Works by Beckmann, Roland

Results: 81

Assembly and the gating mechanism of the Pel exopolysaccharide export complex PelBC of Pseudomonas aeruginosa.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60605-8

By:

Benedens, Marius;
Rosales-Hernandez, Cristian;
Straathof, Sabine A. P.;
Loschwitz, Jennifer;
Berninghausen, Otto;
Maglia, Giovanni;
Beckmann, Roland;
Kedrov, Alexej

Publication type:

Article

Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 10, p. 767, doi. 10.1038/nsmb.3086

By:

Beckert, Bertrand;
Kedrov, Alexej;
Sohmen, Daniel;
Kempf, Georg;
Wild, Klemens;
Sinning, Irmgard;
Stahlberg, Henning;
Wilson, Daniel N;
Beckmann, Roland

Publication type:

Article

Structural characterization of a eukaryotic chaperone-the ribosome-associated complex.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 1, p. 23, doi. 10.1038/nsmb.2447

By:

Leidig, Christoph;
Bange, Gert;
Kopp, Jürgen;
Amlacher, Stefan;
Aravind, Ajay;
Wickles, Stephan;
Witte, Gregor;
Hurt, Ed;
Beckmann, Roland;
Sinning, Irmgard

Publication type:

Article

Structure of the pre-60S ribosomal subunit with nuclear export factor Arx1 bound at the exit tunnel.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 12, p. 1234, doi. 10.1038/nsmb.2438

By:

Bradatsch, Bettina;
Leidig, Christoph;
Granneman, Sander;
Gnädig, Marén;
Tollervey, David;
Böttcher, Bettina;
Beckmann, Roland;
Hurt, Ed

Publication type:

Article

Structure of the no-go mRNA decay complex Dom34-Hbs1 bound to a stalled 80S ribosome.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 6, p. 715, doi. 10.1038/nsmb.2057

By:

Becker, Thomas;
Armache, Jean-Paul;
Jarasch, Alexander;
Anger, Andreas M.;
Villa, Elizabeth;
Sieber, Heidemarie;
Motaal, Basma Abdel;
Mielke, Thorsten;
Berninghausen, Otto;
Beckmann, Roland

Publication type:

Article

Cryo-EM structure of the ribosome-SecYE complex in the membrane environment.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 5, p. 614, doi. 10.1038/nsmb.2026

By:

Frauenfeld, Jens;
Gumbart, James;
Sluis, Eli O van der;
Funes, Soledad;
Gartmann, Marco;
Beatrix, Birgitta;
Mielke, Thorsten;
Berninghausen, Otto;
Becker, Thomas;
Schulten, Klaus;
Beckmann, Roland

Publication type:

Article

α-Helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnel.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 3, p. 313, doi. 10.1038/nsmb.1756

By:

Bhushan, Shashi;
Gartmann, Marco;
Halic, Mario;
Armache, Jean-Paul;
Jarasch, Alexander;
Mielke, Thorsten;
Berninghausen, Otto;
Wilson, Daniel N.;
Beckmann, Roland

Publication type:

Article

ERj1p uses a universal ribosomal adaptor site to coordinate the 80S ribosome at the membrane.

Published in:

Nature Structural & Molecular Biology, 2005, v. 12, n. 11, p. 1015, doi. 10.1038/nsmb998

By:

Blau, Michael;
Mullapudi, Srinivas;
Becker, Thomas;
Dudek, Johanna;
Zimmermann, Richard;
Penczek, Pawel A;
Beckmann, Roland

Publication type:

Article

Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes.

Published in:

PLoS Biology, 2020, v. 18, n. 7, p. 1, doi. 10.1371/journal.pbio.3000780

By:

Wells, Jennifer N.;
Buschauer, Robert;
Mackens-Kiani, Timur;
Best, Katharina;
Kratzat, Hanna;
Berninghausen, Otto;
Becker, Thomas;
Gilbert, Wendy;
Cheng, Jingdong;
Beckmann, Roland

Publication type:

Article

A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation.

