Works by Benz, Joerg

Results: 30

Systematische Untersuchung von Halogenbrücken in Protein-Ligand- Wechselwirkungen.

Published in:

Angewandte Chemie, 2011, v. 123, n. 1, p. 329, doi. 10.1002/ange.201006781

By:

Hardegger, Leo A.;
Kuhn, Bernd;
Spinnler, Beat;
Anselm, Lilli;
Ecabert, Robert;
Stihle, Martine;
Gsell, Bernard;
Thoma, Ralf;
Diez, Joachim;
Benz, Jörg;
Plancher, Jean-Marc;
Hartmann, Guido;
Banner, David W.;
Haap, Wolfgang;
Diederich, François

Publication type:

Article

Quantifizierung von Kation-π-Wechselwirkungen in Protein-Ligand-Komplexen: Kristallstrukturanalyse eines Komplexes von Faktor Xa und einem quartären Ammonium-Ion-LigandenDiese Arbeit wurde durch die ETH Forschungskommission und F....

Published in:

Angewandte Chemie, 2005, v. 117, n. 28, p. 4474, doi. 10.1002/ange.200500883

By:

Kaspar Schärer;
Martin Morgenthaler;
Ralph Paulini;
Ulrike Obst-Sander;
David W. Banner;
Daniel Schlatter;
Jörg Benz;
Martine Stihle;
François Diederich

Publication type:

Article

A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-43606-3

By:

Jiang, Ming;
Huizenga, Mirjam C. W.;
Wirt, Jonah L.;
Paloczi, Janos;
Amedi, Avand;
van den Berg, Richard J. B. H. N.;
Benz, Joerg;
Collin, Ludovic;
Deng, Hui;
Di, Xinyu;
Driever, Wouter F.;
Florea, Bogdan I.;
Grether, Uwe;
Janssen, Antonius P. A.;
Hankemeier, Thomas;
Heitman, Laura H.;
Lam, Tsang-Wai;
Mohr, Florian;
Pavlovic, Anto;
Ruf, Iris

Publication type:

Article

Novel β‐Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization.

Published in:

Angewandte Chemie International Edition, 2021, v. 60, n. 10, p. 5436, doi. 10.1002/anie.202013890

By:

Benz, Joerg;
Rufer, Arne C.;
Huber, Sylwia;
Ehler, Andreas;
Hug, Melanie;
Topp, Andreas;
Guba, Wolfgang;
Hofmann, Eva Carolina;
Jagasia, Ravi;
Rodríguez Sarmiento, Rosa María

Publication type:

Article

P329G-CAR-J: a novel Jurkat-NFAT-based CAR-T reporter system recognizing the P329G Fc mutation.

Published in:

PEDS: Protein Engineering, Design & Selection, 2019, v. 32, n. 5, p. 207, doi. 10.1093/protein/gzz027

By:

Darowski, Diana;
Jost, Christian;
Stubenrauch, Kay;
Wessels, Uwe;
Benz, Jörg;
Ehler, Andreas;
Freimoser-Grundschober, Anne;
Brünker, Peter;
Mössner, Ekkehard;
Umaña, Pablo;
Kobold, Sebastian;
Klein, Christian

Publication type:

Article

Variable heavy–variable light domain and Fab-arm CrossMabs with charged residue exchanges to enforce correct light chain assembly.

Published in:

PEDS: Protein Engineering, Design & Selection, 2018, v. 31, n. 7/8, p. 289, doi. 10.1093/protein/gzy021

By:

Regula, Joerg Thomas;
Imhof-Jung, Sabine;
Mølhøj, Michael;
Benz, Joerg;
Ehler, Andreas;
Bujotzek, Alexander;
Schaefer, Wolfgang;
Klein, Christian

Publication type:

Article

A novel recombinant human amyloid plaque-specific antibody for the treatment of Alzheimer's disease: Molecular properties and preclinical efficacy

Published in:

2010

By:

Bohrmann, Bernd;
Benz, Joerg;
Baumann, Karlheinz;
Huber, Walter;
Knoflach, Fred;
Messer, Juerg;
Oroszlan, Krisztina;
Ozmen, Laurence;
Richter, Wolfgang;
Nordstedt, Christer;
Loetscher, Hansruedi

Publication type:

Abstract

Prodrug-Activating Chain Exchange (PACE) converts targeted prodrug derivatives to functional bi- or multispecific antibodies.

