Works matching AU Benet, Leslie Z.

Results: 135

In vitro and in vivo irreversible plasma protein binding of beclobric acid enantiomers.

Published in:

Chirality, 1993, v. 5, n. 3, p. 120, doi. 10.1002/chir.530050304

By:

Mayer, Sascha;
Mutschler, Ernst;
Spahn-Langguth, Hildegard;
Benet, Leslie Z.

Publication type:

Article

Evaluation of the relevance of DILI predictive hypotheses in early drug development: review of in vitro methodologies vs. BDDCS classification.

Published in:

Toxicology Research, 2018, v. 7, n. 3, p. 358, doi. 10.1039/c8tx00016f

By:

Chan, Rosa;
Benet, Leslie Z.

Publication type:

Article

Evaluating in vivo data for drug metabolism and transport: lessons from Kirchhoff's Laws.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1456677

By:

Benet, Leslie Z.;
Sodhi, Jasleen K.

Publication type:

Article

Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors.

Published in:

2004

By:

Christians, Uwe;
Gottschalk, Sven;
Miljus, Jelena;
Hainz, Carsten;
Benet, Leslie Z.;
Leibfritz, Dieter;
Serkova, Natalie

Publication type:

journal article

Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers.

Published in:

2000

By:

Soldner, Andrea;
Benet, Leslie Z;
Mutschler, Ernst;
Christians, Uwe;
Soldner, A;
Benet, L Z;
Mutschler, E;
Christians, U

Publication type:

journal article

The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates.

Published in:

2000

By:

Serkova, Natalie;
Litt, Lawrence;
Leibfritz, Dieter;
Hausen, Bernard;
Morris, Randall E;
James, Thomas L;
Benet, Leslie Z;
Christians, Uwe;
Serkova, N;
Litt, L;
Leibfritz, D;
Hausen, B;
Morris, R E;
James, T L;
Benet, L Z;
Christians, U

Publication type:

journal article

Development and validation of an assay to analyze atazanavir in human hair via liquid chromatography/tandem mass spectrometry.

Published in:

Rapid Communications in Mass Spectrometry: RCM, 2018, v. 32, n. 5, p. 431, doi. 10.1002/rcm.8058

By:

Phung, Nhi;
Kuncze, Karen;
Okochi, Hideaki;
Louie, Alexander;
Benet, Leslie Z.;
Ofokotun, Igho;
Haas, David W.;
Currier, Judith S.;
Chawana, Tariro D.;
Sheth, Anandi N.;
Bacchetti, Peter;
Gandhi, Monica;
Horng, Howard

Publication type:

Article

Can In Vitro–In Vivo Extrapolation Be Successful? Recognizing the Incorrect Clearance Assumptions.

Published in:

Clinical Pharmacology & Therapeutics, 2022, v. 111, n. 5, p. 1022, doi. 10.1002/cpt.2482

By:

Benet, Leslie Z.;
Sodhi, Jasleen K.

Publication type:

Article

Effects of Single Dose Rifampin on the Pharmacokinetics of Fluvastatin in Healthy Volunteers.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 110, n. 2, p. 480, doi. 10.1002/cpt.2268

By:

Xiang, Yue;
Okochi, Hideaki;
Kozachenko, Ivan;
Sodhi, Jasleen K.;
Frassetto, Lynda A.;
Benet, Leslie Z.

Publication type:

Article

A Simple Methodology to Differentiate Changes in Bioavailability From Changes in Clearance Following Oral Dosing of Metabolized Drugs.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 108, n. 2, p. 306, doi. 10.1002/cpt.1828

By:

Sodhi, Jasleen K.;
Benet, Leslie Z.

Publication type:

Article

Predicting Interactions between Rifampin and Antihypertensive Drugs Using the Biopharmaceutics Drug Disposition Classification System.

Published in:

Pharmacotherapy, 2020, v. 40, n. 4, p. 274, doi. 10.1002/phar.2380

By:

Liu, Wei;
Yan, Tingting;
Chen, Ken;
Yang, Li;
Benet, Leslie Z.;
Zhai, Suodi

Publication type:

Article

Analyzing Potential Intestinal Transporter Drug-Drug Interactions: Reevaluating Ticagrelor Interaction Studies.

Published in:

Pharmaceutical Research, 2021, v. 38, n. 10, p. 1639, doi. 10.1007/s11095-021-03105-w

By:

Liu, Shuaibing;
Sodhi, Jasleen K.;
Benet, Leslie Z.

