Works by Beavis, Paul A.

Results: 27

Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00728-9

By:

Dushyanthen, Sathana;
Zhi Ling Teo;
Caramia, Franco;
Savas, Peter;
Mintoff, Christopher P.;
Virassamy, Balaji;
Henderson, Melissa A.;
Luen, Stephen J.;
Mansour, Mariam;
Kershaw, Michael H.;
Trapani, Joseph A.;
Neeson, Paul J.;
Salgado, Roberto;
McArthur, Grant A.;
Balko, Justin M.;
Beavis, Paul A.;
Darcy, Phillip K.;
Loi, Sherene

Publication type:

Article

PTPN2 phosphatase deletion in T cells promotes anti‐tumour immunity and CAR T‐cell efficacy in solid tumours.

Published in:

EMBO Journal, 2020, v. 39, n. 2, p. N.PAG, doi. 10.15252/embj.2019103637

By:

Wiede, Florian;
Lu, Kun‐Hui;
Du, Xin;
Liang, Shuwei;
Hochheiser, Katharina;
Dodd, Garron T;
Goh, Pei K;
Kearney, Conor;
Meyran, Deborah;
Beavis, Paul A;
Henderson, Melissa A;
Park, Simone L;
Waithman, Jason;
Zhang, Sheng;
Zhang, Zhong‐Yin;
Oliaro, Jane;
Gebhardt, Thomas;
Darcy, Phillip K;
Tiganis, Tony

Publication type:

Article

Tumor‐derived exosomes modulate T cell function through transfer of RNA.

Published in:

FEBS Journal, 2018, v. 285, n. 6, p. 1030, doi. 10.1111/febs.14413

By:

House, Imran G.;
Petley, Emma V.;
Beavis, Paul A.

Publication type:

Article

Distinct modulation of IFNγ-induced transcription by BET bromodomain and catalytic P300/CBP inhibition in breast cancer.

Published in:

Clinical Epigenetics, 2022, v. 14, n. 1, p. 1, doi. 10.1186/s13148-022-01316-5

By:

Hogg, Simon J.;
Motorna, Olga;
Kearney, Conor J.;
Derrick, Emily B.;
House, Imran G.;
Todorovski, Izabela;
Kelly, Madison J.;
Zethoven, Magnus;
Bromberg, Kenneth D.;
Lai, Albert;
Beavis, Paul A.;
Shortt, Jake;
Johnstone, Ricky W.;
Vervoort, Stephin J.

Publication type:

Article

Distinct modulation of IFNγ-induced transcription by BET bromodomain and catalytic P300/CBP inhibition in breast cancer.

Published in:

Clinical Epigenetics, 2022, v. 14, n. 1, p. 1, doi. 10.1186/s13148-022-01316-5

By:

Hogg, Simon J.;
Motorna, Olga;
Kearney, Conor J.;
Derrick, Emily B.;
House, Imran G.;
Todorovski, Izabela;
Kelly, Madison J.;
Zethoven, Magnus;
Bromberg, Kenneth D.;
Lai, Albert;
Beavis, Paul A.;
Shortt, Jake;
Johnstone, Ricky W.;
Vervoort, Stephin J.

Publication type:

Article

Supercharging adoptive T cell therapy to overcome solid tumor–induced immunosuppression.

Published in:

Science Translational Medicine, 2019, v. 11, n. 495, p. N.PAG, doi. 10.1126/scitranslmed.aaw2293

By:

Mardiana, Sherly;
Solomon, Benjamin J.;
Darcy, Phillip K.;
Beavis, Paul A.

Publication type:

Article

Tumor immune evasion arises through loss of TNF sensitivity.

Published in:

Science Immunology, 2018, v. 3, n. 23, p. 1, doi. 10.1126/sciimmunol.aar3451

By:

Kearney, Conor J.;
Vervoort, Stephin J.;
Hogg, Simon J.;
Ramsbottom, Kelly M.;
Freeman, Andrew J.;
Lalaoui, Najoua;
Pijpers, Lizzy;
Michie, Jessica;
Brown, Kristin K.;
Knight, Deborah A.;
Sutton, Vivien;
Beavis, Paul A.;
Voskoboinik, Ilia;
Darcy, Phil K.;
Silke, John;
Trapani, Joseph A.;
Johnstone, Ricky W.;
Oliaro, Jane

Publication type:

Article

A scalable, spin‐free approach to generate enhanced induced pluripotent stem cell–derived natural killer cells for cancer immunotherapy.

