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PARKINSON’S DISEASE-ASSOCIATED MUTATIONS IN LRRK2 CAUSE CENTROSOMAL DEFECTS VIA RAB8A PHOSPHORYLATION.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1501, doi. 10.1016/j.jalz.2017.07.604
By:
- Madero-Pérez, Jesús;
- Fdez, Elena;
- Fernández, Belén;
- Lara Ordóñez, Antonio J.;
- Ramírez, Marian Blanca;
- Gómez-Suaga, Patricia;
- Waschbüsch, Dieter;
- Lobbestael, Evy;
- Baekelandt, Veerle;
- Nairn, Angus C.;
- Ruiz-Martínez, Javier;
- Aiastui, Ana;
- de Munaín, Adolfo López;
- Lis, Pawel;
- Comptdaer, Thomas;
- Taymans, Jean-Marc;
- Chartier-Harlin, Marie-Christine;
- Beilina, Alexandra;
- Gonnelli, Adriano;
- Cookson, Mark R.
Publication type:
Article
P3-374: PINK1 transfected cell lines exhibit mitochondrial protection in vitro when exposed to mitochondrial toxins
Published in:
2006
By:
- Sandebring, Anna;
- Beilina, Alexandra;
- Behbahani, Homira;
- Cowburn, Richard F.;
- Cookson, Mark R.
Publication type:
Abstract
P3-374: PINK1 transfected cell lines exhibit mitochondrial protection in vitro when exposed to mitochondrial toxins
Published in:
2006
By:
- Sandebring, Anna;
- Beilina, Alexandra;
- Behbahani, Homira;
- Cowburn, Richard F.;
- Cookson, Mark R.
Publication type:
Abstract
Biochemical Characterization of Highly Purified Leucine-Rich Repeat Kinases 1 and 2 Demonstrates Formation of Homodimers.
Published in:
PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0043472
By:
- Civiero, Laura;
- Vancraenenbroeck, Renée;
- Belluzzi, Elisa;
- Beilina, Alexandra;
- Lobbestael, Evy;
- Reyniers, Lauran;
- Gao, Fangye;
- Micetic, Ivan;
- De Maeyer, Marc;
- Bubacco, Luigi;
- Baekelandt, Veerle;
- Cookson, Mark R.;
- Greggio, Elisa;
- Taymans, Jean-Marc;
- Zhenyu Yue
Publication type:
Article
LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding.
Published in:
PLoS ONE, 2011, v. 6, n. 8, p. 1, doi. 10.1371/journal.pone.0023207
By:
- Taymans, Jean-Marc;
- Vancraenenbroeck, Renée;
- Ollikainen, Petri;
- Beilina, Alexandra;
- Lobbestael, Evy;
- Maeyer, Marc De;
- Baekelandt, Veerle;
- Cookson, Mark R.
Publication type:
Article
The Parkinson's Disease Associated LRRK2 Exhibits Weaker In Vitro Phosphorylation of 4E-BP Compared to Autophosphorylation.
Published in:
PLoS ONE, 2010, v. 5, n. 1, p. 1, doi. 10.1371/journal.pone.0008730
By:
- Kumar, Azad;
- Greggio, Elisa;
- Beilina, Alexandra;
- Kaganovich, Alice;
- Diane Chan;
- Taymans, Jean-Marc;
- Wolozin, Benjamin;
- Cookson, Mark R.
Publication type:
Article
Mitochondrial Alterations in PINK1 Deficient Cells Are Influenced by Calcineurin-Dependent Dephosphorylation of Dynamin-Related Protein 1.
Published in:
PLoS ONE, 2009, v. 4, n. 5, p. 1, doi. 10.1371/journal.pone.0005701
By:
- Sandebring, Anna;
- Thomas, Kelly Jean;
- Beilina, Alexandra;
- van der Brug, Marcel;
- Cleland, Megan M.;
- Ahmad, Rili;
- Miller, David W.;
- Zambrano, Ibardo;
- Cowburn, Richard F.;
- Behbahani, Homira;
- Cedazo-Mínguez, Angel;
- Cookson, Mark R.
Publication type:
Article
Correction to: Molecular mechanism of olesoxime-mediated neuroprotection through targeting α-synuclein interaction with mitochondrial VDAC.
Published in:
2020
By:
- Rovini, Amandine;
- Gurnev, Philip A.;
- Beilina, Alexandra;
- Queralt-Martín, María;
- Rosencrans, William;
- Cookson, Mark R.;
- Bezrukov, Sergey M.;
- Rostovtseva, Tatiana K.
Publication type:
Correction Notice
Molecular mechanism of olesoxime-mediated neuroprotection through targeting α-synuclein interaction with mitochondrial VDAC.
