Works by Beigelman, Leonid

Results: 16

SYNTHESIS OF MODIFIED NUCLEOSIDE 5′-TRIPHOSPHATES FOR IN VITRO SELECTION OF CATALYTIC NUCLEIC ACIDS ().

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2001, v. 20, n. 4-7, p. 1113, doi. 10.1081/NCN-100002500

By:

Matulic-Adamic, Jasenka;
Daniher, AndrewT.;
Karpeisky, Alexander;
Haeberli, Peter;
Sweedler, David;
Beigelman, Leonid

Publication type:

Article

Deletion of a single hydrogen bonding atom from the MS2 RNA operator leads to dramatic rearrangements at the RNA–coat protein interface.

Published in:

Nucleic Acids Research, 2000, v. 28, n. 23, p. 4611, doi. 10.1093/nar/28.23.4611

By:

Grahn, Elin;
Stonehouse, Nicola J.;
Adams, Chris J.;
Fridborg, Kerstin;
Beigelman, Leonid;
Matulic-Adamic, Jasenka;
Warriner, Stuart L.;
Stockley, Peter G.;
Liljas, Lars

Publication type:

Article

Synthesis of 7'‐Substituted 2'‐O‐4'‐C‐Ethylene Bridged Nucleic Acid (ENA)‐Thymidine Monomers.

Published in:

European Journal of Organic Chemistry, 2024, v. 27, n. 1, p. 1, doi. 10.1002/ejoc.202300946

By:

Sunchu, Prabhakar;
Gaurrand, Sandrine;
Lambert, Émilie;
Guillemont, Jérôme;
Beigelman, Leonid;
Brioche, Julien;
Piettre, Serge R.

Publication type:

Article

Safety, tolerability, and pharmacokinetics of AL-335 in healthy volunteers and hepatitis C virus-infected subjects.

Published in:

PLoS ONE, 2018, v. 13, n. 10, p. 1, doi. 10.1371/journal.pone.0204974

By:

McClure, Matthew W.;
Berliba, Elina;
Tsertsvadze, Tengiz;
Streinu-Cercel, Adrian;
Vijgen, Leen;
Astruc, Béatrice;
Patat, Alain;
Westland, Christopher;
Chanda, Sushmita;
Zhang, Qingling;
Kakuda, Thomas N.;
Vuong, Jennifer;
Khorlin, Nick;
Beigelman, Leonid;
Blatt, Lawrence M.;
Fry, John

Publication type:

Article

An Improved Synthesis of Inosine 3′-Phosphoramidite.

Published in:

Synthetic Communications, 2000, v. 30, n. 21, p. 3963, doi. 10.1080/00397910008086956

By:

Matulic-Adamic, Jasenka;
Beigelman, Leonid

Publication type:

Article

Synthesis and Enzymic Hydrolysis of Oligoribonucleotides Incorporating 3-Deazaguanosine: The Importance of the Nitrogen-3 Atom of Single Conserved Guanosine Residues on the Catalytic Activity of the Hammerhead Ribozyme.

Published in:

Helvetica Chimica Acta, 2003, v. 86, n. 8, p. 2726

By:

Frank Seela;
Harald Debelak;
Lori Andrews;
Leonid Beigelman

Publication type:

Article

A Practical Synthesis of 3′-Thioguanosine and of Its 3′-Phosphoramidothioite (a Thiophosphoramidite).

Published in:

Helvetica Chimica Acta, 1999, v. 82, n. 12, p. 2141, doi. 10.1002/(SICI)1522-2675(19991215)82:12<2141::AID-HLCA2141>3.0.CO;2-2

By:

Matulic-Adamic, Jasenka;
Beigelman, Leonid

Publication type:

Article

Synthesis and Enzymatic Deprotection of Fully Protected 2′-5′ Oligoadenylates (2-5A): Towards a Prodrug Strategy for Short 2-5A.

Published in:

Chemistry & Biodiversity, 2012, v. 9, n. 4, p. 669, doi. 10.1002/cbdv.201100144

By:

Kiuru, Emilia;
Ora, Mikko;
Beigelman, Leonid;
Blatt, Lawrence;
Lönnberg, Harri

Publication type:

Article

Synthesis and Enzymatic Deprotection of Biodegradably Protected Dinucleoside-2′,5′-monophosphates: 3-(Acetyloxy)-2,2-bis(ethoxycarbonyl)propyl Phosphoesters of 3′- O-(Acyloxymethyl)adenylyl-2′,5′-adenosines.

