Works by Benet, Leslie Z.

Results: 135

Pharmacokinetics and Irreversible Binding of Tolmetin and Its Glucuronic Acid Esters in the Elderly.

Published in:

Pharmacology, 1993, v. 47, n. 5, p. 309, doi. 10.1159/000139112

By:

Munafo, Alain;
Hyneck, Martha L.;
Benet, Leslie Z.

Publication type:

Article

Microsomal Acyl Glucuronidation: Enzyme-Kinetic Studies with Labile Glucuronides.

Published in:

Pharmacology, 1993, v. 46, n. 5, p. 268, doi. 10.1159/000139054

By:

Spahn-Langguth, Hildegard;
Benet, Leslie Z.

Publication type:

Article

The Interconversion of Prednisone and Prednisolone in Human and Rabbit Organs in vitro Is a Function of Tissue Integrity.

Published in:

Pharmacology, 1992, v. 44, n. 5, p. 273, doi. 10.1159/000138930

By:

Hale, Victoria G.;
Benet, Leslie Z.

Publication type:

Article

In vitro Enantioselective Glucuronidation of Fenoprofen.

Published in:

Pharmacology, 1991, v. 43, n. 2, p. 53, doi. 10.1159/000138828

By:

Volland, Christine;
Benet, Leslie Z.

Publication type:

Article

Organic Anion Transport by Basal-Lateral Membranes: Effect of PAH and Furosemide on Each Other's Transport.

Published in:

Pharmacology, 1988, v. 37, n. 4, p. 268, doi. 10.1159/000138476

By:

Gloff, Carol A.;
Mamelok, Richard D.;
Benet, Leslie Z.

Publication type:

Article

Pharmacokinetics and Excretion of Unique Beta-Adrenergic Agonists.

Published in:

Pharmacology, 1987, v. 34, n. 2/3, p. 157, doi. 10.1159/000138265

By:

Ferraiolo, Bobbe L.;
Halldin, Magnus M.;
Asscher, Yael;
Akita, Yasuo;
Melmon, Kenneth L.;
Benet, Leslie Z.;
Castagnoli, Jr., Neal

Publication type:

Article

Dose-Dependent Kinetics of Probenecid in Rhesus Monkeys - Infusion Studies.

Published in:

Pharmacology, 1984, v. 28, n. 4, p. 181, doi. 10.1159/000137960

By:

Chiang, Chia-Whei N.;
Benet, Leslie Z.

Publication type:

Article

Unchanged Absorption of Digoxin Tablets in Patients with Cardiac Failure.

Published in:

Pharmacology, 1984, v. 28, n. 2, p. 90, doi. 10.1159/000137948

By:

Meister, Wolfgang;
Benowitz, Neal L.;
Benet, Leslie Z.

Publication type:

Article

Dose-Dependent Kinetics of Probenecid in Rhesus Monkeys -Intravenous Bolus Studies.

Published in:

Pharmacology, 1981, v. 23, n. 6, p. 326, doi. 10.1159/000137568

By:

Chiang, Chia-Whei N.;
Benet, Leslie Z.

Publication type:

Article

Relationship between Urinary Excretion Rate, Steady-State Plasma Levels and Diuretic Response of Furosemide in the Rat.

Published in:

Pharmacology, 1979, v. 19, n. 6, p. 301, doi. 10.1159/000137329

By:

Smith, David E.;
Benet, Leslie Z.

Publication type:

Article

Pseudoephedrine Pharmacokinetics in the Rat Using a Microanalysis Technique.

Published in:

Pharmacology, 1979, v. 18, n. 6, p. 306, doi. 10.1159/000137270

By:

Till, Alice E.;
Benet, Leslie Z.

Publication type:

Article

Response of authors to Ganju and Dias' comments on 'Inclusion of Placebos and Blinding for Ascending Dose First-in-Human Studies and Other Underpowered Phase 1 Studies Has Not Been Justified and on Balance is Not Useful' by D. A. Parasrampuria and L. Z. Benet.

Published in:

2015

By:

Parasrampuria, Dolly A.;
Benet, Leslie Z.

Publication type:

Letter to the Editor

Inclusion of Placebos and Blinding for Ascending Dose First-in-Human Studies and Other Underpowered Phase 1 Studies has not been Justified and on Balance is Not Useful.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2015, v. 117, n. 1, p. 44, doi. 10.1111/bcpt.12352

By:

Parasrampuria, Dolly A.;
Benet, Leslie Z.

Publication type:

Article

Using Individualized Patient Data for Prediction of Population Dosing Recommendations Versus Predictions of Individualized Patient Dosing.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 6, p. 734, doi. 10.1002/jcph.1859

By:

Benet, Leslie Z.

Publication type:

Article

Liquid chromatographic tandem mass spectrometric assay for the uremic toxin 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid in human plasma.