Published in:
Cellular & Molecular Life Sciences, 2020, v. 77, n. 18, p. 3611, doi. 10.1007/s00018-019-03386-w
By:
- Rovini, Amandine;
- Gurnev, Philip A.;
- Beilina, Alexandra;
- Queralt-Martín, María;
- Rosencrans, William;
- Cookson, Mark R.;
- Bezrukov, Sergey M.;
- Rostovtseva, Tatiana K.
Publication type:
Article
Correction: Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
Published in:
2022
By:
- Mamais, Adamantios;
- Kluss, Jillian H.;
- Bonet-Ponce, Luis;
- Landeck, Natalie;
- Langston, Rebekah G.;
- Smith, Nathan;
- Beilina, Alexandra;
- Kaganovich, Alice;
- Ghosh, Manik C.;
- Pellegrini, Laura;
- Kumaran, Ravindran;
- Papazoglou, Ioannis;
- Heaton, George R.;
- Harvey, Kirsten;
- Bandopadhyay, Rina;
- Maio, Nunziata;
- Kim, Changyoun;
- LaVoie, Matthew J.;
- Gershlick, David C.;
- Cookson, Mark R.
Publication type:
Correction Notice
Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
Published in:
PLoS Biology, 2021, v. 19, n. 12, p. 1, doi. 10.1371/journal.pbio.3001480
By:
- Mamais, Adamantios;
- Kluss, Jillian H.;
- Bonet-Ponce, Luis;
- Landeck, Natalie;
- Langston, Rebekah G.;
- Smith, Nathan;
- Beilina, Alexandra;
- Kaganovich, Alice;
- Ghosh, Manik C.;
- Pellegrini, Laura;
- Kumaran, Ravindran;
- Papazoglou, Ioannis;
- Heaton, George R.;
- Bandopadhyay, Rina;
- Maio, Nunziata;
- Kim, Changyoun;
- LaVoie, Matthew J.;
- Gershlick, David C.;
- Cookson, Mark R.
Publication type:
Article
Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.
Published in:
Proteomics, 2018, v. 18, n. 10, p. 1, doi. 10.1002/pmic.201700444
By:
- Tomkins, James E.;
- Dihanich, Sybille;
- Beilina, Alexandra;
- Ferrari, Raffaele;
- Ilacqua, Nicolò;
- Cookson, Mark R.;
- Lewis, Patrick A.;
- Manzoni, Claudia
Publication type:
Article
Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.
Published in:
Nature Communications, 2014, v. 5, n. 12, p. 5827, doi. 10.1038/ncomms6827
By:
- Chia, Ruth;
- Haddock, Sara;
- Beilina, Alexandra;
- Rudenko, Iakov N.;
- Mamais, Adamantios;
- Kaganovich, Alice;
- Li, Yan;
- Kumaran, Ravindran;
- Nalls, Michael A.;
- Cookson, Mark R.
Publication type:
Article
Genes associated with Parkinson's disease: regulation of autophagy and beyond.
Published in:
Journal of Neurochemistry, 2016, v. 139, p. 91, doi. 10.1111/jnc.13266
By:
- Beilina, Alexandra;
- Cookson, Mark R
Publication type:
Article
Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.
Published in:
Journal of Neurochemistry, 2015, v. 135, n. 6, p. 1242, doi. 10.1111/jnc.13369
By:
- Civiero, Laura;
- Cirnaru, Maria Daniela;
- Beilina, Alexandra;
- Rodella, Umberto;
- Russo, Isabella;
- Belluzzi, Elisa;
- Lobbestael, Evy;
- Reyniers, Lauran;
- Hondhamuni, Geshanthi;
- Lewis, Patrick A.;
- Van den Haute, Chris;
- Baekelandt, Veerle;
- Bandopadhyay, Rina;
- Bubacco, Luigi;
- Piccoli, Giovanni;
- Cookson, Mark R.;
- Taymans, Jean‐Marc;
- Greggio, Elisa
Publication type:
Article
Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.
Published in:
Journal of Neurochemistry, 2014, v. 131, n. 2, p. 239, doi. 10.1111/jnc.12798
By:
- Reyniers, Lauran;
- Del Giudice, Maria Grazia;
- Civiero, Laura;
- Belluzzi, Elisa;
- Lobbestael, Evy;
- Beilina, Alexandra;
- Arrigoni, Giorgio;
- Derua, Rita;
- Waelkens, Etienne;
- Li, Yan;
- Crosio, Claudia;
- Iaccarino, Ciro;
- Cookson, Mark R.;
- Baekelandt, Veerle;
- Greggio, Elisa;
- Taymans, Jean‐Marc
Publication type:
Article
Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice.
Published in:
Human Molecular Genetics, 2018, v. 27, n. 18, p. 3257, doi. 10.1093/hmg/ddy232
By:
- Pellegrini, Laura;
- Hauser, David N;
- Li, Yan;
- Mamais, Adamantios;
- Beilina, Alexandra;
- Kumaran, Ravindran;
- Wetzel, Andrea;
- Nixon-Abell, Jonathon;
- Heaton, George;
- Rudenko, Iakov
Publication type:
Article
LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network.