Published in:

Journal of Cell Biology, 2014, v. 207, n. 4, p. 481, doi. 10.1083/jcb.201408111

By:

Baßler, Jochen;
Paternoga, Helge;
Holdermann, Iris;
Thoms, Matthias;
Granneman, Sander;
Barrio-Garcia, Clara;
Nyarko, Afua;
Stier, Gunter;
Clark, Sarah A.;
Schraivogel, Daniel;
Kallas, Martina;
Beckmann, Roland;
Tollervey, David;
Barbar, Elisar;
Sinning, Irmi;
Hurt, Ed

Publication type:

Article

Modulating co-translational protein folding by rational design and ribosome engineering.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-31906-z

By:

Ahn, Minkoo;
Włodarski, Tomasz;
Mitropoulou, Alkistis;
Chan, Sammy H. S.;
Sidhu, Haneesh;
Plessa, Elena;
Becker, Thomas A.;
Budisa, Nediljko;
Waudby, Christopher A.;
Beckmann, Roland;
Cassaignau, Anaïs M. E.;
Cabrita, Lisa D.;
Christodoulou, John

Publication type:

Article

Inhibition of SRP-dependent protein secretion by the bacterial alarmone (p)ppGpp.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28675-0

By:

Czech, Laura;
Mais, Christopher-Nils;
Kratzat, Hanna;
Sarmah, Pinku;
Giammarinaro, Pietro;
Freibert, Sven-Andreas;
Esser, Hanna Folke;
Musial, Joanna;
Berninghausen, Otto;
Steinchen, Wieland;
Beckmann, Roland;
Koch, Hans-Georg;
Bange, Gert

Publication type:

Article

A distinct assembly pathway of the human 39S late pre-mitoribosome.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-24818-x

By:

Cheng, Jingdong;
Berninghausen, Otto;
Beckmann, Roland

Publication type:

Article

B. subtilis MutS2 splits stalled ribosomes into subunits without mRNA cleavage.

Published in:

EMBO Journal, 2024, v. 43, n. 4, p. 484, doi. 10.1038/s44318-023-00010-3

By:

Park, Esther N;
Mackens-Kiani, Timur;
Berhane, Rebekah;
Esser, Hanna;
Erdenebat, Chimeg;
Burroughs, A Maxwell;
Berninghausen, Otto;
Aravind, L;
Beckmann, Roland;
Green, Rachel;
Buskirk, Allen R

Publication type:

Article

The SARS‐unique domain (SUD) of SARS‐CoV and SARS‐CoV‐2 interacts with human Paip1 to enhance viral RNA translation.

Published in:

EMBO Journal, 2021, v. 40, n. 11, p. 1, doi. 10.15252/embj.2019102277

By:

Lei, Jian;
Ma‐Lauer, Yue;
Han, Yinze;
Thoms, Matthias;
Buschauer, Robert;
Jores, Joerg;
Thiel, Volker;
Beckmann, Roland;
Deng, Wen;
Leonhardt, Heinrich;
Hilgenfeld, Rolf;
von Brunn, Albrecht

Publication type:

Article

Architecture of the active post‐translational Sec translocon.

Published in:

EMBO Journal, 2021, v. 40, n. 3, p. 1, doi. 10.15252/embj.2020105643

By:

Weng, Tsai‐Hsuan;
Steinchen, Wieland;
Beatrix, Birgitta;
Berninghausen, Otto;
Becker, Thomas;
Bange, Gert;
Cheng, Jingdong;
Beckmann, Roland

Publication type:

Article

A structural inventory of native ribosomal ABCE1‐43S pre‐initiation complexes.

Published in:

EMBO Journal, 2021, v. 40, n. 1, p. 1, doi. 10.15252/embj.2020105179

By:

Kratzat, Hanna;
Mackens‐Kiani, Timur;
Ameismeier, Michael;
Potocnjak, Mia;
Cheng, Jingdong;
Dacheux, Estelle;
Namane, Abdelkader;
Berninghausen, Otto;
Herzog, Franz;
Fromont‐Racine, Micheline;
Becker, Thomas;
Beckmann, Roland

Publication type:

Article

Molecular analysis of the ribosome recycling factor ABCE1 bound to the 30S post‐splitting complex.

Published in:

EMBO Journal, 2020, v. 39, n. 9, p. 1, doi. 10.15252/embj.2019103788

By:

Nürenberg‐Goloub, Elina;
Kratzat, Hanna;
Heinemann, Holger;
Heuer, André;
Kötter, Peter;
Berninghausen, Otto;
Becker, Thomas;
Tampé, Robert;
Beckmann, Roland

Publication type:

Article

Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts.

Published in:

EMBO Journal, 2020, v. 39, n. 3, p. N.PAG, doi. 10.15252/embj.2019103365

By:

Tesina, Petr;
Lessen, Laura N;
Buschauer, Robert;
Cheng, Jingdong;
Wu, Colin Chih‐Chien;
Berninghausen, Otto;
Buskirk, Allen R;
Becker, Thomas;
Beckmann, Roland;
Green, Rachel

Publication type:

Article

Collided ribosomes form a unique structural interface to induce Hel2‐driven quality control pathways.

