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Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity.
Published in:
2009
By:
- Beher, Dirk;
- Wu, John;
- Cumine, Suzanne;
- Ki Won Kim;
- Shu-Chen Lu;
- Atangan, Larissa;
- Minghan Wang
Publication type:
Letter
Current directions in tau research: Highlights from Tau 2020.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 5, p. 988, doi. 10.1002/alz.12452
By:
- Sexton, Claire;
- Snyder, Heather;
- Beher, Dirk;
- Boxer, Adam L.;
- Brannelly, Pat;
- Brion, Jean‐Pierre;
- Buée, Luc;
- Cacace, Angela M.;
- Chételat, Gaël;
- Citron, Martin;
- DeVos, Sarah L.;
- Diaz, Kristophe;
- Feldman, Howard H.;
- Frost, Bess;
- Goate, Alison M.;
- Gold, Michael;
- Hyman, Bradley;
- Johnson, Keith;
- Karch, Celeste M.;
- Kerwin, Diana R.
Publication type:
Article
O1‐12‐05: PHASE 1 STUDY IN HEALTHY VOLUNTEERS OF THE O‐GLCNACASE INHIBITOR ASN120290 AS A NOVEL THERAPY FOR PROGRESSIVE SUPRANUCLEAR PALSY AND RELATED TAUOPATHIES.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P251, doi. 10.1016/j.jalz.2018.06.2400
By:
- Ryan, J. Michael;
- Quattropani, Anna;
- Abd-Elaziz, Khalid;
- den Daas, Izaak;
- Schneider, Manfred;
- Ousson, Solenne;
- Neny, Maud;
- Sand, Astrid;
- Hantson, Jennifer;
- Permanne, Bruno;
- Wiessner, Christoph;
- Beher, Dirk
Publication type:
Article
Pharmacological intervention with the novel o-glcnacase inhibitor ASN-561 reduces pathological tau in transgenic mice.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P227, doi. 10.1016/j.jalz.2015.07.257
By:
- Permanne, Bruno;
- Quattropani, Anna;
- Hantson, Jennifer;
- Neny, Maud;
- Ousson, Solenne;
- Sand, Astrid;
- Wiessner, Christoph;
- Beher, Dirk
Publication type:
Article
Preclinical profiles of drug candidates promoting o-linked glycosylation of tau for the treatment of alzheimer's disease and tauopathies.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2014, v. 10, p. P148, doi. 10.1016/j.jalz.2014.04.110
By:
- Quattropani, Anna;
- Beher, Dirk;
- Nény, Maud;
- Ousson, Solenne;
- Hantson, Jennifer;
- Sand, Astrid;
- Permanne, Bruno;
- Wiessner, Christoph
Publication type:
Article
Characterization of endogenous and exogenous gamma-secretase activating protein (GSAP) expression in cells
Published in:
2011
By:
- Hussain, Ishrut;
- Fabrègue, Julien;
- Ousson, Solenne;
- Baguet, Aurelie;
- Genoud, Stephane;
- Borlat, Frederic;
- Antonsson, Bruno;
- Beher, Dirk
Publication type:
Abstract
Validation of the rat pharmacodynamic model for amyloid-beta peptide lowering agents
Published in:
2011
By:
- Permanne, Bruno;
- Beher, Dirk;
- Ousson, Solenne;
- Anderes, Laurence;
- Eligert, Valérie;
- Novo-Perez, Laurence;
- Smith, Paul;
- Quattropani, Anna;
- Hussain, Isruth
Publication type:
Abstract
P1-359: Identification of genes that regulate the processing of the β-amyloid precursor protein and are candidates for association with late-onset Alzheimer’s disease by a genome-wide siRNA screen
Published in:
2006
By:
- Stone, David;
- Majercak, John;
- Ray, Jim;
- Espeseth, Amy;
- Shi, Xiao-Ping;
- Simon, Adam;
- Marine, Shane;
- Stec, Erica;
- Ferrer, Marc;
- Bartz, Steven;
- Gates, Adam;
- Wolffe, Carrie;
- Shughrue, Paul;
- Burchard, Julja;
- Beher, Dirk;
- Rosahl, Thomas;
- Koblan, Ken;
- Strulovici, Berta;
- Hazuda, Daria;
- Shearman, Mark
Publication type:
Abstract
S2-03-02: Mechanistic differences in targeting γ-secretase with inhibitors
Published in:
2006
By:
- Beher, Dirk;
- Clarke, Earl E.;
- Wrigley, Jonathan D.J.;
- Churcher, Ian;
- Ellis, Semantha;
- Lewis, Huw D.;
- Harrison, Timothy;
- Shearman, Mark S.