Published in:

Biological Chemistry, 2022, v. 403, n. 5/6, p. 495, doi. 10.1515/hsz-2021-0401

By:

Dickopf, Steffen;
Buldun, Can;
Vasic, Vedran;
Georges, Guy;
Hage, Carina;
Mayer, Klaus;
Forster, Matthias;
Wessels, Uwe;
Stubenrauch, Kay-Gunnar;
Benz, Jörg;
Ehler, Andreas;
Lauer, Matthias E.;
Ringler, Philippe;
Kobold, Sebastian;
Endres, Stefan;
Klein, Christian;
Brinkmann, Ulrich

Publication type:

Article

Synthesis, Characterization, and in vivo Evaluation of a Novel Potent Autotaxin-Inhibitor.

Published in:

Frontiers in Pharmacology, 2022, v. 12, p. 1, doi. 10.3389/fphar.2021.699535

By:

Hunziker, Daniel;
Reinehr, Sabrina;
Palmhof, Marina;
Wagner, Natalie;
Biniasch, Thomas;
Stute, Gesa;
Mattei, Patrizio;
Schmitz, Petra;
DiGiorgio, Patrick;
Hert, Jérôme;
Rudolph, Markus G.;
Benz, Joerg;
Stihle, Martine;
Gsell, Bernard;
Müller, Stephan;
Gasser, Rodolfo;
Schonhoven, Nina;
Ullmer, Christoph;
Joachim, Stephanie C.

Publication type:

Article

Inhibition of the Cysteine Protease Human Cathepsin L by Triazine Nitriles: Amide⋅⋅⋅Heteroarene π-Stacking Interactions and Chalcogen Bonding in the S3 Pocket.

Published in:

ChemMedChem, 2017, v. 12, n. 3, p. 257, doi. 10.1002/cmdc.201600563

By:

Giroud, Maude;
Ivkovic, Jakov;
Martignoni, Mara;
Fleuti, Marianne;
Trapp, Nils;
Haap, Wolfgang;
Kuglstatter, Andreas;
Benz, Jörg;
Kuhn, Bernd;
Schirmeister, Tanja;
Diederich, François

Publication type:

Article

Comparative Molecular Profiling of the PPARα/γ Activator Aleglitazar: PPAR Selectivity, Activity and Interaction with Cofactors.

Published in:

ChemMedChem, 2012, v. 7, n. 6, p. 1101, doi. 10.1002/cmdc.201100598

By:

Dietz, Michel;
Mohr, Peter;
Kuhn, Bernd;
Maerki, Hans Peter;
Hartman, Peter;
Ruf, Armin;
Benz, Jörg;
Grether, Uwe;
Wright, Matthew B.

Publication type:

Article

Halogen Bonding at the Active Sites of Human Cathepsin L and MEK1 Kinase: Efficient Interactions in Different Environments.

Published in:

ChemMedChem, 2011, v. 6, n. 11, p. 2048, doi. 10.1002/cmdc.201100353

By:

Hardegger, Leo A.;
Kuhn, Bernd;
Spinnler, Beat;
Anselm, Lilli;
Ecabert, Robert;
Stihle, Martine;
Gsell, Bernard;
Thoma, Ralf;
Diez, Joachim;
Benz, Jörg;
Plancher, Jean-Marc;
Hartmann, Guido;
Isshiki, Yoshiaki;
Morikami, Kenji;
Shimma, Nobuo;
Haap, Wolfgang;
Banner, David W.;
Diederich, François

Publication type:

Article

Design and Biological Evaluation of Novel, Balanced Dual PPARα/γ Agonists.

Published in:

ChemMedChem, 2009, v. 4, n. 6, p. 951, doi. 10.1002/cmdc.200800425

By:

Grether, Uwe;
Bénardeau, Agnes;
Benz, Jörg;
Binggeli, Alfred;
Blum, Denise;
Hilpert, Hans;
Kuhn, Bernd;
Märki, Hans Peter;
Meyer, Markus;
Mohr, Peter;
Püntener, Kurt;
Raab, Susanne;
Ruf, Armin;
Schlatter, Daniel

Publication type:

Article

Inside Cover: Design and Biological Evaluation of Novel, Balanced Dual PPARα/γ Agonists (ChemMedChem 6/2009).

Published in:

ChemMedChem, 2009, v. 4, n. 6, p. 886, doi. 10.1002/cmdc.200990027

By:

Grether, Uwe;
Bénardeau, Agnes;
Benz, Jörg;
Binggeli, Alfred;
Blum, Denise;
Hilpert, Hans;
Kuhn, Bernd;
Märki, Hans Peter;
Meyer, Markus;
Mohr, Peter;
Püntener, Kurt;
Raab, Susanne;
Ruf, Armin;
Schlatter, Daniel

Publication type:

Article

Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy.