Published in:

Immunology & Cell Biology, 2024, v. 102, n. 10, p. 924, doi. 10.1111/imcb.12820

By:

Rossi, Gustavo R;
Sun, Jane;
Lin, Cheng‐Yu;
Wong, Joshua KM;
Alim, Louisa;
Lam, Pui Yeng;
Khosrotehrani, Kiarash;
Wolvetang, Ernst;
Cheetham, Seth W;
Derrick, Emily B;
Amoako, Akwasi;
Lehner, Christoph;
Brooks, Andrew J;
Beavis, Paul A;
Souza‐Fonseca‐Guimaraes, Fernando

Publication type:

Article

CD4<sup>+</sup> chimeric antigen receptor T cells in for the long journey.

Published in:

Immunology & Cell Biology, 2022, v. 100, n. 5, p. 304, doi. 10.1111/imcb.12545

By:

Chen, Amanda XY;
Derrick, Emily B;
Beavis, Paul A;
House, Imran G

Publication type:

Article

A novel combination strategy for effectively targeting cancer stem-like cells.

Published in:

Immunology & Cell Biology, 2017, v. 95, n. 7, p. 573, doi. 10.1038/icb.2017.39

By:

Beavis, Paul A;
Petley, Emma V;
Darcy, Phillip K

Publication type:

Article

Differential location of NKT and MAIT cells within lymphoid tissue.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-07704-4

By:

Johnson, Darryl N.;
Ruan, Zheng;
Petley, Emma V.;
Devi, Sapna;
Holz, Lauren E.;
Uldrich, Adam P.;
Mak, Jeffrey Y. W.;
Hor, Jyh Liang;
Mueller, Scott N.;
McCluskey, James;
Fairlie, David P.;
Darcy, Phillip K.;
Beavis, Paul A.;
Heath, William R.;
Godfrey, Dale I.

Publication type:

Article

Activation of p38 mitogen-activated protein kinase is critical step for acquisition of effector function in cytokine-activated T cells, but acts as a negative regulator in T cells activated through the T-cell receptor.

Published in:

Immunology, 2011, v. 132, n. 1, p. 104, doi. 10.1111/j.1365-2567.2010.03345.x

By:

Li, Ching;
Beavis, Paul;
Palfreeman, Andrew C.;
Amjadi, Parisa;
Kennedy, Alan;
Brennan, Fionula M.

Publication type:

Article

Targeting Adenosine Receptor Signaling in Cancer Immunotherapy.

Published in:

International Journal of Molecular Sciences, 2018, v. 19, n. 12, p. 3837, doi. 10.3390/ijms19123837

By:

Sek, Kevin;
Mølck, Christina;
Stewart, Gregory D.;
Kats, Lev;
Darcy, Phillip K.;
Beavis, Paul A.

Publication type:

Article

A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands.

Published in:

British Journal of Pharmacology, 2014, v. 171, n. 14, p. 3364, doi. 10.1111/bph.12683

By:

Swinney, David C;
Beavis, Paul;
Chuang, Kai ‐ Ting;
Zheng, Yue;
Lee, Ina;
Gee, Peter;
Deval, Jerome;
Rotstein, David M;
Dioszegi, Marianna;
Ravendran, Palani;
Zhang, Jun;
Sankuratri, Surya;
Kondru, Rama;
Vauquelin, Georges

Publication type:

Article

Pharmacologic inhibition of dipeptidyl peptidase 1 (cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cells.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1396710

By:

Sutton, Vivien R.;
Watt, Sally V.;
Akhlaghi, Hedieh;
Cipolla, David C.;
Kuan-Ju Chen;
LaSala, Daniel;
McDonald, Patrick P.;
Beavis, Paul A.;
Munoz, Isabelle;
Hodel, Adrian W.;
Noori, Tahereh;
Voskoboinik, Ilia;
Trapani, Joseph A.

Publication type:

Article

Tissue‐specific tumor microenvironments influence responses to immunotherapies.

Published in:

Clinical & Translational Immunology, 2019, v. 8, n. 11, p. 1, doi. 10.1002/cti2.1094

By:

Oliver, Amanda J;
Davey, Ashleigh S;
Keam, Simon P;
Mardiana, Sherly;
Chan, Jack D;
Scheidt, Bianca;
Beavis, Paul A;
House, Imran G;
Van Audernaerde, Jonas RM;
Darcy, Phillip K;
Kershaw, Michael H;
Slaney, Clare Y

Publication type:

Article

CAR T cells take centre stage.

Published in:

Clinical & Translational Immunology, 2019, v. 8, n. 7, p. N.PAG, doi. 10.1002/cti2.1068

By:

Beavis, Paul A;
Darcy, Phillip K

Publication type:

Article

Switching on the green light for chimeric antigen receptor T‐cell therapy.