Publication type:
Abstract
P1-359: Identification of genes that regulate the processing of the β-amyloid precursor protein and are candidates for association with late-onset Alzheimer’s disease by a genome-wide siRNA screen
Published in:
2006
By:
- Stone, David;
- Majercak, John;
- Ray, Jim;
- Espeseth, Amy;
- Shi, Xiao-Ping;
- Simon, Adam;
- Marine, Shane;
- Stec, Erica;
- Ferrer, Marc;
- Bartz, Steven;
- Gates, Adam;
- Wolffe, Carrie;
- Shughrue, Paul;
- Burchard, Julja;
- Beher, Dirk;
- Rosahl, Thomas;
- Koblan, Ken;
- Strulovici, Berta;
- Hazuda, Daria;
- Shearman, Mark
Publication type:
Abstract
S2-03-02: Mechanistic differences in targeting γ-secretase with inhibitors
Published in:
2006
By:
- Beher, Dirk;
- Clarke, Earl E.;
- Wrigley, Jonathan D.J.;
- Churcher, Ian;
- Ellis, Semantha;
- Lewis, Huw D.;
- Harrison, Timothy;
- Shearman, Mark S.
Publication type:
Abstract
Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production.
Published in:
Nature Communications, 2013, v. 4, n. 8, p. 2246, doi. 10.1038/ncomms3246
By:
- Dimitrov, Mitko;
- Alattia, Jean-René;
- Lemmin, Thomas;
- Lehal, Rajwinder;
- Fligier, Andrzej;
- Houacine, Jemila;
- Hussain, Ishrut;
- Radtke, Freddy;
- Dal Peraro, Matteo;
- Beher, Dirk;
- Fraering, Patrick C.
Publication type:
Article
Substrate determinants in the C99 juxtamembrane domains differentially affect γ-secretase cleavage specificity and modulator pharmacology.
Published in:
Journal of Neurochemistry, 2013, v. 125, n. 4, p. 610, doi. 10.1111/jnc.12129
By:
- Ousson, Solenne;
- Saric, Arman;
- Baguet, Aurelie;
- Losberger, Christophe;
- Genoud, Stephane;
- Vilbois, Francis;
- Permanne, Bruno;
- Hussain, Ishrut;
- Beher, Dirk
Publication type:
Article
The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.
Published in:
Acta Neuropathologica, 2019, v. 137, n. 2, p. 239, doi. 10.1007/s00401-018-1929-5
By:
- Walter, Susanne;
- Jumpertz, Thorsten;
- Hüttenrauch, Melanie;
- Ogorek, Isabella;
- Gerber, Hermeto;
- Storck, Steffen E.;
- Zampar, Silvia;
- Dimitrov, Mitko;
- Lehmann, Sandra;
- Lepka, Klaudia;
- Berndt, Carsten;
- Wiltfang, Jens;
- Becker-Pauly, Christoph;
- Beher, Dirk;
- Pietrzik, Claus U.;
- Fraering, Patrick C.;
- Wirths, Oliver;
- Weggen, Sascha
Publication type:
Article
Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400.
Published in:
FEBS Letters, 2013, v. 587, n. 22, p. 3722, doi. 10.1016/j.febslet.2013.09.042
By:
- Cameron, Andrew;
- Giacomozzi, Brandy;
- Joyce, John;
- Gray, Audrey;
- Graham, Danielle;
- Ousson, Solenne;
- Neny, Maud;
- Beher, Dirk;
- Carlson, George;
- O’Moore, Jill;
- Shearman, Mark;
- Hering, Heike
Publication type:
Article
Novel non-carbohydrate O-GlcNAcase inhibitors with CNS drug properties as potential treatment for Alzheimer's disease and tauopathies.
Published in:
2013
By:
- Hering, Heike;
- Graham, Danielle;
- Ousson, Solenne;
- Neny, Maud;
- Gray, Audrey;
- Giacomozzi, Brandy;
- Joyce, John;
- Dutt, Vikram;
- Busch, Michael;
- Cameron, Andrew;
- Liu-Bujalski, Leslie;
- Henry Yu;
- Hui Tian;
- Shearman, Mark;
- Quattropani, Anna;
- Permanne, Bruno;
- Wiessner, Christoph;
- Beher, Dirk
Publication type:
Abstract
C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation.
Published in:
Journal of Neurochemistry, 2006, v. 96, n. 1, p. 218, doi. 10.1111/j.1471-4159.2005.03548.x
By:
- Wang, Jun;
- Beher, Dirk;
- Nyborg, Andrew C.;
- Shearman, Mark S.;
- Golde, Todd E.;
- Goate, Alison
Publication type:
Article
Conserved residues within the putative active site of γ-secretase differentially influence enzyme activity and inhibitor binding.
Published in:
Journal of Neurochemistry, 2004, v. 90, n. 6, p. 1312, doi. 10.1111/j.1471-4159.2004.02596.x
By:
- Wrigley, Jonathan D. J.;
- Nunn, Emma J.;
- Nyabi, Omar;
- Clarke, Earl E.;
- Hunt, Peter;
- Nadin, Alan;
- De Strooper, Bart;
- Shearman, Mark S.;
- Dirk Beher
Publication type:
Article
Proteolytic Fragments of Alzheimer’s Disease-Associated Presenilin 1 Are Present in Synaptic Organelles and Growth Cone Membranes of Rat Brain.
Published in:
Journal of Neurochemistry, 1999, v. 72, n. 4, p. 1564, doi. 10.1046/j.1471-4159.1999.721564.x
By:
- Beher, Dirk;
- Elle, Christine;
- Underwood, John;
- Davis, John B.;
- Ward, Robin;
- Karran, Eric;
- Masters, Colin L.;
- Beyreuther, Konrad;
- Multhaup, Gerd
Publication type:
Article

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