Published in:

Science Translational Medicine, 2019, v. 11, n. 496, p. N.PAG, doi. 10.1126/scitranslmed.aav5989

By:

Claus, Christina;
Ferrara, Claudia;
Xu, Wei;
Sam, Johannes;
Lang, Sabine;
Uhlenbrock, Franziska;
Albrecht, Rosmarie;
Herter, Sylvia;
Schlenker, Ramona;
Hüsser, Tamara;
Diggelmann, Sarah;
Challier, John;
Mössner, Ekkehard;
Hosse, Ralf J.;
Hofer, Thomas;
Brünker, Peter;
Joseph, Catherine;
Benz, Jörg;
Ringler, Philippe;
Stahlberg, Henning

Publication type:

Article

VH-VL orientation prediction for antibody humanization candidate selection: A case study.

Published in:

mAbs (1942-0862), 2016, v. 8, n. 2, p. 288, doi. 10.1080/19420862.2015.1117720

By:

Bujotzek, Alexander;
Lipsmeier, Florian;
Harris, Seth F;
Benz, Jörg;
Kuglstatter, Andreas;
Georges, Guy

Publication type:

Article

MoFvAb: Modeling the Fv region of antibodies.

Published in:

mAbs (1942-0862), 2015, v. 7, n. 5, p. 838, doi. 10.1080/19420862.2015.1068492

By:

Bujotzek, Alexander;
Fuchs, Angelika;
Qu, Changtao;
Benz, Jörg;
Klostermann, Stefan;
Antes, Iris;
Georges, Guy

Publication type:

Article

Generation, characterization and structural data of chymase binding proteins based on the human Fyn kinase SH3 domain.

Published in:

mAbs (1942-0862), 2012, v. 4, n. 4, p. 497, doi. 10.4161/mabs.20452

By:

Schlatter, Daniel;
Brack, Simon;
Banner, David W.;
Batey, Sarah;
Benz, Jörg;
Bertschinger, Julian;
Huber, Walter;
Joseph, Catherine;
Rufer, Arne C.;
van der Klooster, Anita;
Weber, Martin;
Grabulovski, Dragan;
Hennig, Michael

Publication type:

Article

Systematic Investigation of Halogen Bonding in Protein-Ligand Interactions.

Published in:

Angewandte Chemie International Edition, 2011, v. 50, n. 1, p. 314, doi. 10.1002/anie.201006781

By:

Hardegger, Leo A.;
Kuhn, Bernd;
Spinnler, Beat;
Anselm, Lilli;
Ecabert, Robert;
Stihle, Martine;
Gsell, Bernard;
Thoma, Ralf;
Diez, Joachim;
Benz, Jörg;
Plancher, Jean-Marc;
Hartmann, Guido;
Banner, David W.;
Haap, Wolfgang;
Diederich, François

Publication type:

Article

Cation-π Interactions at the Active Site of Factor Xa: Dramatic Enhancement upon Stepwise N-Alkylation of Ammonium Ions.

Published in:

Angewandte Chemie International Edition, 2009, v. 48, n. 4, p. 811, doi. 10.1002/anie.200804695

By:

Salonen, Laura M.;
Bucher, Christoph;
Banner, David W.;
Haap, Wolfgang;
Mary, Jean-Luc;
Benz, Jörg;
Kuster, Olivier;
Seiler, Paul;
Schweizer, W. Bernd;
Diederich, François

Publication type:

Article

A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature.

Published in:

PLoS ONE, 2022, v. 17, n. 9, p. 1, doi. 10.1371/journal.pone.0268590

By:

Kemble, Alicia M.;
Hornsperger, Benoit;
Ruf, Iris;
Richter, Hans;
Benz, Jörg;
Kuhn, Bernd;
Heer, Dominik;
Wittwer, Matthias;
Engelhardt, Britta;
Grether, Uwe;
Collin, Ludovic

Publication type:

Article

A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase.

Published in:

Angewandte Chemie International Edition, 2025, v. 64, n. 10, p. 1, doi. 10.1002/anie.202413405

By:

Hentsch, Axel;
Guberman, Mónica;
Radetzki, Silke;
Kaushik, Sofia;
Huizenga, Mirjam;
Paul, Jerome;
Schippers, Maria;
Benz, Jörg;
Kuhn, Bernd;
Heer, Dominik;
Topp, Andreas;
Esteves Gloria, Ludivine;
Walter, Alexander;
Hochstrasser, Remo;
Wittwer, Matthias B.;
von Kries, Jens Peter;
Collin, Ludovic;
Blaising, Julie;
van der Stelt, Mario;
Lipstein, Noa

Publication type:

Article

The crystal structure of the Physarum polycephalum actin-fragmin kinase: an atypical protein kinase with a specialized substrate-binding domain.