Published in:

EMBO Journal, 2019, v. 38, n. 5, p. 1, doi. 10.15252/embj.2018100276

By:

Ikeuchi, Ken;
Tesina, Petr;
Matsuo, Yoshitaka;
Sugiyama, Takato;
Cheng, Jingdong;
Saeki, Yasushi;
Tanaka, Keiji;
Becker, Thomas;
Beckmann, Roland;
Inada, Toshifumi

Publication type:

Article

Structure of the Bacillus subtilis hibernating 100S ribosome reveals the basis for 70S dimerization.

Published in:

EMBO Journal, 2017, v. 36, n. 14, p. 2061, doi. 10.15252/embj.201696189

By:

Beckert, Bertrand;
Abdelshahid, Maha;
Schäfer, Heinrich;
Steinchen, Wieland;
Arenz, Stefan;
Berninghausen, Otto;
Beckmann, Roland;
Bange, Gert;
Turgay, Kürşad;
Wilson, Daniel N

Publication type:

Article

Localization and dynamic behavior of ribosomal protein L30e.

Published in:

Nature Structural & Molecular Biology, 2005, v. 12, n. 5, p. 467, doi. 10.1038/nsmb933

By:

Halic, Mario;
Becker, Thomas;
Frank, Joachim;
Spahn, Christian M. T.;
Beckmann, Roland

Publication type:

Article

SRP meets the ribosome.

Published in:

Nature Structural & Molecular Biology, 2004, v. 11, n. 11, p. 1049, doi. 10.1038/nsmb853

By:

Wild, Klemens;
Halic, Mario;
Sinning, Irmgard;
Beckmann, Roland

Publication type:

Article

The C-terminal regions of YidC from Rhodopirellula baltica and Oceanicaulis alexandrii bind to ribosomes and partially substitute for SRP receptor function in Escherichia coli.

Published in:

Molecular Microbiology, 2014, v. 91, n. 2, p. 408, doi. 10.1111/mmi.12465

By:

Seitl, Ines;
Wickles, Stephan;
Beckmann, Roland;
Kuhn, Andreas;
Kiefer, Dorothee

Publication type:

Article

Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2.

Published in:

Nature Communications, 2023, v. 14, p. 1, doi. 10.1038/s41467-023-38161-w

By:

Ikeuchi, Ken;
Ivic, Nives;
Buschauer, Robert;
Cheng, Jingdong;
Fröhlich, Thomas;
Matsuo, Yoshitaka;
Berninghausen, Otto;
Inada, Toshifumi;
Becker, Thomas;
Beckmann, Roland

Publication type:

Article

Structural basis for clearing of ribosome collisions by the RQT complex.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-36230-8

By:

Best, Katharina;
Ikeuchi, Ken;
Kater, Lukas;
Best, Daniel;
Musial, Joanna;
Matsuo, Yoshitaka;
Berninghausen, Otto;
Becker, Thomas;
Inada, Toshifumi;
Beckmann, Roland

Publication type:

Article

A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-34097-9

By:

Narita, Momoko;
Denk, Timo;
Matsuo, Yoshitaka;
Sugiyama, Takato;
Kikuguchi, Chisato;
Ito, Sota;
Sato, Nichika;
Suzuki, Toru;
Hashimoto, Satoshi;
Machová, Iva;
Tesina, Petr;
Beckmann, Roland;
Inada, Toshifumi

Publication type:

Article

Author Correction: Modulating co-translational protein folding by rational design and ribosome engineering.

Published in:

2022

By:

Ahn, Minkoo;
Włodarski, Tomasz;
Mitropoulou, Alkistis;
Chan, Sammy H. S.;
Sidhu, Haneesh;
Plessa, Elena;
Becker, Thomas A.;
Budisa, Nediljko;
Waudby, Christopher A.;
Beckmann, Roland;
Cassaignau, Anaïs M. E.;
Cabrita, Lisa D.;
Christodoulou, John

Publication type:

Correction Notice

Suppressor mutations in Rpf2-Rrs1 or Rpl5 bypass the Cgr1 function for pre-ribosomal 5S RNP-rotation.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06660-w

By:

Thoms, Matthias;
Mitterer, Valentin;
Kater, Lukas;
Falquet, Laurent;
Beckmann, Roland;
Kressler, Dieter;
Hurt, Ed

Publication type:

Article

Interdependent action of KH domain proteins Krr1 and Dim2 drive the 40S platform assembly.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-02199-4

By:

Sturm, Miriam;
Jingdong Cheng;
Baßler, Jochen;
Beckmann, Roland;
Hurt, Ed

Publication type:

Article

SAP domain forms a flexible part of DNA aperture in Ku70/80.