Published in:

Chemistry & Biodiversity, 2011, v. 8, n. 2, p. 266, doi. 10.1002/cbdv.201000288

By:

Kiuru, Emilia;
Ora, Mikko;
Beigelman, Leonid;
Blatt, Lawrence;
Lönnberg, Harri

Publication type:

Article

Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH).

Published in:

PLoS ONE, 2020, v. 15, n. 12, p. 1, doi. 10.1371/journal.pone.0240338

By:

Luong, Xuan G.;
Stevens, Sarah K.;
Jekle, Andreas;
Lin, Tse-I;
Gupta, Kusum;
Misner, Dinah;
Chanda, Sushmita;
Mukherjee, Sucheta;
Williams, Caroline;
Stoycheva, Antitsa;
Blatt, Lawrence M.;
Beigelman, Leonid N.;
Symons, Julian A.;
Raboisson, Pierre;
McGowan, David;
Vandyck, Koen;
Deval, Jerome

Publication type:

Article

Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 22, p. 16274, doi. 10.3390/ijms242216274

By:

Jekle, Andreas;
Thatikonda, Santosh Kumar;
Jaisinghani, Ruchika;
Ren, Suping;
Kinkade, April;
Stevens, Sarah K.;
Stoycheva, Antitsa;
Rajwanshi, Vivek K.;
Williams, Caroline;
Deval, Jerome;
Mukherjee, Sucheta;
Zhang, Qingling;
Chanda, Sushmita;
Smith, David B.;
Blatt, Lawrence M.;
Symons, Julian A.;
Gonzalvez, Francois;
Beigelman, Leonid

Publication type:

Article

5',5'-Phosphodiesters and esterase labile triesters of 2'-C-methylribonucleosides.

Published in:

ARKIVOC: Online Journal of Organic Chemistry, 2012, p. 226

By:

Leisvuori, Anna;
Ahmed, Zafar;
Ora, Mikko;
Blatt, Lawrence;
Beigelman, Leonid;
Lönnberg, Harri

Publication type:

Article

Synthesis of 3′,5′-Cyclic Phosphate and Thiophosphate Esters of 2′- C-Methyl Ribonucleosides.

Published in:

Helvetica Chimica Acta, 2012, v. 95, n. 9, p. 1512, doi. 10.1002/hlca.201200099

By:

Leisvuori, Anna;
Ahmed, Zafar;
Ora, Mikko;
Beigelman, Leonid;
Blatt, Lawrence;
Lönnberg, Harri

Publication type:

Article

1‐Deazaadenosine: synthesis and activity of base‐modified hammerhead ribozymes.

Published in:

Nucleic Acids Research, 1998, v. 26, n. 4, p. 1010, doi. 10.1093/nar/26.4.1010

By:

Seela, Frank;
Debelak, Harald;
Usman, Nassim;
Burgin, Alex;
Beigelman, Leonid

Publication type:

Article

Base and Sugar Requirements for RNA Cleavage of Essential Nucleoside Residues in Internal Loop B of the Hairpin Ribozyme: Implications for Secondary Structure.

Published in:

Nucleic Acids Research, 1996, v. 24, n. 4, p. 573, doi. 10.1093/nar/24.4.573

By:

Schmidt, Sabine;
Beigelman, Leonid;
Karpeisky, Alexander;
Usman, Nassim;
Sørensen, Ulrik S.;
Gait, Michael J.

Publication type:

Article

A Comparative Study on the Cleavage of Stereoisomeric Uridylyl (3',5')Uridines [D,D-, D,L- and L,D-UPU] by Acid, Base and Metal Ion Catalysts.

Published in:

Origins of Life & Evolution of the Biosphere, 2002, v. 32, n. 4, p. 303, doi. 10.1023/A:1020515212130

By:

Mikkola, Satu;
Mikhailov, Sergey;
Efimtseva, Ekaterina;
Neuvonen, Kari;
Oivanen, Mikko;
Beigelman, Leonid;
Lönnberg, Harri

Publication type:

Article