Published in:

EMBO Journal, 1999, v. 18, n. 11, p. 2923, doi. 10.1093/emboj/18.11.2923

By:

Steinbacher, Stefan;
Hof, Peter;
Eichinger, Ludwig;
Schleicher, Michael;
Gettemans, Jan;
Vandekerckhove, Joël;
Huber, Robert;
Benz, Jörg

Publication type:

Article

Molecular Recognition at the Active Site of Factor Xa: Cation-π Interactions, Stacking on Planar Peptide Surfaces, and Replacement of Structural Water.

Published in:

Chemistry - A European Journal, 2012, v. 18, n. 1, p. 213, doi. 10.1002/chem.201102571

By:

Salonen, Laura M.;
Holland, Mareike C.;
Kaib, Philip S. J.;
Haap, Wolfgang;
Benz, Jörg;
Mary, Jean-Luc;
Kuster, Olivier;
Schweizer, W. Bernd;
Banner, David W.;
Diederich, François

Publication type:

Article

A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase.

Published in:

Angewandte Chemie, 2025, v. 137, n. 10, p. 1, doi. 10.1002/ange.202413405

By:

Hentsch, Axel;
Guberman, Mónica;
Radetzki, Silke;
Kaushik, Sofia;
Huizenga, Mirjam;
Paul, Jerome;
Schippers, Maria;
Benz, Jörg;
Kuhn, Bernd;
Heer, Dominik;
Topp, Andreas;
Esteves Gloria, Ludivine;
Walter, Alexander;
Hochstrasser, Remo;
Wittwer, Matthias B.;
von Kries, Jens Peter;
Collin, Ludovic;
Blaising, Julie;
van der Stelt, Mario;
Lipstein, Noa

Publication type:

Article

Novel β‐Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization.

Published in:

Angewandte Chemie, 2021, v. 133, n. 10, p. 5496, doi. 10.1002/ange.202013890

By:

Benz, Joerg;
Rufer, Arne C.;
Huber, Sylwia;
Ehler, Andreas;
Hug, Melanie;
Topp, Andreas;
Guba, Wolfgang;
Hofmann, Eva Carolina;
Jagasia, Ravi;
Rodríguez Sarmiento, Rosa María

Publication type:

Article

Quantification of Cation–π Interactions in Protein–Ligand Complexes: Crystal-Structure Analysis of Factor Xa Bound to a Quaternary Ammonium Ion LigandThis work was supported by a grant from the ETH Research Council and by F. Hoffmann-La Roche, Basel. We thank Olivier Kuster, Dr. Thomas Tschopp, and Dr. Alain Gast for the biological assays as well as Dr. Michael Hennig for his support of this work.

Published in:

Angewandte Chemie International Edition, 2005, v. 44, n. 28, p. 4400, doi. 10.1002/anie.200500883

By:

Kaspar Schärer;
Martin Morgenthaler;
Ralph Paulini;
Ulrike Obst-Sander;
David W. Banner;
Daniel Schlatter;
Jörg Benz;
Martine Stihle;
François Diederich

Publication type:

Article

Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody.

Published in:

eLife, 2017, p. 1, doi. 10.7554/eLife.20383

By:

Favuzza, Paola;
Guffart, Elena;
Tamborrini, Marco;
Scherer, Bianca;
Dreyer, Anita M.;
Rufer, Arne C.;
Erny, Johannes;
Hoernschemeyer, Joerg;
Thoma, Ralf;
Schmid, Georg;
Gsell, Bernard;
Lamelas, Araceli;
Benz, Joerg;
Joseph, Catherine;
Matile, Hugues;
Pluschke, Gerd;
Rudolph, Markus G.

Publication type:

Article

Carnitine palmitoyltransferase 2: Analysis of membrane association and complex structure with a substrate analog

Published in:

FEBS Letters, 2007, v. 581, n. 17, p. 3247, doi. 10.1016/j.febslet.2007.05.080

By:

Rufer, Arne C.;
Lomize, Andrei;
Benz, Jörg;
Chomienne, Odile;
Thoma, Ralf;
Hennig, Michael

Publication type:

Article

Hapten-directed spontaneous disulfide shuffling: a universal technology for site-directed covalent coupling of payloads to antibodies.

Published in:

FASEB Journal, 2015, v. 29, n. 5, p. 1763, doi. 10.1096/fj.14-263665

By:

Dengl, Stefan;
Hoffmann, Eike;
Grote, Michael;
Wagner, Cornelia;
Mundigl, Olaf;
Georges, Guy;
Thorey, Irmgard;
Stubenrauch, Kay-Gunnar;
Bujotzek, Alexander;
Josel, Hans-Peter;
Dziadek, Sebastian;
Benz, Joerg;
Brinkmann, Ulrich

Publication type:

Article