Published in:

Clinical & Translational Immunology, 2019, v. 8, n. 5, p. N.PAG, doi. 10.1002/cti2.1046

By:

Mardiana, Sherly;
Lai, Junyun;
House, Imran Geoffrey;
Beavis, Paul Andrew;
Darcy, Phillip Kevin

Publication type:

Article

PD-1 and LAG-3 Checkpoint Blockade: Potential Avenues for Therapy in B-Cell Lymphoma.

Published in:

Cells (2073-4409), 2021, v. 10, n. 5, p. 1152, doi. 10.3390/cells10051152

By:

Tobin, Joshua W. D.;
Bednarska, Karolina;
Campbell, Ashlea;
Keane, Colm;
Beavis, Paul A.;
Guimaraes, Fernando S. F.;
House, Imran;
Lai, Junyun;
Guillerey, Camille

Publication type:

Article

Tissues and Tumor Microenvironment (TME) in 3D: Models to Shed Light on Immunosuppression in Cancer.

Published in:

Cells (2073-4409), 2021, v. 10, n. 4, p. 831, doi. 10.3390/cells10040831

By:

Ho, Teresa;
Msallam, Rasha;
Beavis, Paul A.

Publication type:

Article

The Role of Cytokines and Chemokines in Shaping the Immune Microenvironment of Glioblastoma: Implications for Immunotherapy.

Published in:

Cells (2073-4409), 2021, v. 10, n. 3, p. 607, doi. 10.3390/cells10030607

By:

Yeo, Erica C. F.;
Brown, Michael P.;
Gargett, Tessa;
Ebert, Lisa M.;
Beavis, Paul A.;
Guimaraes, Fernando S. F.;
House, Imran;
Lai, Junyun;
Guillerey, Camille

Publication type:

Article

Targeting Myeloid-Derived Suppressor Cells in Ovarian Cancer.

Published in:

Cells (2073-4409), 2021, v. 10, n. 2, p. 329, doi. 10.3390/cells10020329

By:

Mabuchi, Seiji;
Sasano, Tomoyuki;
Komura, Naoko;
Beavis, Paul A.;
Guimaraes, Fernando S. F.;
House, Imran;
Lai, Junyun;
Guillerey, Camille

Publication type:

Article

CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23331-5

By:

Giuffrida, Lauren;
Sek, Kevin;
Henderson, Melissa A.;
Lai, Junyun;
Chen, Amanda X. Y.;
Meyran, Deborah;
Todd, Kirsten L.;
Petley, Emma V.;
Mardiana, Sherly;
Mølck, Christina;
Stewart, Gregory D.;
Solomon, Benjamin J.;
Parish, Ian A.;
Neeson, Paul J.;
Harrison, Simon J.;
Kats, Lev M.;
House, Imran G.;
Darcy, Phillip K.;
Beavis, Paul A.

Publication type:

Article

Relevance of tumor-infiltrating lymphocytes in breast cancer.

Published in:

BMC Medicine, 2015, v. 13, n. 1, p. 1, doi. 10.1186/s12916-015-0431-3

By:

Dushyanthen, Sathana;
Beavis, Paul A.;
Savas, Peter;
Zhi Ling Teo;
Chenhao Zhou;
Mansour, Mariam;
Darcy, Phillip K.;
Loi, Sherene

Publication type:

Article

Relevance of tumor-infiltrating lymphocytes in breast cancer.

Published in:

BMC Medicine, 2015, v. 13, n. 1, p. 202, doi. 10.1186/s12916-015-0431-3

By:

Dushyanthen, Sathana;
Beavis, Paul A.;
Savas, Peter;
Zhi Ling Teo;
Chenhao Zhou;
Mansour, Mariam;
Darcy, Phillip K.;
Loi, Sherene

Publication type:

Article

Relevance of tumor-infiltrating lymphocytes in breast cancer.

Published in:

2015

By:

Dushyanthen, Sathana;
Beavis, Paul A;
Savas, Peter;
Teo, Zhi Ling;
Zhou, Chenhao;
Mansour, Mariam;
Darcy, Phillip K;
Loi, Sherene

Publication type:

journal article

Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy.

Published in:

2017

By:

Beavis, Paul A.;
Henderson, Melissa A.;
Giuffrida, Lauren;
Mills, Jane K.;
Sek, Kevin;
Cross, Ryan S.;
Davenport, Alexander J.;
John, Liza B.;
Mardiana, Sherly;
Slaney, Clare Y.;
Johnstone, Ricky W.;
Trapani, Joseph A.;
Stagg, John;
Loi, Sherene;
Kats, Lev;
Gyorki, David;
Kershaw, Michael H.;
Darcy, Phillip K.

Publication type:

journal article