Shanmuganathan, Vivekanandan;
Pech, Markus;
Berninghausen, Otto;
Wilson, Daniel N.;
Beckmann, Roland

Publication type:

Article

Structure of a human translation termination complex.

Published in:

Nucleic Acids Research, 2015, v. 43, n. 18, p. 8615, doi. 10.1093/nar/gkv909

By:

Matheis, Sarah;
Berninghausen, Otto;
Becker, Thomas;
Beckmann, Roland

Publication type:

Article

Neurexin Iβ and neuroligin are localized on opposite membranes in mature central synapses.

Published in:

Journal of Neurochemistry, 2007, v. 103, n. 5, p. 1855, doi. 10.1111/j.1471-4159.2007.04918.x

By:

Berninghausen, Otto;
Rahman, M. Atiqur;
Silva, John-Paul;
Davletov, Bazbek;
Hopkins, Colin;
Ushkaryov, Yuri A.

Publication type:

Article

Structure of the no-go mRNA decay complex Dom34-Hbs1 bound to a stalled 80S ribosome.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 6, p. 715, doi. 10.1038/nsmb.2057

By:

Becker, Thomas;
Armache, Jean-Paul;
Jarasch, Alexander;
Anger, Andreas M.;
Villa, Elizabeth;
Sieber, Heidemarie;
Motaal, Basma Abdel;
Mielke, Thorsten;
Berninghausen, Otto;
Beckmann, Roland

Publication type:

Article

Cryo-EM structure of the ribosome-SecYE complex in the membrane environment.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 5, p. 614, doi. 10.1038/nsmb.2026

By:

Frauenfeld, Jens;
Gumbart, James;
Sluis, Eli O van der;
Funes, Soledad;
Gartmann, Marco;
Beatrix, Birgitta;
Mielke, Thorsten;
Berninghausen, Otto;
Becker, Thomas;
Schulten, Klaus;
Beckmann, Roland

Publication type:

Article

α-Helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnel.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 3, p. 313, doi. 10.1038/nsmb.1756

By:

Bhushan, Shashi;
Gartmann, Marco;
Halic, Mario;
Armache, Jean-Paul;
Jarasch, Alexander;
Mielke, Thorsten;
Berninghausen, Otto;
Wilson, Daniel N.;
Beckmann, Roland

Publication type:

Article

The dynamic architecture of Map1- and NatB-ribosome complexes coordinates the sequential modifications of nascent polypeptide chains.

Published in:

PLoS Biology, 2023, v. 21, n. 4, p. 1, doi. 10.1371/journal.pbio.3001995

By:

Knorr, Alexandra G.;
Mackens-Kiani, Timur;
Musial, Joanna;
Berninghausen, Otto;
Becker, Thomas;
Beatrix, Birgitta;
Beckmann, Roland

Publication type:

Article

Concurrent remodelling of nucleolar 60S subunit precursors by the Real ATPase and Spb4 RNA helicase.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.84877

By:

Mitterer, Valentin;
Thorns, Matthias;
Buschauer, Robert;
Berninghausen, Otto;
Hurt, Ed;
Beckmann, Roland

Publication type:

Article

Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission.

Published in:

Nature Cell Biology, 2008, v. 10, n. 2, p. 211, doi. 10.1038/ncb1682

By:

Sowinski, Stefanie;
Jolly, Clare;
Berninghausen, Otto;
Purbhoo, Marco A.;
Chauveau, Anne;
Köhler, Karsten;
Oddos, Stephane;
Eissmann, Philipp;
Brodsky, Frances M.;
Hopkins, Colin;
Önfelt, Björn;
Sattentau, Quentin;
Davis, Daniel M.

Publication type:

Article

Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion.

Published in:

Nature, 2014, v. 506, n. 7486, p. 107, doi. 10.1038/nature12950

By:

Gogala, Marko;
Becker, Thomas;
Beatrix, Birgitta;
Armache, Jean-Paul;
Barrio-Garcia, Clara;
Berninghausen, Otto;
Beckmann, Roland

Publication type:

Article

Structures of the human and Drosophila 80S ribosome.

Published in:

Nature, 2013, v. 497, n. 7447, p. 80, doi. 10.1038/nature12104

By:

Anger, Andreas M.;
Armache, Jean-Paul;
Berninghausen, Otto;
Habeck, Michael;
Subklewe, Marion;
Wilson, Daniel N.;
Beckmann, Roland

Publication type:

Article

Structural basis of highly conserved ribosome recycling in eukaryotes and archaea.