Published in:

Rapid Communications in Mass Spectrometry: RCM, 2006, v. 20, n. 10, p. 1611, doi. 10.1002/rcm.2479

By:

Huang, Yong;
Sun, Hong;
Frassetto, Lynda;
Benet, Leslie Z.;
Lin, Emil T.

Publication type:

Article

Predicting Interactions between Rifampin and Antihypertensive Drugs Using the Biopharmaceutics Drug Disposition Classification System.

Published in:

Pharmacotherapy, 2020, v. 40, n. 4, p. 274, doi. 10.1002/phar.2380

By:

Liu, Wei;
Yan, Tingting;
Chen, Ken;
Yang, Li;
Benet, Leslie Z.;
Zhai, Suodi

Publication type:

Article

Late-Stage Failures of Monoclonal Antibody Drugs: A Retrospective Case Study Analysis.

Published in:

Pharmacology, 2020, v. 105, n. 3/4, p. 145, doi. 10.1159/000505379

By:

Sun, Amy;
Benet, Leslie Z.

Publication type:

Article

Comparison of Furosemide and Vinblastine Secretion from Cell Lines Overexpressing Multidrug Resistance Protein (P-Glycoprotein) and Multidrug Resistance-Associated Proteins (MRP1 and MRP2).

Published in:

Pharmacology, 2002, v. 64, n. 3, p. 126, doi. 10.1159/000056161

By:

Flanagan, Shawn D.;
Cummins, Carolyn L.;
Susanto, Miki;
Xiaoli Liu;
Takahashi, Lori H.;
Benet, Leslie Z.

Publication type:

Article

In vitro Biotransformation of a Novel Antimalarial Cysteine Protease Inhibitor in Human Liver Microsomes.

Published in:

Pharmacology, 1999, v. 58, n. 3, p. 147, doi. 10.1159/000028277

By:

Yuanchao Zhang, J.;
Xisheng Guo, J.;
Lin, Emil T.;
Benet, Leslie Z.

Publication type:

Article

Effects of Ketoconazole on Digoxin Absorption and Disposition in Rat.

Published in:

Pharmacology, 1998, v. 56, n. 6, p. 308, doi. 10.1159/000028214

By:

Salphati, Laurent;
Benet, Leslie Z.

Publication type:

Article

Antiprogestin-Mediated Inactivation of Cytochrome P450 3A4.

Published in:

Pharmacology, 1998, v. 56, n. 3, p. 150, doi. 10.1159/000028193

By:

Jang, Graham R.;
Benet, Leslie Z.

Publication type:

Article

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy.

Published in:

Molecular Carcinogenesis, 1995, v. 13, n. 3, p. 129, doi. 10.1002/mc.2940130302

By:

Wacher, Vincent J.;
Wu, Chi-Yuan;
Benet, Leslie Z.

Publication type:

Article

Chiral Bioequivalence.

Published in:

Clinical Pharmacokinetics, 2000, v. 39, n. 6, p. 459, doi. 10.2165/00003088-200039060-00006

By:

Boni, Joseph P.;
Korth-Bradley, Joan M.;
Richards, Lyette S.;
Chiang, Soong T.;
Hicks, David R.;
Benet, Leslie Z.

Publication type:

Article

A phase I study of targeted, dose-escalated intravenous busulfan in combination with etoposide as myeloablative therapy for autologous stem cell transplantation in acute myeloid leukemia.

Published in:

2015

By:

Mannis, Gabriel N;
Andreadis, Charalambos;
Logan, Aaron C;
Damon, Lloyd E;
Benet, Leslie Z;
Ai, Weiyun Z;
Gaensler, Karin M L;
Kaplan, Lawrence D;
Koplowicz, Yelena B;
Linker, Charles A;
Olin, Rebecca L;
Sayre, Peter H;
Smith, Catherine C;
Sudhindra, Akshay;
Venstrom, Jeffrey M;
Wolf, Jeffrey L;
Martin 3rd, Thomas G;
Martin, Thomas G 3rd

Publication type:

journal article

Comparison of Measures of Adherence to Human Immunodeficiency Virus Preexposure Prophylaxis Among Adolescent and Young Men Who Have Sex With Men in the United States.

Published in:

Clinical Infectious Diseases, 2018, v. 66, n. 2, p. 213, doi. 10.1093/cid/cix755

By:

Koss, Catherine A;
Hosek, Sybil G;
Bacchetti, Peter;
Anderson, Peter L;
Liu, Albert Y;
Horng, Howard;
Benet, Leslie Z;
Kuncze, Karen;
Louie, Alexander;
Saberi, Parya

Publication type:

Article

Impact of a Hospitalwide Increase in Empiric Pediatric Vancomycin Dosing on Initial Trough Concentrations.