Published in:
Human Molecular Genetics, 2018, v. 27, n. 2, p. 385, doi. 10.1093/hmg/ddx410
By:
- Zhiyong Liu;
- Bryant, Nicole;
- Kumaran, Ravindran;
- Beilina, Alexandra;
- Abeliovich, Asa;
- Cookson, Mark R.;
- West, Andrew B.
Publication type:
Article
Hexokinases link DJ-1 to the PINK1/parkin pathway.
Published in:
Molecular Neurodegeneration, 2017, v. 12, p. 1, doi. 10.1186/s13024-017-0212-x
By:
- Hauser, David N.;
- Mamais, Adamantios;
- Conti, Melissa M.;
- Primiani, Christopher T.;
- Kumaran, Ravindran;
- Dillman, Allissa A.;
- Langston, Rebekah G.;
- Beilina, Alexandra;
- Garcia, Joseph H.;
- Diaz-Ruiz, Alberto;
- Bernier, Michel;
- Fiesel, Fabienne C.;
- Xu Hou;
- Springer, Wolfdieter;
- Yan Li;
- de Cabo, Rafael;
- Cookson, Mark R.
Publication type:
Article
DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.
Published in:
Human Molecular Genetics, 2011, v. 20, n. 1, p. 40, doi. 10.1093/hmg/ddq430
By:
- Thomas, Kelly Jean;
- McCoy, Melissa K.;
- Blackinton, Jeff;
- Beilina, Alexandra;
- van der Brug, Marcel;
- Sandebring, Anna;
- Miller, David;
- Maric, Dragan;
- Cedazo-Minguez, Angel;
- Cookson, Mark R.
Publication type:
Article
Induction of inclusion formation and disruption of lamin A/C structure by premutation CGG-repeat RNA in human cultured neural cells.
Published in:
Human Molecular Genetics, 2005, v. 14, n. 23, p. 3661, doi. 10.1093/hmg/ddi394
By:
- Arocena, Dolores Garcia;
- Iwahashi, Christine K.;
- Won, Nelly;
- Beilina, Alexandra;
- Ludwig, Anna L.;
- Tassone, Flora;
- Schwartz, Philip H.;
- Hagerman, Paul J.
Publication type:
Article
Redistribution of transcription start sites within the FMR1 promoter region with expansion of the downstream CGG-repeat element.
Published in:
Human Molecular Genetics, 2004, v. 13, n. 5, p. 543, doi. 10.1093/hmg/ddh053
By:
- Beilina, Alexandra;
- Tassone, Flora;
- Schwartz, Philip H.;
- Sahota, Parminder;
- Hagerman, Paul J.
Publication type:
Article
Association of a common genetic variant with Parkinson's disease is mediated by microglia.
Published in:
Science Translational Medicine, 2022, v. 14, n. 655, p. 1, doi. 10.1126/scitranslmed.abp8869
By:
- Langston, Rebekah G.;
- Beilina, Alexandra;
- Reed, Xylena;
- Kaganovich, Alice;
- Singleton, Andrew B.;
- Blauwendraat, Cornelis;
- Gibbs, J. Raphael;
- Cookson, Mark R.
Publication type:
Article
Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.
Published in:
Journal of Neurochemistry, 2007, v. 102, n. 1, p. 93, doi. 10.1111/j.1471-4159.2007.04523.x
By:
- Greggio, Elisa;
- Lewis, Patrick A.;
- van der Brug, Marcel P.;
- Ahmad, Rili;
- Kaganovich, Alice;
- Ding, Jinhui;
- Beilina, Alexandra;
- Baker, Acacia K.;
- Cookson, Mark R.
Publication type:
Article
Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease.
Published in:
Journal of Neurochemistry, 2005, v. 93, n. 1, p. 246, doi. 10.1111/j.1471-4159.2005.03019.x
By:
- Greggio, Elisa;
- Bergantino, Elisabetta;
- Carter, Donald;
- Ahmad, Rili;
- Costin, Gertrude-Emilia;
- Hearing, Vincent J.;
- Clarimon, Jordi;
- Singleton, Andrew;
- Eerola, Johanna;
- Hellström, Olli;
- Tienari, Pentti J.;
- Miller, David W.;
- Beilina, Alexandra;
- Bubacco, Luigi;
- Cookson, Mark R.
Publication type:
Article
Cell population-specific expression analysis of human cerebellum.
Published in:
BMC Genomics, 2012, v. 13, n. 1, p. 1, doi. 10.1186/1471-2164-13-610
By:
- Kuhn, Alexandre;
- Kumar, Azad;
- Beilina, Alexandra;
- Dillman, Allissa;
- Cookson, Mark R.;
- Singleton, Andrew B.
Publication type:
Article

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