Published in:

Nature, 2012, v. 482, n. 7386, p. 501, doi. 10.1038/nature10829

By:

Becker, Thomas;
Franckenberg, Sibylle;
Wickles, Stephan;
Shoemaker, Christopher J.;
Anger, Andreas M.;
Armache, Jean-Paul;
Sieber, Heidemarie;
Ungewickell, Charlotte;
Berninghausen, Otto;
Daberkow, Ingo;
Karcher, Annette;
Thomm, Michael;
Hopfner, Karl-Peter;
Green, Rachel;
Beckmann, Roland

Publication type:

Article

Structure and mechanism of the Swi2/Snf2 remodeller Mot1 in complex with its substrate TBP.

Published in:

Nature, 2011, v. 475, n. 7356, p. 403, doi. 10.1038/nature10215

By:

Wollmann, Petra;
Cui, Sheng;
Viswanathan, Ramya;
Berninghausen, Otto;
Wells, Melissa N.;
Moldt, Manuela;
Witte, Gregor;
Butryn, Agata;
Wendler, Petra;
Beckmann, Roland;
Auble, David T.;
Hopfner, Karl-Peter

Publication type:

Article

Coupled chaperone action in folding and assembly of hexadecameric Rubisco.

Published in:

Nature, 2010, v. 463, n. 7278, p. 197, doi. 10.1038/nature08651

By:

Cuimin Liu;
Young, Anna L.;
Starling-Windhof, Amanda;
Bracher, Andreas;
Saschenbrecker, Sandra;
Rao, Bharathi Vasudeva;
Rao, Karnam Vasudeva;
Berninghausen, Otto;
Mielke, Thorsten;
Hartl, F. Ulrich;
Beckmann, Roland;
Hayer-Hartl, Manajit

Publication type:

Article

Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae.

Published in:

eLife, 2017, p. 1, doi. 10.7554/eLife.30189.001

By:

Heuer, André;
Thomson, Emma;
Schmidt, Christian;
Berninghausen, Otto;
Becker, Thomas;
Hurt, Ed;
Beckmann, Roland

Publication type:

Article

The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling.

Published in:

eLife, 2017, p. 1, doi. 10.7554/eLife.25642

By:

Ting Su;
Jingdong Cheng;
Sohmen, Daniel;
Hedman, Rickard;
Berninghausen, Otto;
von Heijne, Gunnar;
Wilson, Daniel N.;
Beckmann, Roland

Publication type:

Article

Assembly and the gating mechanism of the Pel exopolysaccharide export complex PelBC of Pseudomonas aeruginosa.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60605-8

By:

Benedens, Marius;
Rosales-Hernandez, Cristian;
Straathof, Sabine A. P.;
Loschwitz, Jennifer;
Berninghausen, Otto;
Maglia, Giovanni;
Beckmann, Roland;
Kedrov, Alexej

Publication type:

Article

H/ACA snR30 snoRNP guides independent 18S rRNA subdomain formation.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-59656-8

By:

Fischer, Paulina;
Thoms, Matthias;
Lau, Benjamin;
Denk, Timo;
Kuvshinova, Maria;
Berninghausen, Otto;
Flemming, Dirk;
Hurt, Ed;
Beckmann, Roland

Publication type:

Article

Structural insights into coordinating 5S RNP rotation with ITS2 pre‐RNA processing during ribosome formation.

Published in:

EMBO Reports, 2023, v. 24, n. 12, p. 1, doi. 10.15252/embr.202357984

By:

Thoms, Matthias;
Lau, Benjamin;
Cheng, Jingdong;
Fromm, Lisa;
Denk, Timo;
Kellner, Nikola;
Flemming, Dirk;
Fischer, Paulina;
Falquet, Laurent;
Berninghausen, Otto;
Beckmann, Roland;
Hurt, Ed

Publication type:

Article

Mechanism of 5S RNP recruitment and helicase‐surveilled rRNA maturation during pre‐60S biogenesis.

Published in:

EMBO Reports, 2023, v. 24, n. 7, p. 1, doi. 10.15252/embr.202356910

By:

Lau, Benjamin;
Huang, Zixuan;
Kellner, Nikola;
Niu, Shuangshuang;
Berninghausen, Otto;
Beckmann, Roland;
Hurt, Ed;
Cheng, Jingdong

Publication type:

Article

Partially inserted nascent chain unzips the lateral gate of the Sec translocon.

Published in:

EMBO Reports, 2019, v. 20, n. 10, p. N.PAG, doi. 10.15252/embr.201948191

By:

Kater, Lukas;
Frieg, Benedikt;
Berninghausen, Otto;
Gohlke, Holger;
Beckmann, Roland;
Kedrov, Alexej

Publication type:

Article