Published in:

Pharmacotherapy, 2011, v. 31, n. 9, p. 871, doi. 10.1592/phco.31.9.871

By:

Frymoyer, Adam;
Guglielmo, B. Joseph;
Wilson, Stephen D.;
Scarpace, Sarah B.;
Benet, Leslie Z.;
Hersh, Adam L.

Publication type:

Article

Understanding drug–drug interaction and pharmacogenomic changes in pharmacokinetics for metabolized drugs.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2019, v. 46, n. 2, p. 155, doi. 10.1007/s10928-019-09626-7

By:

Benet, Leslie Z.;
Bowman, Christine M.;
Koleske, Megan L.;
Rinaldi, Capria L.;
Sodhi, Jasleen K.

Publication type:

Article

Intermittent drug dosing intervals guided by the operational multiple dosing half lives for predictable plasma accumulation and fluctuation.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2011, v. 38, n. 3, p. 369, doi. 10.1007/s10928-011-9198-0

By:

Grover, Anita;
Benet, Leslie Z.

Publication type:

Article

Editorial.

Published in:

2010

By:

Aarons, Leon;
Benet, Leslie Z.

Publication type:

Editorial

Clearance (née Rowland) concepts: a downdate and an update.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2010, v. 37, n. 6, p. 529, doi. 10.1007/s10928-010-9187-8

By:

Benet, Leslie Z.

Publication type:

Article

Membrane transporters in drug development.

Published in:

2010

By:

Giacomini, Kathleen M.;
Shiew-Mei Huang;
Tweedie, Donald J.;
Benet, Leslie Z.;
Brouwer, Kim L. R.;
Xiaoyan Chu;
Dahlin, Amber;
Evers, Raymond;
Fischer, Volker;
Hillgren, Kathleen M.;
Hoffmaster, Keith A.;
Ishikawa, Toshihisa;
Keppler, Dietrich;
Kim, Richard B.;
Lee, Caroline A.;
Niemi, Mikko;
Polli, Joseph W.;
Sugiyama, Yuichi;
Swaan, Peter W.;
Ware, Joseph A.

Publication type:

journal article

Acyl Glucuronides Revisited: Is the Glucuronidation Proces a Toxification as Well as a Detoxification Mechanism??

Published in:

Drug Metabolism Reviews, 1992, v. 24, n. 1, p. 5, doi. 10.3109/03602539208996289

By:

Langguth, Hildegard Spahn;
Benet, Leslie Z.

Publication type:

Article

Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors.

Published in:

2004

By:

Christians, Uwe;
Gottschalk, Sven;
Miljus, Jelena;
Hainz, Carsten;
Benet, Leslie Z.;
Leibfritz, Dieter;
Serkova, Natalie

Publication type:

journal article

Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers.

Published in:

2000

By:

Soldner, Andrea;
Benet, Leslie Z;
Mutschler, Ernst;
Christians, Uwe;
Soldner, A;
Benet, L Z;
Mutschler, E;
Christians, U

Publication type:

journal article

The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates.

Published in:

2000

By:

Serkova, Natalie;
Litt, Lawrence;
Leibfritz, Dieter;
Hausen, Bernard;
Morris, Randall E;
James, Thomas L;
Benet, Leslie Z;
Christians, Uwe;
Serkova, N;
Litt, L;
Leibfritz, D;
Hausen, B;
Morris, R E;
James, T L;
Benet, L Z;
Christians, U

Publication type:

journal article

Predicting Pharmacokinetics/Pharmacodynamics in the Individual Patient: Separating Reality From Hype.

Published in:

Journal of Clinical Pharmacology, 2018, v. 58, n. 8, p. 979, doi. 10.1002/jcph.1105

By:

Benet, Leslie Z.

Publication type:

Article

Effect of the MDR1 C3435T Variant and P-Glycoprotein Induction on Dicloxacillin Pharmacokinetics.

Published in:

Journal of Clinical Pharmacology, 2005, v. 45, n. 4, p. 411, doi. 10.1177/0091270004273492

By:

Putnam, Wendy S.;
Woo, Jonathan M.;
Huang, Yong;
Benet, Leslie Z.

Publication type:

Article

Pharmacokinetics of Cyclosporine Pre- and Post-Liver Transplantation.

Published in:

Journal of Clinical Pharmacology, 2003, v. 43, n. 1, p. 38, doi. 10.1177/0091270002239704

By:

Hebert, Mary F.;
Wacher, Vincent J.;
Roberts, John P.;
Benet, Leslie Z.

Publication type:

Article

Effect of Calcineurin Inhibitor Therapy on P-gp Expression and Function in Lymphocytes of Renal Transplant Patients: A Preliminary Evaluation.

Published in:

Journal of Clinical Pharmacology, 2002, v. 42, n. 3, p. 304, doi. 10.1177/009127000204200307

By:

Parasrampuria, Dolly A.;
Lantz, Marianne V.;
Birnbaum, Jytte L.;
Vincenti, Flavio G.;
Benet, Leslie Z.