Publication type:

Article

Examination of Urinary Excretion of Unchanged Drug in Humans and Preclinical Animal Models: Increasing the Predictability of Poor Metabolism in Humans.

Published in:

Pharmaceutical Research, 2021, v. 38, n. 7, p. 1139, doi. 10.1007/s11095-021-03076-y

By:

Bamfo, Nadia O.;
Hosey-Cojocari, Chelsea;
Benet, Leslie Z.;
Remsberg, Connie M.

Publication type:

Article

Investigating Intestinal Transporter Involvement in Rivaroxaban Disposition through Examination of Changes in Absorption.

Published in:

Pharmaceutical Research, 2021, v. 38, n. 5, p. 795, doi. 10.1007/s11095-021-03039-3

By:

Kou, Wen;
Sodhi, Jasleen K.;
Wu, Xin'an;
Benet, Leslie Z.

Publication type:

Article

Moringa oleifera leaf extracts inhibit 6ß-hydroxylation of testosterone by CYP3A4.

Published in:

Journal of Infection in Developing Countries, 2008, v. 2, n. 5, p. 379, doi. 10.3855/jidc.201

By:

Monera, Tsitsi G.;
Wolfe, Alan R.;
Maponga, Charles C.;
Benet, Leslie Z.;
Guglielmo, Joseph

Publication type:

Article

Effects of short-term alendronate on bone mineral density in haemodialysis patients.

Published in:

Nephrology, 2005, v. 10, n. 4, p. 393, doi. 10.1111/j.1440-1797.2005.00436.x

By:

Wetmore, James B.;
Benet, Leslie Z.;
Kleinstuck, Danja;
Frassetto, Lynda

Publication type:

Article

Tenofovir and emtricitabine concentrations in hair are comparable between individuals on tenofovir disoproxil fumarate versus tenofovir alafenamide‐based ART.

Published in:

Drug Testing & Analysis, 2021, v. 13, n. 7, p. 1354, doi. 10.1002/dta.3033

By:

Okochi, Hideaki;
Louie, Alexander;
Phung, Nhi;
Zhang, Kevin;
Tallerico, Regina M.;
Kuncze, Karen;
Spinelli, Matthew A.;
Koss, Catherine A.;
Benet, Leslie Z.;
Gandhi, Monica

Publication type:

Article

Batch Selection via In Vitro/In Vivo Correlation in Pharmacokinetic Bioequivalence Testing.

Published in:

AAPS PharmSciTech, 2021, v. 22, n. 7, p. 1, doi. 10.1208/s12249-021-02064-0

By:

Burmeister Getz, Elise;
Carroll, Kevin J.;
Mielke, Johanna;
Jones, Byron;
Benet, Leslie Z.

Publication type:

Article

Disposition of Zomepirac Sodium in Man.

Published in:

1982

By:

O'NEILL, PATRICK J.;
YORGEY, KARL A.;
RENZI, NED L.;
WILLIAMS, ROGER L.;
BENET, LESLIE Z.

Publication type:

Other

Hydrochlorothiazide Pharmacokinetics and Pharmacologic Effect: The Influence of Indomethacin.

Published in:

1982

By:

WILLIAMS, ROGER L.;
DAVIES, RICHARD O.;
BERMAN, RAYANNE S.;
HOLMES, GEOFFREY I.;
HUBER, PAUL;
GEE, WINNIE LIANG;
LIN, EMIL T.;
BENET, LESLIE Z.

Publication type:

Other

Effects of Indomethacin and Carprofen on Renal Homeostasis in Rheumatoid Arthritis Patients and in Healthy Individuals.

Published in:

1981

By:

WILLIAMS, ROGER L.;
FURST, DANIEL E.;
MANDEL, H. GEORGE;
NICOLL, DIANA;
KONIKOFF, JOHN J.;
BENET, LESLIE Z.

Publication type:

Other

Acute Massive Chloral Hydrate Intoxication Treated with Hemodialysis: A Clinical Pharmacokinetic Analysis.

Published in:

1978

By:

STALKER, NANCY E.;
GAMBERTOGLIO, JOHN G.;
FUKUMITSU, CLIFFORD J.;
NAUGHTON, JAMES L.;
BENET, LESLIE Z.

Publication type:

Other

Basic Principles of Pharmacokinetics.