Published in:

FEBS Journal, 2021, v. 288, n. 14, p. 4382, doi. 10.1111/febs.15732

By:

Hnízda, Aleš;
Tesina, Petr;
Nguyen, Thanh‐Binh;
Kukačka, Zdeněk;
Kater, Lukas;
Chaplin, Amanda K.;
Beckmann, Roland;
Ascher, David B.;
Novák, Petr;
Blundell, Tom L.

Publication type:

Article

SecM-Stalled Ribosomes Adopt an Altered Geometry at the Peptidyl Transferase Center.

Published in:

PLoS Biology, 2011, v. 9, n. 1, p. 1, doi. 10.1371/journal.pbio.1000581

By:

Bhushan, Shashi;
Hoffmann, Thomas;
Seidelt, Birgit;
Frauenfeld, Jens;
Mielke, Thorsten;
Berninghausen, Otto;
Wilson, Daniel N.;
Beckmann, Roland

Publication type:

Article

Structural insights into coordinating 5S RNP rotation with ITS2 pre‐RNA processing during ribosome formation.

Published in:

EMBO Reports, 2023, v. 24, n. 12, p. 1, doi. 10.15252/embr.202357984

By:

Thoms, Matthias;
Lau, Benjamin;
Cheng, Jingdong;
Fromm, Lisa;
Denk, Timo;
Kellner, Nikola;
Flemming, Dirk;
Fischer, Paulina;
Falquet, Laurent;
Berninghausen, Otto;
Beckmann, Roland;
Hurt, Ed

Publication type:

Article

Mechanism of 5S RNP recruitment and helicase‐surveilled rRNA maturation during pre‐60S biogenesis.

Published in:

EMBO Reports, 2023, v. 24, n. 7, p. 1, doi. 10.15252/embr.202356910

By:

Lau, Benjamin;
Huang, Zixuan;
Kellner, Nikola;
Niu, Shuangshuang;
Berninghausen, Otto;
Beckmann, Roland;
Hurt, Ed;
Cheng, Jingdong

Publication type:

Article

Partially inserted nascent chain unzips the lateral gate of the Sec translocon.

Published in:

EMBO Reports, 2019, v. 20, n. 10, p. N.PAG, doi. 10.15252/embr.201948191

By:

Kater, Lukas;
Frieg, Benedikt;
Berninghausen, Otto;
Gohlke, Holger;
Beckmann, Roland;
Kedrov, Alexej

Publication type:

Article

DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-20949-3

By:

Beckmann, Roland;
Jensen, Kristian;
Fenn, Sebastian;
Speck, Janina;
Krause, Katrin;
Meier, Anastasia;
Röth, Melanie;
Fauser, Sascha;
Kimbung, Raymond;
Logan, Derek T.;
Steegmaier, Martin;
Kettenberger, Hubert

Publication type:

Article

Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation.

Published in:

EMBO Journal, 2004, v. 23, n. 5, p. 1008, doi. 10.1038/sj.emboj.7600102

By:

Christian M. T. Spahn, Stanley J.;
Gomez- Lorenzo, Maria G.;
Grassucci, Robert A.;
Rene Jørgensen, Robert A.;
Andersen, Gregers R.;
Beckmann, Roland;
Penczek, Pawel A.;
Ballesta, Juan P. G.;
Joachim Frank

Publication type:

Article

Response to Paoli.

Published in:

Nature Structural Biology, 2001, v. 8, n. 9, p. 745, doi. 10.1038/nsb0901-745

By:

Groft, Caroline M.;
Beckmann, Roland;
Sali, Andrej;
Burley, Stephen K.

Publication type:

Article

Crystal structures of ribosome anti-association factor IF6.

Published in:

Nature Structural Biology, 2000, v. 7, n. 12, p. 1156

By:

Groft, Caroline M.;
Beckmann, Roland;
Sali, Andrej;
Burley, Stephen K.