Publication type:

Article

Preliminary Evaluation of Progestins as Inducers of Cytochrome P450 3A4 Activity in Postmenopausal Women.

Published in:

Journal of Clinical Pharmacology, 1998, v. 38, n. 12, p. 1137, doi. 10.1177/009127009803801208

By:

Tsunoda, Shirley M.;
Harris, Robert Z.;
Mroczkowski, Patrick J.;
Benet, Leslie Z.

Publication type:

Article

Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Subjects and Patients with Noninsulin-Dependent Diabetes Mellitus.

Published in:

Journal of Clinical Pharmacology, 1996, v. 36, n. 11, p. 1012, doi. 10.1177/009127009603601105

By:

Sambol, Nancy C.;
Chiang, Janie;
O'Conner, Michael;
Liu, Chui Y.;
Lin, Emil T.;
Goodman, Anita M.;
Benet, Leslie Z.;
Karam, John H.

Publication type:

Article

Kidney Function and Age Are Both Predictors of Pharmacokinetics of Metformin.

Published in:

1995

By:

Sambol, Nancy C.;
Chiang, Janie;
Lin, Emil T.;
Goodman, Anita M.;
Liu, Chui Y.;
Benet, Leslie Z.;
Cogan, Martin G.

Publication type:

Other

Immunopharmacodynamic Studies of Cyclosporine in Patients Awaiting Renal Transplantation.

Published in:

1995

By:

d'Uscio, Claudia H.;
Aweeka, Francesca T.;
Prueksaritanont, Thomayant;
Tomlanovich, Stephen J.;
Gupta, Suneel K.;
Lantz, Marianne V.;
Gambertoglio, John G.;
Garovoy, Marvin R.;
Benet, Leslie Z.

Publication type:

Other

Comparison of the Effects of Cyclosporin A on the Metabolism of Perfused Rat Brain Slices During Normoxia and Hypoxia.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2002, v. 22, n. 3, p. 342, doi. 10.1097/00004647-200203000-00012

By:

Serkova, Natalie;
Donohoe, Paul;
Gottschalk, Sven;
Hainz, Carsten;
Niemann, Claus U;
Bickler, Philip E;
Litt, Lawrence;
Benet, Leslie Z;
Leibfritz, Dieter;
Christians, Uwe

Publication type:

Article

Preparative Chromatography of Furosemide 1-O-Acyl-Glucuronide from Urine Using Micronized Amberiite XAD-2 and its Application to Other 1-O-Acyl-Glucuronides.

Published in:

Preparative Biochemistry & Biotechnology, 1998, v. 28, n. 1, p. 37, doi. 10.1080/10826069808010125

By:

Mizuma, Takashi;
Benet, Leslie Z.;
Lin, Emil T.

Publication type:

Article

Basic Principles of Pharmacokinetics.

Published in:

Toxicologic Pathology, 1995, v. 23, n. 2, p. 115, doi. 10.1177/019262339502300203

By:

Benet, Leslie Z.;
Zia-Amirhosseini, Parnian

Publication type:

Article

Effects of Single Dose Rifampin on the Pharmacokinetics of Fluvastatin in Healthy Volunteers.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 110, n. 2, p. 480, doi. 10.1002/cpt.2268

By:

Xiang, Yue;
Okochi, Hideaki;
Kozachenko, Ivan;
Sodhi, Jasleen K.;
Frassetto, Lynda A.;
Benet, Leslie Z.

Publication type:

Article

A Simple Methodology to Differentiate Changes in Bioavailability From Changes in Clearance Following Oral Dosing of Metabolized Drugs.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 108, n. 2, p. 306, doi. 10.1002/cpt.1828

By:

Sodhi, Jasleen K.;
Benet, Leslie Z.

Publication type:

Article

Batch‐to‐Batch and Within‐Subject Variability: What Do We Know and How Do These Variabilities Affect Clinical Pharmacology and Bioequivalence?

Published in:

Clinical Pharmacology & Therapeutics, 2019, v. 105, n. 2, p. 326, doi. 10.1002/cpt.1294

By:

Benet, Leslie Z.;
Jayachandran, Priya;
Carroll, Kevin J.;
Burmeister Getz, Elise

Publication type:

Article

Evaluating Within‐Subject Variability for Narrow Therapeutic Index Drugs.

Published in:

Clinical Pharmacology & Therapeutics, 2019, v. 105, n. 2, p. 411, doi. 10.1002/cpt.1293

By:

Jayachandran, Priya;
Okochi, Hideaki;
Frassetto, Lynda A.;
Park, Wansu;
Fang, Lanyan;
Zhao, Liang;
Benet, Leslie Z.

Publication type:

Article