Published in:

Toxicologic Pathology, 1995, v. 23, n. 2, p. 115, doi. 10.1177/019262339502300203

By:

Benet, Leslie Z.;
Zia-Amirhosseini, Parnian

Publication type:

Article

Understanding drug–drug interaction and pharmacogenomic changes in pharmacokinetics for metabolized drugs.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2019, v. 46, n. 2, p. 155, doi. 10.1007/s10928-019-09626-7

By:

Benet, Leslie Z.;
Bowman, Christine M.;
Koleske, Megan L.;
Rinaldi, Capria L.;
Sodhi, Jasleen K.

Publication type:

Article

Intermittent drug dosing intervals guided by the operational multiple dosing half lives for predictable plasma accumulation and fluctuation.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2011, v. 38, n. 3, p. 369, doi. 10.1007/s10928-011-9198-0

By:

Grover, Anita;
Benet, Leslie Z.

Publication type:

Article

Clearance (née Rowland) concepts: a downdate and an update.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2010, v. 37, n. 6, p. 529, doi. 10.1007/s10928-010-9187-8

By:

Benet, Leslie Z.

Publication type:

Article

Editorial.

Published in:

2010

By:

Aarons, Leon;
Benet, Leslie Z.

Publication type:

Editorial

Novel percutaneous adventitial drug delivery system for regional vascular treatment.

Published in:

Catheterization & Cardiovascular Interventions, 2004, v. 63, n. 2, p. 222, doi. 10.1002/ccd.20167

By:

Fumiaki Ikeno;
Jennifer Lyons;
Hideaki Kaneda;
Muhammad Baluom;
Leslie Z. Benet;
Mehrdad Rezaee

Publication type:

Article

In vitro Biotransformation of a Novel Antimalarial Cysteine Protease Inhibitor in Human Liver Microsomes.

Published in:

Pharmacology, 1999, v. 58, n. 3, p. 147, doi. 10.1159/000028277

By:

Yuanchao Zhang, J.;
Xisheng Guo, J.;
Lin, Emil T.;
Benet, Leslie Z.

Publication type:

Article

Effects of Ketoconazole on Digoxin Absorption and Disposition in Rat.

Published in:

Pharmacology, 1998, v. 56, n. 6, p. 308, doi. 10.1159/000028214

By:

Salphati, Laurent;
Benet, Leslie Z.

Publication type:

Article

Antiprogestin-Mediated Inactivation of Cytochrome P450 3A4.

Published in:

Pharmacology, 1998, v. 56, n. 3, p. 150, doi. 10.1159/000028193

By:

Jang, Graham R.;
Benet, Leslie Z.

Publication type:

Article

Pharmacokinetics and Irreversible Binding of Tolmetin and Its Glucuronic Acid Esters in the Elderly.

Published in:

Pharmacology, 1993, v. 47, n. 5, p. 309, doi. 10.1159/000139112

By:

Munafo, Alain;
Hyneck, Martha L.;
Benet, Leslie Z.

Publication type:

Article

Microsomal Acyl Glucuronidation: Enzyme-Kinetic Studies with Labile Glucuronides.

Published in:

Pharmacology, 1993, v. 46, n. 5, p. 268, doi. 10.1159/000139054

By:

Spahn-Langguth, Hildegard;
Benet, Leslie Z.

Publication type:

Article

The Interconversion of Prednisone and Prednisolone in Human and Rabbit Organs in vitro Is a Function of Tissue Integrity.

Published in:

Pharmacology, 1992, v. 44, n. 5, p. 273, doi. 10.1159/000138930

By:

Hale, Victoria G.;
Benet, Leslie Z.

Publication type:

Article

In vitro Enantioselective Glucuronidation of Fenoprofen.

Published in:

Pharmacology, 1991, v. 43, n. 2, p. 53, doi. 10.1159/000138828

By:

Volland, Christine;
Benet, Leslie Z.

Publication type:

Article

Organic Anion Transport by Basal-Lateral Membranes: Effect of PAH and Furosemide on Each Other's Transport.

Published in:

Pharmacology, 1988, v. 37, n. 4, p. 268, doi. 10.1159/000138476

By:

Gloff, Carol A.;
Mamelok, Richard D.;
Benet, Leslie Z.

Publication type:

Article

Pharmacokinetics and Excretion of Unique Beta-Adrenergic Agonists.

Published in:

Pharmacology, 1987, v. 34, n. 2/3, p. 157, doi. 10.1159/000138265

By:

Ferraiolo, Bobbe L.;
Halldin, Magnus M.;
Asscher, Yael;
Akita, Yasuo;
Melmon, Kenneth L.;
Benet, Leslie Z.;
Castagnoli, Jr., Neal

Publication type:

Article

Dose-Dependent Kinetics of Probenecid in Rhesus Monkeys - Infusion Studies.