Publication type:

Article

H/ACA snR30 snoRNP guides independent 18S rRNA subdomain formation.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-59656-8

By:

Fischer, Paulina;
Thoms, Matthias;
Lau, Benjamin;
Denk, Timo;
Kuvshinova, Maria;
Berninghausen, Otto;
Flemming, Dirk;
Hurt, Ed;
Beckmann, Roland

Publication type:

Article

Sucrose sensing through nascent peptide-meditated ribosome stalling at the stop codon of Arabidopsis bZIP11 uORF2.

Published in:

FEBS Letters, 2017, v. 591, n. 9, p. 1266, doi. 10.1002/1873-3468.12634

By:

Yamashita, Yui;
Takamatsu, Seidai;
Glasbrenner, Michael;
Becker, Thomas;
Naito, Satoshi;
Beckmann, Roland

Publication type:

Article

Small protein domains fold inside the ribosome exit tunnel.

Published in:

FEBS Letters, 2016, v. 590, n. 5, p. 655, doi. 10.1002/1873-3468.12098

By:

Marino, Jacopo;
Heijne, Gunnar;
Beckmann, Roland

Publication type:

Article

Structure of the signal recognition particle interacting with the elongation-arrested ribosome.

Published in:

2004

By:

Halic, Mario;
Becker, Thomas;
Pool, Martin R.;
Spahn, Christian M.T.;
Grassucci, Robert A.;
Frank, Joachim;
Beckmann, Roland

Publication type:

Letter

Concurrent remodelling of nucleolar 60S subunit precursors by the Real ATPase and Spb4 RNA helicase.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.84877

By:

Mitterer, Valentin;
Thorns, Matthias;
Buschauer, Robert;
Berninghausen, Otto;
Hurt, Ed;
Beckmann, Roland

Publication type:

Article

Highly conserved ribosome biogenesis pathways between human and yeast revealed by the MDN1-NLE1 interaction and NLE1 containing pre-60S subunits Open Access.

Published in:

Nucleic Acids Research, 2025, v. 53, n. 7, p. 1, doi. 10.1093/nar/gkaf255

By:

Fiorentino, Federica;
Thoms, Matthias;
Wild, Klemens;
Denk, Timo;
Cheng, Jingdong;
Zeman, Jakub;
Sinning, Irmgard;
Hurt, Ed;
Beckmann, Roland

Publication type:

Article

The ribosome as a platform to coordinate mRNA decay.

Published in:

2025

By:

Müller, Martin B D;
Becker, Thomas;
Denk, Timo;
Hashimoto, Satoshi;
Inada, Toshifumi;
Beckmann, Roland

Publication type:

Literature Review

Two modes of Cue2-mediated mRNA cleavage with distinct substrate recognition initiate no-go decay.

Published in:

Nucleic Acids Research, 2023, v. 51, n. 1, p. 253, doi. 10.1093/nar/gkac1172

By:

Tomomatsu, Shota;
Watanabe, Atsuya;
Tesina, Petr;
Hashimoto, Satoshi;
Ikeuchi, Ken;
Li, Sihan;
Matsuo, Yoshitaka;
Beckmann, Roland;
Inada, Toshifumi

Publication type:

Article

nucleoplasmic phase of pre-40S formation prior to nuclear export.

Published in:

Nucleic Acids Research, 2022, v. 50, n. 20, p. 11924, doi. 10.1093/nar/gkac961

By:

Cheng, Jingdong;
Lau, Benjamin;
Thoms, Matthias;
Ameismeier, Michael;
Berninghausen, Otto;
Hurt, Ed;
Beckmann, Roland

Publication type:

Article

In vitro structural maturation of an early stage pre-40S particle coupled with U3 snoRNA release and central pseudoknot formation.

Published in:

Nucleic Acids Research, 2022, v. 50, n. 20, p. 11916, doi. 10.1093/nar/gkac910

By:

Cheng, Jingdong;
La Venuta, Giuseppe;
Lau, Benjamin;
Berninghausen, Otto;
Beckmann, Roland;
Hurt, Ed

Publication type:

Article

Structural basis of l-tryptophan-dependent inhibition of release factor 2 by the TnaC arrest peptide.

Published in:

Nucleic Acids Research, 2021, v. 49, n. 16, p. 9539, doi. 10.1093/nar/gkab665

By:

Su, Ting;
Kudva, Renuka;
Becker, Thomas;
Buschauer, Robert;
Komar, Tobias;
Berninghausen, Otto;
von Heijne, Gunnar;
Cheng, Jingdong;
Beckmann, Roland

Publication type:

Article