Published in:

Pharmacology, 1984, v. 28, n. 4, p. 181, doi. 10.1159/000137960

By:

Chiang, Chia-Whei N.;
Benet, Leslie Z.

Publication type:

Article

Unchanged Absorption of Digoxin Tablets in Patients with Cardiac Failure.

Published in:

Pharmacology, 1984, v. 28, n. 2, p. 90, doi. 10.1159/000137948

By:

Meister, Wolfgang;
Benowitz, Neal L.;
Benet, Leslie Z.

Publication type:

Article

Dose-Dependent Kinetics of Probenecid in Rhesus Monkeys -Intravenous Bolus Studies.

Published in:

Pharmacology, 1981, v. 23, n. 6, p. 326, doi. 10.1159/000137568

By:

Chiang, Chia-Whei N.;
Benet, Leslie Z.

Publication type:

Article

Relationship between Urinary Excretion Rate, Steady-State Plasma Levels and Diuretic Response of Furosemide in the Rat.

Published in:

Pharmacology, 1979, v. 19, n. 6, p. 301, doi. 10.1159/000137329

By:

Smith, David E.;
Benet, Leslie Z.

Publication type:

Article

Pseudoephedrine Pharmacokinetics in the Rat Using a Microanalysis Technique.

Published in:

Pharmacology, 1979, v. 18, n. 6, p. 306, doi. 10.1159/000137270

By:

Till, Alice E.;
Benet, Leslie Z.

Publication type:

Article

An Explanation of Why Dose-Corrected Area Under the Curve for Alternate Administration Routes Can Be Greater than for Intravenous Dosing.

Published in:

AAPS Journal, 2024, v. 26, n. 1, p. 1, doi. 10.1208/s12248-024-00887-w

By:

Wakuda, Hirokazu;
Xiang, Yue;
Sodhi, Jasleen K.;
Uemura, Naoto;
Benet, Leslie Z.

Publication type:

Article

The Uses and Advantages of Kirchhoff's Laws vs. Differential Equations in Pharmacology, Pharmacokinetics, and (Even) Chemistry.

Published in:

AAPS Journal, 2023, v. 25, n. 3, p. 1, doi. 10.1208/s12248-023-00801-w

By:

Benet, Leslie Z.;
Sodhi, Jasleen K.

Publication type:

Article

State of the Art and Uses for the Biopharmaceutics Drug Disposition Classification System (BDDCS): New Additions, Revisions, and Citation References.

Published in:

AAPS Journal, 2022, v. 24, n. 2, p. 1, doi. 10.1208/s12248-022-00687-0

By:

Bocci, Giovanni;
Oprea, Tudor I.;
Benet, Leslie Z.

Publication type:

Article

There is Only One Valid Definition of Clearance: Critical Examination of Clearance Concepts Reveals the Potential for Errors in Clinical Drug Dosing Decisions.

Published in:

AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00591-z

By:

Benet, Leslie Z.;
Sodhi, Jasleen K.;
Makrygiorgos, George;
Mesbah, Ali

Publication type:

Article

Investigating the Theoretical Basis for In Vitro–In Vivo Extrapolation (IVIVE) in Predicting Drug Metabolic Clearance and Proposing Future Experimental Pathways.

Published in:

AAPS Journal, 2020, v. 22, n. 5, p. 1, doi. 10.1208/s12248-020-00501-9

By:

Benet, Leslie Z.;
Sodhi, Jasleen K.

Publication type:

Article

The Necessity of Using Changes in Absorption Time to Implicate Intestinal Transporter Involvement in Oral Drug-Drug Interactions.

Published in:

AAPS Journal, 2020, v. 22, n. 5, p. N.PAG, doi. 10.1208/s12248-020-00469-6

By:

Sodhi, Jasleen K.;
Benet, Leslie Z.

Publication type:

Article

How Transporters Have Changed Basic Pharmacokinetic Understanding.

Published in:

AAPS Journal, 2019, v. 21, n. 6, p. 1, doi. 10.1208/s12248-019-0373-3

By:

Benet, Leslie Z.;
Bowman, Christine M.;
Sodhi, Jasleen K.

Publication type:

Article

Why Drugs Fail in Late Stages of Development: Case Study Analyses from the Last Decade and Recommendations.

Published in:

AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-018-0204-y

By:

Parasrampuria, Dolly A.;
Benet, Leslie Z.;
Sharma, Amarnath

Publication type:

Article